Browse PIK3CG

Summary
SymbolPIK3CG
Namephosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
Aliases phosphoinositide-3-kinase, catalytic, gamma polypeptide; PI3CG; PI3Kgamma; PIK3; p110gamma; p120-PI3K; 1-pho ......
Chromosomal Location7q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm Cell membrane
Domain PF00454 Phosphatidylinositol 3- and 4-kinase
PF00792 Phosphoinositide 3-kinase C2
PF00794 PI3-kinase family
PF00613 Phosphoinositide 3-kinase family
Function

Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Links G-protein coupled receptor activation to PIP3 production. Involved in immune, inflammatory and allergic responses. Modulates leukocyte chemotaxis to inflammatory sites and in response to chemoattractant agents. May control leukocyte polarization and migration by regulating the spatial accumulation of PIP3 and by regulating the organization of F-actin formation and integrin-based adhesion at the leading edge. Controls motility of dendritic cells. Together with PIK3CD is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in T-lymphocyte migration. Regulates T-lymphocyte proliferation and cytokine production. Together with PIK3CD participates in T-lymphocyte development. Required for B-lymphocyte development and signaling. Together with PIK3CD participates in neutrophil respiratory burst. Together with PIK3CD is involved in neutrophil chemotaxis and extravasation. Together with PIK3CB promotes platelet aggregation and thrombosis. Regulates alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) adhesive function in platelets downstream of P2Y12 through a lipid kinase activity-independent mechanism. May have also a lipid kinase activity-dependent function in platelet aggregation. Involved in endothelial progenitor cell migration. Negative regulator of cardiac contractility. Modulates cardiac contractility by anchoring protein kinase A (PKA) and PDE3B activation, reducing cAMP levels. Regulates cardiac contractility also by promoting beta-adrenergic receptor internalization by binding to GRK2 and by non-muscle tropomyosin phosphorylation. Also has serine/threonine protein kinase activity: both lipid and protein kinase activities are required for beta-adrenergic receptor endocytosis. May also have a scaffolding role in modulating cardiac contractility. Contributes to cardiac hypertrophy under pathological stress. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis.

> Gene Ontology
 
Biological Process GO:0001525 angiogenesis
GO:0002250 adaptive immune response
GO:0002263 cell activation involved in immune response
GO:0002274 myeloid leukocyte activation
GO:0002275 myeloid cell activation involved in immune response
GO:0002279 mast cell activation involved in immune response
GO:0002366 leukocyte activation involved in immune response
GO:0002407 dendritic cell chemotaxis
GO:0002443 leukocyte mediated immunity
GO:0002444 myeloid leukocyte mediated immunity
GO:0002448 mast cell mediated immunity
GO:0002526 acute inflammatory response
GO:0002673 regulation of acute inflammatory response
GO:0002675 positive regulation of acute inflammatory response
GO:0002679 respiratory burst involved in defense response
GO:0003012 muscle system process
GO:0003013 circulatory system process
GO:0003015 heart process
GO:0006638 neutral lipid metabolic process
GO:0006639 acylglycerol metabolic process
GO:0006641 triglyceride metabolic process
GO:0006644 phospholipid metabolic process
GO:0006650 glycerophospholipid metabolic process
GO:0006661 phosphatidylinositol biosynthetic process
GO:0006816 calcium ion transport
GO:0006874 cellular calcium ion homeostasis
GO:0006875 cellular metal ion homeostasis
GO:0006887 exocytosis
GO:0006936 muscle contraction
GO:0006937 regulation of muscle contraction
GO:0006941 striated muscle contraction
GO:0006942 regulation of striated muscle contraction
GO:0007159 leukocyte cell-cell adhesion
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007596 blood coagulation
GO:0007599 hemostasis
GO:0008015 blood circulation
GO:0008016 regulation of heart contraction
GO:0008654 phospholipid biosynthetic process
GO:0009894 regulation of catabolic process
GO:0009895 negative regulation of catabolic process
GO:0010818 T cell chemotaxis
GO:0010896 regulation of triglyceride catabolic process
GO:0010897 negative regulation of triglyceride catabolic process
GO:0010959 regulation of metal ion transport
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0014074 response to purine-containing compound
GO:0016042 lipid catabolic process
GO:0019216 regulation of lipid metabolic process
GO:0019433 triglyceride catabolic process
GO:0030168 platelet activation
GO:0030258 lipid modification
GO:0030593 neutrophil chemotaxis
GO:0030595 leukocyte chemotaxis
GO:0031329 regulation of cellular catabolic process
GO:0031330 negative regulation of cellular catabolic process
GO:0031349 positive regulation of defense response
GO:0032103 positive regulation of response to external stimulus
GO:0032252 secretory granule localization
GO:0032418 lysosome localization
GO:0032943 mononuclear cell proliferation
GO:0033627 cell adhesion mediated by integrin
GO:0033628 regulation of cell adhesion mediated by integrin
GO:0033674 positive regulation of kinase activity
GO:0034109 homotypic cell-cell adhesion
GO:0034762 regulation of transmembrane transport
GO:0034765 regulation of ion transmembrane transport
GO:0035747 natural killer cell chemotaxis
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process
GO:0036336 dendritic cell migration
GO:0042098 T cell proliferation
GO:0042110 T cell activation
GO:0043299 leukocyte degranulation
GO:0043303 mast cell degranulation
GO:0043405 regulation of MAP kinase activity
GO:0043406 positive regulation of MAP kinase activity
GO:0043410 positive regulation of MAPK cascade
GO:0043491 protein kinase B signaling
GO:0044057 regulation of system process
GO:0044242 cellular lipid catabolic process
GO:0044346 fibroblast apoptotic process
GO:0045017 glycerolipid biosynthetic process
GO:0045055 regulated exocytosis
GO:0045123 cellular extravasation
GO:0045576 mast cell activation
GO:0045730 respiratory burst
GO:0045822 negative regulation of heart contraction
GO:0045833 negative regulation of lipid metabolic process
GO:0045860 positive regulation of protein kinase activity
GO:0045932 negative regulation of muscle contraction
GO:0045988 negative regulation of striated muscle contraction
GO:0046461 neutral lipid catabolic process
GO:0046464 acylglycerol catabolic process
GO:0046474 glycerophospholipid biosynthetic process
GO:0046486 glycerolipid metabolic process
GO:0046488 phosphatidylinositol metabolic process
GO:0046503 glycerolipid catabolic process
GO:0046651 lymphocyte proliferation
GO:0046683 response to organophosphorus
GO:0046834 lipid phosphorylation
GO:0046854 phosphatidylinositol phosphorylation
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048017 inositol lipid-mediated signaling
GO:0048247 lymphocyte chemotaxis
GO:0048514 blood vessel morphogenesis
GO:0050727 regulation of inflammatory response
GO:0050729 positive regulation of inflammatory response
GO:0050817 coagulation
GO:0050878 regulation of body fluid levels
GO:0050900 leukocyte migration
GO:0050994 regulation of lipid catabolic process
GO:0050995 negative regulation of lipid catabolic process
GO:0051480 regulation of cytosolic calcium ion concentration
GO:0051591 response to cAMP
GO:0051640 organelle localization
GO:0051648 vesicle localization
GO:0051656 establishment of organelle localization
GO:0051896 regulation of protein kinase B signaling
GO:0051897 positive regulation of protein kinase B signaling
GO:0051924 regulation of calcium ion transport
GO:0055074 calcium ion homeostasis
GO:0055117 regulation of cardiac muscle contraction
GO:0055118 negative regulation of cardiac muscle contraction
GO:0060047 heart contraction
GO:0060048 cardiac muscle contraction
GO:0060326 cell chemotaxis
GO:0070486 leukocyte aggregation
GO:0070489 T cell aggregation
GO:0070527 platelet aggregation
GO:0070588 calcium ion transmembrane transport
GO:0070661 leukocyte proliferation
GO:0070838 divalent metal ion transport
GO:0071320 cellular response to cAMP
GO:0071407 cellular response to organic cyclic compound
GO:0071417 cellular response to organonitrogen compound
GO:0071593 lymphocyte aggregation
GO:0071621 granulocyte chemotaxis
GO:0071900 regulation of protein serine/threonine kinase activity
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0072503 cellular divalent inorganic cation homeostasis
GO:0072507 divalent inorganic cation homeostasis
GO:0072511 divalent inorganic cation transport
GO:0072672 neutrophil extravasation
GO:0072676 lymphocyte migration
GO:0072678 T cell migration
GO:0090207 regulation of triglyceride metabolic process
GO:0090209 negative regulation of triglyceride metabolic process
GO:0090257 regulation of muscle system process
GO:0097284 hepatocyte apoptotic process
GO:0097529 myeloid leukocyte migration
GO:0097530 granulocyte migration
GO:1903169 regulation of calcium ion transmembrane transport
GO:1903522 regulation of blood circulation
GO:1903523 negative regulation of blood circulation
GO:1904019 epithelial cell apoptotic process
GO:1904062 regulation of cation transmembrane transport
GO:1990266 neutrophil migration
GO:2000269 regulation of fibroblast apoptotic process
GO:2000270 negative regulation of fibroblast apoptotic process
Molecular Function GO:0004674 protein serine/threonine kinase activity
GO:0016303 1-phosphatidylinositol-3-kinase activity
GO:0016307 phosphatidylinositol phosphate kinase activity
GO:0035004 phosphatidylinositol 3-kinase activity
GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity
GO:0046875 ephrin receptor binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0052742 phosphatidylinositol kinase activity
GO:0052813 phosphatidylinositol bisphosphate kinase activity
Cellular Component GO:0005942 phosphatidylinositol 3-kinase complex
GO:0005944 phosphatidylinositol 3-kinase complex, class IB
GO:0019898 extrinsic component of membrane
GO:0042629 mast cell granule
GO:0061695 transferase complex, transferring phosphorus-containing groups
GO:0097651 phosphatidylinositol 3-kinase complex, class I
> KEGG and Reactome Pathway
 
KEGG hsa04022 cGMP-PKG signaling pathway
hsa04151 PI3K-Akt signaling pathway
hsa04261 Adrenergic signaling in cardiomyocytes
hsa04611 Platelet activation
hsa04725 Cholinergic synapse
hsa04921 Oxytocin signaling pathway
hsa00562 Inositol phosphate metabolism
Reactome R-HSA-392451: G beta
R-HSA-397795: G-protein beta
R-HSA-388396: GPCR downstream signaling
R-HSA-114604: GPVI-mediated activation cascade
R-HSA-109582: Hemostasis
R-HSA-1430728: Metabolism
R-HSA-556833: Metabolism of lipids and lipoproteins
R-HSA-1483255: PI Metabolism
R-HSA-1483257: Phospholipid metabolism
R-HSA-76002: Platelet activation, signaling and aggregation
R-HSA-162582: Signal Transduction
R-HSA-372790: Signaling by GPCR
R-HSA-1660499: Synthesis of PIPs at the plasma membrane
Summary
SymbolPIK3CG
Namephosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
Aliases phosphoinositide-3-kinase, catalytic, gamma polypeptide; PI3CG; PI3Kgamma; PIK3; p110gamma; p120-PI3K; 1-pho ......
Chromosomal Location7q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between PIK3CG and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between PIK3CG and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
28478231Non-Small Cell Lung CarcinomaInhibit immunity (T cell function)Radiotherapy may up-regulate PD-L1 expression through the phosphoinositide 3-kinase/AKT and signal transducer and activator of transcription 3 pathways.
Summary
SymbolPIK3CG
Namephosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
Aliases phosphoinositide-3-kinase, catalytic, gamma polypeptide; PI3CG; PI3Kgamma; PIK3; p110gamma; p120-PI3K; 1-pho ......
Chromosomal Location7q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of PIK3CG in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolPIK3CG
Namephosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
Aliases phosphoinositide-3-kinase, catalytic, gamma polypeptide; PI3CG; PI3Kgamma; PIK3; p110gamma; p120-PI3K; 1-pho ......
Chromosomal Location7q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of PIK3CG in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.1940.607
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.3560.633
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.5950.318
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.1460.717
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.1220.941
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.1730.936
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.460.315
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.8050.439
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.1080.923
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 481.2430.0709
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.1840.265
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0460.787
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of PIK3CG in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.75.5-1.81
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.76.8-3.11
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)2117195.913.10.355
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)86250250.473
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131115.49.16.31
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.1011.10.36
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.311.1-5.80.642
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.221.4-15.20.315
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11139.109.10.458
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 6116.7016.71
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolPIK3CG
Namephosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
Aliases phosphoinositide-3-kinase, catalytic, gamma polypeptide; PI3CG; PI3Kgamma; PIK3; p110gamma; p120-PI3K; 1-pho ......
Chromosomal Location7q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PIK3CG. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolPIK3CG
Namephosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
Aliases phosphoinositide-3-kinase, catalytic, gamma polypeptide; PI3CG; PI3Kgamma; PIK3; p110gamma; p120-PI3K; 1-pho ......
Chromosomal Location7q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PIK3CG. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PIK3CG.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolPIK3CG
Namephosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
Aliases phosphoinositide-3-kinase, catalytic, gamma polypeptide; PI3CG; PI3Kgamma; PIK3; p110gamma; p120-PI3K; 1-pho ......
Chromosomal Location7q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PIK3CG. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolPIK3CG
Namephosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
Aliases phosphoinositide-3-kinase, catalytic, gamma polypeptide; PI3CG; PI3Kgamma; PIK3; p110gamma; p120-PI3K; 1-pho ......
Chromosomal Location7q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of PIK3CG expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolPIK3CG
Namephosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
Aliases phosphoinositide-3-kinase, catalytic, gamma polypeptide; PI3CG; PI3Kgamma; PIK3; p110gamma; p120-PI3K; 1-pho ......
Chromosomal Location7q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between PIK3CG and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolPIK3CG
Namephosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
Aliases phosphoinositide-3-kinase, catalytic, gamma polypeptide; PI3CG; PI3Kgamma; PIK3; p110gamma; p120-PI3K; 1-pho ......
Chromosomal Location7q22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting PIK3CG collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting PIK3CG.
ID Name Drug Type Targets #Targets
DB02010StaurosporineSmall MoleculeCDK2, CHRM1, CSK, GSK3B, ITK, LCK, MAPKAPK2, PDPK1, PIK3CG, PIM1, ......13
DB02375MyricetinSmall MoleculeJAK1, PIK3CG2
DB02656LY-294002Small MoleculePIK3CG, PIM12
DB04216QuercetinSmall MoleculeACTB, AHR, ATP5A1, ATP5B, ATP5C1, CBR1, CEBPB, CSNK2A1, CSNK2B, CY ......27
DB047695-QUINOXALIN-6-YLMETHYLENE-THIAZOLIDINE-2,4-DIONESmall MoleculePIK3CG1
DB05241XL765Small MoleculeMTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG5
DB068312-((9H-PURIN-6-YLTHIO)METHYL)-5-CHLORO-3-(2-METHOXYPHENYL)QUINAZOLIN-4(3H)-ONESmall MoleculePIK3CD, PIK3CG2
DB06836N-(5-{4-Chloro-3-[(2-hydroxyethyl)sulfamoyl]phenyl}-4-methyl-1,3-thiazol-2-yl)acetamideSmall MoleculePIK3C3, PIK3CG2
DB070735,5-dimethyl-2-morpholin-4-yl-5,6-dihydro-1,3-benzothiazol-7(4H)-oneSmall MoleculePIK3CG1
DB073353-[4-AMINO-1-(1-METHYLETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL]PHENOLSmall MoleculePIK3CG, SRC2
DB07503(5E)-5-[(2,2-DIFLUORO-1,3-BENZODIOXOL-5-YL)METHYLENE]-1,3-THIAZOLIDINE-2,4-DIONESmall MoleculePIK3CG1
DB08059(1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4,3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATESmall MoleculePIK3CA, PIK3CG, PIK3R1, PLK14
DB083001-methyl-3-naphthalen-2-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amineSmall MoleculePIK3CG1