TISIDB

Summary
Symbol	PPP2R1A
Name	protein phosphatase 2, regulatory subunit A, alpha
Aliases	PR65A; PP2A-Aalpha; protein phosphatase 2A, regulatory subunit A, alpha isoform; protein phosphatase 2, 65kD ......
Chromosomal Location	19q13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Cytoplasm Chromosome, centromere Lateral cell membrane Cell projection, dendrite Note=Centromeric localization requires the presence of BUB1.
Domain	PF02985 HEAT repeat
Function	The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT (PubMed:15525651). Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis (PubMed:16580887).

> Gene Ontology [ TOP ]
Biological Process	GO:0000070 mitotic sister chromatid segregation GO:0000086 G2/M transition of mitotic cell cycle GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000188 inactivation of MAPK activity GO:0000212 meiotic spindle organization GO:0000226 microtubule cytoskeleton organization GO:0000819 sister chromatid segregation GO:0000956 nuclear-transcribed mRNA catabolic process GO:0001556 oocyte maturation GO:0001558 regulation of cell growth GO:0001933 negative regulation of protein phosphorylation GO:0006260 DNA replication GO:0006275 regulation of DNA replication GO:0006401 RNA catabolic process GO:0006402 mRNA catabolic process GO:0006469 negative regulation of protein kinase activity GO:0006470 protein dephosphorylation GO:0006643 membrane lipid metabolic process GO:0006665 sphingolipid metabolic process GO:0006672 ceramide metabolic process GO:0006997 nucleus organization GO:0006998 nuclear envelope organization GO:0007051 spindle organization GO:0007059 chromosome segregation GO:0007062 sister chromatid cohesion GO:0007067 mitotic nuclear division GO:0007084 mitotic nuclear envelope reassembly GO:0007126 meiotic nuclear division GO:0007135 meiosis II GO:0007143 female meiotic division GO:0007259 JAK-STAT cascade GO:0007260 tyrosine phosphorylation of STAT protein GO:0007281 germ cell development GO:0007292 female gamete generation GO:0008380 RNA splicing GO:0009994 oocyte differentiation GO:0010921 regulation of phosphatase activity GO:0016049 cell growth GO:0016055 Wnt signaling pathway GO:0016311 dephosphorylation GO:0018108 peptidyl-tyrosine phosphorylation GO:0018212 peptidyl-tyrosine modification GO:0019439 aromatic compound catabolic process GO:0019932 second-messenger-mediated signaling GO:0021700 developmental maturation GO:0022412 cellular process involved in reproduction in multicellular organism GO:0030111 regulation of Wnt signaling pathway GO:0030308 negative regulation of cell growth GO:0031468 nuclear envelope reassembly GO:0033673 negative regulation of kinase activity GO:0034047 regulation of protein phosphatase type 2A activity GO:0034655 nucleobase-containing compound catabolic process GO:0035303 regulation of dephosphorylation GO:0035304 regulation of protein dephosphorylation GO:0038034 signal transduction in absence of ligand GO:0042326 negative regulation of phosphorylation GO:0042503 tyrosine phosphorylation of Stat3 protein GO:0042509 regulation of tyrosine phosphorylation of STAT protein GO:0042516 regulation of tyrosine phosphorylation of Stat3 protein GO:0042518 negative regulation of tyrosine phosphorylation of Stat3 protein GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein GO:0043405 regulation of MAP kinase activity GO:0043407 negative regulation of MAP kinase activity GO:0043409 negative regulation of MAPK cascade GO:0043666 regulation of phosphoprotein phosphatase activity GO:0043900 regulation of multi-organism process GO:0044270 cellular nitrogen compound catabolic process GO:0044770 cell cycle phase transition GO:0044772 mitotic cell cycle phase transition GO:0044839 cell cycle G2/M phase transition GO:0045132 meiotic chromosome segregation GO:0045144 meiotic sister chromatid segregation GO:0045926 negative regulation of growth GO:0046425 regulation of JAK-STAT cascade GO:0046426 negative regulation of JAK-STAT cascade GO:0046700 heterocycle catabolic process GO:0048469 cell maturation GO:0048477 oogenesis GO:0048599 oocyte development GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation GO:0051052 regulation of DNA metabolic process GO:0051177 meiotic sister chromatid cohesion GO:0051231 spindle elongation GO:0051232 meiotic spindle elongation GO:0051304 chromosome separation GO:0051306 mitotic sister chromatid separation GO:0051321 meiotic cell cycle GO:0051348 negative regulation of transferase activity GO:0051445 regulation of meiotic cell cycle GO:0051754 meiotic sister chromatid cohesion, centromeric GO:0060281 regulation of oocyte development GO:0070192 chromosome organization involved in meiotic cell cycle GO:0070262 peptidyl-serine dephosphorylation GO:0070601 centromeric sister chromatid cohesion GO:0071900 regulation of protein serine/threonine kinase activity GO:0071901 negative regulation of protein serine/threonine kinase activity GO:0097191 extrinsic apoptotic signaling pathway GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand GO:0097696 STAT cascade GO:0098813 nuclear chromosome segregation GO:0198738 cell-cell signaling by wnt GO:1900193 regulation of oocyte maturation GO:1901361 organic cyclic compound catabolic process GO:1902532 negative regulation of intracellular signal transduction GO:1903046 meiotic cell cycle process GO:1903429 regulation of cell maturation GO:1903537 meiotic cell cycle process involved in oocyte maturation GO:1903538 regulation of meiotic cell cycle process involved in oocyte maturation GO:1904892 regulation of STAT cascade GO:1904893 negative regulation of STAT cascade GO:2000241 regulation of reproductive process GO:2001233 regulation of apoptotic signaling pathway GO:2001235 positive regulation of apoptotic signaling pathway GO:2001236 regulation of extrinsic apoptotic signaling pathway GO:2001238 positive regulation of extrinsic apoptotic signaling pathway GO:2001239 regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
Molecular Function	GO:0003823 antigen binding GO:0004721 phosphoprotein phosphatase activity GO:0004722 protein serine/threonine phosphatase activity GO:0008601 protein phosphatase type 2A regulator activity GO:0016791 phosphatase activity GO:0019208 phosphatase regulator activity GO:0019888 protein phosphatase regulator activity GO:0042578 phosphoric ester hydrolase activity GO:0046982 protein heterodimerization activity
Cellular Component	GO:0000159 protein phosphatase type 2A complex GO:0000775 chromosome, centromeric region GO:0008287 protein serine/threonine phosphatase complex GO:0098687 chromosomal region GO:1903293 phosphatase complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa03015 mRNA surveillance pathway hsa04071 Sphingolipid signaling pathway hsa04114 Oocyte meiosis hsa04151 PI3K-Akt signaling pathway hsa04152 AMPK signaling pathway hsa04261 Adrenergic signaling in cardiomyocytes hsa04350 TGF-beta signaling pathway hsa04390 Hippo signaling pathway hsa04530 Tight junction hsa04728 Dopaminergic synapse hsa04730 Long-term depression
Reactome	R-HSA-4839748: AMER1 mutants destabilize the destruction complex R-HSA-5467337: APC truncation mutants have impaired AXIN binding R-HSA-170984: ARMS-mediated activation R-HSA-8854518: AURKA Activation by TPX2 R-HSA-5467340: AXIN missense mutants destabilize the destruction complex R-HSA-4839735: AXIN mutants destabilize the destruction complex, activating WNT signaling R-HSA-166054: Activated TLR4 signalling R-HSA-1280218: Adaptive Immune System R-HSA-5620912: Anchoring of the basal body to the plasma membrane R-HSA-422475: Axon guidance R-HSA-196299: Beta-catenin phosphorylation cascade R-HSA-389513: CTLA4 inhibitory signaling R-HSA-1640170: Cell Cycle R-HSA-69278: Cell Cycle, Mitotic R-HSA-380287: Centrosome maturation R-HSA-5617833: Cilium Assembly R-HSA-388841: Costimulation by the CD28 family R-HSA-69273: Cyclin A/B1 associated events during G2/M transition R-HSA-69231: Cyclin D associated events in G1 R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-2172127: DAP12 interactions R-HSA-2424491: DAP12 signaling R-HSA-180024: DARPP-32 events R-HSA-195253: Degradation of beta-catenin by the destruction complex R-HSA-1266738: Developmental Biology R-HSA-4641262: Disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-1643685: Disease R-HSA-5663202: Diseases of signal transduction R-HSA-186763: Downstream signal transduction R-HSA-1168372: Downstream signaling events of B Cell Receptor (BCR) R-HSA-113510: E2F mediated regulation of DNA replication R-HSA-198753: ERK/MAPK targets R-HSA-202670: ERKs are inactivated R-HSA-2871796: FCERI mediated MAPK activation R-HSA-2454202: Fc epsilon receptor (FCERI) signaling R-HSA-170968: Frs2-mediated activation R-HSA-69236: G1 Phase R-HSA-69206: G1/S Transition R-HSA-69275: G2/M Transition R-HSA-180292: GAB1 signalosome R-HSA-179812: GRB2 events in EGFR signaling R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-70326: Glucose metabolism R-HSA-70171: Glycolysis R-HSA-109582: Hemostasis R-HSA-2428924: IGF1R signaling cascade R-HSA-112399: IRS-mediated signalling R-HSA-2428928: IRS-related events triggered by IGF1R R-HSA-168256: Immune System R-HSA-113501: Inhibition of replication initiation of damaged DNA by RB1/E2F1 R-HSA-2995383: Initiation of Nuclear Envelope Reformation R-HSA-168249: Innate Immune System R-HSA-74751: Insulin receptor signalling cascade R-HSA-163685: Integration of energy metabolism R-HSA-912526: Interleukin receptor SHC signaling R-HSA-451927: Interleukin-2 signaling R-HSA-512988: Interleukin-3, 5 and GM-CSF signaling R-HSA-380259: Loss of Nlp from mitotic centrosomes R-HSA-380284: Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-68886: M Phase R-HSA-450294: MAP kinase activation in TLR cascade R-HSA-5683057: MAPK family signaling cascades R-HSA-450282: MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-5684996: MAPK1/MAPK3 signaling R-HSA-2465910: MASTL Facilitates Mitotic Progression R-HSA-1430728: Metabolism R-HSA-71387: Metabolism of carbohydrates R-HSA-5339716: Misspliced GSK3beta mutants stabilize beta-catenin R-HSA-68882: Mitotic Anaphase R-HSA-453279: Mitotic G1-G1/S phases R-HSA-453274: Mitotic G2-G2/M phases R-HSA-2555396: Mitotic Metaphase and Anaphase R-HSA-68877: Mitotic Prometaphase R-HSA-68875: Mitotic Prophase R-HSA-975871: MyD88 cascade initiated on plasma membrane R-HSA-975155: MyD88 dependent cascade initiated on endosome R-HSA-166166: MyD88-independent TLR3/TLR4 cascade R-HSA-166058: MyD88 R-HSA-375165: NCAM signaling for neurite out-growth R-HSA-187037: NGF signalling via TRKA from the plasma membrane R-HSA-5654726: Negative regulation of FGFR1 signaling R-HSA-5654727: Negative regulation of FGFR2 signaling R-HSA-5654732: Negative regulation of FGFR3 signaling R-HSA-5654733: Negative regulation of FGFR4 signaling R-HSA-5675221: Negative regulation of MAPK pathway R-HSA-199418: Negative regulation of the PI3K/AKT network R-HSA-975957: Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-927802: Nonsense-Mediated Decay (NMD) R-HSA-2995410: Nuclear Envelope Reassembly R-HSA-198725: Nuclear Events (kinase and transcription factor activation) R-HSA-111885: Opioid Signalling R-HSA-1852241: Organelle biogenesis and maintenance R-HSA-198203: PI3K/AKT activation R-HSA-6811558: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-1257604: PIP3 activates AKT signaling R-HSA-163767: PP2A-mediated dephosphorylation of key metabolic factors R-HSA-418346: Platelet homeostasis R-HSA-432142: Platelet sensitization by LDL R-HSA-169893: Prolonged ERK activation events R-HSA-5673000: RAF activation R-HSA-5673001: RAF/MAP kinase cascade R-HSA-8853659: RET signaling R-HSA-195258: RHO GTPase Effectors R-HSA-5663220: RHO GTPases Activate Formins R-HSA-380270: Recruitment of mitotic centrosome proteins and complexes R-HSA-2565942: Regulation of PLK1 Activity at G2/M Transition R-HSA-5633007: Regulation of TP53 Activity R-HSA-6804757: Regulation of TP53 Degradation R-HSA-6806003: Regulation of TP53 Expression and Degradation R-HSA-2500257: Resolution of Sister Chromatid Cohesion R-HSA-2730905: Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-5358747: S33 mutants of beta-catenin aren't phosphorylated R-HSA-5358749: S37 mutants of beta-catenin aren't phosphorylated R-HSA-5358751: S45 mutants of beta-catenin aren't phosphorylated R-HSA-180336: SHC1 events in EGFR signaling R-HSA-112412: SOS-mediated signalling R-HSA-2467813: Separation of Sister Chromatids R-HSA-162582: Signal Transduction R-HSA-177929: Signaling by EGFR R-HSA-190236: Signaling by FGFR R-HSA-5654736: Signaling by FGFR1 R-HSA-5654738: Signaling by FGFR2 R-HSA-5654741: Signaling by FGFR3 R-HSA-5654743: Signaling by FGFR4 R-HSA-372790: Signaling by GPCR R-HSA-74752: Signaling by Insulin receptor R-HSA-449147: Signaling by Interleukins R-HSA-2586552: Signaling by Leptin R-HSA-186797: Signaling by PDGF R-HSA-194315: Signaling by Rho GTPases R-HSA-1433557: Signaling by SCF-KIT R-HSA-2404192: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-194138: Signaling by VEGF R-HSA-4791275: Signaling by WNT in cancer R-HSA-195721: Signaling by Wnt R-HSA-983705: Signaling by the B Cell Receptor (BCR) R-HSA-166520: Signalling by NGF R-HSA-187687: Signalling to ERKs R-HSA-167044: Signalling to RAS R-HSA-187706: Signalling to p38 via RIT and RIN R-HSA-1295596: Spry regulation of FGF signaling R-HSA-5358752: T41 mutants of beta-catenin aren't phosphorylated R-HSA-201681: TCF dependent signaling in response to WNT R-HSA-168180: TRAF6 Mediated Induction of proinflammatory cytokines R-HSA-975138: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-937061: TRIF-mediated TLR3/TLR4 signaling R-HSA-168142: Toll Like Receptor 10 (TLR10) Cascade R-HSA-181438: Toll Like Receptor 2 (TLR2) Cascade R-HSA-168164: Toll Like Receptor 3 (TLR3) Cascade R-HSA-166016: Toll Like Receptor 4 (TLR4) Cascade R-HSA-168176: Toll Like Receptor 5 (TLR5) Cascade R-HSA-168181: Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168138: Toll Like Receptor 9 (TLR9) Cascade R-HSA-168179: Toll Like Receptor TLR1 R-HSA-168188: Toll Like Receptor TLR6 R-HSA-168898: Toll-Like Receptors Cascades R-HSA-3700989: Transcriptional Regulation by TP53 R-HSA-5467348: Truncations of AMER1 destabilize the destruction complex R-HSA-4420097: VEGFA-VEGFR2 Pathway R-HSA-5218921: VEGFR2 mediated cell proliferation R-HSA-4839743: phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex R-HSA-4839744: truncated APC mutants destabilize the destruction complex

> KEGG and Reactome Pathway

[ TOP ]

KEGG

hsa03015 mRNA surveillance pathway
hsa04071 Sphingolipid signaling pathway
hsa04114 Oocyte meiosis
hsa04151 PI3K-Akt signaling pathway
hsa04152 AMPK signaling pathway
hsa04261 Adrenergic signaling in cardiomyocytes
hsa04350 TGF-beta signaling pathway
hsa04390 Hippo signaling pathway
hsa04530 Tight junction
hsa04728 Dopaminergic synapse
hsa04730 Long-term depression

Reactome

R-HSA-4839748: AMER1 mutants destabilize the destruction complex
R-HSA-5467337: APC truncation mutants have impaired AXIN binding
R-HSA-170984: ARMS-mediated activation
R-HSA-8854518: AURKA Activation by TPX2
R-HSA-5467340: AXIN missense mutants destabilize the destruction complex
R-HSA-4839735: AXIN mutants destabilize the destruction complex, activating WNT signaling
R-HSA-166054: Activated TLR4 signalling
R-HSA-1280218: Adaptive Immune System
R-HSA-5620912: Anchoring of the basal body to the plasma membrane
R-HSA-422475: Axon guidance
R-HSA-196299: Beta-catenin phosphorylation cascade
R-HSA-389513: CTLA4 inhibitory signaling
R-HSA-1640170: Cell Cycle
R-HSA-69278: Cell Cycle, Mitotic
R-HSA-380287: Centrosome maturation
R-HSA-5617833: Cilium Assembly
R-HSA-388841: Costimulation by the CD28 family
R-HSA-69273: Cyclin A/B1 associated events during G2/M transition
R-HSA-69231: Cyclin D associated events in G1
R-HSA-1280215: Cytokine Signaling in Immune system
R-HSA-2172127: DAP12 interactions
R-HSA-2424491: DAP12 signaling
R-HSA-180024: DARPP-32 events
R-HSA-195253: Degradation of beta-catenin by the destruction complex
R-HSA-1266738: Developmental Biology
R-HSA-4641262: Disassembly of the destruction complex and recruitment of AXIN to the membrane
R-HSA-1643685: Disease
R-HSA-5663202: Diseases of signal transduction
R-HSA-186763: Downstream signal transduction
R-HSA-1168372: Downstream signaling events of B Cell Receptor (BCR)
R-HSA-113510: E2F mediated regulation of DNA replication
R-HSA-198753: ERK/MAPK targets
R-HSA-202670: ERKs are inactivated
R-HSA-2871796: FCERI mediated MAPK activation
R-HSA-2454202: Fc epsilon receptor (FCERI) signaling
R-HSA-170968: Frs2-mediated activation
R-HSA-69236: G1 Phase
R-HSA-69206: G1/S Transition
R-HSA-69275: G2/M Transition
R-HSA-180292: GAB1 signalosome
R-HSA-179812: GRB2 events in EGFR signaling
R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK
R-HSA-74160: Gene Expression
R-HSA-212436: Generic Transcription Pathway
R-HSA-70326: Glucose metabolism
R-HSA-70171: Glycolysis
R-HSA-109582: Hemostasis
R-HSA-2428924: IGF1R signaling cascade
R-HSA-112399: IRS-mediated signalling
R-HSA-2428928: IRS-related events triggered by IGF1R
R-HSA-168256: Immune System
R-HSA-113501: Inhibition of replication initiation of damaged DNA by RB1/E2F1
R-HSA-2995383: Initiation of Nuclear Envelope Reformation
R-HSA-168249: Innate Immune System
R-HSA-74751: Insulin receptor signalling cascade
R-HSA-163685: Integration of energy metabolism
R-HSA-912526: Interleukin receptor SHC signaling
R-HSA-451927: Interleukin-2 signaling
R-HSA-512988: Interleukin-3, 5 and GM-CSF signaling
R-HSA-380259: Loss of Nlp from mitotic centrosomes
R-HSA-380284: Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-68886: M Phase
R-HSA-450294: MAP kinase activation in TLR cascade
R-HSA-5683057: MAPK family signaling cascades
R-HSA-450282: MAPK targets/ Nuclear events mediated by MAP kinases
R-HSA-5684996: MAPK1/MAPK3 signaling
R-HSA-2465910: MASTL Facilitates Mitotic Progression
R-HSA-1430728: Metabolism
R-HSA-71387: Metabolism of carbohydrates
R-HSA-5339716: Misspliced GSK3beta mutants stabilize beta-catenin
R-HSA-68882: Mitotic Anaphase
R-HSA-453279: Mitotic G1-G1/S phases
R-HSA-453274: Mitotic G2-G2/M phases
R-HSA-2555396: Mitotic Metaphase and Anaphase
R-HSA-68877: Mitotic Prometaphase
R-HSA-68875: Mitotic Prophase
R-HSA-975871: MyD88 cascade initiated on plasma membrane
R-HSA-975155: MyD88 dependent cascade initiated on endosome
R-HSA-166166: MyD88-independent TLR3/TLR4 cascade
R-HSA-166058: MyD88
R-HSA-375165: NCAM signaling for neurite out-growth
R-HSA-187037: NGF signalling via TRKA from the plasma membrane
R-HSA-5654726: Negative regulation of FGFR1 signaling
R-HSA-5654727: Negative regulation of FGFR2 signaling
R-HSA-5654732: Negative regulation of FGFR3 signaling
R-HSA-5654733: Negative regulation of FGFR4 signaling
R-HSA-5675221: Negative regulation of MAPK pathway
R-HSA-199418: Negative regulation of the PI3K/AKT network
R-HSA-975957: Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
R-HSA-927802: Nonsense-Mediated Decay (NMD)
R-HSA-2995410: Nuclear Envelope Reassembly
R-HSA-198725: Nuclear Events (kinase and transcription factor activation)
R-HSA-111885: Opioid Signalling
R-HSA-1852241: Organelle biogenesis and maintenance
R-HSA-198203: PI3K/AKT activation
R-HSA-6811558: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-1257604: PIP3 activates AKT signaling
R-HSA-163767: PP2A-mediated dephosphorylation of key metabolic factors
R-HSA-418346: Platelet homeostasis
R-HSA-432142: Platelet sensitization by LDL
R-HSA-169893: Prolonged ERK activation events
R-HSA-5673000: RAF activation
R-HSA-5673001: RAF/MAP kinase cascade
R-HSA-8853659: RET signaling
R-HSA-195258: RHO GTPase Effectors
R-HSA-5663220: RHO GTPases Activate Formins
R-HSA-380270: Recruitment of mitotic centrosome proteins and complexes
R-HSA-2565942: Regulation of PLK1 Activity at G2/M Transition
R-HSA-5633007: Regulation of TP53 Activity
R-HSA-6804757: Regulation of TP53 Degradation
R-HSA-6806003: Regulation of TP53 Expression and Degradation
R-HSA-2500257: Resolution of Sister Chromatid Cohesion
R-HSA-2730905: Role of LAT2/NTAL/LAB on calcium mobilization
R-HSA-5358747: S33 mutants of beta-catenin aren't phosphorylated
R-HSA-5358749: S37 mutants of beta-catenin aren't phosphorylated
R-HSA-5358751: S45 mutants of beta-catenin aren't phosphorylated
R-HSA-180336: SHC1 events in EGFR signaling
R-HSA-112412: SOS-mediated signalling
R-HSA-2467813: Separation of Sister Chromatids
R-HSA-162582: Signal Transduction
R-HSA-177929: Signaling by EGFR
R-HSA-190236: Signaling by FGFR
R-HSA-5654736: Signaling by FGFR1
R-HSA-5654738: Signaling by FGFR2
R-HSA-5654741: Signaling by FGFR3
R-HSA-5654743: Signaling by FGFR4
R-HSA-372790: Signaling by GPCR
R-HSA-74752: Signaling by Insulin receptor
R-HSA-449147: Signaling by Interleukins
R-HSA-2586552: Signaling by Leptin
R-HSA-186797: Signaling by PDGF
R-HSA-194315: Signaling by Rho GTPases
R-HSA-1433557: Signaling by SCF-KIT
R-HSA-2404192: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
R-HSA-194138: Signaling by VEGF
R-HSA-4791275: Signaling by WNT in cancer
R-HSA-195721: Signaling by Wnt
R-HSA-983705: Signaling by the B Cell Receptor (BCR)
R-HSA-166520: Signalling by NGF
R-HSA-187687: Signalling to ERKs
R-HSA-167044: Signalling to RAS
R-HSA-187706: Signalling to p38 via RIT and RIN
R-HSA-1295596: Spry regulation of FGF signaling
R-HSA-5358752: T41 mutants of beta-catenin aren't phosphorylated
R-HSA-201681: TCF dependent signaling in response to WNT
R-HSA-168180: TRAF6 Mediated Induction of proinflammatory cytokines
R-HSA-975138: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-HSA-937061: TRIF-mediated TLR3/TLR4 signaling
R-HSA-168142: Toll Like Receptor 10 (TLR10) Cascade
R-HSA-181438: Toll Like Receptor 2 (TLR2) Cascade
R-HSA-168164: Toll Like Receptor 3 (TLR3) Cascade
R-HSA-166016: Toll Like Receptor 4 (TLR4) Cascade
R-HSA-168176: Toll Like Receptor 5 (TLR5) Cascade
R-HSA-168181: Toll Like Receptor 7/8 (TLR7/8) Cascade
R-HSA-168138: Toll Like Receptor 9 (TLR9) Cascade
R-HSA-168179: Toll Like Receptor TLR1
R-HSA-168188: Toll Like Receptor TLR6
R-HSA-168898: Toll-Like Receptors Cascades
R-HSA-3700989: Transcriptional Regulation by TP53
R-HSA-5467348: Truncations of AMER1 destabilize the destruction complex
R-HSA-4420097: VEGFA-VEGFR2 Pathway
R-HSA-5218921: VEGFR2 mediated cell proliferation
R-HSA-4839743: phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
R-HSA-4839744: truncated APC mutants destabilize the destruction complex

Summary
Symbol	PPP2R1A
Name	protein phosphatase 2, regulatory subunit A, alpha
Aliases	PR65A; PP2A-Aalpha; protein phosphatase 2A, regulatory subunit A, alpha isoform; protein phosphatase 2, 65kD ......
Chromosomal Location	19q13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between PPP2R1A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	PPP2R1A
Name	protein phosphatase 2, regulatory subunit A, alpha
Aliases	PR65A; PP2A-Aalpha; protein phosphatase 2A, regulatory subunit A, alpha isoform; protein phosphatase 2, 65kD ......
Chromosomal Location	19q13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of PPP2R1A in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	STARS Score: 3.94; FDR: 0.025	Resistant to T cell-mediated killing
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	PPP2R1A
Name	protein phosphatase 2, regulatory subunit A, alpha
Aliases	PR65A; PP2A-Aalpha; protein phosphatase 2A, regulatory subunit A, alpha isoform; protein phosphatase 2, 65kD ......
Chromosomal Location	19q13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of PPP2R1A in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0.16	0.57
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-0.208	0.948
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	0.433	0.848
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.257	0.505
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0.203	0.932
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.327	0.914
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	-0.128	0.768
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-0.227	0.909
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-0.068	0.976
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.285	0.9
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0.338	0.921
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	0.025	0.685

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of PPP2R1A in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	5.9	-5.9	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	7.1	-7.1	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	7.4	4.1	3.3	0.61
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	7.4	5.1	2.3	0.647
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	0	0	0	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	0	0	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	0	7.4	-7.4	0.169
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	7.7	-7.7	0.371
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	7.1	-7.1	0.467
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	PPP2R1A
Name	protein phosphatase 2, regulatory subunit A, alpha
Aliases	PR65A; PP2A-Aalpha; protein phosphatase 2A, regulatory subunit A, alpha isoform; protein phosphatase 2, 65kD ......
Chromosomal Location	19q13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PPP2R1A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	PPP2R1A
Name	protein phosphatase 2, regulatory subunit A, alpha
Aliases	PR65A; PP2A-Aalpha; protein phosphatase 2A, regulatory subunit A, alpha isoform; protein phosphatase 2, 65kD ......
Chromosomal Location	19q13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PPP2R1A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PPP2R1A. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	PPP2R1A
Name	protein phosphatase 2, regulatory subunit A, alpha
Aliases	PR65A; PP2A-Aalpha; protein phosphatase 2A, regulatory subunit A, alpha isoform; protein phosphatase 2, 65kD ......
Chromosomal Location	19q13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PPP2R1A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	PPP2R1A
Name	protein phosphatase 2, regulatory subunit A, alpha
Aliases	PR65A; PP2A-Aalpha; protein phosphatase 2A, regulatory subunit A, alpha isoform; protein phosphatase 2, 65kD ......
Chromosomal Location	19q13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of PPP2R1A expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	PPP2R1A
Name	protein phosphatase 2, regulatory subunit A, alpha
Aliases	PR65A; PP2A-Aalpha; protein phosphatase 2A, regulatory subunit A, alpha isoform; protein phosphatase 2, 65kD ......
Chromosomal Location	19q13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between PPP2R1A and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	PPP2R1A
Name	protein phosphatase 2, regulatory subunit A, alpha
Aliases	PR65A; PP2A-Aalpha; protein phosphatase 2A, regulatory subunit A, alpha isoform; protein phosphatase 2, 65kD ......
Chromosomal Location	19q13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting PPP2R1A collected from DrugBank database.

> Drugs from DrugBank database

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Details on drugs targeting PPP2R1A.

ID	Name	Drug Type	Targets	#Targets
DB02506	2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid	Small Molecule	PPP1CA, PPP2CA, PPP2R1A, PPP2R2A, PPP2R5C	5
DB06905	(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid	Small Molecule	PPP2CA, PPP2R1A, PPP2R5C	3

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