TISIDB

Summary
Symbol	PTPRB
Name	protein tyrosine phosphatase, receptor type, B
Aliases	PTPB; HPTP-BETA; HPTPB; R-PTP-BETA; VEPTP; VE-PTP; protein tyrosine phosphatase, receptor type, beta polypep ......
Chromosomal Location	12q15-q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Membrane Single-pass type I membrane protein
Domain	PF00041 Fibronectin type III domain PF00102 Protein-tyrosine phosphatase
Function	Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin (By similarity).

> Gene Ontology [ TOP ]
Biological Process	GO:0001525 angiogenesis GO:0006470 protein dephosphorylation GO:0016311 dephosphorylation GO:0035335 peptidyl-tyrosine dephosphorylation GO:0048514 blood vessel morphogenesis
Molecular Function	GO:0004721 phosphoprotein phosphatase activity GO:0004725 protein tyrosine phosphatase activity GO:0005001 transmembrane receptor protein tyrosine phosphatase activity GO:0016791 phosphatase activity GO:0019198 transmembrane receptor protein phosphatase activity GO:0042578 phosphoric ester hydrolase activity
Cellular Component	GO:0043235 receptor complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04520 Adherens junction
Reactome	R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-6798695: Neutrophil degranulation

Summary
Symbol	PTPRB
Name	protein tyrosine phosphatase, receptor type, B
Aliases	PTPB; HPTP-BETA; HPTPB; R-PTP-BETA; VEPTP; VE-PTP; protein tyrosine phosphatase, receptor type, beta polypep ......
Chromosomal Location	12q15-q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between PTPRB and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining

[ TOP ]

Literatures describing the relation between PTPRB and anti-tumor immunity in human cancer.

PMID	Cancer type	Relation to immunity	Evidence sentences
16489031	Glioblastoma	Inhibit immunity	Targeting of the receptor protein tyrosine phosphatase beta with a monoclonal antibody delays tumor growth in a glioblastoma model.

Summary
Symbol	PTPRB
Name	protein tyrosine phosphatase, receptor type, B
Aliases	PTPB; HPTP-BETA; HPTPB; R-PTP-BETA; VEPTP; VE-PTP; protein tyrosine phosphatase, receptor type, beta polypep ......
Chromosomal Location	12q15-q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of PTPRB in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	PTPRB
Name	protein tyrosine phosphatase, receptor type, B
Aliases	PTPB; HPTP-BETA; HPTPB; R-PTP-BETA; VEPTP; VE-PTP; protein tyrosine phosphatase, receptor type, beta polypep ......
Chromosomal Location	12q15-q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the expression difference of PTPRB in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-0.094	0.761
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-0.102	0.885
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.085	0.873
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-0.209	0.55
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-0.661	0.761
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.353	0.89
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.194	0.629
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	0.389	0.772
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-0.018	0.99
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	1.074	0.333
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	2.64	0.0574
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.365	0.00173

> Mutation difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the mutation difference of PTPRB in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	14.3	0	14.3	0.196
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	20	0	20	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	22.2	11	11.2	0.194
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	22.2	13.6	8.6	0.353
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	23.8	17.6	6.2	0.709
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	37.5	16.7	20.8	0.58
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	15.4	18.2	-2.8	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	11.1	6.2	4.9	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	11.1	-11.1	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	25	0	25	0.364
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	13.2	11.1	2.1	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	18.2	15.4	2.8	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	6.2	7.1	-0.9	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	PTPRB
Name	protein tyrosine phosphatase, receptor type, B
Aliases	PTPB; HPTP-BETA; HPTPB; R-PTP-BETA; VEPTP; VE-PTP; protein tyrosine phosphatase, receptor type, beta polypep ......
Chromosomal Location	12q15-q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PTPRB. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	PTPRB
Name	protein tyrosine phosphatase, receptor type, B
Aliases	PTPB; HPTP-BETA; HPTPB; R-PTP-BETA; VEPTP; VE-PTP; protein tyrosine phosphatase, receptor type, beta polypep ......
Chromosomal Location	12q15-q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PTPRB. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PTPRB. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	PTPRB
Name	protein tyrosine phosphatase, receptor type, B
Aliases	PTPB; HPTP-BETA; HPTPB; R-PTP-BETA; VEPTP; VE-PTP; protein tyrosine phosphatase, receptor type, beta polypep ......
Chromosomal Location	12q15-q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PTPRB. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	PTPRB
Name	protein tyrosine phosphatase, receptor type, B
Aliases	PTPB; HPTP-BETA; HPTPB; R-PTP-BETA; VEPTP; VE-PTP; protein tyrosine phosphatase, receptor type, beta polypep ......
Chromosomal Location	12q15-q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of PTPRB expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	PTPRB
Name	protein tyrosine phosphatase, receptor type, B
Aliases	PTPB; HPTP-BETA; HPTPB; R-PTP-BETA; VEPTP; VE-PTP; protein tyrosine phosphatase, receptor type, beta polypep ......
Chromosomal Location	12q15-q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between PTPRB and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	PTPRB
Name	protein tyrosine phosphatase, receptor type, B
Aliases	PTPB; HPTP-BETA; HPTPB; R-PTP-BETA; VEPTP; VE-PTP; protein tyrosine phosphatase, receptor type, beta polypep ......
Chromosomal Location	12q15-q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting PTPRB collected from DrugBank database.

> Drugs from DrugBank database

[ TOP ]

Details on drugs targeting PTPRB.

ID	Name	Drug Type	Targets	#Targets
DB06989	{4-[2-BENZYL-3-METHOXY-2-(METHOXYCARBONYL)-3-OXOPROPYL]PHENYL}SULFAMIC ACID	Small Molecule	PTPRB	1
DB07068	(4-{4-[(TERT-BUTOXYCARBONYL)AMINO]-2,2-BIS(ETHOXYCARBONYL)BUTYL}PHENYL)SULFAMIC ACID	Small Molecule	PTPRB	1
DB07127	{4-[2,2-BIS(5-METHYL-1,2,4-OXADIAZOL-3-YL)-3-PHENYLPROPYL]PHENYL}SULFAMIC ACID	Small Molecule	PTPRB	1
DB08678	(4-ETHYLPHENYL)SULFAMIC ACID	Small Molecule	PTPRB	1

Browse PTPRB