Browse PARN

Summary
SymbolPARN
Namepoly(A)-specific ribonuclease
Aliases deadenylation nuclease; poly(A)-specific ribonuclease (deadenylation nuclease); DKCB6; PFBMFT4; deadenylatin ......
Chromosomal Location16p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus Cytoplasm Nucleus, nucleolus Note=Some nuclear fraction is nucleolar.
Domain PF04857 CAF1 family ribonuclease
PF01424 R3H domain
PF08675 RNA binding domain
Function

3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization.

> Gene Ontology
 
Biological Process GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening
GO:0000956 nuclear-transcribed mRNA catabolic process
GO:0006401 RNA catabolic process
GO:0006402 mRNA catabolic process
GO:0007292 female gamete generation
GO:0009451 RNA modification
GO:0010608 posttranscriptional regulation of gene expression
GO:0019439 aromatic compound catabolic process
GO:0034655 nucleobase-containing compound catabolic process
GO:0043487 regulation of RNA stability
GO:0043488 regulation of mRNA stability
GO:0044270 cellular nitrogen compound catabolic process
GO:0046700 heterocycle catabolic process
GO:0090305 nucleic acid phosphodiester bond hydrolysis
GO:0090501 RNA phosphodiester bond hydrolysis
GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic
GO:1901361 organic cyclic compound catabolic process
Molecular Function GO:0000175 3'-5'-exoribonuclease activity
GO:0003729 mRNA binding
GO:0003730 mRNA 3'-UTR binding
GO:0004518 nuclease activity
GO:0004527 exonuclease activity
GO:0004532 exoribonuclease activity
GO:0004535 poly(A)-specific ribonuclease activity
GO:0004540 ribonuclease activity
GO:0008408 3'-5' exonuclease activity
GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
GO:0016896 exoribonuclease activity, producing 5'-phosphomonoesters
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa03018 RNA degradation
Reactome R-HSA-380994: ATF4 activates genes
R-HSA-429947: Deadenylation of mRNA
R-HSA-429914: Deadenylation-dependent mRNA decay
R-HSA-74160: Gene Expression
R-HSA-450604: KSRP (KHSRP) binds and destabilizes mRNA
R-HSA-392499: Metabolism of proteins
R-HSA-381042: PERK regulates gene expression
R-HSA-450531: Regulation of mRNA stability by proteins that bind AU-rich elements
R-HSA-381119: Unfolded Protein Response (UPR)
Summary
SymbolPARN
Namepoly(A)-specific ribonuclease
Aliases deadenylation nuclease; poly(A)-specific ribonuclease (deadenylation nuclease); DKCB6; PFBMFT4; deadenylatin ......
Chromosomal Location16p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between PARN and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolPARN
Namepoly(A)-specific ribonuclease
Aliases deadenylation nuclease; poly(A)-specific ribonuclease (deadenylation nuclease); DKCB6; PFBMFT4; deadenylatin ......
Chromosomal Location16p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of PARN in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell logFC: -2.22; FDR: 0.02370 Resistant to T cell-mediated killing
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolPARN
Namepoly(A)-specific ribonuclease
Aliases deadenylation nuclease; poly(A)-specific ribonuclease (deadenylation nuclease); DKCB6; PFBMFT4; deadenylatin ......
Chromosomal Location16p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of PARN in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.4220.0367
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.6980.734
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.220.884
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.0250.933
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.1740.922
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.1620.943
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.0730.832
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.1810.91
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.050.978
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.1790.904
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.4680.828
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.25.75e-05
> Mutation difference between responders and non-responders
 

There is no record.
Summary
SymbolPARN
Namepoly(A)-specific ribonuclease
Aliases deadenylation nuclease; poly(A)-specific ribonuclease (deadenylation nuclease); DKCB6; PFBMFT4; deadenylatin ......
Chromosomal Location16p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PARN. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolPARN
Namepoly(A)-specific ribonuclease
Aliases deadenylation nuclease; poly(A)-specific ribonuclease (deadenylation nuclease); DKCB6; PFBMFT4; deadenylatin ......
Chromosomal Location16p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PARN. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PARN.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolPARN
Namepoly(A)-specific ribonuclease
Aliases deadenylation nuclease; poly(A)-specific ribonuclease (deadenylation nuclease); DKCB6; PFBMFT4; deadenylatin ......
Chromosomal Location16p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PARN. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolPARN
Namepoly(A)-specific ribonuclease
Aliases deadenylation nuclease; poly(A)-specific ribonuclease (deadenylation nuclease); DKCB6; PFBMFT4; deadenylatin ......
Chromosomal Location16p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of PARN expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolPARN
Namepoly(A)-specific ribonuclease
Aliases deadenylation nuclease; poly(A)-specific ribonuclease (deadenylation nuclease); DKCB6; PFBMFT4; deadenylatin ......
Chromosomal Location16p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between PARN and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolPARN
Namepoly(A)-specific ribonuclease
Aliases deadenylation nuclease; poly(A)-specific ribonuclease (deadenylation nuclease); DKCB6; PFBMFT4; deadenylatin ......
Chromosomal Location16p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting PARN collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.