Browse PTN

Summary
SymbolPTN
Namepleiotrophin
Aliases HBNF; HBGF8; heparin binding growth factor 8; NEGF1; neurite growth-promoting factor 1; HB-GAM; HBBM; HBNF-1 ......
Chromosomal Location7q33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Secreted
Domain PF01091 PTN/MK heparin-binding protein family
PF05196 PTN/MK heparin-binding protein family
Function

Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells (PubMed:1768439, PubMed:1733956). Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation (PubMed:11278720). Binds to cell-surface target proteins via their chondroitin sulfate groups (PubMed:26896299). Down-regulates PTPRZ1 activity (PubMed:16814777).

> Gene Ontology
 
Biological Process GO:0001101 response to acid chemical
GO:0001503 ossification
GO:0001525 angiogenesis
GO:0001654 eye development
GO:0001666 response to hypoxia
GO:0001754 eye photoreceptor cell differentiation
GO:0001889 liver development
GO:0001941 postsynaptic membrane organization
GO:0003158 endothelium development
GO:0003407 neural retina development
GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway
GO:0007423 sensory organ development
GO:0007507 heart development
GO:0007528 neuromuscular junction development
GO:0007584 response to nutrient
GO:0007611 learning or memory
GO:0007612 learning
GO:0008360 regulation of cell shape
GO:0009314 response to radiation
GO:0009411 response to UV
GO:0009416 response to light stimulus
GO:0009991 response to extracellular stimulus
GO:0010463 mesenchymal cell proliferation
GO:0010464 regulation of mesenchymal cell proliferation
GO:0010720 positive regulation of cell development
GO:0010721 negative regulation of cell development
GO:0010810 regulation of cell-substrate adhesion
GO:0010811 positive regulation of cell-substrate adhesion
GO:0010975 regulation of neuron projection development
GO:0010976 positive regulation of neuron projection development
GO:0014009 glial cell proliferation
GO:0014013 regulation of gliogenesis
GO:0014014 negative regulation of gliogenesis
GO:0014823 response to activity
GO:0016525 negative regulation of angiogenesis
GO:0021510 spinal cord development
GO:0021536 diencephalon development
GO:0021549 cerebellum development
GO:0021794 thalamus development
GO:0022037 metencephalon development
GO:0022604 regulation of cell morphogenesis
GO:0022612 gland morphogenesis
GO:0030282 bone mineralization
GO:0030323 respiratory tube development
GO:0030324 lung development
GO:0030336 negative regulation of cell migration
GO:0030900 forebrain development
GO:0030902 hindbrain development
GO:0031214 biomineral tissue development
GO:0031346 positive regulation of cell projection organization
GO:0031589 cell-substrate adhesion
GO:0031667 response to nutrient levels
GO:0031668 cellular response to extracellular stimulus
GO:0031669 cellular response to nutrient levels
GO:0031670 cellular response to nutrient
GO:0032355 response to estradiol
GO:0032570 response to progesterone
GO:0033273 response to vitamin
GO:0033280 response to vitamin D
GO:0034644 cellular response to UV
GO:0036119 response to platelet-derived growth factor
GO:0036120 cellular response to platelet-derived growth factor stimulus
GO:0036293 response to decreased oxygen levels
GO:0036294 cellular response to decreased oxygen levels
GO:0040013 negative regulation of locomotion
GO:0042063 gliogenesis
GO:0042391 regulation of membrane potential
GO:0042493 response to drug
GO:0042698 ovulation cycle
GO:0043010 camera-type eye development
GO:0043113 receptor clustering
GO:0043200 response to amino acid
GO:0044708 single-organism behavior
GO:0044849 estrous cycle
GO:0045446 endothelial cell differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0045765 regulation of angiogenesis
GO:0045785 positive regulation of cell adhesion
GO:0045837 negative regulation of membrane potential
GO:0046530 photoreceptor cell differentiation
GO:0048167 regulation of synaptic plasticity
GO:0048511 rhythmic process
GO:0048514 blood vessel morphogenesis
GO:0048545 response to steroid hormone
GO:0048592 eye morphogenesis
GO:0048593 camera-type eye morphogenesis
GO:0048732 gland development
GO:0050673 epithelial cell proliferation
GO:0050678 regulation of epithelial cell proliferation
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050768 negative regulation of neurogenesis
GO:0050769 positive regulation of neurogenesis
GO:0050803 regulation of synapse structure or activity
GO:0050804 modulation of synaptic transmission
GO:0050806 positive regulation of synaptic transmission
GO:0050807 regulation of synapse organization
GO:0050808 synapse organization
GO:0050890 cognition
GO:0051271 negative regulation of cellular component movement
GO:0051302 regulation of cell division
GO:0051668 localization within membrane
GO:0051781 positive regulation of cell division
GO:0051961 negative regulation of nervous system development
GO:0051962 positive regulation of nervous system development
GO:0060040 retinal bipolar neuron differentiation
GO:0060041 retina development in camera-type eye
GO:0060042 retina morphogenesis in camera-type eye
GO:0060219 camera-type eye photoreceptor cell differentiation
GO:0060221 retinal rod cell differentiation
GO:0060251 regulation of glial cell proliferation
GO:0060253 negative regulation of glial cell proliferation
GO:0060291 long-term synaptic potentiation
GO:0060541 respiratory system development
GO:0061008 hepaticobiliary system development
GO:0070482 response to oxygen levels
GO:0071214 cellular response to abiotic stimulus
GO:0071295 cellular response to vitamin
GO:0071305 cellular response to vitamin D
GO:0071340 skeletal muscle acetylcholine-gated channel clustering
GO:0071396 cellular response to lipid
GO:0071407 cellular response to organic cyclic compound
GO:0071453 cellular response to oxygen levels
GO:0071456 cellular response to hypoxia
GO:0071478 cellular response to radiation
GO:0071482 cellular response to light stimulus
GO:0071496 cellular response to external stimulus
GO:0072201 negative regulation of mesenchymal cell proliferation
GO:0072574 hepatocyte proliferation
GO:0072575 epithelial cell proliferation involved in liver morphogenesis
GO:0072576 liver morphogenesis
GO:0072657 protein localization to membrane
GO:0090596 sensory organ morphogenesis
GO:1901342 regulation of vasculature development
GO:1901343 negative regulation of vasculature development
GO:1901626 regulation of postsynaptic membrane organization
GO:1901628 positive regulation of postsynaptic membrane organization
GO:1901654 response to ketone
GO:1903829 positive regulation of cellular protein localization
GO:1903909 regulation of receptor clustering
GO:1903911 positive regulation of receptor clustering
GO:1904373 response to kainic acid
GO:1904389 rod bipolar cell differentiation
GO:1904391 response to ciliary neurotrophic factor
GO:1904393 regulation of skeletal muscle acetylcholine-gated channel clustering
GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering
GO:1904396 regulation of neuromuscular junction development
GO:1904397 negative regulation of neuromuscular junction development
GO:1904398 positive regulation of neuromuscular junction development
GO:1990089 response to nerve growth factor
GO:2000027 regulation of organ morphogenesis
GO:2000146 negative regulation of cell motility
GO:2000181 negative regulation of blood vessel morphogenesis
GO:2000345 regulation of hepatocyte proliferation
GO:2000347 positive regulation of hepatocyte proliferation
Molecular Function GO:0001948 glycoprotein binding
GO:0004857 enzyme inhibitor activity
GO:0004864 protein phosphatase inhibitor activity
GO:0005539 glycosaminoglycan binding
GO:0008083 growth factor activity
GO:0008201 heparin binding
GO:0019208 phosphatase regulator activity
GO:0019212 phosphatase inhibitor activity
GO:0019838 growth factor binding
GO:0019888 protein phosphatase regulator activity
GO:0035373 chondroitin sulfate proteoglycan binding
GO:0035374 chondroitin sulfate binding
GO:0038085 vascular endothelial growth factor binding
GO:0043394 proteoglycan binding
GO:1901681 sulfur compound binding
GO:1904399 heparan sulfate binding
Cellular Component GO:0005578 proteinaceous extracellular matrix
GO:0005604 basement membrane
GO:0031594 neuromuscular junction
GO:0044420 extracellular matrix component
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolPTN
Namepleiotrophin
Aliases HBNF; HBGF8; heparin binding growth factor 8; NEGF1; neurite growth-promoting factor 1; HB-GAM; HBBM; HBNF-1 ......
Chromosomal Location7q33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between PTN and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolPTN
Namepleiotrophin
Aliases HBNF; HBGF8; heparin binding growth factor 8; NEGF1; neurite growth-promoting factor 1; HB-GAM; HBBM; HBNF-1 ......
Chromosomal Location7q33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of PTN in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolPTN
Namepleiotrophin
Aliases HBNF; HBGF8; heparin binding growth factor 8; NEGF1; neurite growth-promoting factor 1; HB-GAM; HBBM; HBNF-1 ......
Chromosomal Location7q33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of PTN in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-1.4380.0372
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-2.440.0877
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.70.532
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.1820.777
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.9130.519
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.7430.675
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.240.687
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.210.834
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.30.777
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.0890.948
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.4970.79
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.6390.0389
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of PTN in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277304.1-4.10.561
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 01407.1-7.11
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275903.4-3.41
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.85.9-1.11
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.79.1-1.41
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.67.4-4.80.565
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.515.4-10.90.541
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolPTN
Namepleiotrophin
Aliases HBNF; HBGF8; heparin binding growth factor 8; NEGF1; neurite growth-promoting factor 1; HB-GAM; HBBM; HBNF-1 ......
Chromosomal Location7q33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PTN. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolPTN
Namepleiotrophin
Aliases HBNF; HBGF8; heparin binding growth factor 8; NEGF1; neurite growth-promoting factor 1; HB-GAM; HBBM; HBNF-1 ......
Chromosomal Location7q33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PTN. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PTN.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolPTN
Namepleiotrophin
Aliases HBNF; HBGF8; heparin binding growth factor 8; NEGF1; neurite growth-promoting factor 1; HB-GAM; HBBM; HBNF-1 ......
Chromosomal Location7q33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PTN. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolPTN
Namepleiotrophin
Aliases HBNF; HBGF8; heparin binding growth factor 8; NEGF1; neurite growth-promoting factor 1; HB-GAM; HBBM; HBNF-1 ......
Chromosomal Location7q33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of PTN expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolPTN
Namepleiotrophin
Aliases HBNF; HBGF8; heparin binding growth factor 8; NEGF1; neurite growth-promoting factor 1; HB-GAM; HBBM; HBNF-1 ......
Chromosomal Location7q33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between PTN and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolPTN
Namepleiotrophin
Aliases HBNF; HBGF8; heparin binding growth factor 8; NEGF1; neurite growth-promoting factor 1; HB-GAM; HBBM; HBNF-1 ......
Chromosomal Location7q33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting PTN collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.