Browse PTPN1

Summary
SymbolPTPN1
Nameprotein tyrosine phosphatase, non-receptor type 1
Aliases PTP1B; protein tyrosine phosphatase, placental; protein-tyrosine phosphatase 1B; PTP-1B; Tyrosine-protein ph ......
Chromosomal Location20q13.1-q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Endoplasmic reticulum membrane Peripheral membrane protein Cytoplasmic side Note=Interacts with EPHA3 at the cell membrane.
Domain PF00102 Protein-tyrosine phosphatase
Function

Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET.

> Gene Ontology
 
Biological Process GO:0000187 activation of MAPK activity
GO:0001933 negative regulation of protein phosphorylation
GO:0001959 regulation of cytokine-mediated signaling pathway
GO:0006469 negative regulation of protein kinase activity
GO:0006470 protein dephosphorylation
GO:0006984 ER-nucleus signaling pathway
GO:0006986 response to unfolded protein
GO:0006987 activation of signaling protein activity involved in unfolded protein response
GO:0007254 JNK cascade
GO:0007257 activation of JUN kinase activity
GO:0007259 JAK-STAT cascade
GO:0008286 insulin receptor signaling pathway
GO:0009894 regulation of catabolic process
GO:0009896 positive regulation of catabolic process
GO:0016311 dephosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0018212 peptidyl-tyrosine modification
GO:0030100 regulation of endocytosis
GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway
GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0031098 stress-activated protein kinase signaling cascade
GO:0031329 regulation of cellular catabolic process
GO:0031331 positive regulation of cellular catabolic process
GO:0031532 actin cytoskeleton reorganization
GO:0032069 regulation of nuclease activity
GO:0032075 positive regulation of nuclease activity
GO:0032147 activation of protein kinase activity
GO:0032386 regulation of intracellular transport
GO:0032801 receptor catabolic process
GO:0032868 response to insulin
GO:0032869 cellular response to insulin stimulus
GO:0032872 regulation of stress-activated MAPK cascade
GO:0032874 positive regulation of stress-activated MAPK cascade
GO:0033157 regulation of intracellular protein transport
GO:0033673 negative regulation of kinase activity
GO:0033674 positive regulation of kinase activity
GO:0034340 response to type I interferon
GO:0034620 cellular response to unfolded protein
GO:0034976 response to endoplasmic reticulum stress
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0035791 platelet-derived growth factor receptor-beta signaling pathway
GO:0035966 response to topologically incorrect protein
GO:0035967 cellular response to topologically incorrect protein
GO:0036498 IRE1-mediated unfolded protein response
GO:0036499 PERK-mediated unfolded protein response
GO:0042326 negative regulation of phosphorylation
GO:0043112 receptor metabolic process
GO:0043405 regulation of MAP kinase activity
GO:0043406 positive regulation of MAP kinase activity
GO:0043407 negative regulation of MAP kinase activity
GO:0043409 negative regulation of MAPK cascade
GO:0043410 positive regulation of MAPK cascade
GO:0043434 response to peptide hormone
GO:0043506 regulation of JUN kinase activity
GO:0043507 positive regulation of JUN kinase activity
GO:0045088 regulation of innate immune response
GO:0045860 positive regulation of protein kinase activity
GO:0046328 regulation of JNK cascade
GO:0046330 positive regulation of JNK cascade
GO:0046626 regulation of insulin receptor signaling pathway
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048012 hepatocyte growth factor receptor signaling pathway
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0051348 negative regulation of transferase activity
GO:0051403 stress-activated MAPK cascade
GO:0060337 type I interferon signaling pathway
GO:0060338 regulation of type I interferon-mediated signaling pathway
GO:0060396 growth hormone receptor signaling pathway
GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway
GO:0060416 response to growth hormone
GO:0060627 regulation of vesicle-mediated transport
GO:0060759 regulation of response to cytokine stimulus
GO:0061097 regulation of protein tyrosine kinase activity
GO:0061098 positive regulation of protein tyrosine kinase activity
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070302 regulation of stress-activated protein kinase signaling cascade
GO:0070304 positive regulation of stress-activated protein kinase signaling cascade
GO:0070371 ERK1 and ERK2 cascade
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0071357 cellular response to type I interferon
GO:0071375 cellular response to peptide hormone stimulus
GO:0071378 cellular response to growth hormone stimulus
GO:0071417 cellular response to organonitrogen compound
GO:0071900 regulation of protein serine/threonine kinase activity
GO:0071901 negative regulation of protein serine/threonine kinase activity
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0090287 regulation of cellular response to growth factor stimulus
GO:0090288 negative regulation of cellular response to growth factor stimulus
GO:0097193 intrinsic apoptotic signaling pathway
GO:0097696 STAT cascade
GO:1900076 regulation of cellular response to insulin stimulus
GO:1900077 negative regulation of cellular response to insulin stimulus
GO:1900101 regulation of endoplasmic reticulum unfolded protein response
GO:1900102 negative regulation of endoplasmic reticulum unfolded protein response
GO:1900103 positive regulation of endoplasmic reticulum unfolded protein response
GO:1901652 response to peptide
GO:1901653 cellular response to peptide
GO:1902202 regulation of hepatocyte growth factor receptor signaling pathway
GO:1902235 regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1902532 negative regulation of intracellular signal transduction
GO:1903573 negative regulation of response to endoplasmic reticulum stress
GO:1903894 regulation of IRE1-mediated unfolded protein response
GO:1903896 positive regulation of IRE1-mediated unfolded protein response
GO:1903897 regulation of PERK-mediated unfolded protein response
GO:1903898 negative regulation of PERK-mediated unfolded protein response
GO:1990264 peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity
GO:2000644 regulation of receptor catabolic process
GO:2000646 positive regulation of receptor catabolic process
GO:2001233 regulation of apoptotic signaling pathway
GO:2001234 negative regulation of apoptotic signaling pathway
GO:2001242 regulation of intrinsic apoptotic signaling pathway
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
Molecular Function GO:0004721 phosphoprotein phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0005158 insulin receptor binding
GO:0016791 phosphatase activity
GO:0019902 phosphatase binding
GO:0019903 protein phosphatase binding
GO:0030971 receptor tyrosine kinase binding
GO:0042578 phosphoric ester hydrolase activity
GO:0045296 cadherin binding
GO:0046875 ephrin receptor binding
GO:0050839 cell adhesion molecule binding
GO:0051721 protein phosphatase 2A binding
GO:0098631 protein binding involved in cell adhesion
GO:0098632 protein binding involved in cell-cell adhesion
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:1990782 protein tyrosine kinase binding
Cellular Component GO:0005769 early endosome
GO:0005913 cell-cell adherens junction
GO:0097443 sorting endosome
GO:0098552 side of membrane
GO:0098554 cytoplasmic side of endoplasmic reticulum membrane
GO:0098562 cytoplasmic side of membrane
> KEGG and Reactome Pathway
 
KEGG hsa04520 Adherens junction
hsa04910 Insulin signaling pathway
Reactome R-HSA-1280215: Cytokine Signaling in Immune system
R-HSA-982772: Growth hormone receptor signaling
R-HSA-109582: Hemostasis
R-HSA-168256: Immune System
R-HSA-354192: Integrin alphaIIb beta3 signaling
R-HSA-913531: Interferon Signaling
R-HSA-909733: Interferon alpha/beta signaling
R-HSA-877300: Interferon gamma signaling
R-HSA-6807004: Negative regulation of MET activity
R-HSA-8849472: PTK6 Down-Regulation
R-HSA-76009: Platelet Aggregation (Plug Formation)
R-HSA-76002: Platelet activation, signaling and aggregation
R-HSA-912694: Regulation of IFNA signaling
R-HSA-877312: Regulation of IFNG signaling
R-HSA-162582: Signal Transduction
R-HSA-6806834: Signaling by MET
R-HSA-8848021: Signaling by PTK6
Summary
SymbolPTPN1
Nameprotein tyrosine phosphatase, non-receptor type 1
Aliases PTP1B; protein tyrosine phosphatase, placental; protein-tyrosine phosphatase 1B; PTP-1B; Tyrosine-protein ph ......
Chromosomal Location20q13.1-q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between PTPN1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between PTPN1 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
24958858Prostate NeoplasmInhibit immunity (T cell function); resistant to immunotherapyThe clinical relevance of this mechanism, whereby the androgen milieu modulates CD4 T-cell differentiation, was ascertained as we found that androgen deprivation reduced expression of Ptpn1 in CD4 cells from patients undergoing androgen deprivation therapy for prostate cancer.
22962263Lung Carcinoma; MelanomaPromote immunityA comprehensive approach using transcriptome analysis, argonaute protein immunoprecipitation, and luciferase reporter assay revealed that the genes PTPN1, HOXA1, and TP53I11 were miR-210 target genes regulated in hypoxic cells. In support of their primary importance in mediating the immunosuppressive effects of miR-210, coordinate silencing of PTPN1, HOXA1, and TP53I11 dramatically decreased tumor cell susceptibility to CTL-mediated lysis.
29708510MelanomaInhibit immunityInvestigation of the suppressive pathway demonstrated a role for PTP1b complexing with Mer. Substantiating the role of PTP1b, M1 cytokine suppression was also lost in macrophages from PTP1b-KO mice.
Summary
SymbolPTPN1
Nameprotein tyrosine phosphatase, non-receptor type 1
Aliases PTP1B; protein tyrosine phosphatase, placental; protein-tyrosine phosphatase 1B; PTP-1B; Tyrosine-protein ph ......
Chromosomal Location20q13.1-q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of PTPN1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX STARS Score: 3.60; FDR: 0.044 Resistant to T cell-mediated killing
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen Total # shRNA with >= 4-fold: 1 Resistant to T-cell proliferation
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolPTPN1
Nameprotein tyrosine phosphatase, non-receptor type 1
Aliases PTP1B; protein tyrosine phosphatase, placental; protein-tyrosine phosphatase 1B; PTP-1B; Tyrosine-protein ph ......
Chromosomal Location20q13.1-q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of PTPN1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.070.721
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.6840.769
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.3810.828
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.020.939
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.1670.93
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.2610.917
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.1620.706
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.1020.957
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.2860.888
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.2790.859
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.5820.804
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0370.556
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of PTPN1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.72.711
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.73.40.31
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolPTPN1
Nameprotein tyrosine phosphatase, non-receptor type 1
Aliases PTP1B; protein tyrosine phosphatase, placental; protein-tyrosine phosphatase 1B; PTP-1B; Tyrosine-protein ph ......
Chromosomal Location20q13.1-q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PTPN1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolPTPN1
Nameprotein tyrosine phosphatase, non-receptor type 1
Aliases PTP1B; protein tyrosine phosphatase, placental; protein-tyrosine phosphatase 1B; PTP-1B; Tyrosine-protein ph ......
Chromosomal Location20q13.1-q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PTPN1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PTPN1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolPTPN1
Nameprotein tyrosine phosphatase, non-receptor type 1
Aliases PTP1B; protein tyrosine phosphatase, placental; protein-tyrosine phosphatase 1B; PTP-1B; Tyrosine-protein ph ......
Chromosomal Location20q13.1-q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PTPN1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolPTPN1
Nameprotein tyrosine phosphatase, non-receptor type 1
Aliases PTP1B; protein tyrosine phosphatase, placental; protein-tyrosine phosphatase 1B; PTP-1B; Tyrosine-protein ph ......
Chromosomal Location20q13.1-q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of PTPN1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolPTPN1
Nameprotein tyrosine phosphatase, non-receptor type 1
Aliases PTP1B; protein tyrosine phosphatase, placental; protein-tyrosine phosphatase 1B; PTP-1B; Tyrosine-protein ph ......
Chromosomal Location20q13.1-q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between PTPN1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolPTPN1
Nameprotein tyrosine phosphatase, non-receptor type 1
Aliases PTP1B; protein tyrosine phosphatase, placental; protein-tyrosine phosphatase 1B; PTP-1B; Tyrosine-protein ph ......
Chromosomal Location20q13.1-q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting PTPN1 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting PTPN1.
ID Name Drug Type Targets #Targets
DB01133Tiludronic acidSmall MoleculeATP6V1A, PTPN12
DB017343-(Oxalyl-Amino)-Naphthalene-2-Carboxylic AcidSmall MoleculePTPN11
DB01820Compound 12, N-Acetyl-4-[(Carboxycarbonyl)(2-Carboxyphenyl)Amino]-N-Pentyl-1-NapthylalaniamideSmall MoleculePTPN11
DB02014Compound 9Small MoleculePTPN11
DB020722-(Oxalyl-Amino)-4,7-Dihydro-5h-Thieno[2,3-C]Thiopyran-3-Carboxylic AcidSmall MoleculePTPN11
DB022593-(3,5-Dibromo-4-Hydroxy-Benzoyl)-2-Ethyl-Benzofuran-6-Sulfonic Acid (4-Sulfamoyl-Phenyl)-AmideSmall MoleculePTPN11
DB02420[[4-(Aminomethyl)Phenyl]Amino]Oxo-Acetic Acid,Small MoleculePTPN11
DB024362-{4-[(2s)-2-[({[(1s)-1-Carboxy-2-Phenylethyl]Amino}Carbonyl)Amino]-3-Oxo-3-(Pentylamino)Propyl]Phenoxy}Malonic AcidSmall MoleculePTPN11
DB02615Compound 19Small MoleculeESR1, PTPN12
DB02620Sp7343-Sp7964Small MoleculePTPN11
DB026222-(Oxalyl-Amino)-Benzoic AcidSmall MoleculePTPN11
DB02651{[2-(1h-1,2,3-Benzotriazol-1-Yl)-2-(3,4-Difluorophenyl)Propane-1,3-Diyl]Bis[4,1-Phenylene(Difluoromethylene)]}Bis(Phosphonic Acid)Small MoleculePTPN11
DB02662Novo Nordisk a/S CompoundSmall MoleculePTPN11
DB02784N-[4-(2-{2-[3-(2-Bromo-Acetylamino)-Propionylamino]-3-Hydroxy-Propionylamino}-Ethyl)-Phenyl]-Oxalamic AcidSmall MoleculePTPN11
DB028277-(1,1-Dioxo-1h-Benzo[D]Isothiazol-3-Yloxymethyl)-2-(Oxalyl-Amino)-4,7-Dihydro-5h-Thieno[2,3-C]Pyran-3-Carboxylic AcidSmall MoleculePTPN11
DB02977PNU177836Small MoleculePTPN11
DB031022-(Oxalyl-Amino)-4,7-Dihydro-5h-Thieno[2,3-C]Pyran-3-Carboxylic AcidSmall MoleculePTPN11
DB03154{[7-(Difluoro-Phosphono-Methyl)-Naphthalen-2-Yl]-Difluoro-Methyl}-Phosphonic AcidSmall MoleculePTPN11
DB033113-(3,5-Dibromo-4-Hydroxy-Benzoyl)-2-Ethyl-Benzofuran-6-Sulfonic Acid [4-(Thiazol-2-Ylsulfamoyl)-Phenyl]-AmideSmall MoleculePTPN11
DB034834-Benzoylamino-4-{1-{1-Carbamoyl-2-[4-(Difluoro-Phosphono-Methyl)-Phenyl]-Ethylcarbamoyl}-2-[4-(Difluoro-Phosphono-Methyl)-Phenyl]-Ethylcarbamoyl}-Butyric AcidSmall MoleculePTPN11
DB03557N-{1-[5-(1-Carbamoyl-2-Mercapto-Ethylcarbamoyl)-Pentylcarbamoyl]-2-[4-(Difluoro-Phosphono-Methyl)-Phenyl]-Ethyl}-3-{2-[4-(Difluoro-Phosphono-Methyl)-Phenyl]-Acetylamino}-Succinamic AcidSmall MoleculePTPN11
DB03661Cysteinesulfonic AcidSmall MoleculeCDC25B, CTSL, GLIPR2, PTPN14
DB036702-(Oxalyl-Amino)-4,5,6,7-Tetrahydro-Thieno[2,3-C]Pyridine-3-Carboxylic AcidSmall MoleculePTPN11
DB037144-Carbamoyl-4-{[6-(Difluoro-Phosphono-Methyl)-Naphthalene-2-Carbonyl]-Amino}-Butyric AcidSmall MoleculePTPN11
DB03982Compound 5, 2-(Naphthalen-1-Yl-Oxalyl-Amino)-BenzoicacidSmall MoleculePTPN11
DB040016-(Oxalyl-Amino)-1h-Indole-5-Carboxylic AcidSmall MoleculePTPN11
DB04088N-(Allyloxycarbonyl)-4-[N-(Carboxy-Formyl)-2-(Benzoic Acid)-Amino]-L-Phenylalaninyl-Amino-Butyloxy-(6-Hydroxy-Benzoic Acid Methyl Ester)Small MoleculePTPN11
DB041423-(3,5-Dibromo-4-Hydroxy-Benzoyl)-2-Ethyl-Benzofuran-6-Sulfonic Acid DimethylamideSmall MoleculePTPN11
DB04204[(4-{4-[4-(Difluoro-Phosphono-Methyl)-Phenyl]-Butyl}-Phenyl)-Difluoro-Methyl]-Phosphonic AcidSmall MoleculePTPN11
DB04285{4-[(2s,4e)-2-(1,3-Benzothiazol-2-Yl)-2-(1h-1,2,3-Benzotriazol-1-Yl)-5-Phenylpent-4-Enyl]Phenyl}(Difluoro)Methylphosphonic AcidSmall MoleculePTPN11
DB045252-(Carboxymethoxy)-5-[(2s)-2-({(2s)-2-[(3-Carboxypropanoyl)Amino] -3-Phenylpropanoyl}Amino)-3-Oxo-3-(Pentylamino)Propyl]Benzoic AcidSmall MoleculePTPN11
DB048001-METHYL-3-PHENYL-1H-PYRAZOL-5-YLSULFAMIC ACIDSmall MoleculePTPN11
DB05506ISIS 113715Small MoleculePTPN11
DB06333TrodusquemineBiotechPTPN1, SLC6A2, SLC6A33
DB06521ErtiprotafibSmall MoleculeIKBKB, PPARA, PPARG, PTPN14
DB068294-BROMO-3-(CARBOXYMETHOXY)-5-[3-(CYCLOHEXYLAMINO)PHENYL]THIOPHENE-2-CARBOXYLIC ACIDSmall MoleculePTPN11
DB06887[(3S)-3-(Methylcarbamoyl)-2-{[(2-methyl-2-propanyl)oxy]carbonyl}-1,2,3,4-tetrahydro-7-isoquinolinyl]sulfamic acidSmall MoleculePTPN11
DB071304-BROMO-3-(CARBOXYMETHOXY)-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACIDSmall MoleculePTPN11
DB071345-(4-CHLORO-5-PHENYL-3-THIENYL)-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDESmall MoleculePTPN11
DB071974-BROMO-3-(CARBOXYMETHOXY)-5-(4-HYDROXYPHENYL)THIOPHENE-2-CARBOXYLIC ACIDSmall MoleculePTPN11
DB07263[{2-bromo-4-[(2R)-3-oxo-2,3-diphenylpropyl]phenyl}(difluoro)methyl]phosphonic acidSmall MoleculePTPN11
DB072895-[3-(BENZYLAMINO)PHENYL]-4-BROMO-3-(CARBOXYMETHOXY)THIOPHENE-2-CARBOXYLIC ACIDSmall MoleculePTPN11
DB072952-[(7-HYDROXY-NAPHTHALEN-1-YL)-OXALYL-AMINO]-BENZOIC ACIDSmall MoleculePTPN11
DB072983-(CARBOXYMETHOXY)THIENO[2,3-B]PYRIDINE-2-CARBOXYLIC ACIDSmall MoleculePTPN11
DB074804-PHOSPHONOOXY-PHENYL-METHYL-[4-PHOSPHONOOXY]BENZENSmall MoleculePTPN11
DB07651N-ACETYL-L-PHENYLALANYL-4-[DIFLUORO(PHOSPHONO)METHYL]-L-PHENYLALANINAMIDESmall MoleculePTPN11
DB07719[(3R)-3-(Methylcarbamoyl)-2-{[(2-methyl-2-propanyl)oxy]carbonyl}-1,2,3,4-tetrahydro-7-isoquinolinyl]sulfamic acidSmall MoleculePTPN11
DB077305-(3-HYDROXYPHENYL)ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDESmall MoleculePTPN11
DB080015-(3-{3-[3-HYDROXY-2-(METHOXYCARBONYL)PHENOXY]PROPENYL}PHENYL)-4-(HYDROXYMETHYL)ISOXAZOLE-3-CARBOXYLIC ACIDSmall MoleculePTPN11
DB08003ISOTHIAZOLIDINONE ANALOGSmall MoleculePTPN11
DB081474-[3-(dibenzylamino)phenyl]-2,4-dioxobutanoic acidSmall MoleculePTPN11
DB08371PARA-(BENZOYL)-PHENYLALANINESmall MoleculePTPN1, YARS2
DB083976-(DIFLUORO-PHOSPHONO-METHYL)-NAPHTHALENE-2-CARBOXYLIC ACIDSmall MoleculePTPN11
DB08549(3R)-METHYLCARBAMOYL-7-SULFOAMINO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID BENZYL ESTERSmall MoleculePTPN11
DB085915-(4-METHOXYBIPHENYL-3-YL)-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDESmall MoleculePTPN11
DB085931,2,5-THIADIAZOLIDIN-3-ONE-1,1-DIOXIDESmall MoleculePTPN11
DB08783(4-{(2S)-2-[(tert-butoxycarbonyl)amino]-3-methoxy-3-oxopropyl}phenyl)methaneseleninic acidSmall MoleculePTPN11