Summary | |
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Symbol | PDLIM7 |
Name | PDZ and LIM domain 7 (enigma) |
Aliases | ENIGMA; LMP1; LMP3; 1110003B01Rik; LMP; Lim mineralization protein 3; protein enigma; LIM mineralization pro ...... |
Chromosomal Location | 5q35.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Cytoplasm, cytoskeleton Note=Colocalizes with RET to the cell periphery and in some cytoskeletal components. Colocalizes with TPM2 near the Z line in muscle. Colocalizes with TBX4 and TBX5 to actin filaments (By similarity). |
Domain |
PF00412 LIM domain PF00595 PDZ domain (Also known as DHR or GLGF) |
Function |
May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway (By similarity). |
Biological Process |
GO:0001503 ossification GO:0001649 osteoblast differentiation GO:0006898 receptor-mediated endocytosis GO:0030278 regulation of ossification GO:0045667 regulation of osteoblast differentiation GO:0045669 positive regulation of osteoblast differentiation GO:0045778 positive regulation of ossification |
Molecular Function | - |
Cellular Component |
GO:0001725 stress fiber GO:0001726 ruffle GO:0005924 cell-substrate adherens junction GO:0005925 focal adhesion GO:0015629 actin cytoskeleton GO:0030055 cell-substrate junction GO:0031252 cell leading edge GO:0032432 actin filament bundle GO:0042641 actomyosin GO:0097517 contractile actin filament bundle |
KEGG | - |
Reactome |
R-HSA-422475: Axon guidance R-HSA-1266738: Developmental Biology R-HSA-8853659: RET signaling |
Summary | |
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Symbol | PDLIM7 |
Name | PDZ and LIM domain 7 (enigma) |
Aliases | ENIGMA; LMP1; LMP3; 1110003B01Rik; LMP; Lim mineralization protein 3; protein enigma; LIM mineralization pro ...... |
Chromosomal Location | 5q35.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between PDLIM7 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between PDLIM7 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | PDLIM7 |
Name | PDZ and LIM domain 7 (enigma) |
Aliases | ENIGMA; LMP1; LMP3; 1110003B01Rik; LMP; Lim mineralization protein 3; protein enigma; LIM mineralization pro ...... |
Chromosomal Location | 5q35.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of PDLIM7 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | PDLIM7 |
Name | PDZ and LIM domain 7 (enigma) |
Aliases | ENIGMA; LMP1; LMP3; 1110003B01Rik; LMP; Lim mineralization protein 3; protein enigma; LIM mineralization pro ...... |
Chromosomal Location | 5q35.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of PDLIM7 in various data sets.
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Points in the above scatter plot represent the mutation difference of PDLIM7 in various data sets.
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Summary | |
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Symbol | PDLIM7 |
Name | PDZ and LIM domain 7 (enigma) |
Aliases | ENIGMA; LMP1; LMP3; 1110003B01Rik; LMP; Lim mineralization protein 3; protein enigma; LIM mineralization pro ...... |
Chromosomal Location | 5q35.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PDLIM7. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | PDLIM7 |
Name | PDZ and LIM domain 7 (enigma) |
Aliases | ENIGMA; LMP1; LMP3; 1110003B01Rik; LMP; Lim mineralization protein 3; protein enigma; LIM mineralization pro ...... |
Chromosomal Location | 5q35.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PDLIM7. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PDLIM7. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | PDLIM7 |
Name | PDZ and LIM domain 7 (enigma) |
Aliases | ENIGMA; LMP1; LMP3; 1110003B01Rik; LMP; Lim mineralization protein 3; protein enigma; LIM mineralization pro ...... |
Chromosomal Location | 5q35.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PDLIM7. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | PDLIM7 |
Name | PDZ and LIM domain 7 (enigma) |
Aliases | ENIGMA; LMP1; LMP3; 1110003B01Rik; LMP; Lim mineralization protein 3; protein enigma; LIM mineralization pro ...... |
Chromosomal Location | 5q35.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of PDLIM7 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | PDLIM7 |
Name | PDZ and LIM domain 7 (enigma) |
Aliases | ENIGMA; LMP1; LMP3; 1110003B01Rik; LMP; Lim mineralization protein 3; protein enigma; LIM mineralization pro ...... |
Chromosomal Location | 5q35.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between PDLIM7 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | PDLIM7 |
Name | PDZ and LIM domain 7 (enigma) |
Aliases | ENIGMA; LMP1; LMP3; 1110003B01Rik; LMP; Lim mineralization protein 3; protein enigma; LIM mineralization pro ...... |
Chromosomal Location | 5q35.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting PDLIM7 collected from DrugBank database. |
There is no record. |