Browse PPP1R15A

Summary
SymbolPPP1R15A
Nameprotein phosphatase 1, regulatory subunit 15A
Aliases GADD34; growth arrest and DNA-damage-inducible 34; protein phosphatase 1, regulatory (inhibitor) subunit 15A ......
Chromosomal Location19q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side Note=Associates with membranes via an N-terminal amphipathic intramembrane region.
Domain PF10488 Phosphatase-1 catalytic subunit binding region
Function

Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on 'Ser-15'.

> Gene Ontology
 
Biological Process GO:0001933 negative regulation of protein phosphorylation
GO:0006356 regulation of transcription from RNA polymerase I promoter
GO:0006360 transcription from RNA polymerase I promoter
GO:0006413 translational initiation
GO:0006417 regulation of translation
GO:0006446 regulation of translational initiation
GO:0006470 protein dephosphorylation
GO:0006984 ER-nucleus signaling pathway
GO:0006986 response to unfolded protein
GO:0007050 cell cycle arrest
GO:0010608 posttranscriptional regulation of gene expression
GO:0010921 regulation of phosphatase activity
GO:0010922 positive regulation of phosphatase activity
GO:0010923 negative regulation of phosphatase activity
GO:0010998 regulation of translational initiation by eIF2 alpha phosphorylation
GO:0016311 dephosphorylation
GO:0018105 peptidyl-serine phosphorylation
GO:0018209 peptidyl-serine modification
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0032056 positive regulation of translation in response to stress
GO:0032058 positive regulation of translational initiation in response to stress
GO:0032515 negative regulation of phosphoprotein phosphatase activity
GO:0032516 positive regulation of phosphoprotein phosphatase activity
GO:0033135 regulation of peptidyl-serine phosphorylation
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034248 regulation of cellular amide metabolic process
GO:0034250 positive regulation of cellular amide metabolic process
GO:0034620 cellular response to unfolded protein
GO:0034976 response to endoplasmic reticulum stress
GO:0035303 regulation of dephosphorylation
GO:0035304 regulation of protein dephosphorylation
GO:0035305 negative regulation of dephosphorylation
GO:0035306 positive regulation of dephosphorylation
GO:0035307 positive regulation of protein dephosphorylation
GO:0035308 negative regulation of protein dephosphorylation
GO:0035966 response to topologically incorrect protein
GO:0035967 cellular response to topologically incorrect protein
GO:0036490 regulation of translation in response to endoplasmic reticulum stress
GO:0036491 regulation of translation initiation in response to endoplasmic reticulum stress
GO:0036492 eiF2alpha phosphorylation in response to endoplasmic reticulum stress
GO:0036496 regulation of translational initiation by eIF2 alpha dephosphorylation
GO:0036497 eIF2alpha dephosphorylation in response to endoplasmic reticulum stress
GO:0036499 PERK-mediated unfolded protein response
GO:0042326 negative regulation of phosphorylation
GO:0043555 regulation of translation in response to stress
GO:0043558 regulation of translational initiation in response to stress
GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress
GO:0043620 regulation of DNA-templated transcription in response to stress
GO:0043666 regulation of phosphoprotein phosphatase activity
GO:0045727 positive regulation of translation
GO:0045786 negative regulation of cell cycle
GO:0045943 positive regulation of transcription from RNA polymerase I promoter
GO:0045948 positive regulation of translational initiation
GO:0051346 negative regulation of hydrolase activity
GO:0060734 regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070262 peptidyl-serine dephosphorylation
GO:0070972 protein localization to endoplasmic reticulum
GO:0097193 intrinsic apoptotic signaling pathway
GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress
GO:1900101 regulation of endoplasmic reticulum unfolded protein response
GO:1900102 negative regulation of endoplasmic reticulum unfolded protein response
GO:1902308 regulation of peptidyl-serine dephosphorylation
GO:1902310 positive regulation of peptidyl-serine dephosphorylation
GO:1903573 negative regulation of response to endoplasmic reticulum stress
GO:1903897 regulation of PERK-mediated unfolded protein response
GO:1903898 negative regulation of PERK-mediated unfolded protein response
GO:1903912 negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
GO:1903916 regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation
GO:1903917 positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation
GO:1990441 negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
Molecular Function GO:0008047 enzyme activator activity
GO:0008157 protein phosphatase 1 binding
GO:0008599 protein phosphatase type 1 regulator activity
GO:0019208 phosphatase regulator activity
GO:0019211 phosphatase activator activity
GO:0019888 protein phosphatase regulator activity
GO:0019902 phosphatase binding
GO:0019903 protein phosphatase binding
GO:0071862 protein phosphatase type 1 activator activity
GO:0072542 protein phosphatase activator activity
Cellular Component GO:0000164 protein phosphatase type 1 complex
GO:0005741 mitochondrial outer membrane
GO:0008287 protein serine/threonine phosphatase complex
GO:0019867 outer membrane
GO:0031968 organelle outer membrane
GO:1903293 phosphatase complex
> KEGG and Reactome Pathway
 
KEGG hsa04141 Protein processing in endoplasmic reticulum
Reactome R-HSA-2173788: Downregulation of TGF-beta receptor signaling
R-HSA-162582: Signal Transduction
R-HSA-170834: Signaling by TGF-beta Receptor Complex
R-HSA-2173789: TGF-beta receptor signaling activates SMADs
Summary
SymbolPPP1R15A
Nameprotein phosphatase 1, regulatory subunit 15A
Aliases GADD34; growth arrest and DNA-damage-inducible 34; protein phosphatase 1, regulatory (inhibitor) subunit 15A ......
Chromosomal Location19q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between PPP1R15A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolPPP1R15A
Nameprotein phosphatase 1, regulatory subunit 15A
Aliases GADD34; growth arrest and DNA-damage-inducible 34; protein phosphatase 1, regulatory (inhibitor) subunit 15A ......
Chromosomal Location19q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of PPP1R15A in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 STARS Score: 6.49; FDR: 0.000 Resistant to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX STARS Score: 5.48; FDR: 0.002 Resistant to T cell-mediated killing
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolPPP1R15A
Nameprotein phosphatase 1, regulatory subunit 15A
Aliases GADD34; growth arrest and DNA-damage-inducible 34; protein phosphatase 1, regulatory (inhibitor) subunit 15A ......
Chromosomal Location19q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of PPP1R15A in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.0940.738
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.1560.955
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.0330.985
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.3110.49
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.2720.92
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.3560.921
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.2920.513
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.4390.793
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.1710.928
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.5840.729
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.4330.55
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.1360.177
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of PPP1R15A in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.41.460.177
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.41.75.70.231
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolPPP1R15A
Nameprotein phosphatase 1, regulatory subunit 15A
Aliases GADD34; growth arrest and DNA-damage-inducible 34; protein phosphatase 1, regulatory (inhibitor) subunit 15A ......
Chromosomal Location19q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PPP1R15A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolPPP1R15A
Nameprotein phosphatase 1, regulatory subunit 15A
Aliases GADD34; growth arrest and DNA-damage-inducible 34; protein phosphatase 1, regulatory (inhibitor) subunit 15A ......
Chromosomal Location19q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PPP1R15A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PPP1R15A.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolPPP1R15A
Nameprotein phosphatase 1, regulatory subunit 15A
Aliases GADD34; growth arrest and DNA-damage-inducible 34; protein phosphatase 1, regulatory (inhibitor) subunit 15A ......
Chromosomal Location19q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PPP1R15A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolPPP1R15A
Nameprotein phosphatase 1, regulatory subunit 15A
Aliases GADD34; growth arrest and DNA-damage-inducible 34; protein phosphatase 1, regulatory (inhibitor) subunit 15A ......
Chromosomal Location19q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of PPP1R15A expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolPPP1R15A
Nameprotein phosphatase 1, regulatory subunit 15A
Aliases GADD34; growth arrest and DNA-damage-inducible 34; protein phosphatase 1, regulatory (inhibitor) subunit 15A ......
Chromosomal Location19q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between PPP1R15A and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolPPP1R15A
Nameprotein phosphatase 1, regulatory subunit 15A
Aliases GADD34; growth arrest and DNA-damage-inducible 34; protein phosphatase 1, regulatory (inhibitor) subunit 15A ......
Chromosomal Location19q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting PPP1R15A collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.