Browse RAB1A

Summary
SymbolRAB1A
NameRAB1A, member RAS oncogene family
Aliases YPT1; Rab GTPase YPT1 homolog (yeast); GTP binding protein Rab1a; RAB1, member RAS oncogene family; Rab GTPa ......
Chromosomal Location2p14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Golgi apparatus Endoplasmic reticulum Early endosome Cytoplasm, cytosol Membrane Melanosome Note=Alternates between membrane-associated and cytosolic forms.
Domain PF00071 Ras family
Function

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion. Regulates the level of CASR present at the cell membrane. Plays a role in cell adhesion and cell migration, via its role in protein trafficking. Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria. Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport.

> Gene Ontology
 
Biological Process GO:0000045 autophagosome assembly
GO:0002790 peptide secretion
GO:0006888 ER to Golgi vesicle-mediated transport
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER
GO:0006900 membrane budding
GO:0006901 vesicle coating
GO:0006903 vesicle targeting
GO:0006914 autophagy
GO:0007018 microtubule-based movement
GO:0007030 Golgi organization
GO:0007033 vacuole organization
GO:0009100 glycoprotein metabolic process
GO:0009306 protein secretion
GO:0009914 hormone transport
GO:0010817 regulation of hormone levels
GO:0010970 transport along microtubule
GO:0015833 peptide transport
GO:0016050 vesicle organization
GO:0016236 macroautophagy
GO:0019058 viral life cycle
GO:0019068 virion assembly
GO:0023061 signal release
GO:0030072 peptide hormone secretion
GO:0030252 growth hormone secretion
GO:0030705 cytoskeleton-dependent intracellular transport
GO:0031589 cell-substrate adhesion
GO:0032400 melanosome localization
GO:0032401 establishment of melanosome localization
GO:0032402 melanosome transport
GO:0032637 interleukin-8 production
GO:0033059 cellular pigmentation
GO:0034446 substrate adhesion-dependent cell spreading
GO:0035459 cargo loading into vesicle
GO:0042742 defense response to bacterium
GO:0042886 amide transport
GO:0043473 pigmentation
GO:0046879 hormone secretion
GO:0047496 vesicle transport along microtubule
GO:0048193 Golgi vesicle transport
GO:0048199 vesicle targeting, to, from or within Golgi
GO:0048207 vesicle targeting, rough ER to cis-Golgi
GO:0048208 COPII vesicle coating
GO:0050663 cytokine secretion
GO:0051640 organelle localization
GO:0051648 vesicle localization
GO:0051650 establishment of vesicle localization
GO:0051656 establishment of organelle localization
GO:0051668 localization within membrane
GO:0051875 pigment granule localization
GO:0051904 pigment granule transport
GO:0051905 establishment of pigment granule localization
GO:0072384 organelle transport along microtubule
GO:0072606 interleukin-8 secretion
GO:0090110 cargo loading into COPII-coated vesicle
GO:0090114 COPII-coated vesicle budding
GO:0098542 defense response to other organism
GO:0099518 vesicle cytoskeletal trafficking
GO:1903018 regulation of glycoprotein metabolic process
GO:1903020 positive regulation of glycoprotein metabolic process
GO:1905037 autophagosome organization
Molecular Function GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0019001 guanyl nucleotide binding
GO:0032561 guanyl ribonucleotide binding
GO:0045296 cadherin binding
GO:0050839 cell adhesion molecule binding
GO:0098631 protein binding involved in cell adhesion
GO:0098632 protein binding involved in cell-cell adhesion
GO:0098641 cadherin binding involved in cell-cell adhesion
Cellular Component GO:0005769 early endosome
GO:0005913 cell-cell adherens junction
GO:0042470 melanosome
GO:0048770 pigment granule
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-446203: Asparagine N-linked glycosylation
R-HSA-6811434: COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-6807878: COPI-mediated anterograde transport
R-HSA-204005: COPII (Coat Protein 2) Mediated Vesicle Transport
R-HSA-1640170: Cell Cycle
R-HSA-69278: Cell Cycle, Mitotic
R-HSA-199977: ER to Golgi Anterograde Transport
R-HSA-162658: Golgi Cisternae Pericentriolar Stack Reorganization
R-HSA-8856688: Golgi-to-ER retrograde transport
R-HSA-6811442: Intra-Golgi and retrograde Golgi-to-ER traffic
R-HSA-68886: M Phase
R-HSA-199991: Membrane Trafficking
R-HSA-392499: Metabolism of proteins
R-HSA-68875: Mitotic Prophase
R-HSA-597592: Post-translational protein modification
R-HSA-8876198: RAB GEFs exchange GTP for GDP on RABs
R-HSA-8873719: RAB geranylgeranylation
R-HSA-948021: Transport to the Golgi and subsequent modification
R-HSA-5653656: Vesicle-mediated transport
Summary
SymbolRAB1A
NameRAB1A, member RAS oncogene family
Aliases YPT1; Rab GTPase YPT1 homolog (yeast); GTP binding protein Rab1a; RAB1, member RAS oncogene family; Rab GTPa ......
Chromosomal Location2p14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between RAB1A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolRAB1A
NameRAB1A, member RAS oncogene family
Aliases YPT1; Rab GTPase YPT1 homolog (yeast); GTP binding protein Rab1a; RAB1, member RAS oncogene family; Rab GTPa ......
Chromosomal Location2p14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of RAB1A in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell logFC: -2.39; FDR: 0.03500 Resistant to T cell-mediated killing
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolRAB1A
NameRAB1A, member RAS oncogene family
Aliases YPT1; Rab GTPase YPT1 homolog (yeast); GTP binding protein Rab1a; RAB1, member RAS oncogene family; Rab GTPa ......
Chromosomal Location2p14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of RAB1A in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.0450.832
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.0011
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.0740.972
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.2590.442
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.5210.776
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.0730.975
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0790.868
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.2060.922
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.0480.984
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.0760.973
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.3320.922
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0530.357
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of RAB1A in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.703.70.27
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.703.70.314
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91622.2022.20.12
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59200200.357
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.63.7-1.11
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.57.7-3.21
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolRAB1A
NameRAB1A, member RAS oncogene family
Aliases YPT1; Rab GTPase YPT1 homolog (yeast); GTP binding protein Rab1a; RAB1, member RAS oncogene family; Rab GTPa ......
Chromosomal Location2p14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of RAB1A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolRAB1A
NameRAB1A, member RAS oncogene family
Aliases YPT1; Rab GTPase YPT1 homolog (yeast); GTP binding protein Rab1a; RAB1, member RAS oncogene family; Rab GTPa ......
Chromosomal Location2p14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of RAB1A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by RAB1A.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolRAB1A
NameRAB1A, member RAS oncogene family
Aliases YPT1; Rab GTPase YPT1 homolog (yeast); GTP binding protein Rab1a; RAB1, member RAS oncogene family; Rab GTPa ......
Chromosomal Location2p14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of RAB1A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolRAB1A
NameRAB1A, member RAS oncogene family
Aliases YPT1; Rab GTPase YPT1 homolog (yeast); GTP binding protein Rab1a; RAB1, member RAS oncogene family; Rab GTPa ......
Chromosomal Location2p14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of RAB1A expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolRAB1A
NameRAB1A, member RAS oncogene family
Aliases YPT1; Rab GTPase YPT1 homolog (yeast); GTP binding protein Rab1a; RAB1, member RAS oncogene family; Rab GTPa ......
Chromosomal Location2p14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between RAB1A and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolRAB1A
NameRAB1A, member RAS oncogene family
Aliases YPT1; Rab GTPase YPT1 homolog (yeast); GTP binding protein Rab1a; RAB1, member RAS oncogene family; Rab GTPa ......
Chromosomal Location2p14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting RAB1A collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.