TISIDB

Summary
Symbol	PRG2
Name	proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
Aliases	BMPG; bone-marrow proteoglycan; eosinophil granule major basic protein; eosinophil major basic protein; natu ......
Chromosomal Location	11q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Bone marrow proteoglycan: Secreted. Note=The proform is secreted.; SUBCELLULAR LOCATION: Eosinophil granule major basic protein: Cytoplasmic vesicle, secretory vesicle. Note=The proform is secreted. The mature protein is found in the matrix of the eosinophil's large specific granule (crystalloid core).
Domain	PF00059 Lectin C-type domain
Function	Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA.

> Gene Ontology [ TOP ]
Biological Process	GO:0001818 negative regulation of cytokine production GO:0001819 positive regulation of cytokine production GO:0002215 defense response to nematode GO:0032613 interleukin-10 production GO:0032633 interleukin-4 production GO:0032653 regulation of interleukin-10 production GO:0032673 regulation of interleukin-4 production GO:0032693 negative regulation of interleukin-10 production GO:0032753 positive regulation of interleukin-4 production GO:0042035 regulation of cytokine biosynthetic process GO:0042089 cytokine biosynthetic process GO:0042107 cytokine metabolic process GO:0042742 defense response to bacterium GO:0098542 defense response to other organism
Molecular Function	GO:0005539 glycosaminoglycan binding GO:0008201 heparin binding GO:0030246 carbohydrate binding GO:1901681 sulfur compound binding
Cellular Component	GO:0030133 transport vesicle

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-6798695: Neutrophil degranulation

Summary
Symbol	PRG2
Name	proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
Aliases	BMPG; bone-marrow proteoglycan; eosinophil granule major basic protein; eosinophil major basic protein; natu ......
Chromosomal Location	11q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between PRG2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	PRG2
Name	proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
Aliases	BMPG; bone-marrow proteoglycan; eosinophil granule major basic protein; eosinophil major basic protein; natu ......
Chromosomal Location	11q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of PRG2 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	Second most enriched score: 0.6	Sensitive to T cell-mediated killing
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	PRG2
Name	proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
Aliases	BMPG; bone-marrow proteoglycan; eosinophil granule major basic protein; eosinophil major basic protein; natu ......
Chromosomal Location	11q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of PRG2 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0.248	0.475
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	0.051	0.948
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	0.404	0.422
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-1.413	0.14
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-1.838	0.255
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	-0.855	0.596
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	-0.581	0.361
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-0.074	0.937
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-1.305	0.175
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	-0.351	0.526
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	-0.351	0.655
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.537	0.0139

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of PRG2 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	0	0	1
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	0	0	1
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	0	0	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	0	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	2.6	2.6	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	6.2	6.2	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	1

Summary
Symbol	PRG2
Name	proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
Aliases	BMPG; bone-marrow proteoglycan; eosinophil granule major basic protein; eosinophil major basic protein; natu ......
Chromosomal Location	11q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PRG2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	PRG2
Name	proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
Aliases	BMPG; bone-marrow proteoglycan; eosinophil granule major basic protein; eosinophil major basic protein; natu ......
Chromosomal Location	11q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PRG2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PRG2. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	PRG2
Name	proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
Aliases	BMPG; bone-marrow proteoglycan; eosinophil granule major basic protein; eosinophil major basic protein; natu ......
Chromosomal Location	11q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PRG2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	PRG2
Name	proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
Aliases	BMPG; bone-marrow proteoglycan; eosinophil granule major basic protein; eosinophil major basic protein; natu ......
Chromosomal Location	11q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of PRG2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	PRG2
Name	proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
Aliases	BMPG; bone-marrow proteoglycan; eosinophil granule major basic protein; eosinophil major basic protein; natu ......
Chromosomal Location	11q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between PRG2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	PRG2
Name	proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
Aliases	BMPG; bone-marrow proteoglycan; eosinophil granule major basic protein; eosinophil major basic protein; natu ......
Chromosomal Location	11q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting PRG2 collected from DrugBank database.

> Drugs from DrugBank database

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Details on drugs targeting PRG2.

ID	Name	Drug Type	Targets	#Targets
DB00020	Sargramostim	Biotech	CSF2RA, CSF2RB, IL3RA, PRG2, SDC2	5

Browse PRG2