TISIDB

Summary
Symbol	PAN3
Name	PAN3 poly(A) specific ribonuclease subunit
Aliases	PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae); PAB-dependent poly(A)-specific ribonucle ......
Chromosomal Location	13q12.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Cytoplasm, P-body
Domain	-
Function	Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins.

> Gene Ontology [ TOP ]
Biological Process	GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA GO:0000956 nuclear-transcribed mRNA catabolic process GO:0006397 mRNA processing GO:0006401 RNA catabolic process GO:0006402 mRNA catabolic process GO:0010603 regulation of cytoplasmic mRNA processing body assembly GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly GO:0019439 aromatic compound catabolic process GO:0022613 ribonucleoprotein complex biogenesis GO:0022618 ribonucleoprotein complex assembly GO:0033962 cytoplasmic mRNA processing body assembly GO:0034655 nucleobase-containing compound catabolic process GO:0044089 positive regulation of cellular component biogenesis GO:0044270 cellular nitrogen compound catabolic process GO:0046700 heterocycle catabolic process GO:0071826 ribonucleoprotein complex subunit organization GO:0090305 nucleic acid phosphodiester bond hydrolysis GO:0090501 RNA phosphodiester bond hydrolysis GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic GO:1901361 organic cyclic compound catabolic process GO:1902115 regulation of organelle assembly GO:1902117 positive regulation of organelle assembly
Molecular Function	GO:0000175 3'-5'-exoribonuclease activity GO:0004518 nuclease activity GO:0004527 exonuclease activity GO:0004532 exoribonuclease activity GO:0004535 poly(A)-specific ribonuclease activity GO:0004540 ribonuclease activity GO:0008408 3'-5' exonuclease activity GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters GO:0016896 exoribonuclease activity, producing 5'-phosphomonoesters
Cellular Component	GO:0000932 cytoplasmic mRNA processing body GO:0031251 PAN complex GO:0035770 ribonucleoprotein granule GO:0036464 cytoplasmic ribonucleoprotein granule

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa03018 RNA degradation
Reactome	R-HSA-429947: Deadenylation of mRNA R-HSA-429914: Deadenylation-dependent mRNA decay R-HSA-74160: Gene Expression

Summary
Symbol	PAN3
Name	PAN3 poly(A) specific ribonuclease subunit
Aliases	PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae); PAB-dependent poly(A)-specific ribonucle ......
Chromosomal Location	13q12.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between PAN3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	PAN3
Name	PAN3 poly(A) specific ribonuclease subunit
Aliases	PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae); PAB-dependent poly(A)-specific ribonucle ......
Chromosomal Location	13q12.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of PAN3 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	PAN3
Name	PAN3 poly(A) specific ribonuclease subunit
Aliases	PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae); PAB-dependent poly(A)-specific ribonucle ......
Chromosomal Location	13q12.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of PAN3 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0.318	0.271
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	0.307	0.833
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	0.327	0.76
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.082	0.752
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0.312	0.878
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	-0.205	0.939
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	-0.168	0.632
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-0.125	0.939
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-0.191	0.915
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.17	0.874
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0.909	0.533
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.029	0.59

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of PAN3 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	3.7	2.7	1	1
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	3.7	3.4	0.3	1
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	0	5.9	-5.9	0.447
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	9.1	-9.1	0.458
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	33.3	0	33.3	0.0365
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	20	0	20	0.357
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	50	0	50	0.109
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	5.3	0	5.3	0.507
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	9.1	0	9.1	0.519
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	PAN3
Name	PAN3 poly(A) specific ribonuclease subunit
Aliases	PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae); PAB-dependent poly(A)-specific ribonucle ......
Chromosomal Location	13q12.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PAN3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	PAN3
Name	PAN3 poly(A) specific ribonuclease subunit
Aliases	PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae); PAB-dependent poly(A)-specific ribonucle ......
Chromosomal Location	13q12.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PAN3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PAN3. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	PAN3
Name	PAN3 poly(A) specific ribonuclease subunit
Aliases	PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae); PAB-dependent poly(A)-specific ribonucle ......
Chromosomal Location	13q12.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PAN3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	PAN3
Name	PAN3 poly(A) specific ribonuclease subunit
Aliases	PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae); PAB-dependent poly(A)-specific ribonucle ......
Chromosomal Location	13q12.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of PAN3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	PAN3
Name	PAN3 poly(A) specific ribonuclease subunit
Aliases	PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae); PAB-dependent poly(A)-specific ribonucle ......
Chromosomal Location	13q12.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between PAN3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	PAN3
Name	PAN3 poly(A) specific ribonuclease subunit
Aliases	PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae); PAB-dependent poly(A)-specific ribonucle ......
Chromosomal Location	13q12.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting PAN3 collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

Browse PAN3