Browse PPARD

Summary
SymbolPPARD
Nameperoxisome proliferator-activated receptor delta
Aliases NUC1; NUCII; FAAR; NR1C2; peroxisome proliferative activated receptor, delta; NUCI; PPARB; PPAR-beta; PPAR-d ......
Chromosomal Location6p21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus.
Domain PF00104 Ligand-binding domain of nuclear hormone receptor
PF00105 Zinc finger
Function

Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.

> Gene Ontology
 
Biological Process GO:0001523 retinoid metabolic process
GO:0001558 regulation of cell growth
GO:0001666 response to hypoxia
GO:0001667 ameboidal-type cell migration
GO:0001890 placenta development
GO:0001893 maternal placenta development
GO:0002237 response to molecule of bacterial origin
GO:0002790 peptide secretion
GO:0002791 regulation of peptide secretion
GO:0002793 positive regulation of peptide secretion
GO:0003013 circulatory system process
GO:0003018 vascular process in circulatory system
GO:0005996 monosaccharide metabolic process
GO:0006006 glucose metabolic process
GO:0006029 proteoglycan metabolic process
GO:0006066 alcohol metabolic process
GO:0006091 generation of precursor metabolites and energy
GO:0006352 DNA-templated transcription, initiation
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006631 fatty acid metabolic process
GO:0006635 fatty acid beta-oxidation
GO:0006644 phospholipid metabolic process
GO:0006720 isoprenoid metabolic process
GO:0006721 terpenoid metabolic process
GO:0006766 vitamin metabolic process
GO:0006775 fat-soluble vitamin metabolic process
GO:0006776 vitamin A metabolic process
GO:0006820 anion transport
GO:0006869 lipid transport
GO:0007272 ensheathment of neurons
GO:0007507 heart development
GO:0007565 female pregnancy
GO:0007566 embryo implantation
GO:0007584 response to nutrient
GO:0008015 blood circulation
GO:0008202 steroid metabolic process
GO:0008203 cholesterol metabolic process
GO:0008366 axon ensheathment
GO:0008544 epidermis development
GO:0008643 carbohydrate transport
GO:0008645 hexose transport
GO:0008654 phospholipid biosynthetic process
GO:0009062 fatty acid catabolic process
GO:0009100 glycoprotein metabolic process
GO:0009299 mRNA transcription
GO:0009306 protein secretion
GO:0009743 response to carbohydrate
GO:0009746 response to hexose
GO:0009749 response to glucose
GO:0009755 hormone-mediated signaling pathway
GO:0009914 hormone transport
GO:0009991 response to extracellular stimulus
GO:0010631 epithelial cell migration
GO:0010712 regulation of collagen metabolic process
GO:0010713 negative regulation of collagen metabolic process
GO:0010817 regulation of hormone levels
GO:0010876 lipid localization
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014812 muscle cell migration
GO:0014823 response to activity
GO:0014841 skeletal muscle satellite cell proliferation
GO:0014842 regulation of skeletal muscle satellite cell proliferation
GO:0014855 striated muscle cell proliferation
GO:0014856 skeletal muscle cell proliferation
GO:0014857 regulation of skeletal muscle cell proliferation
GO:0014909 smooth muscle cell migration
GO:0014910 regulation of smooth muscle cell migration
GO:0014912 negative regulation of smooth muscle cell migration
GO:0015711 organic anion transport
GO:0015718 monocarboxylic acid transport
GO:0015749 monosaccharide transport
GO:0015758 glucose transport
GO:0015833 peptide transport
GO:0015908 fatty acid transport
GO:0016042 lipid catabolic process
GO:0016049 cell growth
GO:0016054 organic acid catabolic process
GO:0016101 diterpenoid metabolic process
GO:0016125 sterol metabolic process
GO:0019318 hexose metabolic process
GO:0019395 fatty acid oxidation
GO:0023061 signal release
GO:0030072 peptide hormone secretion
GO:0030073 insulin secretion
GO:0030258 lipid modification
GO:0030308 negative regulation of cell growth
GO:0030336 negative regulation of cell migration
GO:0030522 intracellular receptor signaling pathway
GO:0031099 regeneration
GO:0031348 negative regulation of defense response
GO:0031589 cell-substrate adhesion
GO:0031667 response to nutrient levels
GO:0032024 positive regulation of insulin secretion
GO:0032102 negative regulation of response to external stimulus
GO:0032496 response to lipopolysaccharide
GO:0032963 collagen metabolic process
GO:0032964 collagen biosynthetic process
GO:0032965 regulation of collagen biosynthetic process
GO:0032966 negative regulation of collagen biosynthetic process
GO:0033002 muscle cell proliferation
GO:0033189 response to vitamin A
GO:0033273 response to vitamin
GO:0034284 response to monosaccharide
GO:0034440 lipid oxidation
GO:0035150 regulation of tube size
GO:0036293 response to decreased oxygen levels
GO:0036294 cellular response to decreased oxygen levels
GO:0040013 negative regulation of locomotion
GO:0042246 tissue regeneration
GO:0042311 vasodilation
GO:0042312 regulation of vasodilation
GO:0042692 muscle cell differentiation
GO:0042886 amide transport
GO:0043401 steroid hormone mediated signaling pathway
GO:0043403 skeletal muscle tissue regeneration
GO:0043415 positive regulation of skeletal muscle tissue regeneration
GO:0043416 regulation of skeletal muscle tissue regeneration
GO:0043616 keratinocyte proliferation
GO:0044057 regulation of system process
GO:0044236 multicellular organism metabolic process
GO:0044242 cellular lipid catabolic process
GO:0044246 regulation of multicellular organismal metabolic process
GO:0044252 negative regulation of multicellular organismal metabolic process
GO:0044259 multicellular organismal macromolecule metabolic process
GO:0044282 small molecule catabolic process
GO:0044706 multi-multicellular organism process
GO:0044723 single-organism carbohydrate metabolic process
GO:0045444 fat cell differentiation
GO:0045445 myoblast differentiation
GO:0045598 regulation of fat cell differentiation
GO:0045600 positive regulation of fat cell differentiation
GO:0045661 regulation of myoblast differentiation
GO:0045662 negative regulation of myoblast differentiation
GO:0045682 regulation of epidermis development
GO:0045684 positive regulation of epidermis development
GO:0045909 positive regulation of vasodilation
GO:0045926 negative regulation of growth
GO:0045927 positive regulation of growth
GO:0046395 carboxylic acid catabolic process
GO:0046697 decidualization
GO:0046879 hormone secretion
GO:0046883 regulation of hormone secretion
GO:0046887 positive regulation of hormone secretion
GO:0046942 carboxylic acid transport
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048017 inositol lipid-mediated signaling
GO:0048545 response to steroid hormone
GO:0048608 reproductive structure development
GO:0048638 regulation of developmental growth
GO:0048639 positive regulation of developmental growth
GO:0048659 smooth muscle cell proliferation
GO:0048660 regulation of smooth muscle cell proliferation
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0050673 epithelial cell proliferation
GO:0050678 regulation of epithelial cell proliferation
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050708 regulation of protein secretion
GO:0050714 positive regulation of protein secretion
GO:0050727 regulation of inflammatory response
GO:0050728 negative regulation of inflammatory response
GO:0050796 regulation of insulin secretion
GO:0050880 regulation of blood vessel size
GO:0051047 positive regulation of secretion
GO:0051147 regulation of muscle cell differentiation
GO:0051148 negative regulation of muscle cell differentiation
GO:0051222 positive regulation of protein transport
GO:0051271 negative regulation of cellular component movement
GO:0051450 myoblast proliferation
GO:0051546 keratinocyte migration
GO:0060135 maternal process involved in female pregnancy
GO:0060612 adipose tissue development
GO:0061041 regulation of wound healing
GO:0061448 connective tissue development
GO:0061458 reproductive system development
GO:0061614 pri-miRNA transcription from RNA polymerase II promoter
GO:0070482 response to oxygen levels
GO:0071216 cellular response to biotic stimulus
GO:0071219 cellular response to molecule of bacterial origin
GO:0071222 cellular response to lipopolysaccharide
GO:0071383 cellular response to steroid hormone stimulus
GO:0071396 cellular response to lipid
GO:0071407 cellular response to organic cyclic compound
GO:0071453 cellular response to oxygen levels
GO:0071456 cellular response to hypoxia
GO:0072329 monocarboxylic acid catabolic process
GO:0090066 regulation of anatomical structure size
GO:0090087 regulation of peptide transport
GO:0090130 tissue migration
GO:0090132 epithelium migration
GO:0090276 regulation of peptide hormone secretion
GO:0090277 positive regulation of peptide hormone secretion
GO:0090303 positive regulation of wound healing
GO:1901615 organic hydroxy compound metabolic process
GO:1902652 secondary alcohol metabolic process
GO:1902893 regulation of pri-miRNA transcription from RNA polymerase II promoter
GO:1902894 negative regulation of pri-miRNA transcription from RNA polymerase II promoter
GO:1903034 regulation of response to wounding
GO:1903036 positive regulation of response to wounding
GO:1903522 regulation of blood circulation
GO:1903524 positive regulation of blood circulation
GO:1903532 positive regulation of secretion by cell
GO:1904951 positive regulation of establishment of protein localization
GO:2000146 negative regulation of cell motility
GO:2000288 positive regulation of myoblast proliferation
GO:2000291 regulation of myoblast proliferation
Molecular Function GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0003707 steroid hormone receptor activity
GO:0003713 transcription coactivator activity
GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
GO:0005504 fatty acid binding
GO:0008134 transcription factor binding
GO:0008144 drug binding
GO:0031406 carboxylic acid binding
GO:0033293 monocarboxylic acid binding
GO:0036041 long-chain fatty acid binding
GO:0043168 anion binding
GO:0046982 protein heterodimerization activity
GO:0051059 NF-kappaB binding
GO:0070539 linoleic acid binding
GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding
Cellular Component GO:0000785 chromatin
GO:0000790 nuclear chromatin
GO:0044454 nuclear chromosome part
> KEGG and Reactome Pathway
 
KEGG hsa03320 PPAR signaling pathway
hsa04310 Wnt signaling pathway
Reactome R-HSA-535734: Fatty acid, triacylglycerol, and ketone body metabolism
R-HSA-74160: Gene Expression
R-HSA-212436: Generic Transcription Pathway
R-HSA-200425: Import of palmitoyl-CoA into the mitochondrial matrix
R-HSA-1430728: Metabolism
R-HSA-556833: Metabolism of lipids and lipoproteins
R-HSA-383280: Nuclear Receptor transcription pathway
R-HSA-70268: Pyruvate metabolism
R-HSA-71406: Pyruvate metabolism and Citric Acid (TCA) cycle
R-HSA-204174: Regulation of pyruvate dehydrogenase (PDH) complex
R-HSA-162582: Signal Transduction
R-HSA-5362517: Signaling by Retinoic Acid
R-HSA-1428517: The citric acid (TCA) cycle and respiratory electron transport
Summary
SymbolPPARD
Nameperoxisome proliferator-activated receptor delta
Aliases NUC1; NUCII; FAAR; NR1C2; peroxisome proliferative activated receptor, delta; NUCI; PPARB; PPAR-beta; PPAR-d ......
Chromosomal Location6p21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between PPARD and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolPPARD
Nameperoxisome proliferator-activated receptor delta
Aliases NUC1; NUCII; FAAR; NR1C2; peroxisome proliferative activated receptor, delta; NUCI; PPARB; PPAR-beta; PPAR-d ......
Chromosomal Location6p21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of PPARD in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.51 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolPPARD
Nameperoxisome proliferator-activated receptor delta
Aliases NUC1; NUCII; FAAR; NR1C2; peroxisome proliferative activated receptor, delta; NUCI; PPARB; PPAR-beta; PPAR-d ......
Chromosomal Location6p21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of PPARD in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.2480.431
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.0580.976
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.3870.789
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.1840.644
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.1280.949
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.260.921
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0080.982
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.2460.869
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.2630.871
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.1170.928
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.0270.553
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0050.951
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of PPARD in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277301.4-1.41
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275901.7-1.71
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 382703.7-3.70.415
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 161407.1-7.10.467
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 111307.7-7.71
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 51208.3-8.31
Summary
SymbolPPARD
Nameperoxisome proliferator-activated receptor delta
Aliases NUC1; NUCII; FAAR; NR1C2; peroxisome proliferative activated receptor, delta; NUCI; PPARB; PPAR-beta; PPAR-d ......
Chromosomal Location6p21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PPARD. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolPPARD
Nameperoxisome proliferator-activated receptor delta
Aliases NUC1; NUCII; FAAR; NR1C2; peroxisome proliferative activated receptor, delta; NUCI; PPARB; PPAR-beta; PPAR-d ......
Chromosomal Location6p21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PPARD. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PPARD.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolPPARD
Nameperoxisome proliferator-activated receptor delta
Aliases NUC1; NUCII; FAAR; NR1C2; peroxisome proliferative activated receptor, delta; NUCI; PPARB; PPAR-beta; PPAR-d ......
Chromosomal Location6p21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PPARD. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolPPARD
Nameperoxisome proliferator-activated receptor delta
Aliases NUC1; NUCII; FAAR; NR1C2; peroxisome proliferative activated receptor, delta; NUCI; PPARB; PPAR-beta; PPAR-d ......
Chromosomal Location6p21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of PPARD expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolPPARD
Nameperoxisome proliferator-activated receptor delta
Aliases NUC1; NUCII; FAAR; NR1C2; peroxisome proliferative activated receptor, delta; NUCI; PPARB; PPAR-beta; PPAR-d ......
Chromosomal Location6p21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between PPARD and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolPPARD
Nameperoxisome proliferator-activated receptor delta
Aliases NUC1; NUCII; FAAR; NR1C2; peroxisome proliferative activated receptor, delta; NUCI; PPARB; PPAR-beta; PPAR-d ......
Chromosomal Location6p21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting PPARD collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting PPARD.
ID Name Drug Type Targets #Targets
DB00132Alpha-Linolenic AcidSmall MoleculeELOVL4, FADS1, FADS2, NR1H4, PPARA, PPARD, PPARG, RXRA, SLC8A1, TR ......10
DB00159IcosapentSmall MoleculeACSL3, ACSL4, FADS1, FFAR1, PPARA, PPARD, PPARG, PTGS1, PTGS2, SLC ......11
DB00197TroglitazoneSmall MoleculeACSL4, ESRRA, ESRRG, GSTP1, PPARA, PPARD, PPARG, SERPINE1, SLC29A19
DB00313Valproic AcidSmall MoleculeABAT, ACADSB, ALDH5A1, HDAC2, HDAC9, OGDH, PPARA, PPARD, PPARG, SC ......23
DB00374TreprostinilSmall MoleculeP2RY12, PPARD, PTGIR3
DB00412RosiglitazoneSmall MoleculeACSL4, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG7
DB00605SulindacSmall MoleculeAKR1B1, AKR1B10, MAPK3, PPARD, PTGDR2, PTGS1, PTGS27
DB01039FenofibrateSmall MoleculeNR1I2, PPARA, PPARD, PPARG4
DB01132PioglitazoneSmall MoleculeMAOB, PPARA, PPARD, PPARG4
DB01393BezafibrateSmall MoleculeNR1I2, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG7
DB02746Phthalic AcidSmall MoleculeESR1, ESR2, PGR, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG9
DB03338Heptyl-Beta-D-GlucopyranosideSmall MoleculeFKBP1A, PPARD2
DB04224Oleic AcidSmall MoleculeGLTP, PMP2, PPARA, PPARD, PPARG, RXRA6
DB04801(11E)-OCTADEC-11-ENOIC ACIDSmall MoleculePPARD1
DB05187ElafibranorSmall MoleculePPARA, PPARD, PPARG3
DB05188KD3010Small MoleculePPARD1
DB05416GW-501516Small MoleculePPARA, PPARD2
DB07070(2S)-2-{3-[({[2-fluoro-4-(trifluoromethyl)phenyl]carbonyl}amino)methyl]-4-methoxybenzyl}butanoic acidSmall MoleculePPARD1
DB076912-({[3-(3,4-dihydroisoquinolin-2(1H)-ylsulfonyl)phenyl]carbonyl}amino)benzoic acidSmall MoleculePPARD1
DB07724IndeglitazarSmall MoleculeNCOA1, PPARA, PPARD, PPARG4
DB08078{4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy}acetic acidSmall MoleculePPARD1
DB09006ClinofibrateSmall MoleculePPARA, PPARD, PPARG3
DB09462GlycerinSmall MoleculeADH1B, ARF1, GSTP1, HPGDS, ISYNA1, ITPR1, NAGA, PAEP, PAPSS1, PLA2 ......13
DB13873Fenofibric acidSmall MoleculeNR1I2, PPARA, PPARD, PPARG4