Browse RAB7A

Summary
SymbolRAB7A
NameRAB7A, member RAS oncogene family
Aliases RAB7, member RAS oncogene family; PRO2706; Ras-associated protein RAB7; Ras-related protein Rab-7a
Chromosomal Location3q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasmic vesicle, phagosome membrane Peripheral membrane protein Cytoplasmic side Late endosome membrane Peripheral membrane protein Cytoplasmic side Lysosome membrane Peripheral membrane protein Cytoplasmic side Melanosome membrane Peripheral membrane protein Cytoplasmic side Cytoplasmic vesicle, autophagosome membrane Peripheral membrane protein Cytoplasmic side Lipid droplet Endosome membrane Note=Colocalizes with OSBPL1A at the late endosome (PubMed:16176980). Found in the ruffled border (a late endosomal-like compartment in the plasma membrane) of bone-resorbing osteoclasts. Recruited to phagosomes containing S.aureus or Mycobacterium (PubMed:21255211). Lipid droplet localization is increased upon ADRB2 stimulation (By similarity).
Domain PF00071 Ras family
Function

Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. Plays important roles in microbial pathogen infection and survival, as well as in participating in the life cycle of viruses. Microbial pathogens possess survival strategies governed by RAB7A, sometimes by employing RAB7A function (e.g. Salmonella) and sometimes by excluding RAB7A function (e.g. Mycobacterium). In concert with RAC1, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. Controls the endosomal trafficking and neurite outgrowth signaling of NTRK1/TRKA (PubMed:11179213, PubMed:12944476, PubMed:14617358, PubMed:20028791, PubMed:21255211). Regulates the endocytic trafficking of the EGF-EGFR complex by regulating its lysosomal degradation. Involved in the ADRB2-stimulated lipolysis through lipophagy, a cytosolic lipase-independent autophagic pathway (By similarity). Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).

> Gene Ontology
 
Biological Process GO:0000045 autophagosome assembly
GO:0001845 phagolysosome assembly
GO:0001894 tissue homeostasis
GO:0002478 antigen processing and presentation of exogenous peptide antigen
GO:0002495 antigen processing and presentation of peptide antigen via MHC class II
GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
GO:0006622 protein targeting to lysosome
GO:0006623 protein targeting to vacuole
GO:0006885 regulation of pH
GO:0006887 exocytosis
GO:0006906 vesicle fusion
GO:0006909 phagocytosis
GO:0006914 autophagy
GO:0007033 vacuole organization
GO:0007034 vacuolar transport
GO:0007040 lysosome organization
GO:0007041 lysosomal transport
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007174 epidermal growth factor catabolic process
GO:0008333 endosome to lysosome transport
GO:0009894 regulation of catabolic process
GO:0009896 positive regulation of catabolic process
GO:0010506 regulation of autophagy
GO:0016042 lipid catabolic process
GO:0016050 vesicle organization
GO:0016197 endosomal transport
GO:0016236 macroautophagy
GO:0016241 regulation of macroautophagy
GO:0016482 cytosolic transport
GO:0017157 regulation of exocytosis
GO:0019058 viral life cycle
GO:0019076 viral release from host cell
GO:0019882 antigen processing and presentation
GO:0019884 antigen processing and presentation of exogenous antigen
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0022406 membrane docking
GO:0022615 protein to membrane docking
GO:0030004 cellular monovalent inorganic cation homeostasis
GO:0030641 regulation of cellular pH
GO:0038127 ERBB signaling pathway
GO:0042058 regulation of epidermal growth factor receptor signaling pathway
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0042147 retrograde transport, endosome to Golgi
GO:0042176 regulation of protein catabolic process
GO:0043900 regulation of multi-organism process
GO:0043902 positive regulation of multi-organism process
GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism
GO:0044088 regulation of vacuole organization
GO:0044242 cellular lipid catabolic process
GO:0044766 multi-organism transport
GO:0044801 single-organism membrane fusion
GO:0045022 early endosome to late endosome transport
GO:0045453 bone resorption
GO:0045732 positive regulation of protein catabolic process
GO:0045851 pH reduction
GO:0045921 positive regulation of exocytosis
GO:0046849 bone remodeling
GO:0048002 antigen processing and presentation of peptide antigen
GO:0048284 organelle fusion
GO:0048524 positive regulation of viral process
GO:0048771 tissue remodeling
GO:0048871 multicellular organismal homeostasis
GO:0050792 regulation of viral process
GO:0051047 positive regulation of secretion
GO:0051452 intracellular pH reduction
GO:0051453 regulation of intracellular pH
GO:0055067 monovalent inorganic cation homeostasis
GO:0060249 anatomical structure homeostasis
GO:0060627 regulation of vesicle-mediated transport
GO:0061025 membrane fusion
GO:0061462 protein localization to lysosome
GO:0061724 lipophagy
GO:0072665 protein localization to vacuole
GO:0072666 establishment of protein localization to vacuole
GO:0080171 lytic vacuole organization
GO:0090174 organelle membrane fusion
GO:0090382 phagosome maturation
GO:0090383 phagosome acidification
GO:0090385 phagosome-lysosome fusion
GO:0098927 vesicle-mediated transport between endosomal compartments
GO:1901184 regulation of ERBB signaling pathway
GO:1901185 negative regulation of ERBB signaling pathway
GO:1902115 regulation of organelle assembly
GO:1902579 multi-organism localization
GO:1902581 multi-organism cellular localization
GO:1902583 multi-organism intracellular transport
GO:1903532 positive regulation of secretion by cell
GO:1903541 regulation of exosomal secretion
GO:1903543 positive regulation of exosomal secretion
GO:1905037 autophagosome organization
GO:1990182 exosomal secretion
GO:2000785 regulation of autophagosome assembly
Molecular Function GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0017016 Ras GTPase binding
GO:0017048 Rho GTPase binding
GO:0019001 guanyl nucleotide binding
GO:0019003 GDP binding
GO:0031267 small GTPase binding
GO:0032561 guanyl ribonucleotide binding
GO:0048365 Rac GTPase binding
GO:0051020 GTPase binding
GO:1905394 retromer complex binding
Cellular Component GO:0000306 extrinsic component of vacuolar membrane
GO:0000407 pre-autophagosomal structure
GO:0000421 autophagosome membrane
GO:0005765 lysosomal membrane
GO:0005770 late endosome
GO:0005776 autophagosome
GO:0005811 lipid particle
GO:0010008 endosome membrane
GO:0019898 extrinsic component of membrane
GO:0030139 endocytic vesicle
GO:0030141 secretory granule
GO:0030424 axon
GO:0030659 cytoplasmic vesicle membrane
GO:0030666 endocytic vesicle membrane
GO:0030670 phagocytic vesicle membrane
GO:0030904 retromer complex
GO:0031312 extrinsic component of organelle membrane
GO:0031902 late endosome membrane
GO:0032419 extrinsic component of lysosome membrane
GO:0033162 melanosome membrane
GO:0033267 axon part
GO:0034045 pre-autophagosomal structure membrane
GO:0042470 melanosome
GO:0042599 lamellar body
GO:0043195 terminal bouton
GO:0043679 axon terminus
GO:0044306 neuron projection terminus
GO:0044440 endosomal part
GO:0045009 chitosome
GO:0045335 phagocytic vesicle
GO:0048770 pigment granule
GO:0097208 alveolar lamellar body
GO:0098793 presynapse
GO:0098852 lytic vacuole membrane
GO:0099503 secretory vesicle
> KEGG and Reactome Pathway
 
KEGG hsa04140 Regulation of autophagy
hsa04144 Endocytosis
hsa04145 Phagosome
Reactome R-HSA-1280218: Adaptive Immune System
R-HSA-168256: Immune System
R-HSA-168249: Innate Immune System
R-HSA-2132295: MHC class II antigen presentation
R-HSA-199991: Membrane Trafficking
R-HSA-392499: Metabolism of proteins
R-HSA-6798695: Neutrophil degranulation
R-HSA-597592: Post-translational protein modification
R-HSA-8876198: RAB GEFs exchange GTP for GDP on RABs
R-HSA-8873719: RAB geranylgeranylation
R-HSA-8854214: TBC/RABGAPs
R-HSA-5653656: Vesicle-mediated transport
Summary
SymbolRAB7A
NameRAB7A, member RAS oncogene family
Aliases RAB7, member RAS oncogene family; PRO2706; Ras-associated protein RAB7; Ras-related protein Rab-7a
Chromosomal Location3q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between RAB7A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolRAB7A
NameRAB7A, member RAS oncogene family
Aliases RAB7, member RAS oncogene family; PRO2706; Ras-associated protein RAB7; Ras-related protein Rab-7a
Chromosomal Location3q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of RAB7A in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell logFC: -2.34; FDR: 0.04630 Resistant to T cell-mediated killing
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolRAB7A
NameRAB7A, member RAS oncogene family
Aliases RAB7, member RAS oncogene family; PRO2706; Ras-associated protein RAB7; Ras-related protein Rab-7a
Chromosomal Location3q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of RAB7A in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.3490.148
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.8360.823
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.0020.999
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.2080.507
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.0850.965
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.5830.819
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.1160.82
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.020.993
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.230.931
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.0920.965
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.3550.914
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.1070.064
> Mutation difference between responders and non-responders
 

There is no record.
Summary
SymbolRAB7A
NameRAB7A, member RAS oncogene family
Aliases RAB7, member RAS oncogene family; PRO2706; Ras-associated protein RAB7; Ras-related protein Rab-7a
Chromosomal Location3q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of RAB7A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolRAB7A
NameRAB7A, member RAS oncogene family
Aliases RAB7, member RAS oncogene family; PRO2706; Ras-associated protein RAB7; Ras-related protein Rab-7a
Chromosomal Location3q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of RAB7A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by RAB7A.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolRAB7A
NameRAB7A, member RAS oncogene family
Aliases RAB7, member RAS oncogene family; PRO2706; Ras-associated protein RAB7; Ras-related protein Rab-7a
Chromosomal Location3q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of RAB7A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolRAB7A
NameRAB7A, member RAS oncogene family
Aliases RAB7, member RAS oncogene family; PRO2706; Ras-associated protein RAB7; Ras-related protein Rab-7a
Chromosomal Location3q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of RAB7A expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolRAB7A
NameRAB7A, member RAS oncogene family
Aliases RAB7, member RAS oncogene family; PRO2706; Ras-associated protein RAB7; Ras-related protein Rab-7a
Chromosomal Location3q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between RAB7A and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolRAB7A
NameRAB7A, member RAS oncogene family
Aliases RAB7, member RAS oncogene family; PRO2706; Ras-associated protein RAB7; Ras-related protein Rab-7a
Chromosomal Location3q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting RAB7A collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting RAB7A.
ID Name Drug Type Targets #Targets
DB04315Guanosine-5'-DiphosphateSmall MoleculeADSSL1, ARF1, ARF4, ARF6, ARL1, ARL3, ARL5A, ARL5B, CDC42, EEF1A1, ......36