TISIDB

Summary
Symbol	PIEZO2
Name	piezo-type mechanosensitive ion channel component 2
Aliases	FLJ23403; FLJ23144; HsT748; HsT771; FLJ34907; FAM38B2; C18orf30; C18orf58; FAM38B; chromosome 18 open readin ......
Chromosomal Location	18p11.21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Membrane Multi-pass membrane protein
Domain	PF15917 Piezo PF12166 Piezo non-specific cation channel
Function	Component of a mechanosensitive channel required for rapidly adapting mechanically activated (MA) currents. Required for Merkel-cell mechanotransduction. Plays a major role in light-touch mechanosensation.

> Gene Ontology [ TOP ]
Biological Process	GO:0009581 detection of external stimulus GO:0009582 detection of abiotic stimulus GO:0009612 response to mechanical stimulus GO:0050954 sensory perception of mechanical stimulus GO:0050974 detection of mechanical stimulus involved in sensory perception GO:0050982 detection of mechanical stimulus
Molecular Function	GO:0005216 ion channel activity GO:0008381 mechanically-gated ion channel activity GO:0015267 channel activity GO:0022803 passive transmembrane transporter activity GO:0022833 mechanically gated channel activity GO:0022836 gated channel activity GO:0022838 substrate-specific channel activity
Cellular Component	-

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	-

Summary
Symbol	PIEZO2
Name	piezo-type mechanosensitive ion channel component 2
Aliases	FLJ23403; FLJ23144; HsT748; HsT771; FLJ34907; FAM38B2; C18orf30; C18orf58; FAM38B; chromosome 18 open readin ......
Chromosomal Location	18p11.21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between PIEZO2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	PIEZO2
Name	piezo-type mechanosensitive ion channel component 2
Aliases	FLJ23403; FLJ23144; HsT748; HsT771; FLJ34907; FAM38B2; C18orf30; C18orf58; FAM38B; chromosome 18 open readin ......
Chromosomal Location	18p11.21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of PIEZO2 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	PIEZO2
Name	piezo-type mechanosensitive ion channel component 2
Aliases	FLJ23403; FLJ23144; HsT748; HsT771; FLJ34907; FAM38B2; C18orf30; C18orf58; FAM38B; chromosome 18 open readin ......
Chromosomal Location	18p11.21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of PIEZO2 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-0.833	0.0791
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-0.312	0.681
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-1.235	0.11
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-0.528	0.157
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-0.507	0.809
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	-0.558	0.828
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.83	0.0838
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	0.561	0.673
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	1.289	0.317
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.013	0.991
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	1.638	0.227
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.656	0.000226

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of PIEZO2 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	7.1	0	7.1	0.452
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	10	0	10	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	3.7	4.1	-0.4	1
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	3.7	5.1	-1.4	1
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	19	5.9	13.1	0.355
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	25	0	25	0.473
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	15.4	9.1	6.3	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	11.1	6.2	4.9	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	11.1	-11.1	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	25	0	25	0.364
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	15.8	0	15.8	0.037
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	22.7	0	22.7	0.134
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	6.2	0	6.2	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	PIEZO2
Name	piezo-type mechanosensitive ion channel component 2
Aliases	FLJ23403; FLJ23144; HsT748; HsT771; FLJ34907; FAM38B2; C18orf30; C18orf58; FAM38B; chromosome 18 open readin ......
Chromosomal Location	18p11.21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PIEZO2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	PIEZO2
Name	piezo-type mechanosensitive ion channel component 2
Aliases	FLJ23403; FLJ23144; HsT748; HsT771; FLJ34907; FAM38B2; C18orf30; C18orf58; FAM38B; chromosome 18 open readin ......
Chromosomal Location	18p11.21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PIEZO2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PIEZO2. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	PIEZO2
Name	piezo-type mechanosensitive ion channel component 2
Aliases	FLJ23403; FLJ23144; HsT748; HsT771; FLJ34907; FAM38B2; C18orf30; C18orf58; FAM38B; chromosome 18 open readin ......
Chromosomal Location	18p11.21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PIEZO2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	PIEZO2
Name	piezo-type mechanosensitive ion channel component 2
Aliases	FLJ23403; FLJ23144; HsT748; HsT771; FLJ34907; FAM38B2; C18orf30; C18orf58; FAM38B; chromosome 18 open readin ......
Chromosomal Location	18p11.21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of PIEZO2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	PIEZO2
Name	piezo-type mechanosensitive ion channel component 2
Aliases	FLJ23403; FLJ23144; HsT748; HsT771; FLJ34907; FAM38B2; C18orf30; C18orf58; FAM38B; chromosome 18 open readin ......
Chromosomal Location	18p11.21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between PIEZO2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	PIEZO2
Name	piezo-type mechanosensitive ion channel component 2
Aliases	FLJ23403; FLJ23144; HsT748; HsT771; FLJ34907; FAM38B2; C18orf30; C18orf58; FAM38B; chromosome 18 open readin ......
Chromosomal Location	18p11.21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting PIEZO2 collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

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