Browse PFKFB3

Summary
SymbolPFKFB3
Name6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
Aliases IPFK2; PFK2; iPFK-2; 6-phosphofructo-2-kinase/ fructose-2,6-bisphosphatase; 6PF-2-K/Fru-2,6-P2ase 3; 6PF-2-K ......
Chromosomal Location10p15.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location -
Domain PF01591 6-phosphofructo-2-kinase
PF00300 Histidine phosphatase superfamily (branch 1)
Function

Synthesis and degradation of fructose 2,6-bisphosphate.

> Gene Ontology
 
Biological Process GO:0005996 monosaccharide metabolic process
GO:0006000 fructose metabolic process
GO:0006003 fructose 2,6-bisphosphate metabolic process
GO:0006006 glucose metabolic process
GO:0006007 glucose catabolic process
GO:0006090 pyruvate metabolic process
GO:0006091 generation of precursor metabolites and energy
GO:0006096 glycolytic process
GO:0006165 nucleoside diphosphate phosphorylation
GO:0006732 coenzyme metabolic process
GO:0006733 oxidoreduction coenzyme metabolic process
GO:0006734 NADH metabolic process
GO:0006735 NADH regeneration
GO:0006757 ATP generation from ADP
GO:0009116 nucleoside metabolic process
GO:0009119 ribonucleoside metabolic process
GO:0009123 nucleoside monophosphate metabolic process
GO:0009126 purine nucleoside monophosphate metabolic process
GO:0009132 nucleoside diphosphate metabolic process
GO:0009135 purine nucleoside diphosphate metabolic process
GO:0009141 nucleoside triphosphate metabolic process
GO:0009144 purine nucleoside triphosphate metabolic process
GO:0009150 purine ribonucleotide metabolic process
GO:0009161 ribonucleoside monophosphate metabolic process
GO:0009167 purine ribonucleoside monophosphate metabolic process
GO:0009179 purine ribonucleoside diphosphate metabolic process
GO:0009185 ribonucleoside diphosphate metabolic process
GO:0009199 ribonucleoside triphosphate metabolic process
GO:0009205 purine ribonucleoside triphosphate metabolic process
GO:0016052 carbohydrate catabolic process
GO:0016311 dephosphorylation
GO:0019318 hexose metabolic process
GO:0019320 hexose catabolic process
GO:0019362 pyridine nucleotide metabolic process
GO:0019674 NAD metabolic process
GO:0042278 purine nucleoside metabolic process
GO:0044262 cellular carbohydrate metabolic process
GO:0044282 small molecule catabolic process
GO:0044723 single-organism carbohydrate metabolic process
GO:0044724 single-organism carbohydrate catabolic process
GO:0046031 ADP metabolic process
GO:0046034 ATP metabolic process
GO:0046128 purine ribonucleoside metabolic process
GO:0046365 monosaccharide catabolic process
GO:0046496 nicotinamide nucleotide metabolic process
GO:0046835 carbohydrate phosphorylation
GO:0046939 nucleotide phosphorylation
GO:0051186 cofactor metabolic process
GO:0061615 glycolytic process through fructose-6-phosphate
GO:0061620 glycolytic process through glucose-6-phosphate
GO:0061621 canonical glycolysis
GO:0061718 glucose catabolic process to pyruvate
GO:0072524 pyridine-containing compound metabolic process
GO:1901657 glycosyl compound metabolic process
Molecular Function GO:0003873 6-phosphofructo-2-kinase activity
GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity
GO:0008443 phosphofructokinase activity
GO:0016791 phosphatase activity
GO:0019200 carbohydrate kinase activity
GO:0019203 carbohydrate phosphatase activity
GO:0042578 phosphoric ester hydrolase activity
GO:0050308 sugar-phosphatase activity
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa04066 HIF-1 signaling pathway
hsa04152 AMPK signaling pathway
hsa00051 Fructose and mannose metabolism
Reactome R-HSA-70326: Glucose metabolism
R-HSA-70171: Glycolysis
R-HSA-1430728: Metabolism
R-HSA-71387: Metabolism of carbohydrates
Summary
SymbolPFKFB3
Name6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
Aliases IPFK2; PFK2; iPFK-2; 6-phosphofructo-2-kinase/ fructose-2,6-bisphosphatase; 6PF-2-K/Fru-2,6-P2ase 3; 6PF-2-K ......
Chromosomal Location10p15.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between PFKFB3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolPFKFB3
Name6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
Aliases IPFK2; PFK2; iPFK-2; 6-phosphofructo-2-kinase/ fructose-2,6-bisphosphatase; 6PF-2-K/Fru-2,6-P2ase 3; 6PF-2-K ......
Chromosomal Location10p15.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of PFKFB3 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen Total # shRNA with >= 4-fold: 1 Resistant to T-cell proliferation
24476824shRNAmelanomaB16Secondary screen Total # shRNA with >= 4-fold: 2 Resistant to T-cell proliferation
Summary
SymbolPFKFB3
Name6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
Aliases IPFK2; PFK2; iPFK-2; 6-phosphofructo-2-kinase/ fructose-2,6-bisphosphatase; 6PF-2-K/Fru-2,6-P2ase 3; 6PF-2-K ......
Chromosomal Location10p15.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of PFKFB3 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.1020.656
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.1970.928
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.0230.987
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.260.495
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.5930.809
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.1630.959
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0850.851
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.2850.874
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.1280.949
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.2320.889
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.8230.737
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.420.0013
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of PFKFB3 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.72.711
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.73.40.31
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.85.9-1.11
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)86016.7-16.70.429
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91622.26.2160.53
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 594011.128.90.505
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolPFKFB3
Name6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
Aliases IPFK2; PFK2; iPFK-2; 6-phosphofructo-2-kinase/ fructose-2,6-bisphosphatase; 6PF-2-K/Fru-2,6-P2ase 3; 6PF-2-K ......
Chromosomal Location10p15.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PFKFB3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolPFKFB3
Name6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
Aliases IPFK2; PFK2; iPFK-2; 6-phosphofructo-2-kinase/ fructose-2,6-bisphosphatase; 6PF-2-K/Fru-2,6-P2ase 3; 6PF-2-K ......
Chromosomal Location10p15.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PFKFB3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PFKFB3.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolPFKFB3
Name6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
Aliases IPFK2; PFK2; iPFK-2; 6-phosphofructo-2-kinase/ fructose-2,6-bisphosphatase; 6PF-2-K/Fru-2,6-P2ase 3; 6PF-2-K ......
Chromosomal Location10p15.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PFKFB3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolPFKFB3
Name6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
Aliases IPFK2; PFK2; iPFK-2; 6-phosphofructo-2-kinase/ fructose-2,6-bisphosphatase; 6PF-2-K/Fru-2,6-P2ase 3; 6PF-2-K ......
Chromosomal Location10p15.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of PFKFB3 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolPFKFB3
Name6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
Aliases IPFK2; PFK2; iPFK-2; 6-phosphofructo-2-kinase/ fructose-2,6-bisphosphatase; 6PF-2-K/Fru-2,6-P2ase 3; 6PF-2-K ......
Chromosomal Location10p15.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between PFKFB3 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolPFKFB3
Name6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
Aliases IPFK2; PFK2; iPFK-2; 6-phosphofructo-2-kinase/ fructose-2,6-bisphosphatase; 6PF-2-K/Fru-2,6-P2ase 3; 6PF-2-K ......
Chromosomal Location10p15.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting PFKFB3 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.