| Summary | |
|---|---|
| Symbol | PIK3CA |
| Name | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha |
| Aliases | phosphoinositide-3-kinase, catalytic, alpha polypeptide; CLOVE; CWS5; MCMTC; p110-alpha; PI3-kinase p110 sub ...... |
| Chromosomal Location | 3q26.3 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
| Subcellular Location | - |
| Domain |
PF00454 Phosphatidylinositol 3- and 4-kinase PF00792 Phosphoinositide 3-kinase C2 PF02192 PI3-kinase family PF00794 PI3-kinase family PF00613 Phosphoinositide 3-kinase family |
| Function |
Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF. Regulates invadopodia formation through the PDPK1-AKT1 pathway. Participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. Participates in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway. Also has serine-protein kinase activity: phosphorylates PIK3R1 (p85alpha regulatory subunit), EIF4EBP1 and HRAS. Plays a role in the positive regulation of phagocytosis and pinocytosis (By similarity). |
| Biological Process |
GO:0001525 angiogenesis GO:0001667 ameboidal-type cell migration GO:0001678 cellular glucose homeostasis GO:0001889 liver development GO:0002429 immune response-activating cell surface receptor signaling pathway GO:0002431 Fc receptor mediated stimulatory signaling pathway GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis GO:0002694 regulation of leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0002757 immune response-activating signal transduction GO:0002764 immune response-regulating signaling pathway GO:0002768 immune response-regulating cell surface receptor signaling pathway GO:0003012 muscle system process GO:0003013 circulatory system process GO:0003015 heart process GO:0005996 monosaccharide metabolic process GO:0006006 glucose metabolic process GO:0006091 generation of precursor metabolites and energy GO:0006304 DNA modification GO:0006305 DNA alkylation GO:0006306 DNA methylation GO:0006644 phospholipid metabolic process GO:0006650 glycerophospholipid metabolic process GO:0006661 phosphatidylinositol biosynthetic process GO:0006909 phagocytosis GO:0006936 muscle contraction GO:0006941 striated muscle contraction GO:0007159 leukocyte cell-cell adhesion GO:0007173 epidermal growth factor receptor signaling pathway GO:0007596 blood coagulation GO:0007599 hemostasis GO:0008015 blood circulation GO:0008286 insulin receptor signaling pathway GO:0008654 phospholipid biosynthetic process GO:0009743 response to carbohydrate GO:0009746 response to hexose GO:0009749 response to glucose GO:0010631 epithelial cell migration GO:0014065 phosphatidylinositol 3-kinase signaling GO:0014066 regulation of phosphatidylinositol 3-kinase signaling GO:0015980 energy derivation by oxidation of organic compounds GO:0018105 peptidyl-serine phosphorylation GO:0018209 peptidyl-serine modification GO:0019318 hexose metabolic process GO:0022407 regulation of cell-cell adhesion GO:0022409 positive regulation of cell-cell adhesion GO:0030168 platelet activation GO:0030258 lipid modification GO:0031294 lymphocyte costimulation GO:0031295 T cell costimulation GO:0032147 activation of protein kinase activity GO:0032259 methylation GO:0032868 response to insulin GO:0032869 cellular response to insulin stimulus GO:0033135 regulation of peptidyl-serine phosphorylation GO:0033138 positive regulation of peptidyl-serine phosphorylation GO:0033500 carbohydrate homeostasis GO:0033674 positive regulation of kinase activity GO:0034284 response to monosaccharide GO:0035264 multicellular organism growth GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase GO:0038093 Fc receptor signaling pathway GO:0038094 Fc-gamma receptor signaling pathway GO:0038095 Fc-epsilon receptor signaling pathway GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038127 ERBB signaling pathway GO:0038128 ERBB2 signaling pathway GO:0040014 regulation of multicellular organism growth GO:0042110 T cell activation GO:0042593 glucose homeostasis GO:0043276 anoikis GO:0043414 macromolecule methylation GO:0043434 response to peptide hormone GO:0043457 regulation of cellular respiration GO:0043467 regulation of generation of precursor metabolites and energy GO:0043491 protein kinase B signaling GO:0043523 regulation of neuron apoptotic process GO:0043524 negative regulation of neuron apoptotic process GO:0043542 endothelial cell migration GO:0044028 DNA hypomethylation GO:0044029 hypomethylation of CpG island GO:0044030 regulation of DNA methylation GO:0044346 fibroblast apoptotic process GO:0044723 single-organism carbohydrate metabolic process GO:0044728 DNA methylation or demethylation GO:0045017 glycerolipid biosynthetic process GO:0045333 cellular respiration GO:0045785 positive regulation of cell adhesion GO:0045860 positive regulation of protein kinase activity GO:0046474 glycerophospholipid biosynthetic process GO:0046486 glycerolipid metabolic process GO:0046488 phosphatidylinositol metabolic process GO:0046834 lipid phosphorylation GO:0046854 phosphatidylinositol phosphorylation GO:0048010 vascular endothelial growth factor receptor signaling pathway GO:0048015 phosphatidylinositol-mediated signaling GO:0048017 inositol lipid-mediated signaling GO:0048514 blood vessel morphogenesis GO:0048638 regulation of developmental growth GO:0048732 gland development GO:0048871 multicellular organismal homeostasis GO:0050817 coagulation GO:0050851 antigen receptor-mediated signaling pathway GO:0050852 T cell receptor signaling pathway GO:0050863 regulation of T cell activation GO:0050865 regulation of cell activation GO:0050867 positive regulation of cell activation GO:0050870 positive regulation of T cell activation GO:0050878 regulation of body fluid levels GO:0050900 leukocyte migration GO:0051052 regulation of DNA metabolic process GO:0051249 regulation of lymphocyte activation GO:0051251 positive regulation of lymphocyte activation GO:0051402 neuron apoptotic process GO:0060047 heart contraction GO:0060048 cardiac muscle contraction GO:0060612 adipose tissue development GO:0061008 hepaticobiliary system development GO:0061448 connective tissue development GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0070997 neuron death GO:0071322 cellular response to carbohydrate stimulus GO:0071326 cellular response to monosaccharide stimulus GO:0071331 cellular response to hexose stimulus GO:0071333 cellular response to glucose stimulus GO:0071375 cellular response to peptide hormone stimulus GO:0071417 cellular response to organonitrogen compound GO:0071514 genetic imprinting GO:0071593 lymphocyte aggregation GO:0090130 tissue migration GO:0090132 epithelium migration GO:0097009 energy homeostasis GO:1901214 regulation of neuron death GO:1901215 negative regulation of neuron death GO:1901652 response to peptide GO:1901653 cellular response to peptide GO:1903037 regulation of leukocyte cell-cell adhesion GO:1903039 positive regulation of leukocyte cell-cell adhesion GO:2000209 regulation of anoikis GO:2000269 regulation of fibroblast apoptotic process GO:2000270 negative regulation of fibroblast apoptotic process GO:2000653 regulation of genetic imprinting GO:2000811 negative regulation of anoikis |
| Molecular Function |
GO:0004674 protein serine/threonine kinase activity GO:0008047 enzyme activator activity GO:0016303 1-phosphatidylinositol-3-kinase activity GO:0016307 phosphatidylinositol phosphate kinase activity GO:0019207 kinase regulator activity GO:0019209 kinase activator activity GO:0019887 protein kinase regulator activity GO:0030295 protein kinase activator activity GO:0035004 phosphatidylinositol 3-kinase activity GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity GO:0043560 insulin receptor substrate binding GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0052742 phosphatidylinositol kinase activity GO:0052813 phosphatidylinositol bisphosphate kinase activity |
| Cellular Component |
GO:0005942 phosphatidylinositol 3-kinase complex GO:0005943 phosphatidylinositol 3-kinase complex, class IA GO:0019898 extrinsic component of membrane GO:0030027 lamellipodium GO:0031252 cell leading edge GO:0061695 transferase complex, transferring phosphorus-containing groups GO:0097651 phosphatidylinositol 3-kinase complex, class I |
| KEGG |
hsa04012 ErbB signaling pathway hsa04014 Ras signaling pathway hsa04015 Rap1 signaling pathway hsa04024 cAMP signaling pathway hsa04062 Chemokine signaling pathway hsa04066 HIF-1 signaling pathway hsa04068 FoxO signaling pathway hsa04070 Phosphatidylinositol signaling system hsa04071 Sphingolipid signaling pathway hsa04140 Regulation of autophagy hsa04150 mTOR signaling pathway hsa04151 PI3K-Akt signaling pathway hsa04152 AMPK signaling pathway hsa04210 Apoptosis hsa04360 Axon guidance hsa04370 VEGF signaling pathway hsa04380 Osteoclast differentiation hsa04510 Focal adhesion hsa04550 Signaling pathways regulating pluripotency of stem cells hsa04611 Platelet activation hsa04620 Toll-like receptor signaling pathway hsa04630 Jak-STAT signaling pathway hsa04650 Natural killer cell mediated cytotoxicity hsa04660 T cell receptor signaling pathway hsa04662 B cell receptor signaling pathway hsa04664 Fc epsilon RI signaling pathway hsa04666 Fc gamma R-mediated phagocytosis hsa04668 TNF signaling pathway hsa04670 Leukocyte transendothelial migration hsa04722 Neurotrophin signaling pathway hsa04725 Cholinergic synapse hsa04750 Inflammatory mediator regulation of TRP channels hsa04810 Regulation of actin cytoskeleton hsa04910 Insulin signaling pathway hsa04914 Progesterone-mediated oocyte maturation hsa04915 Estrogen signaling pathway hsa04917 Prolactin signaling pathway hsa04919 Thyroid hormone signaling pathway hsa04960 Aldosterone-regulated sodium reabsorption hsa04973 Carbohydrate digestion and absorption hsa00562 Inositol phosphate metabolism |
| Reactome |
R-HSA-1280218: Adaptive Immune System R-HSA-422475: Axon guidance R-HSA-389356: CD28 co-stimulation R-HSA-389357: CD28 dependent PI3K/Akt signaling R-HSA-202733: Cell surface interactions at the vascular wall R-HSA-1500931: Cell-Cell communication R-HSA-2219530: Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-5637810: Constitutive Signaling by EGFRvIII R-HSA-1236382: Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-388841: Costimulation by the CD28 family R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-2172127: DAP12 interactions R-HSA-2424491: DAP12 signaling R-HSA-1266738: Developmental Biology R-HSA-1643685: Disease R-HSA-5663202: Diseases of signal transduction R-HSA-202424: Downstream TCR signaling R-HSA-186763: Downstream signal transduction R-HSA-1168372: Downstream signaling events of B Cell Receptor (BCR) R-HSA-5654687: Downstream signaling of activated FGFR1 R-HSA-5654696: Downstream signaling of activated FGFR2 R-HSA-5654708: Downstream signaling of activated FGFR3 R-HSA-5654716: Downstream signaling of activated FGFR4 R-HSA-1839124: FGFR1 mutant receptor activation R-HSA-2454202: Fc epsilon receptor (FCERI) signaling R-HSA-2029480: Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-416482: G alpha (12/13) signalling events R-HSA-416476: G alpha (q) signalling events R-HSA-392451: G beta R-HSA-397795: G-protein beta R-HSA-180292: GAB1 signalosome R-HSA-388396: GPCR downstream signaling R-HSA-114604: GPVI-mediated activation cascade R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-109582: Hemostasis R-HSA-2428924: IGF1R signaling cascade R-HSA-112399: IRS-mediated signalling R-HSA-2428928: IRS-related events triggered by IGF1R R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-74751: Insulin receptor signalling cascade R-HSA-912526: Interleukin receptor SHC signaling R-HSA-451927: Interleukin-2 signaling R-HSA-512988: Interleukin-3, 5 and GM-CSF signaling R-HSA-8851907: MET activates PI3K/AKT signaling R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins R-HSA-187037: NGF signalling via TRKA from the plasma membrane R-HSA-199418: Negative regulation of the PI3K/AKT network R-HSA-373753: Nephrin interactions R-HSA-1483255: PI Metabolism R-HSA-5654689: PI-3K cascade R-HSA-5654695: PI-3K cascade R-HSA-5654710: PI-3K cascade R-HSA-5654720: PI-3K cascade R-HSA-109704: PI3K Cascade R-HSA-1963642: PI3K events in ERBB2 signaling R-HSA-1250342: PI3K events in ERBB4 signaling R-HSA-2219528: PI3K/AKT Signaling in Cancer R-HSA-198203: PI3K/AKT activation R-HSA-6811558: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-1257604: PIP3 activates AKT signaling R-HSA-1483257: Phospholipid metabolism R-HSA-76002: Platelet activation, signaling and aggregation R-HSA-8853659: RET signaling R-HSA-912631: Regulation of signaling by CBL R-HSA-2730905: Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2029485: Role of phospholipids in phagocytosis R-HSA-162582: Signal Transduction R-HSA-177929: Signaling by EGFR R-HSA-1643713: Signaling by EGFR in Cancer R-HSA-5637812: Signaling by EGFRvIII in Cancer R-HSA-1227986: Signaling by ERBB2 R-HSA-1236394: Signaling by ERBB4 R-HSA-190236: Signaling by FGFR R-HSA-1226099: Signaling by FGFR in disease R-HSA-5654736: Signaling by FGFR1 R-HSA-5655302: Signaling by FGFR1 in disease R-HSA-5654738: Signaling by FGFR2 R-HSA-5655253: Signaling by FGFR2 in disease R-HSA-5654741: Signaling by FGFR3 R-HSA-8853334: Signaling by FGFR3 fusions in cancer R-HSA-5655332: Signaling by FGFR3 in disease R-HSA-8853338: Signaling by FGFR3 point mutants in cancer R-HSA-5654743: Signaling by FGFR4 R-HSA-5655291: Signaling by FGFR4 in disease R-HSA-372790: Signaling by GPCR R-HSA-74752: Signaling by Insulin receptor R-HSA-449147: Signaling by Interleukins R-HSA-5637815: Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-6806834: Signaling by MET R-HSA-186797: Signaling by PDGF R-HSA-1433557: Signaling by SCF-KIT R-HSA-2404192: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-194138: Signaling by VEGF R-HSA-1839117: Signaling by cytosolic FGFR1 fusion mutants R-HSA-983705: Signaling by the B Cell Receptor (BCR) R-HSA-166520: Signalling by NGF R-HSA-1660499: Synthesis of PIPs at the plasma membrane R-HSA-202403: TCR signaling R-HSA-210993: Tie2 Signaling R-HSA-4420097: VEGFA-VEGFR2 Pathway |
| Summary | |
|---|---|
| Symbol | PIK3CA |
| Name | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha |
| Aliases | phosphoinositide-3-kinase, catalytic, alpha polypeptide; CLOVE; CWS5; MCMTC; p110-alpha; PI3-kinase p110 sub ...... |
| Chromosomal Location | 3q26.3 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content | Literatures that report relations between PIK3CA and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
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Literatures describing the relation between PIK3CA and anti-tumor immunity in human cancer.
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| Summary | |
|---|---|
| Symbol | PIK3CA |
| Name | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha |
| Aliases | phosphoinositide-3-kinase, catalytic, alpha polypeptide; CLOVE; CWS5; MCMTC; p110-alpha; PI3-kinase p110 sub ...... |
| Chromosomal Location | 3q26.3 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
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> High-throughput Screening
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Statistical results of PIK3CA in screening data sets for detecting immune reponses.
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| Summary | |
|---|---|
| Symbol | PIK3CA |
| Name | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha |
| Aliases | phosphoinositide-3-kinase, catalytic, alpha polypeptide; CLOVE; CWS5; MCMTC; p110-alpha; PI3-kinase p110 sub ...... |
| Chromosomal Location | 3q26.3 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
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Points in the above scatter plot represent the expression difference of PIK3CA in various data sets.
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Points in the above scatter plot represent the mutation difference of PIK3CA in various data sets.
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| Summary | |
|---|---|
| Symbol | PIK3CA |
| Name | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha |
| Aliases | phosphoinositide-3-kinase, catalytic, alpha polypeptide; CLOVE; CWS5; MCMTC; p110-alpha; PI3-kinase p110 sub ...... |
| Chromosomal Location | 3q26.3 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PIK3CA. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
| Summary | |
|---|---|
| Symbol | PIK3CA |
| Name | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha |
| Aliases | phosphoinositide-3-kinase, catalytic, alpha polypeptide; CLOVE; CWS5; MCMTC; p110-alpha; PI3-kinase p110 sub ...... |
| Chromosomal Location | 3q26.3 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PIK3CA. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PIK3CA. > Immunoinhibitor > Immunostimulator > MHC molecule |
| Summary | |
|---|---|
| Symbol | PIK3CA |
| Name | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha |
| Aliases | phosphoinositide-3-kinase, catalytic, alpha polypeptide; CLOVE; CWS5; MCMTC; p110-alpha; PI3-kinase p110 sub ...... |
| Chromosomal Location | 3q26.3 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PIK3CA. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
| Summary | |
|---|---|
| Symbol | PIK3CA |
| Name | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha |
| Aliases | phosphoinositide-3-kinase, catalytic, alpha polypeptide; CLOVE; CWS5; MCMTC; p110-alpha; PI3-kinase p110 sub ...... |
| Chromosomal Location | 3q26.3 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Distribution of PIK3CA expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
| Summary | |
|---|---|
| Symbol | PIK3CA |
| Name | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha |
| Aliases | phosphoinositide-3-kinase, catalytic, alpha polypeptide; CLOVE; CWS5; MCMTC; p110-alpha; PI3-kinase p110 sub ...... |
| Chromosomal Location | 3q26.3 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Associations between PIK3CA and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
| Summary | |
|---|---|
| Symbol | PIK3CA |
| Name | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha |
| Aliases | phosphoinositide-3-kinase, catalytic, alpha polypeptide; CLOVE; CWS5; MCMTC; p110-alpha; PI3-kinase p110 sub ...... |
| Chromosomal Location | 3q26.3 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content | Drugs targeting PIK3CA collected from DrugBank database. |
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Details on drugs targeting PIK3CA.
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