Browse PPP3CC

Summary
SymbolPPP3CC
Nameprotein phosphatase 3, catalytic subunit, gamma isozyme
Aliases CALNA3; PP2Bgamma; calcineurin A gamma; protein phosphatase 2B, catalytic subunit, gamma isoform; protein ph ......
Chromosomal Location8p21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location -
Domain PF00149 Calcineurin-like phosphoesterase
Function

Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.

> Gene Ontology
 
Biological Process GO:0001844 protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:0006470 protein dephosphorylation
GO:0006839 mitochondrial transport
GO:0007006 mitochondrial membrane organization
GO:0008637 apoptotic mitochondrial changes
GO:0010821 regulation of mitochondrion organization
GO:0010822 positive regulation of mitochondrion organization
GO:0016311 dephosphorylation
GO:0035794 positive regulation of mitochondrial membrane permeability
GO:0046902 regulation of mitochondrial membrane permeability
GO:0051204 protein insertion into mitochondrial membrane
GO:0051205 protein insertion into membrane
GO:0070585 protein localization to mitochondrion
GO:0072655 establishment of protein localization to mitochondrion
GO:0072657 protein localization to membrane
GO:0090150 establishment of protein localization to membrane
GO:0090559 regulation of membrane permeability
GO:0097345 mitochondrial outer membrane permeabilization
GO:1900739 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1901028 regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process
GO:1902110 positive regulation of mitochondrial membrane permeability involved in apoptotic process
GO:1902686 mitochondrial outer membrane permeabilization involved in programmed cell death
GO:1903747 regulation of establishment of protein localization to mitochondrion
GO:1903749 positive regulation of establishment of protein localization to mitochondrion
GO:1903829 positive regulation of cellular protein localization
GO:1904951 positive regulation of establishment of protein localization
GO:2001233 regulation of apoptotic signaling pathway
GO:2001235 positive regulation of apoptotic signaling pathway
Molecular Function GO:0004721 phosphoprotein phosphatase activity
GO:0005516 calmodulin binding
GO:0016791 phosphatase activity
GO:0042578 phosphoric ester hydrolase activity
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa04010 MAPK signaling pathway
hsa04020 Calcium signaling pathway
hsa04022 cGMP-PKG signaling pathway
hsa04114 Oocyte meiosis
hsa04310 Wnt signaling pathway
hsa04360 Axon guidance
hsa04370 VEGF signaling pathway
hsa04380 Osteoclast differentiation
hsa04650 Natural killer cell mediated cytotoxicity
hsa04660 T cell receptor signaling pathway
hsa04662 B cell receptor signaling pathway
hsa04720 Long-term potentiation
hsa04724 Glutamatergic synapse
hsa04728 Dopaminergic synapse
hsa04921 Oxytocin signaling pathway
hsa04922 Glucagon signaling pathway
Reactome R-HSA-111447: Activation of BAD and translocation to mitochondria
R-HSA-114452: Activation of BH3-only proteins
R-HSA-109581: Apoptosis
R-HSA-180024: DARPP-32 events
R-HSA-109606: Intrinsic Pathway for Apoptosis
R-HSA-111885: Opioid Signalling
R-HSA-5357801: Programmed Cell Death
R-HSA-162582: Signal Transduction
R-HSA-372790: Signaling by GPCR
Summary
SymbolPPP3CC
Nameprotein phosphatase 3, catalytic subunit, gamma isozyme
Aliases CALNA3; PP2Bgamma; calcineurin A gamma; protein phosphatase 2B, catalytic subunit, gamma isoform; protein ph ......
Chromosomal Location8p21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between PPP3CC and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolPPP3CC
Nameprotein phosphatase 3, catalytic subunit, gamma isozyme
Aliases CALNA3; PP2Bgamma; calcineurin A gamma; protein phosphatase 2B, catalytic subunit, gamma isoform; protein ph ......
Chromosomal Location8p21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of PPP3CC in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen Total # shRNA with >= 4-fold: 1 Resistant to T-cell proliferation
24476824shRNAmelanomaB16Secondary screen Total # shRNA with >= 4-fold: 3 Resistant to T-cell proliferation
Summary
SymbolPPP3CC
Nameprotein phosphatase 3, catalytic subunit, gamma isozyme
Aliases CALNA3; PP2Bgamma; calcineurin A gamma; protein phosphatase 2B, catalytic subunit, gamma isoform; protein ph ......
Chromosomal Location8p21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of PPP3CC in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.0060.983
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.460.769
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.3370.743
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.0050.988
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.0340.983
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.0330.987
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0620.864
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.0770.951
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.1170.937
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.5090.607
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.5870.704
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.1630.0546
> Mutation difference between responders and non-responders
 

There is no record.
Summary
SymbolPPP3CC
Nameprotein phosphatase 3, catalytic subunit, gamma isozyme
Aliases CALNA3; PP2Bgamma; calcineurin A gamma; protein phosphatase 2B, catalytic subunit, gamma isoform; protein ph ......
Chromosomal Location8p21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PPP3CC. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolPPP3CC
Nameprotein phosphatase 3, catalytic subunit, gamma isozyme
Aliases CALNA3; PP2Bgamma; calcineurin A gamma; protein phosphatase 2B, catalytic subunit, gamma isoform; protein ph ......
Chromosomal Location8p21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PPP3CC. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PPP3CC.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolPPP3CC
Nameprotein phosphatase 3, catalytic subunit, gamma isozyme
Aliases CALNA3; PP2Bgamma; calcineurin A gamma; protein phosphatase 2B, catalytic subunit, gamma isoform; protein ph ......
Chromosomal Location8p21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PPP3CC. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolPPP3CC
Nameprotein phosphatase 3, catalytic subunit, gamma isozyme
Aliases CALNA3; PP2Bgamma; calcineurin A gamma; protein phosphatase 2B, catalytic subunit, gamma isoform; protein ph ......
Chromosomal Location8p21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of PPP3CC expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolPPP3CC
Nameprotein phosphatase 3, catalytic subunit, gamma isozyme
Aliases CALNA3; PP2Bgamma; calcineurin A gamma; protein phosphatase 2B, catalytic subunit, gamma isoform; protein ph ......
Chromosomal Location8p21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between PPP3CC and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolPPP3CC
Nameprotein phosphatase 3, catalytic subunit, gamma isozyme
Aliases CALNA3; PP2Bgamma; calcineurin A gamma; protein phosphatase 2B, catalytic subunit, gamma isoform; protein ph ......
Chromosomal Location8p21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting PPP3CC collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.