TISIDB

Summary
Symbol	PTPRZ1
Name	protein tyrosine phosphatase, receptor-type, Z polypeptide 1
Aliases	PTP18; RPTPB; phosphacan; PTPZ; HPTPZ; HPTPzeta; PTP-ZETA; R-PTP-zeta-2; RPTPbeta; protein tyrosine phosphat ......
Chromosomal Location	7q31.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Isoform 1: Cell membrane; Single-pass type I membrane protein. Secreted Note=A secreted form is apparently generated by shedding of the extracellular domain. ; SUBCELLULAR LOCATION: Isoform 2: Secreted
Domain	PF00194 Eukaryotic-type carbonic anhydrase PF00041 Fibronectin type III domain PF00102 Protein-tyrosine phosphatase
Function	Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades (By similarity).

> Gene Ontology [ TOP ]
Biological Process	GO:0002244 hematopoietic progenitor cell differentiation GO:0006470 protein dephosphorylation GO:0007409 axonogenesis GO:0007611 learning or memory GO:0010001 glial cell differentiation GO:0014013 regulation of gliogenesis GO:0016311 dephosphorylation GO:0035335 peptidyl-tyrosine dephosphorylation GO:0042063 gliogenesis GO:0044708 single-organism behavior GO:0048667 cell morphogenesis involved in neuron differentiation GO:0048709 oligodendrocyte differentiation GO:0050890 cognition GO:0061351 neural precursor cell proliferation GO:0061564 axon development GO:0070444 oligodendrocyte progenitor proliferation GO:0070445 regulation of oligodendrocyte progenitor proliferation GO:2000177 regulation of neural precursor cell proliferation
Molecular Function	GO:0004721 phosphoprotein phosphatase activity GO:0004725 protein tyrosine phosphatase activity GO:0005001 transmembrane receptor protein tyrosine phosphatase activity GO:0016791 phosphatase activity GO:0019198 transmembrane receptor protein phosphatase activity GO:0042578 phosphoric ester hydrolase activity
Cellular Component	GO:0005578 proteinaceous extracellular matrix GO:0044420 extracellular matrix component GO:0072534 perineuronal net

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	-

Summary
Symbol	PTPRZ1
Name	protein tyrosine phosphatase, receptor-type, Z polypeptide 1
Aliases	PTP18; RPTPB; phosphacan; PTPZ; HPTPZ; HPTPzeta; PTP-ZETA; R-PTP-zeta-2; RPTPbeta; protein tyrosine phosphat ......
Chromosomal Location	7q31.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between PTPRZ1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	PTPRZ1
Name	protein tyrosine phosphatase, receptor-type, Z polypeptide 1
Aliases	PTP18; RPTPB; phosphacan; PTPZ; HPTPZ; HPTPzeta; PTP-ZETA; R-PTP-zeta-2; RPTPbeta; protein tyrosine phosphat ......
Chromosomal Location	7q31.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of PTPRZ1 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	PTPRZ1
Name	protein tyrosine phosphatase, receptor-type, Z polypeptide 1
Aliases	PTP18; RPTPB; phosphacan; PTPZ; HPTPZ; HPTPzeta; PTP-ZETA; R-PTP-zeta-2; RPTPbeta; protein tyrosine phosphat ......
Chromosomal Location	7q31.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of PTPRZ1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0.024	0.975
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-0.856	0.686
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	0.699	0.569
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.29	0.562
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0.698	0.716
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	-0.228	0.922
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.015	0.987
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-0.298	0.877
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0.468	0.814
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	-0.979	0.343
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	-1.026	0.451
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.897	0.0355

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of PTPRZ1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	14.3	0	14.3	0.196
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	20	0	20	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	11.1	1.4	9.7	0.0589
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	11.1	1.7	9.4	0.0895
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	0	0	0	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	11.1	0	11.1	0.36
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	25	0	25	0.364
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	5.3	11.1	-5.8	0.642
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	9.1	23.1	-14	0.337
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	PTPRZ1
Name	protein tyrosine phosphatase, receptor-type, Z polypeptide 1
Aliases	PTP18; RPTPB; phosphacan; PTPZ; HPTPZ; HPTPzeta; PTP-ZETA; R-PTP-zeta-2; RPTPbeta; protein tyrosine phosphat ......
Chromosomal Location	7q31.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PTPRZ1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	PTPRZ1
Name	protein tyrosine phosphatase, receptor-type, Z polypeptide 1
Aliases	PTP18; RPTPB; phosphacan; PTPZ; HPTPZ; HPTPzeta; PTP-ZETA; R-PTP-zeta-2; RPTPbeta; protein tyrosine phosphat ......
Chromosomal Location	7q31.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PTPRZ1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PTPRZ1. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	PTPRZ1
Name	protein tyrosine phosphatase, receptor-type, Z polypeptide 1
Aliases	PTP18; RPTPB; phosphacan; PTPZ; HPTPZ; HPTPzeta; PTP-ZETA; R-PTP-zeta-2; RPTPbeta; protein tyrosine phosphat ......
Chromosomal Location	7q31.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PTPRZ1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	PTPRZ1
Name	protein tyrosine phosphatase, receptor-type, Z polypeptide 1
Aliases	PTP18; RPTPB; phosphacan; PTPZ; HPTPZ; HPTPzeta; PTP-ZETA; R-PTP-zeta-2; RPTPbeta; protein tyrosine phosphat ......
Chromosomal Location	7q31.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of PTPRZ1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	PTPRZ1
Name	protein tyrosine phosphatase, receptor-type, Z polypeptide 1
Aliases	PTP18; RPTPB; phosphacan; PTPZ; HPTPZ; HPTPzeta; PTP-ZETA; R-PTP-zeta-2; RPTPbeta; protein tyrosine phosphat ......
Chromosomal Location	7q31.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between PTPRZ1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	PTPRZ1
Name	protein tyrosine phosphatase, receptor-type, Z polypeptide 1
Aliases	PTP18; RPTPB; phosphacan; PTPZ; HPTPZ; HPTPzeta; PTP-ZETA; R-PTP-zeta-2; RPTPbeta; protein tyrosine phosphat ......
Chromosomal Location	7q31.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting PTPRZ1 collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

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