TISIDB

Summary
Symbol	RAB4A
Name	RAB4A, member RAS oncogene family
Aliases	HRES-1/RAB4; RAB4; Ras-related protein Rab-4A
Chromosomal Location	1q42-q43
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Membrane; Peripheral membrane protein Cytoplasm Early endosome membrane Peripheral membrane protein Recycling endosome membrane Peripheral membrane protein Note=Generally associated with membranes. Cytoplasmic when phosphorylated by CDK1.
Domain	PF00071 Ras family
Function	Protein transport. Probably involved in vesicular traffic (By similarity).

> Gene Ontology [ TOP ]
Biological Process	GO:0007265 Ras protein signal transduction GO:0019882 antigen processing and presentation GO:0030100 regulation of endocytosis GO:0032482 Rab protein signal transduction GO:0032781 positive regulation of ATPase activity GO:0043462 regulation of ATPase activity GO:0060627 regulation of vesicle-mediated transport
Molecular Function	GO:0000149 SNARE binding GO:0001671 ATPase activator activity GO:0003924 GTPase activity GO:0005525 GTP binding GO:0008047 enzyme activator activity GO:0008565 protein transporter activity GO:0019001 guanyl nucleotide binding GO:0019003 GDP binding GO:0019905 syntaxin binding GO:0032561 guanyl ribonucleotide binding GO:0035254 glutamate receptor binding GO:0035255 ionotropic glutamate receptor binding GO:0051117 ATPase binding GO:0060589 nucleoside-triphosphatase regulator activity GO:0060590 ATPase regulator activity
Cellular Component	GO:0030141 secretory granule GO:0032593 insulin-responsive compartment GO:0055037 recycling endosome GO:0099503 secretory vesicle

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04144 Endocytosis
Reactome	R-HSA-8875656: MET receptor recycling R-HSA-199991: Membrane Trafficking R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins R-HSA-392499: Metabolism of proteins R-HSA-1483255: PI Metabolism R-HSA-1483257: Phospholipid metabolism R-HSA-597592: Post-translational protein modification R-HSA-8873719: RAB geranylgeranylation R-HSA-162582: Signal Transduction R-HSA-6806834: Signaling by MET R-HSA-1660499: Synthesis of PIPs at the plasma membrane R-HSA-8854214: TBC/RABGAPs R-HSA-1445148: Translocation of GLUT4 to the plasma membrane R-HSA-5653656: Vesicle-mediated transport

> KEGG and Reactome Pathway

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KEGG

hsa04144 Endocytosis

Reactome

R-HSA-8875656: MET receptor recycling
R-HSA-199991: Membrane Trafficking
R-HSA-1430728: Metabolism
R-HSA-556833: Metabolism of lipids and lipoproteins
R-HSA-392499: Metabolism of proteins
R-HSA-1483255: PI Metabolism
R-HSA-1483257: Phospholipid metabolism
R-HSA-597592: Post-translational protein modification
R-HSA-8873719: RAB geranylgeranylation
R-HSA-162582: Signal Transduction
R-HSA-6806834: Signaling by MET
R-HSA-1660499: Synthesis of PIPs at the plasma membrane
R-HSA-8854214: TBC/RABGAPs
R-HSA-1445148: Translocation of GLUT4 to the plasma membrane
R-HSA-5653656: Vesicle-mediated transport

Summary
Symbol	RAB4A
Name	RAB4A, member RAS oncogene family
Aliases	HRES-1/RAB4; RAB4; Ras-related protein Rab-4A
Chromosomal Location	1q42-q43
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between RAB4A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	RAB4A
Name	RAB4A, member RAS oncogene family
Aliases	HRES-1/RAB4; RAB4; Ras-related protein Rab-4A
Chromosomal Location	1q42-q43
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of RAB4A in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	RAB4A
Name	RAB4A, member RAS oncogene family
Aliases	HRES-1/RAB4; RAB4; Ras-related protein Rab-4A
Chromosomal Location	1q42-q43
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of RAB4A in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0.64	0.00586
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	0.471	0.811
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	0.769	0.573
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.191	0.572
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0.213	0.888
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.165	0.932
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	-0.103	0.764
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-0.228	0.881
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0.027	0.988
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.089	0.951
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0.281	0.896
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	0.059	0.405

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of RAB4A in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	7.1	7.1	0.452
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	10	10	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	3.7	3.7	0.27
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	3.7	3.7	0.314
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	0	0	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	0	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	2.6	2.6	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	6.2	6.2	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	1

Summary
Symbol	RAB4A
Name	RAB4A, member RAS oncogene family
Aliases	HRES-1/RAB4; RAB4; Ras-related protein Rab-4A
Chromosomal Location	1q42-q43
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of RAB4A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	RAB4A
Name	RAB4A, member RAS oncogene family
Aliases	HRES-1/RAB4; RAB4; Ras-related protein Rab-4A
Chromosomal Location	1q42-q43
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of RAB4A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by RAB4A. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	RAB4A
Name	RAB4A, member RAS oncogene family
Aliases	HRES-1/RAB4; RAB4; Ras-related protein Rab-4A
Chromosomal Location	1q42-q43
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of RAB4A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	RAB4A
Name	RAB4A, member RAS oncogene family
Aliases	HRES-1/RAB4; RAB4; Ras-related protein Rab-4A
Chromosomal Location	1q42-q43
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of RAB4A expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	RAB4A
Name	RAB4A, member RAS oncogene family
Aliases	HRES-1/RAB4; RAB4; Ras-related protein Rab-4A
Chromosomal Location	1q42-q43
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between RAB4A and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	RAB4A
Name	RAB4A, member RAS oncogene family
Aliases	HRES-1/RAB4; RAB4; Ras-related protein Rab-4A
Chromosomal Location	1q42-q43
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting RAB4A collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

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