TISIDB

Summary
Symbol	PACSIN2
Name	protein kinase C and casein kinase substrate in neurons 2
Aliases	SDPII; syndapin II; cytoplasmic phosphoprotein PACSIN2; syndapin 2; syndapin-2; syndapin-II; syndapin2; Prot ......
Chromosomal Location	22q13.2-q13.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Cytoplasm Cytoplasm, cytoskeleton Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome. Recycling endosome membrane. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection Membrane, caveola. Note=Detected at the neck of flask-shaped caveolae. Localization to tubular recycling endosomes probably requires interaction with MICALL1 and EHD1.
Domain	PF00611 Fes/CIP4 PF00018 SH3 domain
Function	Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. May also play a role in the formation of caveolae at the cell membrane. Recruits DNM2 to caveolae, and thereby plays a role in caveola-mediated endocytosis.

> Gene Ontology [ TOP ]
Biological Process	GO:0001765 membrane raft assembly GO:0007009 plasma membrane organization GO:0030100 regulation of endocytosis GO:0031579 membrane raft organization GO:0036010 protein localization to endosome GO:0044091 membrane biogenesis GO:0044854 plasma membrane raft assembly GO:0044857 plasma membrane raft organization GO:0045806 negative regulation of endocytosis GO:0051051 negative regulation of transport GO:0060627 regulation of vesicle-mediated transport GO:0070836 caveola assembly GO:0071709 membrane assembly GO:0072584 caveolin-mediated endocytosis GO:0072665 protein localization to vacuole GO:0097320 membrane tubulation
Molecular Function	GO:0043168 anion binding GO:0045296 cadherin binding GO:0050839 cell adhesion molecule binding GO:0070300 phosphatidic acid binding GO:0098631 protein binding involved in cell adhesion GO:0098632 protein binding involved in cell-cell adhesion GO:0098641 cadherin binding involved in cell-cell adhesion
Cellular Component	GO:0001726 ruffle GO:0005769 early endosome GO:0005901 caveola GO:0005913 cell-cell adherens junction GO:0005924 cell-substrate adherens junction GO:0005925 focal adhesion GO:0010008 endosome membrane GO:0019898 extrinsic component of membrane GO:0030055 cell-substrate junction GO:0030659 cytoplasmic vesicle membrane GO:0031252 cell leading edge GO:0031253 cell projection membrane GO:0031256 leading edge membrane GO:0032587 ruffle membrane GO:0044440 endosomal part GO:0044853 plasma membrane raft GO:0045121 membrane raft GO:0055037 recycling endosome GO:0055038 recycling endosome membrane GO:0098589 membrane region GO:0098857 membrane microdomain

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-8856828: Clathrin-mediated endocytosis R-HSA-199991: Membrane Trafficking R-HSA-5653656: Vesicle-mediated transport

Summary
Symbol	PACSIN2
Name	protein kinase C and casein kinase substrate in neurons 2
Aliases	SDPII; syndapin II; cytoplasmic phosphoprotein PACSIN2; syndapin 2; syndapin-2; syndapin-II; syndapin2; Prot ......
Chromosomal Location	22q13.2-q13.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between PACSIN2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	PACSIN2
Name	protein kinase C and casein kinase substrate in neurons 2
Aliases	SDPII; syndapin II; cytoplasmic phosphoprotein PACSIN2; syndapin 2; syndapin-2; syndapin-II; syndapin2; Prot ......
Chromosomal Location	22q13.2-q13.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of PACSIN2 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	PACSIN2
Name	protein kinase C and casein kinase substrate in neurons 2
Aliases	SDPII; syndapin II; cytoplasmic phosphoprotein PACSIN2; syndapin 2; syndapin-2; syndapin-II; syndapin2; Prot ......
Chromosomal Location	22q13.2-q13.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the expression difference of PACSIN2 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0.24	0.426
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	0.398	0.884
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	0.124	0.951
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.044	0.901
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-0.256	0.903
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.422	0.874
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.295	0.506
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	0.377	0.853
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0.229	0.919
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.371	0.812
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0.91	0.694
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.099	0.0948

> Mutation difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the mutation difference of PACSIN2 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	11.1	0	11.1	0.0181
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	11.1	0	11.1	0.0286
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	4.8	0	4.8	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	7.7	0	7.7	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	11.1	6.2	4.9	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	11.1	-11.1	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	25	0	25	0.364
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	0	0	0	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	PACSIN2
Name	protein kinase C and casein kinase substrate in neurons 2
Aliases	SDPII; syndapin II; cytoplasmic phosphoprotein PACSIN2; syndapin 2; syndapin-2; syndapin-II; syndapin2; Prot ......
Chromosomal Location	22q13.2-q13.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PACSIN2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	PACSIN2
Name	protein kinase C and casein kinase substrate in neurons 2
Aliases	SDPII; syndapin II; cytoplasmic phosphoprotein PACSIN2; syndapin 2; syndapin-2; syndapin-II; syndapin2; Prot ......
Chromosomal Location	22q13.2-q13.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PACSIN2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PACSIN2. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	PACSIN2
Name	protein kinase C and casein kinase substrate in neurons 2
Aliases	SDPII; syndapin II; cytoplasmic phosphoprotein PACSIN2; syndapin 2; syndapin-2; syndapin-II; syndapin2; Prot ......
Chromosomal Location	22q13.2-q13.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PACSIN2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	PACSIN2
Name	protein kinase C and casein kinase substrate in neurons 2
Aliases	SDPII; syndapin II; cytoplasmic phosphoprotein PACSIN2; syndapin 2; syndapin-2; syndapin-II; syndapin2; Prot ......
Chromosomal Location	22q13.2-q13.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of PACSIN2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	PACSIN2
Name	protein kinase C and casein kinase substrate in neurons 2
Aliases	SDPII; syndapin II; cytoplasmic phosphoprotein PACSIN2; syndapin 2; syndapin-2; syndapin-II; syndapin2; Prot ......
Chromosomal Location	22q13.2-q13.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between PACSIN2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	PACSIN2
Name	protein kinase C and casein kinase substrate in neurons 2
Aliases	SDPII; syndapin II; cytoplasmic phosphoprotein PACSIN2; syndapin 2; syndapin-2; syndapin-II; syndapin2; Prot ......
Chromosomal Location	22q13.2-q13.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting PACSIN2 collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

Browse PACSIN2