TISIDB

Summary
Symbol	RAB38
Name	RAB38, member RAS oncogene family
Aliases	NY-MEL-1; rrGTPbp; melanoma antigen NY-MEL-1; Ras-related protein Rab-38
Chromosomal Location	11q14
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Cell membrane Lipid-anchor Cytoplasmic side Melanosome Cytoplasmic vesicle, phagosome Cytoplasmic vesicle, phagosome membrane Lipid-anchor Cytoplasmic side Melanosome membrane Note=Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211). The BLOC-3 complex, a heterodimer of HPS1 and HPS4 promotes its membrane localization (PubMed:23084991).
Domain	PF00071 Ras family
Function	May be involved in melanosomal transport and docking. Involved in the proper sorting of TYRP1. Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with ANKRD27 and VAMP7 (By similarity). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis (PubMed:21255211). Plays an important role in the control of melanin production and melanosome biogenesis (PubMed:23084991). In concert with RAB32, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity).

> Gene Ontology [ TOP ]
Biological Process	GO:0006885 regulation of pH GO:0007034 vacuolar transport GO:0016050 vesicle organization GO:0016197 endosomal transport GO:0021700 developmental maturation GO:0030004 cellular monovalent inorganic cation homeostasis GO:0030641 regulation of cellular pH GO:0032438 melanosome organization GO:0033059 cellular pigmentation GO:0033363 secretory granule organization GO:0035646 endosome to melanosome transport GO:0043473 pigmentation GO:0043476 pigment accumulation GO:0043482 cellular pigment accumulation GO:0043485 endosome to pigment granule transport GO:0045851 pH reduction GO:0048066 developmental pigmentation GO:0048753 pigment granule organization GO:0048757 pigment granule maturation GO:0050931 pigment cell differentiation GO:0051452 intracellular pH reduction GO:0051453 regulation of intracellular pH GO:0055067 monovalent inorganic cation homeostasis GO:0060155 platelet dense granule organization GO:0072657 protein localization to membrane GO:0090382 phagosome maturation GO:0090383 phagosome acidification GO:1903232 melanosome assembly
Molecular Function	GO:0003924 GTPase activity GO:0005525 GTP binding GO:0019001 guanyl nucleotide binding GO:0030742 GTP-dependent protein binding GO:0032561 guanyl ribonucleotide binding GO:0035650 AP-1 adaptor complex binding GO:0035651 AP-3 adaptor complex binding GO:0036461 BLOC-2 complex binding
Cellular Component	GO:0005769 early endosome GO:0005802 trans-Golgi network GO:0030139 endocytic vesicle GO:0030659 cytoplasmic vesicle membrane GO:0030666 endocytic vesicle membrane GO:0030670 phagocytic vesicle membrane GO:0031984 organelle subcompartment GO:0033162 melanosome membrane GO:0042470 melanosome GO:0044232 organelle membrane contact site GO:0044233 ER-mitochondrion membrane contact site GO:0045009 chitosome GO:0045335 phagocytic vesicle GO:0048770 pigment granule GO:0098791 Golgi subcompartment

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-199991: Membrane Trafficking R-HSA-392499: Metabolism of proteins R-HSA-597592: Post-translational protein modification R-HSA-8876198: RAB GEFs exchange GTP for GDP on RABs R-HSA-8873719: RAB geranylgeranylation R-HSA-5653656: Vesicle-mediated transport

Summary
Symbol	RAB38
Name	RAB38, member RAS oncogene family
Aliases	NY-MEL-1; rrGTPbp; melanoma antigen NY-MEL-1; Ras-related protein Rab-38
Chromosomal Location	11q14
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between RAB38 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	RAB38
Name	RAB38, member RAS oncogene family
Aliases	NY-MEL-1; rrGTPbp; melanoma antigen NY-MEL-1; Ras-related protein Rab-38
Chromosomal Location	11q14
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of RAB38 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	RAB38
Name	RAB38, member RAS oncogene family
Aliases	NY-MEL-1; rrGTPbp; melanoma antigen NY-MEL-1; Ras-related protein Rab-38
Chromosomal Location	11q14
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of RAB38 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	1.244	0.0192
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	1.002	0.684
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	1.414	0.467
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-0.724	0.244
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-1.38	0.216
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.091	0.938
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	-1.314	0.058
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-0.251	0.887
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-2.611	0.198
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	-0.173	0.874
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0.075	0.961
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.445	0.0597

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of RAB38 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	0	0	1
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	0	0	1
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	4.8	4.8	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	12.5	12.5	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	0	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	0	0	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	1

Summary
Symbol	RAB38
Name	RAB38, member RAS oncogene family
Aliases	NY-MEL-1; rrGTPbp; melanoma antigen NY-MEL-1; Ras-related protein Rab-38
Chromosomal Location	11q14
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of RAB38. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	RAB38
Name	RAB38, member RAS oncogene family
Aliases	NY-MEL-1; rrGTPbp; melanoma antigen NY-MEL-1; Ras-related protein Rab-38
Chromosomal Location	11q14
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of RAB38. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by RAB38. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	RAB38
Name	RAB38, member RAS oncogene family
Aliases	NY-MEL-1; rrGTPbp; melanoma antigen NY-MEL-1; Ras-related protein Rab-38
Chromosomal Location	11q14
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of RAB38. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	RAB38
Name	RAB38, member RAS oncogene family
Aliases	NY-MEL-1; rrGTPbp; melanoma antigen NY-MEL-1; Ras-related protein Rab-38
Chromosomal Location	11q14
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of RAB38 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	RAB38
Name	RAB38, member RAS oncogene family
Aliases	NY-MEL-1; rrGTPbp; melanoma antigen NY-MEL-1; Ras-related protein Rab-38
Chromosomal Location	11q14
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between RAB38 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	RAB38
Name	RAB38, member RAS oncogene family
Aliases	NY-MEL-1; rrGTPbp; melanoma antigen NY-MEL-1; Ras-related protein Rab-38
Chromosomal Location	11q14
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting RAB38 collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

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