TISIDB

Summary
Symbol	QKI
Name	QKI, KH domain containing, RNA binding
Aliases	QK3; quaking homolog, KH domain RNA binding (mouse); Hqk; QK; QK1; hqkI; RNA binding protein HQK; homolog of ......
Chromosomal Location	6q26
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Nucleus Cytoplasm
Domain	PF00013 KH domain PF16551 Putative nuclear localisation signal of quaking PF16544 Homodimerisation region of STAR domain protein
Function	RNA-binding protein that plays a central role in myelinization (PubMed:16641098). Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Regulates target mRNA stability (PubMed:23630077). In addition, acts by regulating pre-mRNA splicing, mRNA export and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia (PubMed:16641098). Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor (By similarity).

> Gene Ontology [ TOP ]
Biological Process	GO:0001570 vasculogenesis GO:0001676 long-chain fatty acid metabolic process GO:0006397 mRNA processing GO:0006403 RNA localization GO:0006417 regulation of translation GO:0006631 fatty acid metabolic process GO:0006633 fatty acid biosynthetic process GO:0007272 ensheathment of neurons GO:0007281 germ cell development GO:0007283 spermatogenesis GO:0007286 spermatid development GO:0008366 axon ensheathment GO:0008380 RNA splicing GO:0010608 posttranscriptional regulation of gene expression GO:0015931 nucleobase-containing compound transport GO:0016053 organic acid biosynthetic process GO:0017148 negative regulation of translation GO:0022412 cellular process involved in reproduction in multicellular organism GO:0034248 regulation of cellular amide metabolic process GO:0034249 negative regulation of cellular amide metabolic process GO:0042552 myelination GO:0042692 muscle cell differentiation GO:0042759 long-chain fatty acid biosynthetic process GO:0043487 regulation of RNA stability GO:0043488 regulation of mRNA stability GO:0044283 small molecule biosynthetic process GO:0046394 carboxylic acid biosynthetic process GO:0048232 male gamete generation GO:0048514 blood vessel morphogenesis GO:0048515 spermatid differentiation GO:0050657 nucleic acid transport GO:0050658 RNA transport GO:0050779 RNA destabilization GO:0051028 mRNA transport GO:0051236 establishment of RNA localization GO:0061157 mRNA destabilization GO:0061158 3'-UTR-mediated mRNA destabilization GO:0072330 monocarboxylic acid biosynthetic process
Molecular Function	GO:0003729 mRNA binding GO:0017124 SH3 domain binding
Cellular Component	-

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-1643685: Disease R-HSA-5663202: Diseases of signal transduction R-HSA-6802957: Oncogenic MAPK signaling R-HSA-6802952: Signaling by BRAF and RAF fusions

Summary
Symbol	QKI
Name	QKI, KH domain containing, RNA binding
Aliases	QK3; quaking homolog, KH domain RNA binding (mouse); Hqk; QK; QK1; hqkI; RNA binding protein HQK; homolog of ......
Chromosomal Location	6q26
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between QKI and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	QKI
Name	QKI, KH domain containing, RNA binding
Aliases	QK3; quaking homolog, KH domain RNA binding (mouse); Hqk; QK; QK1; hqkI; RNA binding protein HQK; homolog of ......
Chromosomal Location	6q26
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of QKI in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	Second most enriched score: 0.52	Sensitive to T cell-mediated killing
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	QKI
Name	QKI, KH domain containing, RNA binding
Aliases	QK3; quaking homolog, KH domain RNA binding (mouse); Hqk; QK; QK1; hqkI; RNA binding protein HQK; homolog of ......
Chromosomal Location	6q26
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the expression difference of QKI in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0.164	0.551
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	0.199	0.915
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	0.144	0.912
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-0.306	0.237
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-0.12	0.963
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	-0.54	0.87
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.086	0.854
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	0.192	0.931
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0.035	0.988
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.629	0.644
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	1.591	0.437
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.094	0.134

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of QKI in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	0	2.7	-2.7	1
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	0	3.4	-3.4	1
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	4.8	0	4.8	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	7.7	0	7.7	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	0	0	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	0	0	0	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	QKI
Name	QKI, KH domain containing, RNA binding
Aliases	QK3; quaking homolog, KH domain RNA binding (mouse); Hqk; QK; QK1; hqkI; RNA binding protein HQK; homolog of ......
Chromosomal Location	6q26
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of QKI. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	QKI
Name	QKI, KH domain containing, RNA binding
Aliases	QK3; quaking homolog, KH domain RNA binding (mouse); Hqk; QK; QK1; hqkI; RNA binding protein HQK; homolog of ......
Chromosomal Location	6q26
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of QKI. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by QKI. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	QKI
Name	QKI, KH domain containing, RNA binding
Aliases	QK3; quaking homolog, KH domain RNA binding (mouse); Hqk; QK; QK1; hqkI; RNA binding protein HQK; homolog of ......
Chromosomal Location	6q26
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of QKI. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	QKI
Name	QKI, KH domain containing, RNA binding
Aliases	QK3; quaking homolog, KH domain RNA binding (mouse); Hqk; QK; QK1; hqkI; RNA binding protein HQK; homolog of ......
Chromosomal Location	6q26
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of QKI expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	QKI
Name	QKI, KH domain containing, RNA binding
Aliases	QK3; quaking homolog, KH domain RNA binding (mouse); Hqk; QK; QK1; hqkI; RNA binding protein HQK; homolog of ......
Chromosomal Location	6q26
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between QKI and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	QKI
Name	QKI, KH domain containing, RNA binding
Aliases	QK3; quaking homolog, KH domain RNA binding (mouse); Hqk; QK; QK1; hqkI; RNA binding protein HQK; homolog of ......
Chromosomal Location	6q26
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting QKI collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

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