Browse PTK7

Summary
SymbolPTK7
Nameprotein tyrosine kinase 7 (inactive)
Aliases CCK4; colon carcinoma kinase 4; PTK7 protein tyrosine kinase 7; protein tyrosine kinase 7; CCK-4; pseudo tyr ......
Chromosomal Location6p21.1-p12.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Membrane Single-pass type I membrane protein Cell junction Note=Colocalizes with MMP14 at cell junctions. Also localizes at the leading edge of migrating cells.
Domain PF07679 Immunoglobulin I-set domain
PF07714 Protein tyrosine kinase
Function

Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.

> Gene Ontology
 
Biological Process GO:0001101 response to acid chemical
GO:0001736 establishment of planar polarity
GO:0001738 morphogenesis of a polarized epithelium
GO:0001838 embryonic epithelial tube formation
GO:0001841 neural tube formation
GO:0001843 neural tube closure
GO:0003205 cardiac chamber development
GO:0003231 cardiac ventricle development
GO:0003279 cardiac septum development
GO:0003281 ventricular septum development
GO:0003401 axis elongation
GO:0007163 establishment or maintenance of cell polarity
GO:0007164 establishment of tissue polarity
GO:0007423 sensory organ development
GO:0007507 heart development
GO:0010720 positive regulation of cell development
GO:0010975 regulation of neuron projection development
GO:0010976 positive regulation of neuron projection development
GO:0014020 primary neural tube formation
GO:0016055 Wnt signaling pathway
GO:0016331 morphogenesis of embryonic epithelium
GO:0021915 neural tube development
GO:0030010 establishment of cell polarity
GO:0030323 respiratory tube development
GO:0030324 lung development
GO:0030859 polarized epithelial cell differentiation
GO:0031346 positive regulation of cell projection organization
GO:0031532 actin cytoskeleton reorganization
GO:0032526 response to retinoic acid
GO:0035088 establishment or maintenance of apical/basal cell polarity
GO:0035089 establishment of apical/basal cell polarity
GO:0035148 tube formation
GO:0035239 tube morphogenesis
GO:0035567 non-canonical Wnt signaling pathway
GO:0042249 establishment of planar polarity of embryonic epithelium
GO:0042471 ear morphogenesis
GO:0042472 inner ear morphogenesis
GO:0043583 ear development
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity
GO:0045198 establishment of epithelial cell apical/basal polarity
GO:0045666 positive regulation of neuron differentiation
GO:0045995 regulation of embryonic development
GO:0048562 embryonic organ morphogenesis
GO:0048568 embryonic organ development
GO:0048839 inner ear development
GO:0050769 positive regulation of neurogenesis
GO:0051962 positive regulation of nervous system development
GO:0060026 convergent extension
GO:0060070 canonical Wnt signaling pathway
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0060484 lung-associated mesenchyme development
GO:0060485 mesenchyme development
GO:0060541 respiratory system development
GO:0060560 developmental growth involved in morphogenesis
GO:0060562 epithelial tube morphogenesis
GO:0060606 tube closure
GO:0060976 coronary vasculature development
GO:0061162 establishment of monopolar cell polarity
GO:0061245 establishment or maintenance of bipolar cell polarity
GO:0061339 establishment or maintenance of monopolar cell polarity
GO:0071229 cellular response to acid chemical
GO:0071300 cellular response to retinoic acid
GO:0071396 cellular response to lipid
GO:0072175 epithelial tube formation
GO:0090102 cochlea development
GO:0090103 cochlea morphogenesis
GO:0090162 establishment of epithelial cell polarity
GO:0090175 regulation of establishment of planar polarity
GO:0090177 establishment of planar polarity involved in neural tube closure
GO:0090178 regulation of establishment of planar polarity involved in neural tube closure
GO:0090179 planar cell polarity pathway involved in neural tube closure
GO:0090596 sensory organ morphogenesis
GO:0198738 cell-cell signaling by wnt
GO:1905276 regulation of epithelial tube formation
GO:1905330 regulation of morphogenesis of an epithelium
GO:2000027 regulation of organ morphogenesis
Molecular Function GO:0015026 coreceptor activity
GO:0071936 coreceptor activity involved in Wnt signaling pathway
GO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway
Cellular Component GO:0005924 cell-substrate adherens junction
GO:0005925 focal adhesion
GO:0030055 cell-substrate junction
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolPTK7
Nameprotein tyrosine kinase 7 (inactive)
Aliases CCK4; colon carcinoma kinase 4; PTK7 protein tyrosine kinase 7; protein tyrosine kinase 7; CCK-4; pseudo tyr ......
Chromosomal Location6p21.1-p12.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between PTK7 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between PTK7 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
28077676Triple-Negative Breast Carcinoma; Ovarian Carcinoma; Non-Small Cell Lung CarcinomaInhibit immunityA PTK7-targeted antibody-drug conjugate reduces tumor-initiating cells and induces sustained tumor regressions. The PTK7-targeted ADC induced sustained tumor regressions and outperformed standard-of-care chemotherapy. In addition to reducing the TIC frequency, the PTK7-targeted ADC may have additional antitumor mechanisms of action, including the inhibition of angiogenesis and the stimulation of immune cells.
Summary
SymbolPTK7
Nameprotein tyrosine kinase 7 (inactive)
Aliases CCK4; colon carcinoma kinase 4; PTK7 protein tyrosine kinase 7; protein tyrosine kinase 7; CCK-4; pseudo tyr ......
Chromosomal Location6p21.1-p12.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of PTK7 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.67 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolPTK7
Nameprotein tyrosine kinase 7 (inactive)
Aliases CCK4; colon carcinoma kinase 4; PTK7 protein tyrosine kinase 7; protein tyrosine kinase 7; CCK-4; pseudo tyr ......
Chromosomal Location6p21.1-p12.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of PTK7 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.330.505
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-1.2810.511
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.3570.823
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.0040.991
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.1480.948
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.1780.952
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.3150.505
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.1530.927
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.4880.792
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.1010.952
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.1280.599
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.2830.0185
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of PTK7 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.15.91.21
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1031033.3-23.30.423
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277311.15.55.60.384
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 01407.1-7.11
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275911.15.160.373
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)2117011.8-11.80.193
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)1311018.2-18.20.199
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.611.1-8.50.299
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.523.1-18.60.134
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolPTK7
Nameprotein tyrosine kinase 7 (inactive)
Aliases CCK4; colon carcinoma kinase 4; PTK7 protein tyrosine kinase 7; protein tyrosine kinase 7; CCK-4; pseudo tyr ......
Chromosomal Location6p21.1-p12.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PTK7. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolPTK7
Nameprotein tyrosine kinase 7 (inactive)
Aliases CCK4; colon carcinoma kinase 4; PTK7 protein tyrosine kinase 7; protein tyrosine kinase 7; CCK-4; pseudo tyr ......
Chromosomal Location6p21.1-p12.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PTK7. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PTK7.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolPTK7
Nameprotein tyrosine kinase 7 (inactive)
Aliases CCK4; colon carcinoma kinase 4; PTK7 protein tyrosine kinase 7; protein tyrosine kinase 7; CCK-4; pseudo tyr ......
Chromosomal Location6p21.1-p12.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PTK7. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolPTK7
Nameprotein tyrosine kinase 7 (inactive)
Aliases CCK4; colon carcinoma kinase 4; PTK7 protein tyrosine kinase 7; protein tyrosine kinase 7; CCK-4; pseudo tyr ......
Chromosomal Location6p21.1-p12.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of PTK7 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolPTK7
Nameprotein tyrosine kinase 7 (inactive)
Aliases CCK4; colon carcinoma kinase 4; PTK7 protein tyrosine kinase 7; protein tyrosine kinase 7; CCK-4; pseudo tyr ......
Chromosomal Location6p21.1-p12.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between PTK7 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolPTK7
Nameprotein tyrosine kinase 7 (inactive)
Aliases CCK4; colon carcinoma kinase 4; PTK7 protein tyrosine kinase 7; protein tyrosine kinase 7; CCK-4; pseudo tyr ......
Chromosomal Location6p21.1-p12.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting PTK7 collected from DrugBank database.
> Drugs from DrugBank database
 

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