TISIDB

Summary
Symbol	PPP2R3C
Name	protein phosphatase 2, regulatory subunit B'', gamma
Aliases	FLJ20644; G4-1; G5PR; C14orf10; chromosome 14 open reading frame 10; protein phosphatase 2 (formerly 2A), re ......
Chromosomal Location	14q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Nucleus Cytoplasm Note=Excluded from the nucleoli. Localization is cell cycle-dependent. Localizes to the cytoplasm during cytokinesis.
Domain	-
Function	May regulate MCM3AP phosphorylation through phosphatase recruitment. May act as a negative regulator of ABCB1 expression and function through the dephosphorylation of ABCB1 by TFPI2/PPP2R3C complex. May play a role in the activation-induced cell death of B-cells.

> Gene Ontology [ TOP ]
Biological Process	GO:0000226 microtubule cytoskeleton organization GO:0001776 leukocyte homeostasis GO:0001782 B cell homeostasis GO:0002260 lymphocyte homeostasis GO:0002521 leukocyte differentiation GO:0002694 regulation of leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0002759 regulation of antimicrobial humoral response GO:0002831 regulation of response to biotic stimulus GO:0002920 regulation of humoral immune response GO:0003254 regulation of membrane depolarization GO:0006959 humoral immune response GO:0019730 antimicrobial humoral response GO:0030098 lymphocyte differentiation GO:0030183 B cell differentiation GO:0030865 cortical cytoskeleton organization GO:0032147 activation of protein kinase activity GO:0032844 regulation of homeostatic process GO:0033674 positive regulation of kinase activity GO:0042113 B cell activation GO:0042391 regulation of membrane potential GO:0043029 T cell homeostasis GO:0043900 regulation of multi-organism process GO:0045577 regulation of B cell differentiation GO:0045579 positive regulation of B cell differentiation GO:0045619 regulation of lymphocyte differentiation GO:0045621 positive regulation of lymphocyte differentiation GO:0045860 positive regulation of protein kinase activity GO:0048536 spleen development GO:0048872 homeostasis of number of cells GO:0050864 regulation of B cell activation GO:0050865 regulation of cell activation GO:0050867 positive regulation of cell activation GO:0050871 positive regulation of B cell activation GO:0051249 regulation of lymphocyte activation GO:0051251 positive regulation of lymphocyte activation GO:0051881 regulation of mitochondrial membrane potential GO:0051882 mitochondrial depolarization GO:0051899 membrane depolarization GO:0051900 regulation of mitochondrial depolarization GO:1902105 regulation of leukocyte differentiation GO:1902107 positive regulation of leukocyte differentiation GO:1903706 regulation of hemopoiesis GO:1903708 positive regulation of hemopoiesis GO:2000021 regulation of ion homeostasis
Molecular Function	-
Cellular Component	GO:0005813 centrosome GO:0005819 spindle

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa03015 mRNA surveillance pathway hsa04071 Sphingolipid signaling pathway hsa04151 PI3K-Akt signaling pathway hsa04152 AMPK signaling pathway hsa04261 Adrenergic signaling in cardiomyocytes hsa04728 Dopaminergic synapse
Reactome	-

Summary
Symbol	PPP2R3C
Name	protein phosphatase 2, regulatory subunit B'', gamma
Aliases	FLJ20644; G4-1; G5PR; C14orf10; chromosome 14 open reading frame 10; protein phosphatase 2 (formerly 2A), re ......
Chromosomal Location	14q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between PPP2R3C and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	PPP2R3C
Name	protein phosphatase 2, regulatory subunit B'', gamma
Aliases	FLJ20644; G4-1; G5PR; C14orf10; chromosome 14 open reading frame 10; protein phosphatase 2 (formerly 2A), re ......
Chromosomal Location	14q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of PPP2R3C in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	Total # shRNA with >= 4-fold: 1	Resistant to T-cell proliferation
24476824	shRNA	melanoma	B16	Secondary screen	Total # shRNA with >= 4-fold: 1	Resistant to T-cell proliferation

Summary
Symbol	PPP2R3C
Name	protein phosphatase 2, regulatory subunit B'', gamma
Aliases	FLJ20644; G4-1; G5PR; C14orf10; chromosome 14 open reading frame 10; protein phosphatase 2 (formerly 2A), re ......
Chromosomal Location	14q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of PPP2R3C in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0.211	0.336
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	0.593	0.747
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.071	0.959
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-0.158	0.661
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-0.726	0.559
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.558	0.711
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	-0.197	0.566
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-0.186	0.903
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-0.204	0.904
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.113	0.937
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0.376	0.865
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.003	0.966

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of PPP2R3C in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	3.7	3.7	0.27
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	3.7	3.7	0.314
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	0	0	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	0	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	2.6	2.6	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	4.5	4.5	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	1

Summary
Symbol	PPP2R3C
Name	protein phosphatase 2, regulatory subunit B'', gamma
Aliases	FLJ20644; G4-1; G5PR; C14orf10; chromosome 14 open reading frame 10; protein phosphatase 2 (formerly 2A), re ......
Chromosomal Location	14q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PPP2R3C. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	PPP2R3C
Name	protein phosphatase 2, regulatory subunit B'', gamma
Aliases	FLJ20644; G4-1; G5PR; C14orf10; chromosome 14 open reading frame 10; protein phosphatase 2 (formerly 2A), re ......
Chromosomal Location	14q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PPP2R3C. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PPP2R3C. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	PPP2R3C
Name	protein phosphatase 2, regulatory subunit B'', gamma
Aliases	FLJ20644; G4-1; G5PR; C14orf10; chromosome 14 open reading frame 10; protein phosphatase 2 (formerly 2A), re ......
Chromosomal Location	14q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PPP2R3C. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	PPP2R3C
Name	protein phosphatase 2, regulatory subunit B'', gamma
Aliases	FLJ20644; G4-1; G5PR; C14orf10; chromosome 14 open reading frame 10; protein phosphatase 2 (formerly 2A), re ......
Chromosomal Location	14q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of PPP2R3C expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	PPP2R3C
Name	protein phosphatase 2, regulatory subunit B'', gamma
Aliases	FLJ20644; G4-1; G5PR; C14orf10; chromosome 14 open reading frame 10; protein phosphatase 2 (formerly 2A), re ......
Chromosomal Location	14q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between PPP2R3C and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	PPP2R3C
Name	protein phosphatase 2, regulatory subunit B'', gamma
Aliases	FLJ20644; G4-1; G5PR; C14orf10; chromosome 14 open reading frame 10; protein phosphatase 2 (formerly 2A), re ......
Chromosomal Location	14q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting PPP2R3C collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

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