Browse PLD3

Summary
SymbolPLD3
Namephospholipase D family, member 3
Aliases HU-K4; phospholipase D3; AD19; HUK4; choline phosphatase 3; hindIII K4L homolog; phosphatidylcholine-hydroly ......
Chromosomal Location19q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Endoplasmic reticulum membrane Single-pass type II membrane protein
Domain PF00614 Phospholipase D Active site motif
PF13918 PLD-like domain
Function

May be involved in APP processing.

> Gene Ontology
 
Biological Process GO:0016042 lipid catabolic process
Molecular Function GO:0004620 phospholipase activity
GO:0004630 phospholipase D activity
GO:0008081 phosphoric diester hydrolase activity
GO:0016298 lipase activity
GO:0042578 phosphoric ester hydrolase activity
GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa00564 Glycerophospholipid metabolism
hsa00565 Ether lipid metabolism
hsa01100 Metabolic pathways
Reactome R-HSA-2029480: Fcgamma receptor (FCGR) dependent phagocytosis
R-HSA-1483206: Glycerophospholipid biosynthesis
R-HSA-168256: Immune System
R-HSA-168249: Innate Immune System
R-HSA-1430728: Metabolism
R-HSA-556833: Metabolism of lipids and lipoproteins
R-HSA-1483257: Phospholipid metabolism
R-HSA-2029485: Role of phospholipids in phagocytosis
R-HSA-1483148: Synthesis of PG
Summary
SymbolPLD3
Namephospholipase D family, member 3
Aliases HU-K4; phospholipase D3; AD19; HUK4; choline phosphatase 3; hindIII K4L homolog; phosphatidylcholine-hydroly ......
Chromosomal Location19q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between PLD3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolPLD3
Namephospholipase D family, member 3
Aliases HU-K4; phospholipase D3; AD19; HUK4; choline phosphatase 3; hindIII K4L homolog; phosphatidylcholine-hydroly ......
Chromosomal Location19q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of PLD3 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.98 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolPLD3
Namephospholipase D family, member 3
Aliases HU-K4; phospholipase D3; AD19; HUK4; choline phosphatase 3; hindIII K4L homolog; phosphatidylcholine-hydroly ......
Chromosomal Location19q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of PLD3 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.530.149
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-1.1270.737
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.0940.97
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.1820.709
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.0270.991
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.450.891
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.1490.785
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.1990.923
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.2130.93
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.6010.798
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.7780.828
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.1220.147
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of PLD3 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.15.91.21
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1031033.3-23.30.423
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.41.460.177
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.41.75.70.231
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.1011.10.36
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolPLD3
Namephospholipase D family, member 3
Aliases HU-K4; phospholipase D3; AD19; HUK4; choline phosphatase 3; hindIII K4L homolog; phosphatidylcholine-hydroly ......
Chromosomal Location19q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PLD3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolPLD3
Namephospholipase D family, member 3
Aliases HU-K4; phospholipase D3; AD19; HUK4; choline phosphatase 3; hindIII K4L homolog; phosphatidylcholine-hydroly ......
Chromosomal Location19q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PLD3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PLD3.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolPLD3
Namephospholipase D family, member 3
Aliases HU-K4; phospholipase D3; AD19; HUK4; choline phosphatase 3; hindIII K4L homolog; phosphatidylcholine-hydroly ......
Chromosomal Location19q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PLD3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolPLD3
Namephospholipase D family, member 3
Aliases HU-K4; phospholipase D3; AD19; HUK4; choline phosphatase 3; hindIII K4L homolog; phosphatidylcholine-hydroly ......
Chromosomal Location19q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of PLD3 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolPLD3
Namephospholipase D family, member 3
Aliases HU-K4; phospholipase D3; AD19; HUK4; choline phosphatase 3; hindIII K4L homolog; phosphatidylcholine-hydroly ......
Chromosomal Location19q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between PLD3 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolPLD3
Namephospholipase D family, member 3
Aliases HU-K4; phospholipase D3; AD19; HUK4; choline phosphatase 3; hindIII K4L homolog; phosphatidylcholine-hydroly ......
Chromosomal Location19q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting PLD3 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.