| Summary | |
|---|---|
| Symbol | PSMB5 |
| Name | proteasome subunit beta 5 |
| Aliases | X; MB1; proteasome (prosome, macropain) subunit, beta type, 5; LMPX; PSX large multifunctional protease X; m ...... |
| Chromosomal Location | 14q11.2 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
| Subcellular Location | Cytoplasm Nucleus |
| Domain |
PF00227 Proteasome subunit |
| Function |
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB5 displays a chymotrypsin-like activity. |
| Biological Process |
GO:0000209 protein polyubiquitination GO:0001736 establishment of planar polarity GO:0001738 morphogenesis of a polarized epithelium GO:0002218 activation of innate immune response GO:0002220 innate immune response activating cell surface receptor signaling pathway GO:0002223 stimulatory C-type lectin receptor signaling pathway GO:0002429 immune response-activating cell surface receptor signaling pathway GO:0002474 antigen processing and presentation of peptide antigen via MHC class I GO:0002478 antigen processing and presentation of exogenous peptide antigen GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002757 immune response-activating signal transduction GO:0002758 innate immune response-activating signal transduction GO:0002764 immune response-regulating signaling pathway GO:0002768 immune response-regulating cell surface receptor signaling pathway GO:0006520 cellular amino acid metabolic process GO:0006521 regulation of cellular amino acid metabolic process GO:0006979 response to oxidative stress GO:0007164 establishment of tissue polarity GO:0007346 regulation of mitotic cell cycle GO:0009308 amine metabolic process GO:0009894 regulation of catabolic process GO:0009896 positive regulation of catabolic process GO:0010498 proteasomal protein catabolic process GO:0010565 regulation of cellular ketone metabolic process GO:0010608 posttranscriptional regulation of gene expression GO:0016055 Wnt signaling pathway GO:0019882 antigen processing and presentation GO:0019884 antigen processing and presentation of exogenous antigen GO:0030111 regulation of Wnt signaling pathway GO:0030177 positive regulation of Wnt signaling pathway GO:0030178 negative regulation of Wnt signaling pathway GO:0031145 anaphase-promoting complex-dependent catabolic process GO:0031329 regulation of cellular catabolic process GO:0031331 positive regulation of cellular catabolic process GO:0031349 positive regulation of defense response GO:0031396 regulation of protein ubiquitination GO:0031397 negative regulation of protein ubiquitination GO:0031398 positive regulation of protein ubiquitination GO:0033209 tumor necrosis factor-mediated signaling pathway GO:0033238 regulation of cellular amine metabolic process GO:0034612 response to tumor necrosis factor GO:0035567 non-canonical Wnt signaling pathway GO:0038061 NIK/NF-kappaB signaling GO:0038093 Fc receptor signaling pathway GO:0038095 Fc-epsilon receptor signaling pathway GO:0042176 regulation of protein catabolic process GO:0042180 cellular ketone metabolic process GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043487 regulation of RNA stability GO:0043488 regulation of mRNA stability GO:0044106 cellular amine metabolic process GO:0045088 regulation of innate immune response GO:0045089 positive regulation of innate immune response GO:0045732 positive regulation of protein catabolic process GO:0045862 positive regulation of proteolysis GO:0048002 antigen processing and presentation of peptide antigen GO:0050851 antigen receptor-mediated signaling pathway GO:0050852 T cell receptor signaling pathway GO:0051348 negative regulation of transferase activity GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition GO:0051438 regulation of ubiquitin-protein transferase activity GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle GO:0051443 positive regulation of ubiquitin-protein transferase activity GO:0051444 negative regulation of ubiquitin-protein transferase activity GO:0060070 canonical Wnt signaling pathway GO:0060071 Wnt signaling pathway, planar cell polarity pathway GO:0060828 regulation of canonical Wnt signaling pathway GO:0071356 cellular response to tumor necrosis factor GO:0090090 negative regulation of canonical Wnt signaling pathway GO:0090175 regulation of establishment of planar polarity GO:0090263 positive regulation of canonical Wnt signaling pathway GO:0198738 cell-cell signaling by wnt GO:1901987 regulation of cell cycle phase transition GO:1901990 regulation of mitotic cell cycle phase transition GO:1903050 regulation of proteolysis involved in cellular protein catabolic process GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process GO:1903320 regulation of protein modification by small protein conjugation or removal GO:1903321 negative regulation of protein modification by small protein conjugation or removal GO:1903322 positive regulation of protein modification by small protein conjugation or removal GO:1903362 regulation of cellular protein catabolic process GO:1903364 positive regulation of cellular protein catabolic process GO:1904666 regulation of ubiquitin protein ligase activity GO:1904667 negative regulation of ubiquitin protein ligase activity GO:1904668 positive regulation of ubiquitin protein ligase activity GO:1905330 regulation of morphogenesis of an epithelium GO:2000027 regulation of organ morphogenesis GO:2000058 regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process |
| Molecular Function |
GO:0004175 endopeptidase activity GO:0004298 threonine-type endopeptidase activity GO:0070003 threonine-type peptidase activity |
| Cellular Component |
GO:0000502 proteasome complex GO:0005813 centrosome GO:0005839 proteasome core complex GO:1905368 peptidase complex GO:1905369 endopeptidase complex |
| KEGG |
hsa03050 Proteasome |
| Reactome |
R-HSA-5619084: ABC transporter disorders R-HSA-382556: ABC-family proteins mediated transport R-HSA-174143: APC/C-mediated degradation of cell cycle proteins R-HSA-174154: APC/C R-HSA-176409: APC/C R-HSA-174178: APC/C R-HSA-179419: APC R-HSA-170984: ARMS-mediated activation R-HSA-450408: AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-176814: Activation of APC/C and APC/C R-HSA-1169091: Activation of NF-kappaB in B cells R-HSA-1280218: Adaptive Immune System R-HSA-1236975: Antigen processing-Cross presentation R-HSA-983168: Antigen processing R-HSA-109581: Apoptosis R-HSA-68867: Assembly of the pre-replicative complex R-HSA-4608870: Asymmetric localization of PCP proteins R-HSA-174084: Autodegradation of Cdh1 by Cdh1 R-HSA-349425: Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-422475: Axon guidance R-HSA-3858494: Beta-catenin independent WNT signaling R-HSA-5621481: C-type lectin receptors (CLRs) R-HSA-69017: CDK-mediated phosphorylation and removal of Cdc6 R-HSA-68827: CDT1 association with the CDC6 R-HSA-5607764: CLEC7A (Dectin-1) signaling R-HSA-174184: Cdc20 R-HSA-1640170: Cell Cycle R-HSA-69620: Cell Cycle Checkpoints R-HSA-69278: Cell Cycle, Mitotic R-HSA-2262749: Cellular response to hypoxia R-HSA-2262752: Cellular responses to stress R-HSA-983169: Class I MHC mediated antigen processing & presentation R-HSA-1236978: Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-69656: Cyclin A R-HSA-69202: Cyclin E associated events during G1/S transition R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-2172127: DAP12 interactions R-HSA-2424491: DAP12 signaling R-HSA-69306: DNA Replication R-HSA-69002: DNA Replication Pre-Initiation R-HSA-5607761: Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5678895: Defective CFTR causes cystic fibrosis R-HSA-4641257: Degradation of AXIN R-HSA-4641258: Degradation of DVL R-HSA-5610780: Degradation of GLI1 by the proteasome R-HSA-5610783: Degradation of GLI2 by the proteasome R-HSA-195253: Degradation of beta-catenin by the destruction complex R-HSA-5688426: Deubiquitination R-HSA-1266738: Developmental Biology R-HSA-1643685: Disease R-HSA-5663202: Diseases of signal transduction R-HSA-5619115: Disorders of transmembrane transporters R-HSA-202424: Downstream TCR signaling R-HSA-186763: Downstream signal transduction R-HSA-1168372: Downstream signaling events of B Cell Receptor (BCR) R-HSA-1236974: ER-Phagosome pathway R-HSA-8854050: FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-2871796: FCERI mediated MAPK activation R-HSA-2871837: FCERI mediated NF-kB activation R-HSA-2454202: Fc epsilon receptor (FCERI) signaling R-HSA-170968: Frs2-mediated activation R-HSA-69615: G1/S DNA Damage Checkpoints R-HSA-69206: G1/S Transition R-HSA-69481: G2/M Checkpoints R-HSA-69275: G2/M Transition R-HSA-5610785: GLI3 is processed to GLI3R by the proteasome R-HSA-179812: GRB2 events in EGFR signaling R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-74160: Gene Expression R-HSA-162906: HIV Infection R-HSA-5610787: Hedgehog 'off' state R-HSA-5632684: Hedgehog 'on' state R-HSA-5358346: Hedgehog ligand biogenesis R-HSA-5387390: Hh mutants abrogate ligand secretion R-HSA-5362768: Hh mutants that don't undergo autocatalytic processing are degraded by ERAD R-HSA-162909: Host Interactions of HIV factors R-HSA-2428924: IGF1R signaling cascade R-HSA-112399: IRS-mediated signalling R-HSA-2428928: IRS-related events triggered by IGF1R R-HSA-168256: Immune System R-HSA-5663205: Infectious disease R-HSA-168249: Innate Immune System R-HSA-74751: Insulin receptor signalling cascade R-HSA-912526: Interleukin receptor SHC signaling R-HSA-451927: Interleukin-2 signaling R-HSA-512988: Interleukin-3, 5 and GM-CSF signaling R-HSA-68886: M Phase R-HSA-68874: M/G1 Transition R-HSA-5683057: MAPK family signaling cascades R-HSA-5684996: MAPK1/MAPK3 signaling R-HSA-5687128: MAPK6/MAPK4 signaling R-HSA-1430728: Metabolism R-HSA-71291: Metabolism of amino acids and derivatives R-HSA-351202: Metabolism of polyamines R-HSA-392499: Metabolism of proteins R-HSA-68882: Mitotic Anaphase R-HSA-453279: Mitotic G1-G1/S phases R-HSA-453274: Mitotic G2-G2/M phases R-HSA-2555396: Mitotic Metaphase and Anaphase R-HSA-375165: NCAM signaling for neurite out-growth R-HSA-187037: NGF signalling via TRKA from the plasma membrane R-HSA-5676590: NIK-->noncanonical NF-kB signaling R-HSA-68949: Orc1 removal from chromatin R-HSA-1234176: Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-4086400: PCP/CE pathway R-HSA-597592: Post-translational protein modification R-HSA-5357801: Programmed Cell Death R-HSA-169893: Prolonged ERK activation events R-HSA-5673001: RAF/MAP kinase cascade R-HSA-8853659: RET signaling R-HSA-176408: Regulation of APC/C activators between G1/S and early anaphase R-HSA-169911: Regulation of Apoptosis R-HSA-69304: Regulation of DNA replication R-HSA-1234174: Regulation of Hypoxia-inducible Factor (HIF) by oxygen R-HSA-5658442: Regulation of RAS by GAPs R-HSA-211733: Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-450531: Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-453276: Regulation of mitotic cell cycle R-HSA-350562: Regulation of ornithine decarboxylase (ODC) R-HSA-69300: Removal of licensing factors from origins R-HSA-69242: S Phase R-HSA-187577: SCF(Skp2)-mediated degradation of p27/p21 R-HSA-174113: SCF-beta-TrCP mediated degradation of Emi1 R-HSA-180336: SHC1 events in EGFR signaling R-HSA-112412: SOS-mediated signalling R-HSA-2467813: Separation of Sister Chromatids R-HSA-162582: Signal Transduction R-HSA-177929: Signaling by EGFR R-HSA-372790: Signaling by GPCR R-HSA-5358351: Signaling by Hedgehog R-HSA-74752: Signaling by Insulin receptor R-HSA-449147: Signaling by Interleukins R-HSA-2586552: Signaling by Leptin R-HSA-186797: Signaling by PDGF R-HSA-1433557: Signaling by SCF-KIT R-HSA-2404192: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-194138: Signaling by VEGF R-HSA-195721: Signaling by Wnt R-HSA-983705: Signaling by the B Cell Receptor (BCR) R-HSA-166520: Signalling by NGF R-HSA-187687: Signalling to ERKs R-HSA-167044: Signalling to RAS R-HSA-187706: Signalling to p38 via RIT and RIN R-HSA-69541: Stabilization of p53 R-HSA-69052: Switching of origins to a post-replicative state R-HSA-69239: Synthesis of DNA R-HSA-201681: TCF dependent signaling in response to WNT R-HSA-202403: TCR signaling R-HSA-5668541: TNFR2 non-canonical NF-kB pathway R-HSA-8852276: The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-382551: Transmembrane transport of small molecules R-HSA-5689603: UCH proteinases R-HSA-5689880: Ub-specific processing proteases R-HSA-69601: Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-75815: Ubiquitin-dependent degradation of Cyclin D R-HSA-69229: Ubiquitin-dependent degradation of Cyclin D1 R-HSA-4420097: VEGFA-VEGFR2 Pathway R-HSA-5218921: VEGFR2 mediated cell proliferation R-HSA-180585: Vif-mediated degradation of APOBEC3G R-HSA-180534: Vpu mediated degradation of CD4 R-HSA-69563: p53-Dependent G1 DNA Damage Response R-HSA-69580: p53-Dependent G1/S DNA damage checkpoint R-HSA-69610: p53-Independent DNA Damage Response R-HSA-69613: p53-Independent G1/S DNA damage checkpoint |
| Summary | |
|---|---|
| Symbol | PSMB5 |
| Name | proteasome subunit beta 5 |
| Aliases | X; MB1; proteasome (prosome, macropain) subunit, beta type, 5; LMPX; PSX large multifunctional protease X; m ...... |
| Chromosomal Location | 14q11.2 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content | Literatures that report relations between PSMB5 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
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Literatures describing the relation between PSMB5 and anti-tumor immunity in human cancer.
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| Summary | |
|---|---|
| Symbol | PSMB5 |
| Name | proteasome subunit beta 5 |
| Aliases | X; MB1; proteasome (prosome, macropain) subunit, beta type, 5; LMPX; PSX large multifunctional protease X; m ...... |
| Chromosomal Location | 14q11.2 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
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> High-throughput Screening
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Statistical results of PSMB5 in screening data sets for detecting immune reponses.
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| Summary | |
|---|---|
| Symbol | PSMB5 |
| Name | proteasome subunit beta 5 |
| Aliases | X; MB1; proteasome (prosome, macropain) subunit, beta type, 5; LMPX; PSX large multifunctional protease X; m ...... |
| Chromosomal Location | 14q11.2 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
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Points in the above scatter plot represent the expression difference of PSMB5 in various data sets.
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Points in the above scatter plot represent the mutation difference of PSMB5 in various data sets.
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| Summary | |
|---|---|
| Symbol | PSMB5 |
| Name | proteasome subunit beta 5 |
| Aliases | X; MB1; proteasome (prosome, macropain) subunit, beta type, 5; LMPX; PSX large multifunctional protease X; m ...... |
| Chromosomal Location | 14q11.2 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PSMB5. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
| Summary | |
|---|---|
| Symbol | PSMB5 |
| Name | proteasome subunit beta 5 |
| Aliases | X; MB1; proteasome (prosome, macropain) subunit, beta type, 5; LMPX; PSX large multifunctional protease X; m ...... |
| Chromosomal Location | 14q11.2 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PSMB5. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PSMB5. > Immunoinhibitor > Immunostimulator > MHC molecule |
| Summary | |
|---|---|
| Symbol | PSMB5 |
| Name | proteasome subunit beta 5 |
| Aliases | X; MB1; proteasome (prosome, macropain) subunit, beta type, 5; LMPX; PSX large multifunctional protease X; m ...... |
| Chromosomal Location | 14q11.2 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PSMB5. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
| Summary | |
|---|---|
| Symbol | PSMB5 |
| Name | proteasome subunit beta 5 |
| Aliases | X; MB1; proteasome (prosome, macropain) subunit, beta type, 5; LMPX; PSX large multifunctional protease X; m ...... |
| Chromosomal Location | 14q11.2 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Distribution of PSMB5 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
| Summary | |
|---|---|
| Symbol | PSMB5 |
| Name | proteasome subunit beta 5 |
| Aliases | X; MB1; proteasome (prosome, macropain) subunit, beta type, 5; LMPX; PSX large multifunctional protease X; m ...... |
| Chromosomal Location | 14q11.2 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Associations between PSMB5 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
| Summary | |
|---|---|
| Symbol | PSMB5 |
| Name | proteasome subunit beta 5 |
| Aliases | X; MB1; proteasome (prosome, macropain) subunit, beta type, 5; LMPX; PSX large multifunctional protease X; m ...... |
| Chromosomal Location | 14q11.2 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content | Drugs targeting PSMB5 collected from DrugBank database. |
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Details on drugs targeting PSMB5.
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