Browse POMC

Summary
SymbolPOMC
Nameproopiomelanocortin
Aliases POC; ACTH; NPP; adrenocorticotropin; beta-lipotropin; alpha-melanocyte stimulating hormone; beta-melanocyte ......
Chromosomal Location2p23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Secreted Note=Melanocyte-stimulating hormone alpha and beta-endorphin are stored in separate granules in hypothalamic POMC neurons, suggesting that secretion may be under the control of different regulatory mechanisms.
Domain PF00976 Corticotropin ACTH domain
PF08384 Pro-opiomelanocortin
PF08035 Opioids neuropeptide
Function

Corticotropin: Stimulates the adrenal glands to release cortisol.; FUNCTION: Melanocyte-stimulating hormone alpha: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes.; FUNCTION: Melanocyte-stimulating hormone beta: Increases the pigmentation of skin by increasing melanin production in melanocytes.; FUNCTION: Beta-endorphin: Endogenous orexigenic opiate.; FUNCTION: Met-enkephalin: Endogenous opiate.

> Gene Ontology
 
Biological Process GO:0001818 negative regulation of cytokine production
GO:0003013 circulatory system process
GO:0005976 polysaccharide metabolic process
GO:0005977 glycogen metabolic process
GO:0005996 monosaccharide metabolic process
GO:0006006 glucose metabolic process
GO:0006073 cellular glucan metabolic process
GO:0006091 generation of precursor metabolites and energy
GO:0006109 regulation of carbohydrate metabolic process
GO:0006112 energy reserve metabolic process
GO:0006869 lipid transport
GO:0007218 neuropeptide signaling pathway
GO:0008015 blood circulation
GO:0008217 regulation of blood pressure
GO:0009914 hormone transport
GO:0009991 response to extracellular stimulus
GO:0010675 regulation of cellular carbohydrate metabolic process
GO:0010817 regulation of hormone levels
GO:0010876 lipid localization
GO:0010906 regulation of glucose metabolic process
GO:0015850 organic hydroxy compound transport
GO:0015980 energy derivation by oxidation of organic compounds
GO:0016485 protein processing
GO:0016486 peptide hormone processing
GO:0019318 hexose metabolic process
GO:0023061 signal release
GO:0031667 response to nutrient levels
GO:0032098 regulation of appetite
GO:0032368 regulation of lipid transport
GO:0032640 tumor necrosis factor production
GO:0032680 regulation of tumor necrosis factor production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032881 regulation of polysaccharide metabolic process
GO:0033059 cellular pigmentation
GO:0033500 carbohydrate homeostasis
GO:0035929 steroid hormone secretion
GO:0035930 corticosteroid hormone secretion
GO:0035933 glucocorticoid secretion
GO:0035934 corticosterone secretion
GO:0042445 hormone metabolic process
GO:0042593 glucose homeostasis
GO:0043467 regulation of generation of precursor metabolites and energy
GO:0043473 pigmentation
GO:0044042 glucan metabolic process
GO:0044057 regulation of system process
GO:0044060 regulation of endocrine process
GO:0044262 cellular carbohydrate metabolic process
GO:0044264 cellular polysaccharide metabolic process
GO:0044723 single-organism carbohydrate metabolic process
GO:0046879 hormone secretion
GO:0046883 regulation of hormone secretion
GO:0050886 endocrine process
GO:0051604 protein maturation
GO:0060986 endocrine hormone secretion
GO:0070873 regulation of glycogen metabolic process
GO:0071706 tumor necrosis factor superfamily cytokine production
GO:1903555 regulation of tumor necrosis factor superfamily cytokine production
GO:1903556 negative regulation of tumor necrosis factor superfamily cytokine production
GO:2000831 regulation of steroid hormone secretion
GO:2000846 regulation of corticosteroid hormone secretion
GO:2000849 regulation of glucocorticoid secretion
GO:2000852 regulation of corticosterone secretion
Molecular Function GO:0001664 G-protein coupled receptor binding
GO:0005179 hormone activity
GO:0005184 neuropeptide hormone activity
GO:0031779 melanocortin receptor binding
GO:0031781 type 3 melanocortin receptor binding
GO:0031782 type 4 melanocortin receptor binding
GO:0070996 type 1 melanocortin receptor binding
GO:0071855 neuropeptide receptor binding
Cellular Component GO:0030141 secretory granule
GO:0031983 vesicle lumen
GO:0034774 secretory granule lumen
GO:0060205 cytoplasmic membrane-bounded vesicle lumen
GO:0099503 secretory vesicle
> KEGG and Reactome Pathway
 
KEGG hsa04916 Melanogenesis
hsa04920 Adipocytokine signaling pathway
Reactome R-HSA-193048: Androgen biosynthesis
R-HSA-211859: Biological oxidations
R-HSA-373076: Class A/1 (Rhodopsin-like receptors)
R-HSA-211897: Cytochrome P450 - arranged by substrate type
R-HSA-1280215: Cytokine Signaling in Immune system
R-HSA-5579031: Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
R-HSA-1643685: Disease
R-HSA-5668914: Diseases of metabolism
R-HSA-211976: Endogenous sterols
R-HSA-418594: G alpha (i) signalling events
R-HSA-418555: G alpha (s) signalling events
R-HSA-202040: G-protein activation
R-HSA-388396: GPCR downstream signaling
R-HSA-500792: GPCR ligand binding
R-HSA-194002: Glucocorticoid biosynthesis
R-HSA-168256: Immune System
R-HSA-6785807: Interleukin-4 and 13 signaling
R-HSA-5579029: Metabolic disorders of biological oxidation enzymes
R-HSA-1430728: Metabolism
R-HSA-556833: Metabolism of lipids and lipoproteins
R-HSA-392499: Metabolism of proteins
R-HSA-196071: Metabolism of steroid hormones
R-HSA-111885: Opioid Signalling
R-HSA-209952: Peptide hormone biosynthesis
R-HSA-2980736: Peptide hormone metabolism
R-HSA-375276: Peptide ligand-binding receptors
R-HSA-211945: Phase 1 - Functionalization of compounds
R-HSA-162582: Signal Transduction
R-HSA-372790: Signaling by GPCR
R-HSA-449147: Signaling by Interleukins
R-HSA-209943: Steroid hormones
Summary
SymbolPOMC
Nameproopiomelanocortin
Aliases POC; ACTH; NPP; adrenocorticotropin; beta-lipotropin; alpha-melanocyte stimulating hormone; beta-melanocyte ......
Chromosomal Location2p23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between POMC and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolPOMC
Nameproopiomelanocortin
Aliases POC; ACTH; NPP; adrenocorticotropin; beta-lipotropin; alpha-melanocyte stimulating hormone; beta-melanocyte ......
Chromosomal Location2p23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of POMC in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolPOMC
Nameproopiomelanocortin
Aliases POC; ACTH; NPP; adrenocorticotropin; beta-lipotropin; alpha-melanocyte stimulating hormone; beta-melanocyte ......
Chromosomal Location2p23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of POMC in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-1.170.101
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-1.8860.165
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.6360.544
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.0790.919
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.0550.964
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.1240.924
729033130MelanomaallAnti-PD-1 (nivolumab) 26231.3980.0371
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15112.3960.0221
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.3010.79
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.5740.291
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.2020.759
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0940.686
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of POMC in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.703.70.27
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.703.70.314
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolPOMC
Nameproopiomelanocortin
Aliases POC; ACTH; NPP; adrenocorticotropin; beta-lipotropin; alpha-melanocyte stimulating hormone; beta-melanocyte ......
Chromosomal Location2p23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of POMC. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolPOMC
Nameproopiomelanocortin
Aliases POC; ACTH; NPP; adrenocorticotropin; beta-lipotropin; alpha-melanocyte stimulating hormone; beta-melanocyte ......
Chromosomal Location2p23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of POMC. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by POMC.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolPOMC
Nameproopiomelanocortin
Aliases POC; ACTH; NPP; adrenocorticotropin; beta-lipotropin; alpha-melanocyte stimulating hormone; beta-melanocyte ......
Chromosomal Location2p23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of POMC. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolPOMC
Nameproopiomelanocortin
Aliases POC; ACTH; NPP; adrenocorticotropin; beta-lipotropin; alpha-melanocyte stimulating hormone; beta-melanocyte ......
Chromosomal Location2p23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of POMC expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolPOMC
Nameproopiomelanocortin
Aliases POC; ACTH; NPP; adrenocorticotropin; beta-lipotropin; alpha-melanocyte stimulating hormone; beta-melanocyte ......
Chromosomal Location2p23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between POMC and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolPOMC
Nameproopiomelanocortin
Aliases POC; ACTH; NPP; adrenocorticotropin; beta-lipotropin; alpha-melanocyte stimulating hormone; beta-melanocyte ......
Chromosomal Location2p23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting POMC collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting POMC.
ID Name Drug Type Targets #Targets
DB00836LoperamideSmall MoleculeCACNA1A, NR1I3, OPRD1, OPRK1, OPRM1, POMC6
DB01497EtorphineSmall MoleculeOPRD1, OPRK1, OPRL1, OPRM1, POMC, TRIM136
DB01565DihydromorphineSmall MoleculeOPRD1, OPRK1, OPRM1, POMC, TRIM135