TISIDB

Summary
Symbol	RAB11A
Name	RAB11A, member RAS oncogene family
Aliases	YL8; RAB 11A, member oncogene family; rab-11; Ras-related protein Rab-11A
Chromosomal Location	15q22.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Cell membrane Lipid-anchor Recycling endosome membrane Lipid-anchor Cleavage furrow Cytoplasmic vesicle, phagosome Note=Translocates with RAB11FIP2 from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane (PubMed:11994279). Localizes to the cleavage furrow (PubMed:15601896). Colocalizes with PARD3, PRKCI, EXOC5, OCLN, PODXL and RAB8A in apical membrane initiation sites (AMIS) during the generation of apical surface and lumenogenesis (PubMed:20890297). Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211).
Domain	PF00071 Ras family
Function	The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes. May also play a role in melanosome transport and release from melanocytes.

> Gene Ontology [ TOP ]
Biological Process	GO:0000070 mitotic sister chromatid segregation GO:0000086 G2/M transition of mitotic cell cycle GO:0000226 microtubule cytoskeleton organization GO:0000819 sister chromatid segregation GO:0000910 cytokinesis GO:0001558 regulation of cell growth GO:0001667 ameboidal-type cell migration GO:0003014 renal system process GO:0003091 renal water homeostasis GO:0006887 exocytosis GO:0007009 plasma membrane organization GO:0007032 endosome organization GO:0007033 vacuole organization GO:0007034 vacuolar transport GO:0007051 spindle organization GO:0007059 chromosome segregation GO:0007067 mitotic nuclear division GO:0007080 mitotic metaphase plate congression GO:0007346 regulation of mitotic cell cycle GO:0007409 axonogenesis GO:0008361 regulation of cell size GO:0010389 regulation of G2/M transition of mitotic cell cycle GO:0010631 epithelial cell migration GO:0010632 regulation of epithelial cell migration GO:0010634 positive regulation of epithelial cell migration GO:0010720 positive regulation of cell development GO:0010769 regulation of cell morphogenesis involved in differentiation GO:0010770 positive regulation of cell morphogenesis involved in differentiation GO:0010796 regulation of multivesicular body size GO:0010971 positive regulation of G2/M transition of mitotic cell cycle GO:0010975 regulation of neuron projection development GO:0010976 positive regulation of neuron projection development GO:0016049 cell growth GO:0016197 endosomal transport GO:0022604 regulation of cell morphogenesis GO:0030104 water homeostasis GO:0030307 positive regulation of cell growth GO:0030335 positive regulation of cell migration GO:0030516 regulation of axon extension GO:0030953 astral microtubule organization GO:0031122 cytoplasmic microtubule organization GO:0031346 positive regulation of cell projection organization GO:0032400 melanosome localization GO:0032401 establishment of melanosome localization GO:0032402 melanosome transport GO:0032535 regulation of cellular component size GO:0033059 cellular pigmentation GO:0036257 multivesicular body organization GO:0036258 multivesicular body assembly GO:0040017 positive regulation of locomotion GO:0043473 pigmentation GO:0044770 cell cycle phase transition GO:0044772 mitotic cell cycle phase transition GO:0044839 cell cycle G2/M phase transition GO:0045666 positive regulation of neuron differentiation GO:0045773 positive regulation of axon extension GO:0045787 positive regulation of cell cycle GO:0045927 positive regulation of growth GO:0045931 positive regulation of mitotic cell cycle GO:0048167 regulation of synaptic plasticity GO:0048168 regulation of neuronal synaptic plasticity GO:0048169 regulation of long-term neuronal synaptic plasticity GO:0048227 plasma membrane to endosome transport GO:0048588 developmental cell growth GO:0048638 regulation of developmental growth GO:0048639 positive regulation of developmental growth GO:0048667 cell morphogenesis involved in neuron differentiation GO:0048675 axon extension GO:0048871 multicellular organismal homeostasis GO:0050000 chromosome localization GO:0050769 positive regulation of neurogenesis GO:0050770 regulation of axonogenesis GO:0050772 positive regulation of axonogenesis GO:0050804 modulation of synaptic transmission GO:0050878 regulation of body fluid levels GO:0050891 multicellular organismal water homeostasis GO:0051036 regulation of endosome size GO:0051225 spindle assembly GO:0051272 positive regulation of cellular component movement GO:0051303 establishment of chromosome localization GO:0051310 metaphase plate congression GO:0051640 organelle localization GO:0051648 vesicle localization GO:0051650 establishment of vesicle localization GO:0051656 establishment of organelle localization GO:0051875 pigment granule localization GO:0051904 pigment granule transport GO:0051905 establishment of pigment granule localization GO:0051962 positive regulation of nervous system development GO:0060560 developmental growth involved in morphogenesis GO:0060627 regulation of vesicle-mediated transport GO:0061387 regulation of extent of cell growth GO:0061564 axon development GO:0072657 protein localization to membrane GO:0072659 protein localization to plasma membrane GO:0090066 regulation of anatomical structure size GO:0090068 positive regulation of cell cycle process GO:0090130 tissue migration GO:0090132 epithelium migration GO:0090150 establishment of protein localization to membrane GO:0090307 mitotic spindle assembly GO:0098813 nuclear chromosome segregation GO:1901987 regulation of cell cycle phase transition GO:1901989 positive regulation of cell cycle phase transition GO:1901990 regulation of mitotic cell cycle phase transition GO:1901992 positive regulation of mitotic cell cycle phase transition GO:1902749 regulation of cell cycle G2/M phase transition GO:1902751 positive regulation of cell cycle G2/M phase transition GO:1902850 microtubule cytoskeleton organization involved in mitosis GO:1990138 neuron projection extension GO:1990182 exosomal secretion GO:1990778 protein localization to cell periphery GO:2000147 positive regulation of cell motility
Molecular Function	GO:0000149 SNARE binding GO:0003924 GTPase activity GO:0005525 GTP binding GO:0008017 microtubule binding GO:0015631 tubulin binding GO:0017022 myosin binding GO:0019001 guanyl nucleotide binding GO:0019905 syntaxin binding GO:0031489 myosin V binding GO:0032561 guanyl ribonucleotide binding
Cellular Component	GO:0000922 spindle pole GO:0005770 late endosome GO:0005771 multivesicular body GO:0005802 trans-Golgi network GO:0005813 centrosome GO:0005819 spindle GO:0005828 kinetochore microtubule GO:0005874 microtubule GO:0005876 spindle microtubule GO:0010008 endosome membrane GO:0030133 transport vesicle GO:0030139 endocytic vesicle GO:0030424 axon GO:0030659 cytoplasmic vesicle membrane GO:0031984 organelle subcompartment GO:0032153 cell division site GO:0032154 cleavage furrow GO:0032155 cell division site part GO:0044440 endosomal part GO:0045335 phagocytic vesicle GO:0055037 recycling endosome GO:0055038 recycling endosome membrane GO:0097610 cell surface furrow GO:0098791 Golgi subcompartment

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04144 Endocytosis hsa04961 Endocrine and other factor-regulated calcium reabsorption hsa04962 Vasopressin-regulated water reabsorption hsa04972 Pancreatic secretion
Reactome	R-HSA-5620912: Anchoring of the basal body to the plasma membrane R-HSA-445717: Aquaporin-mediated transport R-HSA-5620920: Cargo trafficking to the periciliary membrane R-HSA-5617833: Cilium Assembly R-HSA-199991: Membrane Trafficking R-HSA-392499: Metabolism of proteins R-HSA-1852241: Organelle biogenesis and maintenance R-HSA-597592: Post-translational protein modification R-HSA-8873719: RAB geranylgeranylation R-HSA-8854214: TBC/RABGAPs R-HSA-1445148: Translocation of GLUT4 to the plasma membrane R-HSA-382551: Transmembrane transport of small molecules R-HSA-432040: Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-5653656: Vesicle-mediated transport R-HSA-5620916: VxPx cargo-targeting to cilium

> KEGG and Reactome Pathway

[ TOP ]

KEGG

hsa04144 Endocytosis
hsa04961 Endocrine and other factor-regulated calcium reabsorption
hsa04962 Vasopressin-regulated water reabsorption
hsa04972 Pancreatic secretion

Reactome

R-HSA-5620912: Anchoring of the basal body to the plasma membrane
R-HSA-445717: Aquaporin-mediated transport
R-HSA-5620920: Cargo trafficking to the periciliary membrane
R-HSA-5617833: Cilium Assembly
R-HSA-199991: Membrane Trafficking
R-HSA-392499: Metabolism of proteins
R-HSA-1852241: Organelle biogenesis and maintenance
R-HSA-597592: Post-translational protein modification
R-HSA-8873719: RAB geranylgeranylation
R-HSA-8854214: TBC/RABGAPs
R-HSA-1445148: Translocation of GLUT4 to the plasma membrane
R-HSA-382551: Transmembrane transport of small molecules
R-HSA-432040: Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-5653656: Vesicle-mediated transport
R-HSA-5620916: VxPx cargo-targeting to cilium

Summary
Symbol	RAB11A
Name	RAB11A, member RAS oncogene family
Aliases	YL8; RAB 11A, member oncogene family; rab-11; Ras-related protein Rab-11A
Chromosomal Location	15q22.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between RAB11A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	RAB11A
Name	RAB11A, member RAS oncogene family
Aliases	YL8; RAB 11A, member oncogene family; rab-11; Ras-related protein Rab-11A
Chromosomal Location	15q22.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of RAB11A in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	RAB11A
Name	RAB11A, member RAS oncogene family
Aliases	YL8; RAB 11A, member oncogene family; rab-11; Ras-related protein Rab-11A
Chromosomal Location	15q22.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the expression difference of RAB11A in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0.585	0.0235
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	0.641	0.792
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	0.55	0.745
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.004	0.991
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-0.382	0.822
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.488	0.811
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	-0.146	0.747
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	0.002	0.999
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-0.296	0.897
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.059	0.98
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0.421	0.906
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	0.183	0.0332

> Mutation difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the mutation difference of RAB11A in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	0	0	0	1
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	0	0	0	1
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	0	0	0	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	11.1	12.5	-1.4	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	11.1	-11.1	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	25	14.3	10.7	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	0	0	0	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	RAB11A
Name	RAB11A, member RAS oncogene family
Aliases	YL8; RAB 11A, member oncogene family; rab-11; Ras-related protein Rab-11A
Chromosomal Location	15q22.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of RAB11A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	RAB11A
Name	RAB11A, member RAS oncogene family
Aliases	YL8; RAB 11A, member oncogene family; rab-11; Ras-related protein Rab-11A
Chromosomal Location	15q22.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of RAB11A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by RAB11A. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	RAB11A
Name	RAB11A, member RAS oncogene family
Aliases	YL8; RAB 11A, member oncogene family; rab-11; Ras-related protein Rab-11A
Chromosomal Location	15q22.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of RAB11A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	RAB11A
Name	RAB11A, member RAS oncogene family
Aliases	YL8; RAB 11A, member oncogene family; rab-11; Ras-related protein Rab-11A
Chromosomal Location	15q22.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of RAB11A expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	RAB11A
Name	RAB11A, member RAS oncogene family
Aliases	YL8; RAB 11A, member oncogene family; rab-11; Ras-related protein Rab-11A
Chromosomal Location	15q22.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between RAB11A and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	RAB11A
Name	RAB11A, member RAS oncogene family
Aliases	YL8; RAB 11A, member oncogene family; rab-11; Ras-related protein Rab-11A
Chromosomal Location	15q22.31
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting RAB11A collected from DrugBank database.

> Drugs from DrugBank database

[ TOP ]

Details on drugs targeting RAB11A.

ID	Name	Drug Type	Targets	#Targets
DB01864	5'-Guanosine-Diphosphate-Monothiophosphate	Small Molecule	ARF6, RAB11A, TGM3	3
DB04315	Guanosine-5'-Diphosphate	Small Molecule	ADSSL1, ARF1, ARF4, ARF6, ARL1, ARL3, ARL5A, ARL5B, CDC42, EEF1A1, ......	36

Browse RAB11A