TISIDB

Summary
Symbol	PAOX
Name	polyamine oxidase (exo-N4-amino)
Aliases	peroxisomal N1-acetyl-spermine/spermidine oxidase; Polyamine oxidase; Peroxisomal N(1)-acetyl-spermine/sperm ......
Chromosomal Location	10q26.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Peroxisome Cytoplasm
Domain	PF01593 Flavin containing amine oxidoreductase
Function	Flavoenzyme which catalyzes the oxidation of N(1)-acetylspermine to spermidine and is thus involved in the polyamine back-conversion. Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)-acetylspermine = N(1)-acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs.

> Gene Ontology [ TOP ]
Biological Process	GO:0006576 cellular biogenic amine metabolic process GO:0006595 polyamine metabolic process GO:0006596 polyamine biosynthetic process GO:0006598 polyamine catabolic process GO:0008215 spermine metabolic process GO:0008216 spermidine metabolic process GO:0008295 spermidine biosynthetic process GO:0009308 amine metabolic process GO:0009309 amine biosynthetic process GO:0009310 amine catabolic process GO:0009445 putrescine metabolic process GO:0009446 putrescine biosynthetic process GO:0009447 putrescine catabolic process GO:0010967 regulation of polyamine biosynthetic process GO:0033238 regulation of cellular amine metabolic process GO:0033240 positive regulation of cellular amine metabolic process GO:0042401 cellular biogenic amine biosynthetic process GO:0042402 cellular biogenic amine catabolic process GO:0044106 cellular amine metabolic process GO:0046203 spermidine catabolic process GO:0046208 spermine catabolic process GO:1901304 regulation of spermidine biosynthetic process GO:1901307 positive regulation of spermidine biosynthetic process GO:1901565 organonitrogen compound catabolic process
Molecular Function	GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor GO:0046592 polyamine oxidase activity GO:0052899 N(1),N(12)-diacetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity GO:0052901 spermine:oxygen oxidoreductase (spermidine-forming) activity GO:0052902 spermidine:oxygen oxidoreductase (3-aminopropanal-forming) activity GO:0052903 N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity GO:0052904 N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity
Cellular Component	GO:0005777 peroxisome GO:0005782 peroxisomal matrix GO:0031907 microbody lumen GO:0042579 microbody GO:0044438 microbody part GO:0044439 peroxisomal part

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04146 Peroxisome
Reactome	R-HSA-140179: Amine Oxidase reactions R-HSA-211859: Biological oxidations R-HSA-351200: Interconversion of polyamines R-HSA-1430728: Metabolism R-HSA-71291: Metabolism of amino acids and derivatives R-HSA-351202: Metabolism of polyamines R-HSA-141334: PAOs oxidise polyamines to amines R-HSA-211945: Phase 1 - Functionalization of compounds

Summary
Symbol	PAOX
Name	polyamine oxidase (exo-N4-amino)
Aliases	peroxisomal N1-acetyl-spermine/spermidine oxidase; Polyamine oxidase; Peroxisomal N(1)-acetyl-spermine/sperm ......
Chromosomal Location	10q26.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between PAOX and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	PAOX
Name	polyamine oxidase (exo-N4-amino)
Aliases	peroxisomal N1-acetyl-spermine/spermidine oxidase; Polyamine oxidase; Peroxisomal N(1)-acetyl-spermine/sperm ......
Chromosomal Location	10q26.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of PAOX in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	logFC: -2.66; FDR: 0.04630	Resistant to T cell-mediated killing
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	PAOX
Name	polyamine oxidase (exo-N4-amino)
Aliases	peroxisomal N1-acetyl-spermine/spermidine oxidase; Polyamine oxidase; Peroxisomal N(1)-acetyl-spermine/sperm ......
Chromosomal Location	10q26.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of PAOX in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-0.001	0.997
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	0.081	0.931
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.06	0.933
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.227	0.626
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0.37	0.798
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.05	0.979
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.366	0.201
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	0.451	0.433
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0.24	0.713
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	-0.152	0.882
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	-0.673	0.644
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	0.012	0.898

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of PAOX in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	0	0	0	1
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	0	0	0	1
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	0	0	0	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	6.2	-6.2	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	11.1	-11.1	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	5.3	0	5.3	0.507
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	4.5	0	4.5	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	6.2	0	6.2	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	PAOX
Name	polyamine oxidase (exo-N4-amino)
Aliases	peroxisomal N1-acetyl-spermine/spermidine oxidase; Polyamine oxidase; Peroxisomal N(1)-acetyl-spermine/sperm ......
Chromosomal Location	10q26.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PAOX. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	PAOX
Name	polyamine oxidase (exo-N4-amino)
Aliases	peroxisomal N1-acetyl-spermine/spermidine oxidase; Polyamine oxidase; Peroxisomal N(1)-acetyl-spermine/sperm ......
Chromosomal Location	10q26.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PAOX. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PAOX. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	PAOX
Name	polyamine oxidase (exo-N4-amino)
Aliases	peroxisomal N1-acetyl-spermine/spermidine oxidase; Polyamine oxidase; Peroxisomal N(1)-acetyl-spermine/sperm ......
Chromosomal Location	10q26.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PAOX. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	PAOX
Name	polyamine oxidase (exo-N4-amino)
Aliases	peroxisomal N1-acetyl-spermine/spermidine oxidase; Polyamine oxidase; Peroxisomal N(1)-acetyl-spermine/sperm ......
Chromosomal Location	10q26.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of PAOX expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	PAOX
Name	polyamine oxidase (exo-N4-amino)
Aliases	peroxisomal N1-acetyl-spermine/spermidine oxidase; Polyamine oxidase; Peroxisomal N(1)-acetyl-spermine/sperm ......
Chromosomal Location	10q26.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between PAOX and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	PAOX
Name	polyamine oxidase (exo-N4-amino)
Aliases	peroxisomal N1-acetyl-spermine/spermidine oxidase; Polyamine oxidase; Peroxisomal N(1)-acetyl-spermine/sperm ......
Chromosomal Location	10q26.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting PAOX collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

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