TISIDB

Summary
Symbol	PTX3
Name	pentraxin 3, long
Aliases	TSG-14; TNFAIP5; pentaxin-related gene, rapidly induced by IL-1 beta; tumor necrosis factor, alpha-induced p ......
Chromosomal Location	3q25
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Secreted.
Domain	PF00354 Pentaxin family
Function	Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility.

> Gene Ontology [ TOP ]
Biological Process	GO:0001878 response to yeast GO:0006809 nitric oxide biosynthetic process GO:0006909 phagocytosis GO:0008228 opsonization GO:0009100 glycoprotein metabolic process GO:0009620 response to fungus GO:0019058 viral life cycle GO:0030100 regulation of endocytosis GO:0030260 entry into host cell GO:0035821 modification of morphology or physiology of other organism GO:0043900 regulation of multi-organism process GO:0043901 negative regulation of multi-organism process GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism GO:0044003 modification by symbiont of host morphology or physiology GO:0044359 modulation of molecular function in other organism GO:0044362 negative regulation of molecular function in other organism GO:0044409 entry into host GO:0044788 modulation by host of viral process GO:0044793 negative regulation by host of viral process GO:0044866 modulation by host of viral exo-alpha-sialidase activity GO:0044867 modulation by host of viral catalytic activity GO:0044868 modulation by host of viral molecular function GO:0044869 negative regulation by host of viral exo-alpha-sialidase activity GO:0044870 modulation by host of viral glycoprotein metabolic process GO:0044871 negative regulation by host of viral glycoprotein metabolic process GO:0045428 regulation of nitric oxide biosynthetic process GO:0045429 positive regulation of nitric oxide biosynthetic process GO:0045807 positive regulation of endocytosis GO:0046209 nitric oxide metabolic process GO:0046596 regulation of viral entry into host cell GO:0046597 negative regulation of viral entry into host cell GO:0046718 viral entry into host cell GO:0048525 negative regulation of viral process GO:0050764 regulation of phagocytosis GO:0050766 positive regulation of phagocytosis GO:0050792 regulation of viral process GO:0051346 negative regulation of hydrolase activity GO:0051701 interaction with host GO:0051702 interaction with symbiont GO:0051806 entry into cell of other organism involved in symbiotic interaction GO:0051817 modification of morphology or physiology of other organism involved in symbiotic interaction GO:0051828 entry into other organism involved in symbiotic interaction GO:0051851 modification by host of symbiont morphology or physiology GO:0052055 modulation by symbiont of host molecular function GO:0052199 negative regulation of catalytic activity in other organism involved in symbiotic interaction GO:0052203 modulation of catalytic activity in other organism involved in symbiotic interaction GO:0052204 negative regulation of molecular function in other organism involved in symbiotic interaction GO:0052205 modulation of molecular function in other organism involved in symbiotic interaction GO:0052403 negative regulation by host of symbiont catalytic activity GO:0052405 negative regulation by host of symbiont molecular function GO:0052422 modulation by host of symbiont catalytic activity GO:0052428 modification by host of symbiont molecular function GO:0060627 regulation of vesicle-mediated transport GO:0072593 reactive oxygen species metabolic process GO:1903015 regulation of exo-alpha-sialidase activity GO:1903016 negative regulation of exo-alpha-sialidase activity GO:1903018 regulation of glycoprotein metabolic process GO:1903019 negative regulation of glycoprotein metabolic process GO:1903409 reactive oxygen species biosynthetic process GO:1903426 regulation of reactive oxygen species biosynthetic process GO:1903428 positive regulation of reactive oxygen species biosynthetic process GO:1903900 regulation of viral life cycle GO:1903901 negative regulation of viral life cycle GO:1904407 positive regulation of nitric oxide metabolic process GO:2000377 regulation of reactive oxygen species metabolic process GO:2000379 positive regulation of reactive oxygen species metabolic process GO:2001057 reactive nitrogen species metabolic process
Molecular Function	GO:0001846 opsonin binding GO:0001848 complement binding GO:0001849 complement component C1q binding GO:0001871 pattern binding GO:0001872 (1->3)-beta-D-glucan binding GO:0030246 carbohydrate binding GO:0030247 polysaccharide binding GO:0046790 virion binding
Cellular Component	-

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-6798695: Neutrophil degranulation

Summary
Symbol	PTX3
Name	pentraxin 3, long
Aliases	TSG-14; TNFAIP5; pentaxin-related gene, rapidly induced by IL-1 beta; tumor necrosis factor, alpha-induced p ......
Chromosomal Location	3q25
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between PTX3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining

[ TOP ]

Literatures describing the relation between PTX3 and anti-tumor immunity in human cancer.

PMID	Cancer type	Relation to immunity	Evidence sentences
24950910	Prostate Carcinoma	Inhibit immunity (biomarker)	In summary, our results encourage further evaluation of PTX3 as a tissue biopsy and blood-borne biomarker to discriminate BPH from prostate cancer.
23861541	Nasopharyngeal Carcinoma	Inhibit immunity	An increase in C/EBPδ abundance in macrophages in response to PGE? resulted in enhanced production of the immunosuppressive cytokine interleukin-10 (IL-10) and of pentraxin 3 (PTX3), which suppresses the ability of macrophages to phagocytose tumor cells.

Summary
Symbol	PTX3
Name	pentraxin 3, long
Aliases	TSG-14; TNFAIP5; pentaxin-related gene, rapidly induced by IL-1 beta; tumor necrosis factor, alpha-induced p ......
Chromosomal Location	3q25
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of PTX3 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	PTX3
Name	pentraxin 3, long
Aliases	TSG-14; TNFAIP5; pentaxin-related gene, rapidly induced by IL-1 beta; tumor necrosis factor, alpha-induced p ......
Chromosomal Location	3q25
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the expression difference of PTX3 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-0.449	0.514
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-0.655	0.607
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.286	0.768
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-0.604	0.411
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-1.239	0.304
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.207	0.894
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	-0.175	0.76
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-0.627	0.49
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0.401	0.666
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.396	0.652
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	1.498	0.17
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.22	0.432

> Mutation difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the mutation difference of PTX3 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	3.7	6.8	-3.1	1
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	3.7	8.5	-4.8	0.66
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	0	0	0	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	0	0	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	5.3	0	5.3	0.507
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	4.5	0	4.5	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	6.2	0	6.2	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	PTX3
Name	pentraxin 3, long
Aliases	TSG-14; TNFAIP5; pentaxin-related gene, rapidly induced by IL-1 beta; tumor necrosis factor, alpha-induced p ......
Chromosomal Location	3q25
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PTX3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	PTX3
Name	pentraxin 3, long
Aliases	TSG-14; TNFAIP5; pentaxin-related gene, rapidly induced by IL-1 beta; tumor necrosis factor, alpha-induced p ......
Chromosomal Location	3q25
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PTX3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PTX3. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	PTX3
Name	pentraxin 3, long
Aliases	TSG-14; TNFAIP5; pentaxin-related gene, rapidly induced by IL-1 beta; tumor necrosis factor, alpha-induced p ......
Chromosomal Location	3q25
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PTX3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	PTX3
Name	pentraxin 3, long
Aliases	TSG-14; TNFAIP5; pentaxin-related gene, rapidly induced by IL-1 beta; tumor necrosis factor, alpha-induced p ......
Chromosomal Location	3q25
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of PTX3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	PTX3
Name	pentraxin 3, long
Aliases	TSG-14; TNFAIP5; pentaxin-related gene, rapidly induced by IL-1 beta; tumor necrosis factor, alpha-induced p ......
Chromosomal Location	3q25
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between PTX3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	PTX3
Name	pentraxin 3, long
Aliases	TSG-14; TNFAIP5; pentaxin-related gene, rapidly induced by IL-1 beta; tumor necrosis factor, alpha-induced p ......
Chromosomal Location	3q25
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting PTX3 collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

Browse PTX3