Browse PLA2G2D

Summary
SymbolPLA2G2D
Namephospholipase A2, group IID
Aliases sPLA2S; PLA2IID; SPLASH; sPLA2-IID; GIID sPLA2; phosphatidylcholine 2-acylhydrolase 2D; secretory phospholip ......
Chromosomal Location1p36.12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Secreted
Domain PF00068 Phospholipase A2
Function

PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. L-alpha-1-palmitoyl-2-linoleoyl phosphatidylethanolamine is more efficiently hydrolyzed than the other phospholipids examined.

> Gene Ontology
 
Biological Process GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
GO:0002521 leukocyte differentiation
GO:0002683 negative regulation of immune system process
GO:0002694 regulation of leukocyte activation
GO:0002695 negative regulation of leukocyte activation
GO:0006575 cellular modified amino acid metabolic process
GO:0006644 phospholipid metabolic process
GO:0006650 glycerophospholipid metabolic process
GO:0006654 phosphatidic acid biosynthetic process
GO:0006658 phosphatidylserine metabolic process
GO:0006820 anion transport
GO:0006869 lipid transport
GO:0007159 leukocyte cell-cell adhesion
GO:0007162 negative regulation of cell adhesion
GO:0010876 lipid localization
GO:0015711 organic anion transport
GO:0015718 monocarboxylic acid transport
GO:0015908 fatty acid transport
GO:0015909 long-chain fatty acid transport
GO:0016042 lipid catabolic process
GO:0022407 regulation of cell-cell adhesion
GO:0022408 negative regulation of cell-cell adhesion
GO:0030098 lymphocyte differentiation
GO:0030217 T cell differentiation
GO:0032309 icosanoid secretion
GO:0032943 mononuclear cell proliferation
GO:0032944 regulation of mononuclear cell proliferation
GO:0032945 negative regulation of mononuclear cell proliferation
GO:0035710 CD4-positive, alpha-beta T cell activation
GO:0036148 phosphatidylglycerol acyl-chain remodeling
GO:0036149 phosphatidylinositol acyl-chain remodeling
GO:0036150 phosphatidylserine acyl-chain remodeling
GO:0036151 phosphatidylcholine acyl-chain remodeling
GO:0036152 phosphatidylethanolamine acyl-chain remodeling
GO:0042098 T cell proliferation
GO:0042110 T cell activation
GO:0042129 regulation of T cell proliferation
GO:0042130 negative regulation of T cell proliferation
GO:0043367 CD4-positive, alpha-beta T cell differentiation
GO:0045066 regulatory T cell differentiation
GO:0046470 phosphatidylcholine metabolic process
GO:0046471 phosphatidylglycerol metabolic process
GO:0046473 phosphatidic acid metabolic process
GO:0046486 glycerolipid metabolic process
GO:0046488 phosphatidylinositol metabolic process
GO:0046631 alpha-beta T cell activation
GO:0046632 alpha-beta T cell differentiation
GO:0046651 lymphocyte proliferation
GO:0046942 carboxylic acid transport
GO:0050482 arachidonic acid secretion
GO:0050670 regulation of lymphocyte proliferation
GO:0050672 negative regulation of lymphocyte proliferation
GO:0050863 regulation of T cell activation
GO:0050865 regulation of cell activation
GO:0050866 negative regulation of cell activation
GO:0050868 negative regulation of T cell activation
GO:0051249 regulation of lymphocyte activation
GO:0051250 negative regulation of lymphocyte activation
GO:0070486 leukocyte aggregation
GO:0070489 T cell aggregation
GO:0070661 leukocyte proliferation
GO:0070663 regulation of leukocyte proliferation
GO:0070664 negative regulation of leukocyte proliferation
GO:0071593 lymphocyte aggregation
GO:0071715 icosanoid transport
GO:0097164 ammonium ion metabolic process
GO:1903037 regulation of leukocyte cell-cell adhesion
GO:1903038 negative regulation of leukocyte cell-cell adhesion
GO:1903963 arachidonate transport
Molecular Function GO:0001948 glycoprotein binding
GO:0004620 phospholipase activity
GO:0004623 phospholipase A2 activity
GO:0005539 glycosaminoglycan binding
GO:0008201 heparin binding
GO:0016298 lipase activity
GO:0043394 proteoglycan binding
GO:0043395 heparan sulfate proteoglycan binding
GO:0052689 carboxylic ester hydrolase activity
GO:1901681 sulfur compound binding
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa04014 Ras signaling pathway
hsa04270 Vascular smooth muscle contraction
hsa04972 Pancreatic secretion
hsa04975 Fat digestion and absorption
hsa00564 Glycerophospholipid metabolism
hsa00565 Ether lipid metabolism
hsa00590 Arachidonic acid metabolism
hsa00591 Linoleic acid metabolism
hsa00592 alpha-Linolenic acid metabolism
hsa01100 Metabolic pathways
Reactome R-HSA-1482788: Acyl chain remodelling of PC
R-HSA-1482839: Acyl chain remodelling of PE
R-HSA-1482925: Acyl chain remodelling of PG
R-HSA-1482922: Acyl chain remodelling of PI
R-HSA-1482801: Acyl chain remodelling of PS
R-HSA-1483206: Glycerophospholipid biosynthesis
R-HSA-1430728: Metabolism
R-HSA-556833: Metabolism of lipids and lipoproteins
R-HSA-1483257: Phospholipid metabolism
R-HSA-1483166: Synthesis of PA
Summary
SymbolPLA2G2D
Namephospholipase A2, group IID
Aliases sPLA2S; PLA2IID; SPLASH; sPLA2-IID; GIID sPLA2; phosphatidylcholine 2-acylhydrolase 2D; secretory phospholip ......
Chromosomal Location1p36.12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between PLA2G2D and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between PLA2G2D and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
27226632MelanomaInhibit immunityAltogether, these results underscore a general role of sPLA2-IID as an immunosuppressive sPLA2 that allows the microenvironmental lipid balance toward an anti-inflammatory state, exerting beneficial or detrimental impact depending upon distinct pathophysiological contexts in inflammation and cancer.
Summary
SymbolPLA2G2D
Namephospholipase A2, group IID
Aliases sPLA2S; PLA2IID; SPLASH; sPLA2-IID; GIID sPLA2; phosphatidylcholine 2-acylhydrolase 2D; secretory phospholip ......
Chromosomal Location1p36.12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of PLA2G2D in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolPLA2G2D
Namephospholipase A2, group IID
Aliases sPLA2S; PLA2IID; SPLASH; sPLA2-IID; GIID sPLA2; phosphatidylcholine 2-acylhydrolase 2D; secretory phospholip ......
Chromosomal Location1p36.12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of PLA2G2D in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.2970.673
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)651.2130.34
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.3750.728
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.5220.5
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.4840.678
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 471.7970.176
729033130MelanomaallAnti-PD-1 (nivolumab) 26231.4370.141
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15112.3470.0875
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.2030.897
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.8750.368
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.6310.631
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.6790.0938
> Mutation difference between responders and non-responders
 

There is no record.
Summary
SymbolPLA2G2D
Namephospholipase A2, group IID
Aliases sPLA2S; PLA2IID; SPLASH; sPLA2-IID; GIID sPLA2; phosphatidylcholine 2-acylhydrolase 2D; secretory phospholip ......
Chromosomal Location1p36.12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PLA2G2D. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolPLA2G2D
Namephospholipase A2, group IID
Aliases sPLA2S; PLA2IID; SPLASH; sPLA2-IID; GIID sPLA2; phosphatidylcholine 2-acylhydrolase 2D; secretory phospholip ......
Chromosomal Location1p36.12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PLA2G2D. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PLA2G2D.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolPLA2G2D
Namephospholipase A2, group IID
Aliases sPLA2S; PLA2IID; SPLASH; sPLA2-IID; GIID sPLA2; phosphatidylcholine 2-acylhydrolase 2D; secretory phospholip ......
Chromosomal Location1p36.12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PLA2G2D. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolPLA2G2D
Namephospholipase A2, group IID
Aliases sPLA2S; PLA2IID; SPLASH; sPLA2-IID; GIID sPLA2; phosphatidylcholine 2-acylhydrolase 2D; secretory phospholip ......
Chromosomal Location1p36.12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of PLA2G2D expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolPLA2G2D
Namephospholipase A2, group IID
Aliases sPLA2S; PLA2IID; SPLASH; sPLA2-IID; GIID sPLA2; phosphatidylcholine 2-acylhydrolase 2D; secretory phospholip ......
Chromosomal Location1p36.12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between PLA2G2D and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolPLA2G2D
Namephospholipase A2, group IID
Aliases sPLA2S; PLA2IID; SPLASH; sPLA2-IID; GIID sPLA2; phosphatidylcholine 2-acylhydrolase 2D; secretory phospholip ......
Chromosomal Location1p36.12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting PLA2G2D collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting PLA2G2D.
ID Name Drug Type Targets #Targets
DB03017Lauric AcidSmall MoleculeADH5, C8G, GLTP, GM2A, HNF4A, LTF, LY96, PLA2G2A, PLA2G2D, PPARA, ......12
DB03193Stearic acidSmall MoleculePLA2G2D, PPARA2