Browse POSTN

Summary
SymbolPOSTN
Nameperiostin, osteoblast specific factor
Aliases periostin; PDLPOSTN; osteoblast specific factor 2 (fasciclin I-like); periodontal ligament-specific periosti ......
Chromosomal Location13q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Golgi apparatus Secreted Secreted, extracellular space, extracellular matrix Note=Colocalizes with BMP1 in the Golgi.
Domain PF02469 Fasciclin domain
Function

Induces cell attachment and spreading and plays a role in cell adhesion (PubMed:12235007). Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX (By similarity).

> Gene Ontology
 
Biological Process GO:0001501 skeletal system development
GO:0001666 response to hypoxia
GO:0001819 positive regulation of cytokine production
GO:0001952 regulation of cell-matrix adhesion
GO:0001953 negative regulation of cell-matrix adhesion
GO:0003013 circulatory system process
GO:0003073 regulation of systemic arterial blood pressure
GO:0007160 cell-matrix adhesion
GO:0007162 negative regulation of cell adhesion
GO:0007219 Notch signaling pathway
GO:0007584 response to nutrient
GO:0008015 blood circulation
GO:0008217 regulation of blood pressure
GO:0008593 regulation of Notch signaling pathway
GO:0009306 protein secretion
GO:0009612 response to mechanical stimulus
GO:0009991 response to extracellular stimulus
GO:0010721 negative regulation of cell development
GO:0010769 regulation of cell morphogenesis involved in differentiation
GO:0010771 negative regulation of cell morphogenesis involved in differentiation
GO:0010810 regulation of cell-substrate adhesion
GO:0010812 negative regulation of cell-substrate adhesion
GO:0014812 muscle cell migration
GO:0014823 response to activity
GO:0014850 response to muscle activity
GO:0014909 smooth muscle cell migration
GO:0014910 regulation of smooth muscle cell migration
GO:0014911 positive regulation of smooth muscle cell migration
GO:0016049 cell growth
GO:0022604 regulation of cell morphogenesis
GO:0030198 extracellular matrix organization
GO:0030335 positive regulation of cell migration
GO:0031099 regeneration
GO:0031589 cell-substrate adhesion
GO:0031667 response to nutrient levels
GO:0031668 cellular response to extracellular stimulus
GO:0031669 cellular response to nutrient levels
GO:0031670 cellular response to nutrient
GO:0032355 response to estradiol
GO:0032571 response to vitamin K
GO:0032602 chemokine production
GO:0032642 regulation of chemokine production
GO:0032722 positive regulation of chemokine production
GO:0033273 response to vitamin
GO:0034446 substrate adhesion-dependent cell spreading
GO:0034612 response to tumor necrosis factor
GO:0035926 chemokine (C-C motif) ligand 2 secretion
GO:0036293 response to decreased oxygen levels
GO:0040017 positive regulation of locomotion
GO:0042246 tissue regeneration
GO:0043062 extracellular structure organization
GO:0044344 cellular response to fibroblast growth factor stimulus
GO:0048588 developmental cell growth
GO:0050663 cytokine secretion
GO:0050707 regulation of cytokine secretion
GO:0050708 regulation of protein secretion
GO:0050714 positive regulation of protein secretion
GO:0050715 positive regulation of cytokine secretion
GO:0051047 positive regulation of secretion
GO:0051222 positive regulation of protein transport
GO:0051272 positive regulation of cellular component movement
GO:0060560 developmental growth involved in morphogenesis
GO:0070482 response to oxygen levels
GO:0071295 cellular response to vitamin
GO:0071307 cellular response to vitamin K
GO:0071356 cellular response to tumor necrosis factor
GO:0071496 cellular response to external stimulus
GO:0071559 response to transforming growth factor beta
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0071774 response to fibroblast growth factor
GO:0072567 chemokine (C-X-C motif) ligand 2 production
GO:0090195 chemokine secretion
GO:0090196 regulation of chemokine secretion
GO:0090197 positive regulation of chemokine secretion
GO:1900024 regulation of substrate adhesion-dependent cell spreading
GO:1900025 negative regulation of substrate adhesion-dependent cell spreading
GO:1901654 response to ketone
GO:1901655 cellular response to ketone
GO:1903532 positive regulation of secretion by cell
GO:1904207 regulation of chemokine (C-C motif) ligand 2 secretion
GO:1904209 positive regulation of chemokine (C-C motif) ligand 2 secretion
GO:1904951 positive regulation of establishment of protein localization
GO:1990138 neuron projection extension
GO:1990523 bone regeneration
GO:2000147 positive regulation of cell motility
GO:2000341 regulation of chemokine (C-X-C motif) ligand 2 production
GO:2000343 positive regulation of chemokine (C-X-C motif) ligand 2 production
Molecular Function GO:0005539 glycosaminoglycan binding
GO:0008201 heparin binding
GO:0050839 cell adhesion molecule binding
GO:1901681 sulfur compound binding
Cellular Component GO:0005578 proteinaceous extracellular matrix
GO:0005802 trans-Golgi network
GO:0031594 neuromuscular junction
GO:0031984 organelle subcompartment
GO:0098791 Golgi subcompartment
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolPOSTN
Nameperiostin, osteoblast specific factor
Aliases periostin; PDLPOSTN; osteoblast specific factor 2 (fasciclin I-like); periodontal ligament-specific periosti ......
Chromosomal Location13q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between POSTN and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between POSTN and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
27193093Breast CarcinomaInhibit immunity (T cell function)Here, we demonstrate that POSTN promotes the pulmonary accumulation of myeloid-derived suppressor cells (MDSCs) during the early stage of breast tumour metastasis.
Summary
SymbolPOSTN
Nameperiostin, osteoblast specific factor
Aliases periostin; PDLPOSTN; osteoblast specific factor 2 (fasciclin I-like); periodontal ligament-specific periosti ......
Chromosomal Location13q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of POSTN in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolPOSTN
Nameperiostin, osteoblast specific factor
Aliases periostin; PDLPOSTN; osteoblast specific factor 2 (fasciclin I-like); periodontal ligament-specific periosti ......
Chromosomal Location13q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of POSTN in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-1.3380.0982
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-2.2930.495
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.6180.777
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-1.2810.051
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-1.6880.395
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.7510.796
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.1430.869
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-1.3180.588
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.9820.735
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.9680.674
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 283.3240.271
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.2310.507
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of POSTN in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141705.9-5.91
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103033.3-33.30.231
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277311.15.55.60.384
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275911.16.84.30.673
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)2117190190.113
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131123.1023.10.223
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916012.5-12.50.52
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47014.3-14.31
1329033130MelanomaallAnti-PD-1 (nivolumab) 382703.7-3.70.415
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221307.7-7.70.371
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolPOSTN
Nameperiostin, osteoblast specific factor
Aliases periostin; PDLPOSTN; osteoblast specific factor 2 (fasciclin I-like); periodontal ligament-specific periosti ......
Chromosomal Location13q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of POSTN. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolPOSTN
Nameperiostin, osteoblast specific factor
Aliases periostin; PDLPOSTN; osteoblast specific factor 2 (fasciclin I-like); periodontal ligament-specific periosti ......
Chromosomal Location13q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of POSTN. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by POSTN.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolPOSTN
Nameperiostin, osteoblast specific factor
Aliases periostin; PDLPOSTN; osteoblast specific factor 2 (fasciclin I-like); periodontal ligament-specific periosti ......
Chromosomal Location13q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of POSTN. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolPOSTN
Nameperiostin, osteoblast specific factor
Aliases periostin; PDLPOSTN; osteoblast specific factor 2 (fasciclin I-like); periodontal ligament-specific periosti ......
Chromosomal Location13q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of POSTN expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolPOSTN
Nameperiostin, osteoblast specific factor
Aliases periostin; PDLPOSTN; osteoblast specific factor 2 (fasciclin I-like); periodontal ligament-specific periosti ......
Chromosomal Location13q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between POSTN and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolPOSTN
Nameperiostin, osteoblast specific factor
Aliases periostin; PDLPOSTN; osteoblast specific factor 2 (fasciclin I-like); periodontal ligament-specific periosti ......
Chromosomal Location13q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting POSTN collected from DrugBank database.
> Drugs from DrugBank database
 

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