TISIDB

Summary
Symbol	PPP1R1B
Name	protein phosphatase 1, regulatory (inhibitor) subunit 1B
Aliases	DARPP-32; FLJ20940; dopamine and cAMP regulated phosphoprotein; DARPP32; dopamine and cAMP-regulated neurona ......
Chromosomal Location	17q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Cytoplasm.
Domain	PF05395 Protein phosphatase inhibitor 1/DARPP-32
Function	Inhibitor of protein-phosphatase 1.

> Gene Ontology [ TOP ]
Biological Process	GO:0001933 negative regulation of protein phosphorylation GO:0001975 response to amphetamine GO:0006469 negative regulation of protein kinase activity GO:0007611 learning or memory GO:0007612 learning GO:0007617 mating behavior GO:0007618 mating GO:0007621 negative regulation of female receptivity GO:0007632 visual behavior GO:0008306 associative learning GO:0008542 visual learning GO:0009314 response to radiation GO:0009416 response to light stimulus GO:0014075 response to amine GO:0019098 reproductive behavior GO:0033673 negative regulation of kinase activity GO:0042326 negative regulation of phosphorylation GO:0044708 single-organism behavior GO:0045924 regulation of female receptivity GO:0050890 cognition GO:0051348 negative regulation of transferase activity GO:0060180 female mating behavior GO:0071900 regulation of protein serine/threonine kinase activity GO:0071901 negative regulation of protein serine/threonine kinase activity
Molecular Function	GO:0001664 G-protein coupled receptor binding GO:0004857 enzyme inhibitor activity GO:0004860 protein kinase inhibitor activity GO:0004862 cAMP-dependent protein kinase inhibitor activity GO:0004864 protein phosphatase inhibitor activity GO:0004865 protein serine/threonine phosphatase inhibitor activity GO:0008599 protein phosphatase type 1 regulator activity GO:0019207 kinase regulator activity GO:0019208 phosphatase regulator activity GO:0019210 kinase inhibitor activity GO:0019212 phosphatase inhibitor activity GO:0019887 protein kinase regulator activity GO:0019888 protein phosphatase regulator activity GO:0030291 protein serine/threonine kinase inhibitor activity GO:0031748 D1 dopamine receptor binding GO:0031749 D2 dopamine receptor binding GO:0031750 D3 dopamine receptor binding GO:0031751 D4 dopamine receptor binding GO:0031752 D5 dopamine receptor binding GO:0050780 dopamine receptor binding
Cellular Component	GO:0043025 neuronal cell body GO:0044297 cell body

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04024 cAMP signaling pathway hsa04728 Dopaminergic synapse
Reactome	R-HSA-180024: DARPP-32 events R-HSA-111885: Opioid Signalling R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR

Summary
Symbol	PPP1R1B
Name	protein phosphatase 1, regulatory (inhibitor) subunit 1B
Aliases	DARPP-32; FLJ20940; dopamine and cAMP regulated phosphoprotein; DARPP32; dopamine and cAMP-regulated neurona ......
Chromosomal Location	17q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between PPP1R1B and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	PPP1R1B
Name	protein phosphatase 1, regulatory (inhibitor) subunit 1B
Aliases	DARPP-32; FLJ20940; dopamine and cAMP regulated phosphoprotein; DARPP32; dopamine and cAMP-regulated neurona ......
Chromosomal Location	17q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of PPP1R1B in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	PPP1R1B
Name	protein phosphatase 1, regulatory (inhibitor) subunit 1B
Aliases	DARPP-32; FLJ20940; dopamine and cAMP regulated phosphoprotein; DARPP32; dopamine and cAMP-regulated neurona ......
Chromosomal Location	17q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the expression difference of PPP1R1B in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0.071	0.891
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-0.858	0.308
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	0.755	0.292
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-0.365	0.619
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-0.384	0.803
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	-0.35	0.834
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	-1.232	0.162
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-0.773	0.534
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-1.517	0.266
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.334	0.626
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0.9	0.332
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.778	0.0427

> Mutation difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the mutation difference of PPP1R1B in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	1.4	-1.4	1
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	1.7	-1.7	1
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	0	0	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	6.2	-6.2	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	11.1	-11.1	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	0	0	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	1

Summary
Symbol	PPP1R1B
Name	protein phosphatase 1, regulatory (inhibitor) subunit 1B
Aliases	DARPP-32; FLJ20940; dopamine and cAMP regulated phosphoprotein; DARPP32; dopamine and cAMP-regulated neurona ......
Chromosomal Location	17q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PPP1R1B. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	PPP1R1B
Name	protein phosphatase 1, regulatory (inhibitor) subunit 1B
Aliases	DARPP-32; FLJ20940; dopamine and cAMP regulated phosphoprotein; DARPP32; dopamine and cAMP-regulated neurona ......
Chromosomal Location	17q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PPP1R1B. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PPP1R1B. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	PPP1R1B
Name	protein phosphatase 1, regulatory (inhibitor) subunit 1B
Aliases	DARPP-32; FLJ20940; dopamine and cAMP regulated phosphoprotein; DARPP32; dopamine and cAMP-regulated neurona ......
Chromosomal Location	17q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PPP1R1B. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	PPP1R1B
Name	protein phosphatase 1, regulatory (inhibitor) subunit 1B
Aliases	DARPP-32; FLJ20940; dopamine and cAMP regulated phosphoprotein; DARPP32; dopamine and cAMP-regulated neurona ......
Chromosomal Location	17q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of PPP1R1B expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	PPP1R1B
Name	protein phosphatase 1, regulatory (inhibitor) subunit 1B
Aliases	DARPP-32; FLJ20940; dopamine and cAMP regulated phosphoprotein; DARPP32; dopamine and cAMP-regulated neurona ......
Chromosomal Location	17q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between PPP1R1B and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	PPP1R1B
Name	protein phosphatase 1, regulatory (inhibitor) subunit 1B
Aliases	DARPP-32; FLJ20940; dopamine and cAMP regulated phosphoprotein; DARPP32; dopamine and cAMP-regulated neurona ......
Chromosomal Location	17q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting PPP1R1B collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

Browse PPP1R1B