TISIDB

Summary
Symbol	PARP1
Name	poly (ADP-ribose) polymerase 1
Aliases	PPOL; ADPRT; ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase); poly (ADP-ribose) polymerase famil ......
Chromosomal Location	1q41-q42
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Nucleus Nucleus, nucleolus Note=Localizes at sites of DNA damage.
Domain	PF00533 BRCA1 C Terminus (BRCT) domain PF08063 PADR1 (NUC008) domain PF00644 Poly(ADP-ribose) polymerase catalytic domain PF02877 Poly(ADP-ribose) polymerase PF05406 WGR domain PF00645 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
Function	Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (PubMed:17177976, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:23230272). Mediates the poly(ADP-ribosyl)ation of APLF and CHFR (PubMed:17396150). Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production (PubMed:17177976). Required for PARP9 and DTX3L recruitment to DNA damage sites (PubMed:23230272). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). Mediates serine ADP-ribosylation of target proteins following interaction with HPF1; HPF1 conferring serine specificity (PubMed:28190768). Mediates the poly(ADP-ribosyl)ation of histones in a HPF1-dependent manner (PubMed:27067600). Involved in the synthesis of ATP in the nucleus, together with NMNAT1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257).

> Gene Ontology [ TOP ]
Biological Process	GO:0000002 mitochondrial genome maintenance GO:0000715 nucleotide-excision repair, DNA damage recognition GO:0000717 nucleotide-excision repair, DNA duplex unwinding GO:0000723 telomere maintenance GO:0000724 double-strand break repair via homologous recombination GO:0000725 recombinational repair GO:0002521 leukocyte differentiation GO:0002573 myeloid leukocyte differentiation GO:0003012 muscle system process GO:0003254 regulation of membrane depolarization GO:0003300 cardiac muscle hypertrophy GO:0006260 DNA replication GO:0006261 DNA-dependent DNA replication GO:0006266 DNA ligation GO:0006271 DNA strand elongation involved in DNA replication GO:0006273 lagging strand elongation GO:0006289 nucleotide-excision repair GO:0006293 nucleotide-excision repair, preincision complex stabilization GO:0006294 nucleotide-excision repair, preincision complex assembly GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion GO:0006302 double-strand break repair GO:0006304 DNA modification GO:0006305 DNA alkylation GO:0006306 DNA methylation GO:0006310 DNA recombination GO:0006471 protein ADP-ribosylation GO:0006486 protein glycosylation GO:0006606 protein import into nucleus GO:0006913 nucleocytoplasmic transport GO:0006979 response to oxidative stress GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007179 transforming growth factor beta receptor signaling pathway GO:0007183 SMAD protein complex assembly GO:0007184 SMAD protein import into nucleus GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress GO:0009100 glycoprotein metabolic process GO:0009101 glycoprotein biosynthetic process GO:0009116 nucleoside metabolic process GO:0009119 ribonucleoside metabolic process GO:0009123 nucleoside monophosphate metabolic process GO:0009126 purine nucleoside monophosphate metabolic process GO:0009141 nucleoside triphosphate metabolic process GO:0009144 purine nucleoside triphosphate metabolic process GO:0009150 purine ribonucleotide metabolic process GO:0009161 ribonucleoside monophosphate metabolic process GO:0009167 purine ribonucleoside monophosphate metabolic process GO:0009199 ribonucleoside triphosphate metabolic process GO:0009205 purine ribonucleoside triphosphate metabolic process GO:0009314 response to radiation GO:0009755 hormone-mediated signaling pathway GO:0010035 response to inorganic substance GO:0010038 response to metal ion GO:0010043 response to zinc ion GO:0010212 response to ionizing radiation GO:0010332 response to gamma radiation GO:0010611 regulation of cardiac muscle hypertrophy GO:0010613 positive regulation of cardiac muscle hypertrophy GO:0010639 negative regulation of organelle organization GO:0010833 telomere maintenance via telomere lengthening GO:0010990 regulation of SMAD protein complex assembly GO:0014742 positive regulation of muscle hypertrophy GO:0014743 regulation of muscle hypertrophy GO:0014896 muscle hypertrophy GO:0014897 striated muscle hypertrophy GO:0016485 protein processing GO:0016540 protein autoprocessing GO:0016925 protein sumoylation GO:0017038 protein import GO:0018205 peptidyl-lysine modification GO:0022616 DNA strand elongation GO:0023019 signal transduction involved in regulation of gene expression GO:0030099 myeloid cell differentiation GO:0030225 macrophage differentiation GO:0030518 intracellular steroid hormone receptor signaling pathway GO:0030520 intracellular estrogen receptor signaling pathway GO:0030522 intracellular receptor signaling pathway GO:0031334 positive regulation of protein complex assembly GO:0031960 response to corticosteroid GO:0032042 mitochondrial DNA metabolic process GO:0032200 telomere organization GO:0032204 regulation of telomere maintenance GO:0032205 negative regulation of telomere maintenance GO:0032259 methylation GO:0032386 regulation of intracellular transport GO:0032388 positive regulation of intracellular transport GO:0032392 DNA geometric change GO:0032508 DNA duplex unwinding GO:0032844 regulation of homeostatic process GO:0032845 negative regulation of homeostatic process GO:0032868 response to insulin GO:0032869 cellular response to insulin stimulus GO:0033044 regulation of chromosome organization GO:0033143 regulation of intracellular steroid hormone receptor signaling pathway GO:0033145 positive regulation of intracellular steroid hormone receptor signaling pathway GO:0033146 regulation of intracellular estrogen receptor signaling pathway GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway GO:0033157 regulation of intracellular protein transport GO:0033683 nucleotide-excision repair, DNA incision GO:0034504 protein localization to nucleus GO:0034599 cellular response to oxidative stress GO:0036446 myofibroblast differentiation GO:0036473 cell death in response to oxidative stress GO:0036475 neuron death in response to oxidative stress GO:0036480 neuron intrinsic apoptotic signaling pathway in response to oxidative stress GO:0042278 purine nucleoside metabolic process GO:0042306 regulation of protein import into nucleus GO:0042307 positive regulation of protein import into nucleus GO:0042391 regulation of membrane potential GO:0042769 DNA damage response, detection of DNA damage GO:0043254 regulation of protein complex assembly GO:0043388 positive regulation of DNA binding GO:0043401 steroid hormone mediated signaling pathway GO:0043413 macromolecule glycosylation GO:0043414 macromolecule methylation GO:0043434 response to peptide hormone GO:0043500 muscle adaptation GO:0043502 regulation of muscle adaptation GO:0043504 mitochondrial DNA repair GO:0043523 regulation of neuron apoptotic process GO:0044030 regulation of DNA methylation GO:0044057 regulation of system process GO:0044089 positive regulation of cellular component biogenesis GO:0044728 DNA methylation or demethylation GO:0044744 protein targeting to nucleus GO:0046034 ATP metabolic process GO:0046128 purine ribonucleoside metabolic process GO:0046822 regulation of nucleocytoplasmic transport GO:0046824 positive regulation of nucleocytoplasmic transport GO:0048545 response to steroid hormone GO:0051052 regulation of DNA metabolic process GO:0051053 negative regulation of DNA metabolic process GO:0051098 regulation of binding GO:0051099 positive regulation of binding GO:0051101 regulation of DNA binding GO:0051103 DNA ligation involved in DNA repair GO:0051169 nuclear transport GO:0051170 nuclear import GO:0051222 positive regulation of protein transport GO:0051385 response to mineralocorticoid GO:0051402 neuron apoptotic process GO:0051604 protein maturation GO:0051881 regulation of mitochondrial membrane potential GO:0051882 mitochondrial depolarization GO:0051899 membrane depolarization GO:0051900 regulation of mitochondrial depolarization GO:0051901 positive regulation of mitochondrial depolarization GO:0060249 anatomical structure homeostasis GO:0060390 regulation of SMAD protein import into nucleus GO:0060391 positive regulation of SMAD protein import into nucleus GO:0065004 protein-DNA complex assembly GO:0070085 glycosylation GO:0070212 protein poly-ADP-ribosylation GO:0070911 global genome nucleotide-excision repair GO:0070997 neuron death GO:0071103 DNA conformation change GO:0071241 cellular response to inorganic substance GO:0071248 cellular response to metal ion GO:0071294 cellular response to zinc ion GO:0071375 cellular response to peptide hormone stimulus GO:0071383 cellular response to steroid hormone stimulus GO:0071396 cellular response to lipid GO:0071407 cellular response to organic cyclic compound GO:0071417 cellular response to organonitrogen compound GO:0071559 response to transforming growth factor beta GO:0071560 cellular response to transforming growth factor beta stimulus GO:0071824 protein-DNA complex subunit organization GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway GO:0090257 regulation of muscle system process GO:0090305 nucleic acid phosphodiester bond hydrolysis GO:0090316 positive regulation of intracellular protein transport GO:0097193 intrinsic apoptotic signaling pathway GO:1900180 regulation of protein localization to nucleus GO:1900182 positive regulation of protein localization to nucleus GO:1900407 regulation of cellular response to oxidative stress GO:1901214 regulation of neuron death GO:1901216 positive regulation of neuron death GO:1901652 response to peptide GO:1901653 cellular response to peptide GO:1901654 response to ketone GO:1901657 glycosyl compound metabolic process GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902593 single-organism nuclear import GO:1902882 regulation of response to oxidative stress GO:1903201 regulation of oxidative stress-induced cell death GO:1903203 regulation of oxidative stress-induced neuron death GO:1903376 regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway GO:1903533 regulation of protein targeting GO:1903829 positive regulation of cellular protein localization GO:1904044 response to aldosterone GO:1904181 positive regulation of membrane depolarization GO:1904356 regulation of telomere maintenance via telomere lengthening GO:1904357 negative regulation of telomere maintenance via telomere lengthening GO:1904589 regulation of protein import GO:1904591 positive regulation of protein import GO:1904645 response to beta-amyloid GO:1904646 cellular response to beta-amyloid GO:1904760 regulation of myofibroblast differentiation GO:1904762 positive regulation of myofibroblast differentiation GO:1904951 positive regulation of establishment of protein localization GO:1990267 response to transition metal nanoparticle GO:1990966 ATP generation from poly-ADP-D-ribose GO:2000021 regulation of ion homeostasis GO:2000677 regulation of transcription regulatory region DNA binding GO:2000679 positive regulation of transcription regulatory region DNA binding GO:2001233 regulation of apoptotic signaling pathway GO:2001242 regulation of intrinsic apoptotic signaling pathway GO:2001251 negative regulation of chromosome organization
Molecular Function	GO:0003909 DNA ligase activity GO:0003910 DNA ligase (ATP) activity GO:0003950 NAD+ ADP-ribosyltransferase activity GO:0008134 transcription factor binding GO:0016757 transferase activity, transferring glycosyl groups GO:0016763 transferase activity, transferring pentosyl groups GO:0016874 ligase activity GO:0016886 ligase activity, forming phosphoric ester bonds GO:0030331 estrogen receptor binding GO:0035257 nuclear hormone receptor binding GO:0035258 steroid hormone receptor binding GO:0042826 histone deacetylase binding GO:0046332 SMAD binding GO:0047485 protein N-terminus binding GO:0048037 cofactor binding GO:0050662 coenzyme binding GO:0051287 NAD binding GO:0051427 hormone receptor binding GO:0070412 R-SMAD binding
Cellular Component	GO:0000781 chromosome, telomeric region GO:0000784 nuclear chromosome, telomeric region GO:0005635 nuclear envelope GO:0005667 transcription factor complex GO:0044454 nuclear chromosome part GO:0098687 chromosomal region

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa03410 Base excision repair hsa04064 NF-kappa B signaling pathway hsa04210 Apoptosis
Reactome	R-HSA-73884: Base Excision Repair R-HSA-5696394: DNA Damage Recognition in GG-NER R-HSA-5693532: DNA Double-Strand Break Repair R-HSA-73894: DNA Repair R-HSA-2173795: Downregulation of SMAD2/3 R-HSA-5696400: Dual Incision in GG-NER R-HSA-5696395: Formation of Incision Complex in GG-NER R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-5696399: Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5685939: HDR through MMEJ (alt-NHEJ) R-HSA-5693538: Homology Directed Repair R-HSA-392499: Metabolism of proteins R-HSA-5696398: Nucleotide Excision Repair R-HSA-110362: POLB-Dependent Long Patch Base Excision Repair R-HSA-597592: Post-translational protein modification R-HSA-110373: Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-73933: Resolution of Abasic Sites (AP sites) R-HSA-3108232: SUMO E3 ligases SUMOylate target proteins R-HSA-2990846: SUMOylation R-HSA-3108214: SUMOylation of DNA damage response and repair proteins R-HSA-162582: Signal Transduction R-HSA-170834: Signaling by TGF-beta Receptor Complex R-HSA-2173793: Transcriptional activity of SMAD2/SMAD3

> KEGG and Reactome Pathway

[ TOP ]

KEGG

hsa03410 Base excision repair
hsa04064 NF-kappa B signaling pathway
hsa04210 Apoptosis

Reactome

R-HSA-73884: Base Excision Repair
R-HSA-5696394: DNA Damage Recognition in GG-NER
R-HSA-5693532: DNA Double-Strand Break Repair
R-HSA-73894: DNA Repair
R-HSA-2173795: Downregulation of SMAD2/3
R-HSA-5696400: Dual Incision in GG-NER
R-HSA-5696395: Formation of Incision Complex in GG-NER
R-HSA-74160: Gene Expression
R-HSA-212436: Generic Transcription Pathway
R-HSA-5696399: Global Genome Nucleotide Excision Repair (GG-NER)
R-HSA-5685939: HDR through MMEJ (alt-NHEJ)
R-HSA-5693538: Homology Directed Repair
R-HSA-392499: Metabolism of proteins
R-HSA-5696398: Nucleotide Excision Repair
R-HSA-110362: POLB-Dependent Long Patch Base Excision Repair
R-HSA-597592: Post-translational protein modification
R-HSA-110373: Resolution of AP sites via the multiple-nucleotide patch replacement pathway
R-HSA-73933: Resolution of Abasic Sites (AP sites)
R-HSA-3108232: SUMO E3 ligases SUMOylate target proteins
R-HSA-2990846: SUMOylation
R-HSA-3108214: SUMOylation of DNA damage response and repair proteins
R-HSA-162582: Signal Transduction
R-HSA-170834: Signaling by TGF-beta Receptor Complex
R-HSA-2173793: Transcriptional activity of SMAD2/SMAD3

Summary
Symbol	PARP1
Name	poly (ADP-ribose) polymerase 1
Aliases	PPOL; ADPRT; ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase); poly (ADP-ribose) polymerase famil ......
Chromosomal Location	1q41-q42
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between PARP1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining

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Literatures describing the relation between PARP1 and anti-tumor immunity in human cancer.

PMID	Cancer type	Relation to immunity	Evidence sentences
28167507	Breast Carcinoma	Promote immunity (T cell function)	PARP Inhibitor Upregulates PD-L1 Expression and Enhances Cancer-Associated Immunosuppression.
26138335	Breast Carcinoma	Inhibit immunity	These results demonstrate that CTLA-4 blockade combined with PARP inhibition induces protective antitumor immunity and significant survival benefit in the BRCA1(-) tumor model, and support clinical testing of this regimen to improve outcomes for women with hereditary ovarian cancer.

Summary
Symbol	PARP1
Name	poly (ADP-ribose) polymerase 1
Aliases	PPOL; ADPRT; ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase); poly (ADP-ribose) polymerase famil ......
Chromosomal Location	1q41-q42
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of PARP1 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	PARP1
Name	poly (ADP-ribose) polymerase 1
Aliases	PPOL; ADPRT; ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase); poly (ADP-ribose) polymerase famil ......
Chromosomal Location	1q41-q42
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of PARP1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0.256	0.326
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	0.651	0.805
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.041	0.984
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.292	0.33
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0.346	0.883
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.228	0.942
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.253	0.568
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-0.102	0.962
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0.683	0.771
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.232	0.888
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0.572	0.821
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	0.218	0.00198

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of PARP1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	3.7	2.7	1	1
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	3.7	3.4	0.3	1
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	0	0	0	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	6.2	-6.2	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	11.1	-11.1	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	2.6	0	2.6	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	4.5	0	4.5	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	7.7	-7.7	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	8.3	-8.3	1

Summary
Symbol	PARP1
Name	poly (ADP-ribose) polymerase 1
Aliases	PPOL; ADPRT; ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase); poly (ADP-ribose) polymerase famil ......
Chromosomal Location	1q41-q42
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PARP1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	PARP1
Name	poly (ADP-ribose) polymerase 1
Aliases	PPOL; ADPRT; ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase); poly (ADP-ribose) polymerase famil ......
Chromosomal Location	1q41-q42
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PARP1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PARP1. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	PARP1
Name	poly (ADP-ribose) polymerase 1
Aliases	PPOL; ADPRT; ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase); poly (ADP-ribose) polymerase famil ......
Chromosomal Location	1q41-q42
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PARP1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	PARP1
Name	poly (ADP-ribose) polymerase 1
Aliases	PPOL; ADPRT; ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase); poly (ADP-ribose) polymerase famil ......
Chromosomal Location	1q41-q42
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of PARP1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	PARP1
Name	poly (ADP-ribose) polymerase 1
Aliases	PPOL; ADPRT; ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase); poly (ADP-ribose) polymerase famil ......
Chromosomal Location	1q41-q42
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between PARP1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	PARP1
Name	poly (ADP-ribose) polymerase 1
Aliases	PPOL; ADPRT; ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase); poly (ADP-ribose) polymerase famil ......
Chromosomal Location	1q41-q42
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting PARP1 collected from DrugBank database.

> Drugs from DrugBank database

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Details on drugs targeting PARP1.

ID	Name	Drug Type	Targets	#Targets
DB00277	Theophylline	Small Molecule	ADORA1, ADORA2A, ADORA2B, CPNE1, HDAC2, HM13, NOMO1, PARP1, PDE3A, ......	14
DB01593	Zinc	Small Molecule	A1BG, A2M, AGT, AHSG, ALDOA, APCS, APLP1, APLP2, APOA1, APOA2, APO ......	119
DB02498	Carba-Nicotinamide-Adenine-Dinucleotide	Small Molecule	PARP1	1
DB02690	NU1025	Small Molecule	PARP1	1
DB02701	Nicotinamide	Small Molecule	BST1, LDHA, PARP1, SIRT5	4
DB03072	2-{3-[4-(4-Fluorophenyl)-3,6-Dihydro-1(2h)-Pyridinyl]Propyl}-8-Methyl-4(3h)-Quinazolinone	Small Molecule	PARP1	1
DB03073	3-Methoxybenzamide	Small Molecule	PARP1	1
DB03509	2-(4-Chlorophenyl)-5-Quinoxalinecarboxamide	Small Molecule	PARP1	1
DB03722	3,4-Dihydro-5-Methyl-Isoquinolinone	Small Molecule	PARP1	1
DB04010	2-(3'-Methoxyphenyl) Benzimidazole-4-Carboxamide	Small Molecule	PARP1	1
DB07096	6-AMINO-BENZO[DE]ISOQUINOLINE-1,3-DIONE	Small Molecule	PARP1	1
DB07232	Veliparib	Small Molecule	PARP1, PARP2	2
DB07330	trans-4-(7-carbamoyl-1H-benzimidazol-2-yl)-1-propylpiperidinium	Small Molecule	PARP1	1
DB07787	5-FLUORO-1-[4-(4-PHENYL-3,6-DIHYDROPYRIDIN-1(2H)-YL)BUTYL]QUINAZOLINE-2,4(1H,3H)-DIONE	Small Molecule	PARP1	1
DB09074	Olaparib	Small Molecule	PARP1, PARP2, PARP3	3
DB11793	Niraparib	Small Molecule	PARP1, PARP2	2
DB12332	Rucaparib	Small Molecule	PARP1, PARP2, PARP3	3
DB13877	Iniparib	Small Molecule	PARP1	1

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