Browse PTPN11

Summary
SymbolPTPN11
Nameprotein tyrosine phosphatase, non-receptor type 11
Aliases BPTP3; SH-PTP2; SHP-2; PTP2C; SHP2; NS1; Noonan syndrome 1; JMML; METCDS; PTP-1D; SH-PTP3; PTP-2C; protein-t ......
Chromosomal Location12q24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm Nucleus
Domain PF00017 SH2 domain
PF00102 Protein-tyrosine phosphatase
Function

Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway (PubMed:28074573). Dephosphorylates GAB1, ARHGAP35 and EGFR (PubMed:28074573). Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73 (PubMed:26742426).

> Gene Ontology
 
Biological Process GO:0000075 cell cycle checkpoint
GO:0000077 DNA damage checkpoint
GO:0000187 activation of MAPK activity
GO:0001501 skeletal system development
GO:0001667 ameboidal-type cell migration
GO:0001894 tissue homeostasis
GO:0001959 regulation of cytokine-mediated signaling pathway
GO:0002694 regulation of leukocyte activation
GO:0002696 positive regulation of leukocyte activation
GO:0002790 peptide secretion
GO:0002791 regulation of peptide secretion
GO:0002792 negative regulation of peptide secretion
GO:0006470 protein dephosphorylation
GO:0006611 protein export from nucleus
GO:0006638 neutral lipid metabolic process
GO:0006639 acylglycerol metabolic process
GO:0006641 triglyceride metabolic process
GO:0006644 phospholipid metabolic process
GO:0006650 glycerophospholipid metabolic process
GO:0006661 phosphatidylinositol biosynthetic process
GO:0006869 lipid transport
GO:0006913 nucleocytoplasmic transport
GO:0007159 leukocyte cell-cell adhesion
GO:0007162 negative regulation of cell adhesion
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007229 integrin-mediated signaling pathway
GO:0007346 regulation of mitotic cell cycle
GO:0007409 axonogenesis
GO:0007423 sensory organ development
GO:0007507 heart development
GO:0007548 sex differentiation
GO:0007596 blood coagulation
GO:0007599 hemostasis
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0008643 carbohydrate transport
GO:0008645 hexose transport
GO:0008654 phospholipid biosynthetic process
GO:0009306 protein secretion
GO:0009755 hormone-mediated signaling pathway
GO:0009914 hormone transport
GO:0010001 glial cell differentiation
GO:0010171 body morphogenesis
GO:0010631 epithelial cell migration
GO:0010817 regulation of hormone levels
GO:0010827 regulation of glucose transport
GO:0010828 positive regulation of glucose transport
GO:0010876 lipid localization
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling
GO:0015749 monosaccharide transport
GO:0015758 glucose transport
GO:0015833 peptide transport
GO:0015850 organic hydroxy compound transport
GO:0016311 dephosphorylation
GO:0021549 cerebellum development
GO:0021575 hindbrain morphogenesis
GO:0021587 cerebellum morphogenesis
GO:0021695 cerebellar cortex development
GO:0021696 cerebellar cortex morphogenesis
GO:0021697 cerebellar cortex formation
GO:0022037 metencephalon development
GO:0022407 regulation of cell-cell adhesion
GO:0022409 positive regulation of cell-cell adhesion
GO:0023061 signal release
GO:0030072 peptide hormone secretion
GO:0030073 insulin secretion
GO:0030099 myeloid cell differentiation
GO:0030168 platelet activation
GO:0030219 megakaryocyte differentiation
GO:0030220 platelet formation
GO:0030252 growth hormone secretion
GO:0030258 lipid modification
GO:0030902 hindbrain development
GO:0031294 lymphocyte costimulation
GO:0031295 T cell costimulation
GO:0031570 DNA integrity checkpoint
GO:0032147 activation of protein kinase activity
GO:0032368 regulation of lipid transport
GO:0032369 negative regulation of lipid transport
GO:0032386 regulation of intracellular transport
GO:0032528 microvillus organization
GO:0032868 response to insulin
GO:0032869 cellular response to insulin stimulus
GO:0033157 regulation of intracellular protein transport
GO:0033277 abortive mitotic cell cycle
GO:0033500 carbohydrate homeostasis
GO:0033627 cell adhesion mediated by integrin
GO:0033628 regulation of cell adhesion mediated by integrin
GO:0033629 negative regulation of cell adhesion mediated by integrin
GO:0033674 positive regulation of kinase activity
GO:0034340 response to type I interferon
GO:0035264 multicellular organism growth
GO:0035265 organ growth
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0035855 megakaryocyte development
GO:0035929 steroid hormone secretion
GO:0035930 corticosteroid hormone secretion
GO:0035933 glucocorticoid secretion
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process
GO:0036302 atrioventricular canal development
GO:0036344 platelet morphogenesis
GO:0038127 ERBB signaling pathway
GO:0038179 neurotrophin signaling pathway
GO:0040014 regulation of multicellular organism growth
GO:0042063 gliogenesis
GO:0042110 T cell activation
GO:0042445 hormone metabolic process
GO:0042593 glucose homeostasis
GO:0042886 amide transport
GO:0043254 regulation of protein complex assembly
GO:0043400 cortisol secretion
GO:0043405 regulation of MAP kinase activity
GO:0043406 positive regulation of MAP kinase activity
GO:0043410 positive regulation of MAPK cascade
GO:0043434 response to peptide hormone
GO:0043583 ear development
GO:0044057 regulation of system process
GO:0044060 regulation of endocrine process
GO:0044344 cellular response to fibroblast growth factor stimulus
GO:0044381 glucose import in response to insulin stimulus
GO:0045017 glycerolipid biosynthetic process
GO:0045088 regulation of innate immune response
GO:0045785 positive regulation of cell adhesion
GO:0045787 positive regulation of cell cycle
GO:0045860 positive regulation of protein kinase activity
GO:0045931 positive regulation of mitotic cell cycle
GO:0046323 glucose import
GO:0046324 regulation of glucose import
GO:0046326 positive regulation of glucose import
GO:0046474 glycerophospholipid biosynthetic process
GO:0046486 glycerolipid metabolic process
GO:0046488 phosphatidylinositol metabolic process
GO:0046676 negative regulation of insulin secretion
GO:0046822 regulation of nucleocytoplasmic transport
GO:0046825 regulation of protein export from nucleus
GO:0046834 lipid phosphorylation
GO:0046854 phosphatidylinositol phosphorylation
GO:0046879 hormone secretion
GO:0046883 regulation of hormone secretion
GO:0046887 positive regulation of hormone secretion
GO:0046888 negative regulation of hormone secretion
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048013 ephrin receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048017 inositol lipid-mediated signaling
GO:0048608 reproductive structure development
GO:0048638 regulation of developmental growth
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0048708 astrocyte differentiation
GO:0048806 genitalia development
GO:0048839 inner ear development
GO:0048871 multicellular organismal homeostasis
GO:0048872 homeostasis of number of cells
GO:0048873 homeostasis of number of cells within a tissue
GO:0050708 regulation of protein secretion
GO:0050709 negative regulation of protein secretion
GO:0050796 regulation of insulin secretion
GO:0050817 coagulation
GO:0050863 regulation of T cell activation
GO:0050865 regulation of cell activation
GO:0050867 positive regulation of cell activation
GO:0050870 positive regulation of T cell activation
GO:0050878 regulation of body fluid levels
GO:0050886 endocrine process
GO:0050900 leukocyte migration
GO:0051047 positive regulation of secretion
GO:0051048 negative regulation of secretion
GO:0051051 negative regulation of transport
GO:0051168 nuclear export
GO:0051169 nuclear transport
GO:0051224 negative regulation of protein transport
GO:0051249 regulation of lymphocyte activation
GO:0051251 positive regulation of lymphocyte activation
GO:0051462 regulation of cortisol secretion
GO:0051463 negative regulation of cortisol secretion
GO:0060020 Bergmann glial cell differentiation
GO:0060123 regulation of growth hormone secretion
GO:0060125 negative regulation of growth hormone secretion
GO:0060249 anatomical structure homeostasis
GO:0060323 head morphogenesis
GO:0060324 face development
GO:0060325 face morphogenesis
GO:0060337 type I interferon signaling pathway
GO:0060338 regulation of type I interferon-mediated signaling pathway
GO:0060348 bone development
GO:0060759 regulation of response to cytokine stimulus
GO:0060986 endocrine hormone secretion
GO:0061458 reproductive system development
GO:0061515 myeloid cell development
GO:0061564 axon development
GO:0061582 intestinal epithelial cell migration
GO:0070371 ERK1 and ERK2 cascade
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070486 leukocyte aggregation
GO:0070489 T cell aggregation
GO:0071357 cellular response to type I interferon
GO:0071375 cellular response to peptide hormone stimulus
GO:0071417 cellular response to organonitrogen compound
GO:0071593 lymphocyte aggregation
GO:0071774 response to fibroblast growth factor
GO:0071900 regulation of protein serine/threonine kinase activity
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0090087 regulation of peptide transport
GO:0090130 tissue migration
GO:0090132 epithelium migration
GO:0090276 regulation of peptide hormone secretion
GO:0090278 negative regulation of peptide hormone secretion
GO:0098751 bone cell development
GO:1900076 regulation of cellular response to insulin stimulus
GO:1900078 positive regulation of cellular response to insulin stimulus
GO:1901652 response to peptide
GO:1901653 cellular response to peptide
GO:1903037 regulation of leukocyte cell-cell adhesion
GO:1903039 positive regulation of leukocyte cell-cell adhesion
GO:1903531 negative regulation of secretion by cell
GO:1903532 positive regulation of secretion by cell
GO:1904950 negative regulation of establishment of protein localization
GO:2000831 regulation of steroid hormone secretion
GO:2000832 negative regulation of steroid hormone secretion
GO:2000846 regulation of corticosteroid hormone secretion
GO:2000847 negative regulation of corticosteroid hormone secretion
GO:2000849 regulation of glucocorticoid secretion
GO:2000850 negative regulation of glucocorticoid secretion
GO:2001273 regulation of glucose import in response to insulin stimulus
GO:2001275 positive regulation of glucose import in response to insulin stimulus
Molecular Function GO:0001664 G-protein coupled receptor binding
GO:0004721 phosphoprotein phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0004726 non-membrane spanning protein tyrosine phosphatase activity
GO:0005070 SH3/SH2 adaptor activity
GO:0005158 insulin receptor binding
GO:0016303 1-phosphatidylinositol-3-kinase activity
GO:0016791 phosphatase activity
GO:0030674 protein binding, bridging
GO:0030971 receptor tyrosine kinase binding
GO:0031748 D1 dopamine receptor binding
GO:0035004 phosphatidylinositol 3-kinase activity
GO:0035591 signaling adaptor activity
GO:0042578 phosphoric ester hydrolase activity
GO:0043274 phospholipase binding
GO:0043560 insulin receptor substrate binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0050780 dopamine receptor binding
GO:0050839 cell adhesion molecule binding
GO:0051427 hormone receptor binding
GO:0051428 peptide hormone receptor binding
GO:0052742 phosphatidylinositol kinase activity
GO:0052813 phosphatidylinositol bisphosphate kinase activity
GO:0060090 binding, bridging
GO:1990782 protein tyrosine kinase binding
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa04014 Ras signaling pathway
hsa04360 Axon guidance
hsa04630 Jak-STAT signaling pathway
hsa04650 Natural killer cell mediated cytotoxicity
hsa04670 Leukocyte transendothelial migration
hsa04722 Neurotrophin signaling pathway
hsa04920 Adipocytokine signaling pathway
Reactome R-HSA-166054: Activated TLR4 signalling
R-HSA-936964: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
R-HSA-1280218: Adaptive Immune System
R-HSA-422475: Axon guidance
R-HSA-389513: CTLA4 inhibitory signaling
R-HSA-202733: Cell surface interactions at the vascular wall
R-HSA-1500931: Cell-Cell communication
R-HSA-2219530: Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-388841: Costimulation by the CD28 family
R-HSA-1280215: Cytokine Signaling in Immune system
R-HSA-2172127: DAP12 interactions
R-HSA-2424491: DAP12 signaling
R-HSA-1266738: Developmental Biology
R-HSA-1643685: Disease
R-HSA-5663202: Diseases of signal transduction
R-HSA-186763: Downstream signal transduction
R-HSA-1168372: Downstream signaling events of B Cell Receptor (BCR)
R-HSA-5654687: Downstream signaling of activated FGFR1
R-HSA-5654696: Downstream signaling of activated FGFR2
R-HSA-5654708: Downstream signaling of activated FGFR3
R-HSA-5654716: Downstream signaling of activated FGFR4
R-HSA-5654693: FRS-mediated FGFR1 signaling
R-HSA-5654700: FRS-mediated FGFR2 signaling
R-HSA-5654706: FRS-mediated FGFR3 signaling
R-HSA-5654712: FRS-mediated FGFR4 signaling
R-HSA-2454202: Fc epsilon receptor (FCERI) signaling
R-HSA-180292: GAB1 signalosome
R-HSA-114604: GPVI-mediated activation cascade
R-HSA-109582: Hemostasis
R-HSA-2428924: IGF1R signaling cascade
R-HSA-112399: IRS-mediated signalling
R-HSA-2428928: IRS-related events triggered by IGF1R
R-HSA-168256: Immune System
R-HSA-168249: Innate Immune System
R-HSA-74751: Insulin receptor signalling cascade
R-HSA-913531: Interferon Signaling
R-HSA-909733: Interferon alpha/beta signaling
R-HSA-877300: Interferon gamma signaling
R-HSA-512988: Interleukin-3, 5 and GM-CSF signaling
R-HSA-6783589: Interleukin-6 family signaling
R-HSA-1059683: Interleukin-6 signaling
R-HSA-5683057: MAPK family signaling cascades
R-HSA-112411: MAPK1 (ERK2) activation
R-HSA-5684996: MAPK1/MAPK3 signaling
R-HSA-110056: MAPK3 (ERK1) activation
R-HSA-8865999: MET activates PTPN11
R-HSA-166166: MyD88-independent TLR3/TLR4 cascade
R-HSA-187037: NGF signalling via TRKA from the plasma membrane
R-HSA-5654726: Negative regulation of FGFR1 signaling
R-HSA-5654727: Negative regulation of FGFR2 signaling
R-HSA-5654732: Negative regulation of FGFR3 signaling
R-HSA-5654733: Negative regulation of FGFR4 signaling
R-HSA-199418: Negative regulation of the PI3K/AKT network
R-HSA-418886: Netrin mediated repulsion signals
R-HSA-373752: Netrin-1 signaling
R-HSA-389948: PD-1 signaling
R-HSA-210990: PECAM1 interactions
R-HSA-5654689: PI-3K cascade
R-HSA-5654695: PI-3K cascade
R-HSA-5654710: PI-3K cascade
R-HSA-5654720: PI-3K cascade
R-HSA-109704: PI3K Cascade
R-HSA-2219528: PI3K/AKT Signaling in Cancer
R-HSA-198203: PI3K/AKT activation
R-HSA-6811558: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-1257604: PIP3 activates AKT signaling
R-HSA-76002: Platelet activation, signaling and aggregation
R-HSA-418346: Platelet homeostasis
R-HSA-432142: Platelet sensitization by LDL
R-HSA-1170546: Prolactin receptor signaling
R-HSA-112409: RAF-independent MAPK1/3 activation
R-HSA-8853659: RET signaling
R-HSA-912694: Regulation of IFNA signaling
R-HSA-877312: Regulation of IFNG signaling
R-HSA-2730905: Role of LAT2/NTAL/LAB on calcium mobilization
R-HSA-162582: Signal Transduction
R-HSA-391160: Signal regulatory protein (SIRP) family interactions
R-HSA-177929: Signaling by EGFR
R-HSA-190236: Signaling by FGFR
R-HSA-5654736: Signaling by FGFR1
R-HSA-5654738: Signaling by FGFR2
R-HSA-5654741: Signaling by FGFR3
R-HSA-5654743: Signaling by FGFR4
R-HSA-74752: Signaling by Insulin receptor
R-HSA-449147: Signaling by Interleukins
R-HSA-2586552: Signaling by Leptin
R-HSA-6806834: Signaling by MET
R-HSA-186797: Signaling by PDGF
R-HSA-1433557: Signaling by SCF-KIT
R-HSA-2404192: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
R-HSA-983705: Signaling by the B Cell Receptor (BCR)
R-HSA-166520: Signalling by NGF
R-HSA-1295596: Spry regulation of FGF signaling
R-HSA-937061: TRIF-mediated TLR3/TLR4 signaling
R-HSA-210993: Tie2 Signaling
R-HSA-168164: Toll Like Receptor 3 (TLR3) Cascade
R-HSA-166016: Toll Like Receptor 4 (TLR4) Cascade
R-HSA-168898: Toll-Like Receptors Cascades
Summary
SymbolPTPN11
Nameprotein tyrosine phosphatase, non-receptor type 11
Aliases BPTP3; SH-PTP2; SHP-2; PTP2C; SHP2; NS1; Noonan syndrome 1; JMML; METCDS; PTP-1D; SH-PTP3; PTP-2C; protein-t ......
Chromosomal Location12q24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between PTPN11 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between PTPN11 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
25972070Head and Neck Squamous Cell CarcinomaPromote immunityEGFR induces HLA downregulation through SHP-2/STAT1 suppression. Abrogating EGFR-induced immune escape mechanisms and restoring STAT1 signaling to reverse HLA downregulation using cetuximab should be combined with strategies to enhance adaptive cellular immunity.
25480946Head and Neck Squamous Cell CarcinomaInhibit immunity (T cell function)SHP-2 activation by fusaruside suppresses p-STAT1/T-bet and production of Th1 cytokines. Overall, these results defined a PD-1/SHP-2/STAT1/T-bet signaling axis mediating the suppressive effects of PD-1 on Th1 immunity at tumor sites. Our findings argue that PD-1 or SHP-2 blockade will be sufficient to restore robust Th1 immunity and T-cell activation and thereby reverse immunosuppression in the tumor microenvironment.
23363816Head and Neck CarcinomaInhibit immunityThese findings suggest for the first time an important role for SHP2 in APM-mediated escape of HNC cells from CTL recognition. Targeting SHP2 could enhance T-cell-based cancer immunotherapy.
Summary
SymbolPTPN11
Nameprotein tyrosine phosphatase, non-receptor type 11
Aliases BPTP3; SH-PTP2; SHP-2; PTP2C; SHP2; NS1; Noonan syndrome 1; JMML; METCDS; PTP-1D; SH-PTP3; PTP-2C; protein-t ......
Chromosomal Location12q24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of PTPN11 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell logFC: -2.99; FDR: 0.00700 Resistant to T cell-mediated killing
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolPTPN11
Nameprotein tyrosine phosphatase, non-receptor type 11
Aliases BPTP3; SH-PTP2; SHP-2; PTP2C; SHP2; NS1; Noonan syndrome 1; JMML; METCDS; PTP-1D; SH-PTP3; PTP-2C; protein-t ......
Chromosomal Location12q24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of PTPN11 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.1340.584
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.1460.945
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.1280.932
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.0060.981
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.0250.991
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.0460.987
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.0330.94
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.0050.998
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.0860.97
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.2830.83
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.7920.692
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0890.138
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of PTPN11 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277311.11.49.70.0589
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275911.11.79.40.0895
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.1011.10.36
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59200200.357
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.33.71.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.27.1-0.91
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolPTPN11
Nameprotein tyrosine phosphatase, non-receptor type 11
Aliases BPTP3; SH-PTP2; SHP-2; PTP2C; SHP2; NS1; Noonan syndrome 1; JMML; METCDS; PTP-1D; SH-PTP3; PTP-2C; protein-t ......
Chromosomal Location12q24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PTPN11. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolPTPN11
Nameprotein tyrosine phosphatase, non-receptor type 11
Aliases BPTP3; SH-PTP2; SHP-2; PTP2C; SHP2; NS1; Noonan syndrome 1; JMML; METCDS; PTP-1D; SH-PTP3; PTP-2C; protein-t ......
Chromosomal Location12q24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PTPN11. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PTPN11.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolPTPN11
Nameprotein tyrosine phosphatase, non-receptor type 11
Aliases BPTP3; SH-PTP2; SHP-2; PTP2C; SHP2; NS1; Noonan syndrome 1; JMML; METCDS; PTP-1D; SH-PTP3; PTP-2C; protein-t ......
Chromosomal Location12q24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PTPN11. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolPTPN11
Nameprotein tyrosine phosphatase, non-receptor type 11
Aliases BPTP3; SH-PTP2; SHP-2; PTP2C; SHP2; NS1; Noonan syndrome 1; JMML; METCDS; PTP-1D; SH-PTP3; PTP-2C; protein-t ......
Chromosomal Location12q24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of PTPN11 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolPTPN11
Nameprotein tyrosine phosphatase, non-receptor type 11
Aliases BPTP3; SH-PTP2; SHP-2; PTP2C; SHP2; NS1; Noonan syndrome 1; JMML; METCDS; PTP-1D; SH-PTP3; PTP-2C; protein-t ......
Chromosomal Location12q24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between PTPN11 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolPTPN11
Nameprotein tyrosine phosphatase, non-receptor type 11
Aliases BPTP3; SH-PTP2; SHP-2; PTP2C; SHP2; NS1; Noonan syndrome 1; JMML; METCDS; PTP-1D; SH-PTP3; PTP-2C; protein-t ......
Chromosomal Location12q24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting PTPN11 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting PTPN11.
ID Name Drug Type Targets #Targets
DB02779Dodecane-TrimethylamineSmall MoleculePTPN111