Browse RAP1A

Summary
SymbolRAP1A
NameRAP1A, member of RAS oncogene family
Aliases KREV-1; SMGP21; C21KG; G-22K; KREV1; GTP-binding protein smg p21A; Ras-related protein Krev-1; Ras-related p ......
Chromosomal Location1p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane Lipid-anchor Cytoplasm Cytoplasm, perinuclear region Cell junction Early endosome Note=Recruited from early endosome to late endosome compartment after nerve growth factor (NGF) stimulation. Localized with RAPGEF2 at cell-cell junctions (By similarity). Colocalized with RAPGEF2 in the perinuclear region.
Domain PF00071 Ras family
Function

Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes. Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions.

> Gene Ontology
 
Biological Process GO:0000186 activation of MAPKK activity
GO:0001505 regulation of neurotransmitter levels
GO:0001570 vasculogenesis
GO:0001678 cellular glucose homeostasis
GO:0001885 endothelial cell development
GO:0001889 liver development
GO:0002064 epithelial cell development
GO:0002790 peptide secretion
GO:0002791 regulation of peptide secretion
GO:0003158 endothelium development
GO:0006836 neurotransmitter transport
GO:0006887 exocytosis
GO:0006909 phagocytosis
GO:0007265 Ras protein signal transduction
GO:0007269 neurotransmitter secretion
GO:0008643 carbohydrate transport
GO:0008645 hexose transport
GO:0009306 protein secretion
GO:0009743 response to carbohydrate
GO:0009746 response to hexose
GO:0009749 response to glucose
GO:0009914 hormone transport
GO:0010712 regulation of collagen metabolic process
GO:0010713 negative regulation of collagen metabolic process
GO:0010720 positive regulation of cell development
GO:0010817 regulation of hormone levels
GO:0010827 regulation of glucose transport
GO:0010828 positive regulation of glucose transport
GO:0010975 regulation of neuron projection development
GO:0010976 positive regulation of neuron projection development
GO:0014074 response to purine-containing compound
GO:0015749 monosaccharide transport
GO:0015758 glucose transport
GO:0015833 peptide transport
GO:0016079 synaptic vesicle exocytosis
GO:0017156 calcium ion regulated exocytosis
GO:0017157 regulation of exocytosis
GO:0017158 regulation of calcium ion-dependent exocytosis
GO:0023061 signal release
GO:0030072 peptide hormone secretion
GO:0030073 insulin secretion
GO:0030100 regulation of endocytosis
GO:0031099 regeneration
GO:0031100 animal organ regeneration
GO:0031346 positive regulation of cell projection organization
GO:0032147 activation of protein kinase activity
GO:0032486 Rap protein signal transduction
GO:0032963 collagen metabolic process
GO:0032964 collagen biosynthetic process
GO:0032965 regulation of collagen biosynthetic process
GO:0032966 negative regulation of collagen biosynthetic process
GO:0033500 carbohydrate homeostasis
GO:0033674 positive regulation of kinase activity
GO:0034284 response to monosaccharide
GO:0034329 cell junction assembly
GO:0034330 cell junction organization
GO:0035690 cellular response to drug
GO:0038179 neurotrophin signaling pathway
GO:0038180 nerve growth factor signaling pathway
GO:0042493 response to drug
GO:0042593 glucose homeostasis
GO:0042886 amide transport
GO:0043405 regulation of MAP kinase activity
GO:0043410 positive regulation of MAPK cascade
GO:0044236 multicellular organism metabolic process
GO:0044246 regulation of multicellular organismal metabolic process
GO:0044252 negative regulation of multicellular organismal metabolic process
GO:0044259 multicellular organismal macromolecule metabolic process
GO:0045055 regulated exocytosis
GO:0045446 endothelial cell differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0045807 positive regulation of endocytosis
GO:0045860 positive regulation of protein kinase activity
GO:0045920 negative regulation of exocytosis
GO:0045955 negative regulation of calcium ion-dependent exocytosis
GO:0046323 glucose import
GO:0046324 regulation of glucose import
GO:0046326 positive regulation of glucose import
GO:0046683 response to organophosphorus
GO:0046879 hormone secretion
GO:0046883 regulation of hormone secretion
GO:0046928 regulation of neurotransmitter secretion
GO:0046929 negative regulation of neurotransmitter secretion
GO:0048489 synaptic vesicle transport
GO:0048514 blood vessel morphogenesis
GO:0048732 gland development
GO:0050708 regulation of protein secretion
GO:0050764 regulation of phagocytosis
GO:0050766 positive regulation of phagocytosis
GO:0050769 positive regulation of neurogenesis
GO:0050796 regulation of insulin secretion
GO:0050804 modulation of synaptic transmission
GO:0050805 negative regulation of synaptic transmission
GO:0051048 negative regulation of secretion
GO:0051051 negative regulation of transport
GO:0051588 regulation of neurotransmitter transport
GO:0051589 negative regulation of neurotransmitter transport
GO:0051591 response to cAMP
GO:0051640 organelle localization
GO:0051648 vesicle localization
GO:0051650 establishment of vesicle localization
GO:0051656 establishment of organelle localization
GO:0051962 positive regulation of nervous system development
GO:0060627 regulation of vesicle-mediated transport
GO:0061008 hepaticobiliary system development
GO:0061028 establishment of endothelial barrier
GO:0070371 ERK1 and ERK2 cascade
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071320 cellular response to cAMP
GO:0071322 cellular response to carbohydrate stimulus
GO:0071326 cellular response to monosaccharide stimulus
GO:0071331 cellular response to hexose stimulus
GO:0071333 cellular response to glucose stimulus
GO:0071407 cellular response to organic cyclic compound
GO:0071417 cellular response to organonitrogen compound
GO:0071900 regulation of protein serine/threonine kinase activity
GO:0090087 regulation of peptide transport
GO:0090276 regulation of peptide hormone secretion
GO:0097327 response to antineoplastic agent
GO:0097421 liver regeneration
GO:0097479 synaptic vesicle localization
GO:0097480 establishment of synaptic vesicle localization
GO:0099003 vesicle-mediated transport in synapse
GO:0099504 synaptic vesicle cycle
GO:0099531 presynaptic process involved in chemical synaptic transmission
GO:0099643 signal release from synapse
GO:1901342 regulation of vasculature development
GO:1901888 regulation of cell junction assembly
GO:1902803 regulation of synaptic vesicle transport
GO:1902804 negative regulation of synaptic vesicle transport
GO:1903305 regulation of regulated secretory pathway
GO:1903306 negative regulation of regulated secretory pathway
GO:1903531 negative regulation of secretion by cell
GO:1904018 positive regulation of vasculature development
GO:1990089 response to nerve growth factor
GO:1990090 cellular response to nerve growth factor stimulus
GO:2000300 regulation of synaptic vesicle exocytosis
GO:2000301 negative regulation of synaptic vesicle exocytosis
GO:2001212 regulation of vasculogenesis
GO:2001214 positive regulation of vasculogenesis
Molecular Function GO:0003924 GTPase activity
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005525 GTP binding
GO:0008565 protein transporter activity
GO:0017016 Ras GTPase binding
GO:0017034 Rap guanyl-nucleotide exchange factor activity
GO:0019001 guanyl nucleotide binding
GO:0031267 small GTPase binding
GO:0032561 guanyl ribonucleotide binding
GO:0051020 GTPase binding
Cellular Component GO:0005769 early endosome
GO:0005770 late endosome
GO:0032045 guanyl-nucleotide exchange factor complex
GO:0043209 myelin sheath
> KEGG and Reactome Pathway
 
KEGG hsa04010 MAPK signaling pathway
hsa04014 Ras signaling pathway
hsa04015 Rap1 signaling pathway
hsa04024 cAMP signaling pathway
hsa04062 Chemokine signaling pathway
hsa04510 Focal adhesion
hsa04530 Tight junction
hsa04611 Platelet activation
hsa04670 Leukocyte transendothelial migration
hsa04720 Long-term potentiation
hsa04722 Neurotrophin signaling pathway
hsa04972 Pancreatic secretion
Reactome R-HSA-170984: ARMS-mediated activation
R-HSA-1280218: Adaptive Immune System
R-HSA-422475: Axon guidance
R-HSA-1280215: Cytokine Signaling in Immune system
R-HSA-2172127: DAP12 interactions
R-HSA-2424491: DAP12 signaling
R-HSA-1266738: Developmental Biology
R-HSA-1643685: Disease
R-HSA-5663202: Diseases of signal transduction
R-HSA-186763: Downstream signal transduction
R-HSA-2871796: FCERI mediated MAPK activation
R-HSA-2454202: Fc epsilon receptor (FCERI) signaling
R-HSA-170968: Frs2-mediated activation
R-HSA-179812: GRB2 events in EGFR signaling
R-HSA-354194: GRB2
R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK
R-HSA-381676: Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-HSA-109582: Hemostasis
R-HSA-2428924: IGF1R signaling cascade
R-HSA-112399: IRS-mediated signalling
R-HSA-2428928: IRS-related events triggered by IGF1R
R-HSA-168256: Immune System
R-HSA-168249: Innate Immune System
R-HSA-74751: Insulin receptor signalling cascade
R-HSA-163685: Integration of energy metabolism
R-HSA-354192: Integrin alphaIIb beta3 signaling
R-HSA-912526: Interleukin receptor SHC signaling
R-HSA-451927: Interleukin-2 signaling
R-HSA-512988: Interleukin-3, 5 and GM-CSF signaling
R-HSA-5674135: MAP2K and MAPK activation
R-HSA-5683057: MAPK family signaling cascades
R-HSA-5684996: MAPK1/MAPK3 signaling
R-HSA-8875555: MET activates RAP1 and RAC1
R-HSA-8875878: MET promotes cell motility
R-HSA-1430728: Metabolism
R-HSA-375165: NCAM signaling for neurite out-growth
R-HSA-187037: NGF signalling via TRKA from the plasma membrane
R-HSA-6798695: Neutrophil degranulation
R-HSA-6802957: Oncogenic MAPK signaling
R-HSA-6802955: Paradoxical activation of RAF signaling by kinase inactive BRAF
R-HSA-76009: Platelet Aggregation (Plug Formation)
R-HSA-76002: Platelet activation, signaling and aggregation
R-HSA-169893: Prolonged ERK activation events
R-HSA-5673001: RAF/MAP kinase cascade
R-HSA-8853659: RET signaling
R-HSA-392517: Rap1 signalling
R-HSA-422356: Regulation of insulin secretion
R-HSA-180336: SHC1 events in EGFR signaling
R-HSA-112412: SOS-mediated signalling
R-HSA-162582: Signal Transduction
R-HSA-6802952: Signaling by BRAF and RAF fusions
R-HSA-177929: Signaling by EGFR
R-HSA-372790: Signaling by GPCR
R-HSA-74752: Signaling by Insulin receptor
R-HSA-449147: Signaling by Interleukins
R-HSA-2586552: Signaling by Leptin
R-HSA-6806834: Signaling by MET
R-HSA-186797: Signaling by PDGF
R-HSA-6802949: Signaling by RAS mutants
R-HSA-1433557: Signaling by SCF-KIT
R-HSA-2404192: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
R-HSA-194138: Signaling by VEGF
R-HSA-6802948: Signaling by high-kinase activity BRAF mutants
R-HSA-6802946: Signaling by moderate kinase activity BRAF mutants
R-HSA-166520: Signalling by NGF
R-HSA-187687: Signalling to ERKs
R-HSA-167044: Signalling to RAS
R-HSA-187706: Signalling to p38 via RIT and RIN
R-HSA-4420097: VEGFA-VEGFR2 Pathway
R-HSA-5218921: VEGFR2 mediated cell proliferation
R-HSA-372708: p130Cas linkage to MAPK signaling for integrins
Summary
SymbolRAP1A
NameRAP1A, member of RAS oncogene family
Aliases KREV-1; SMGP21; C21KG; G-22K; KREV1; GTP-binding protein smg p21A; Ras-related protein Krev-1; Ras-related p ......
Chromosomal Location1p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between RAP1A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between RAP1A and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
23804711Chronic Lymphocytic LeukemiaInhibit immunityTransendothelial migration (TEM) of normal lymphocytes into lymph nodes requires the chemokine-induced activation of Rap1 and αLβ2 integrin. However, in most cases of CLL, Rap1 is refractory to chemokine stimulation, resulting in failed αLβ2 activation and TEM unless α4β1 is coexpressed. In this study, we show that the inability of CXCL12 to induce Rap1 GTP loading in CLL cells results from failure of Rap1-containing endosomes to translocate to the plasma membrane. Taken together, our findings indicate that chemokine unresponsiveness in CLL lymphocytes results from failure of Arf1/phospholipase D1-mediated translocation of Rap1 to the plasma membrane for GTP loading and may be a specific feature of anergy induced by DNA Ags.
Summary
SymbolRAP1A
NameRAP1A, member of RAS oncogene family
Aliases KREV-1; SMGP21; C21KG; G-22K; KREV1; GTP-binding protein smg p21A; Ras-related protein Krev-1; Ras-related p ......
Chromosomal Location1p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of RAP1A in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolRAP1A
NameRAP1A, member of RAS oncogene family
Aliases KREV-1; SMGP21; C21KG; G-22K; KREV1; GTP-binding protein smg p21A; Ras-related protein Krev-1; Ras-related p ......
Chromosomal Location1p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of RAP1A in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.0160.957
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.0450.982
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.0680.961
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.5320.125
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.5840.711
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.4710.802
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.1130.795
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.1030.954
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.1680.934
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.3040.869
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.7550.796
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0340.569
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of RAP1A in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.703.70.27
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.703.70.314
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11139.109.10.458
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 512200200.294
Summary
SymbolRAP1A
NameRAP1A, member of RAS oncogene family
Aliases KREV-1; SMGP21; C21KG; G-22K; KREV1; GTP-binding protein smg p21A; Ras-related protein Krev-1; Ras-related p ......
Chromosomal Location1p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of RAP1A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolRAP1A
NameRAP1A, member of RAS oncogene family
Aliases KREV-1; SMGP21; C21KG; G-22K; KREV1; GTP-binding protein smg p21A; Ras-related protein Krev-1; Ras-related p ......
Chromosomal Location1p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of RAP1A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by RAP1A.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolRAP1A
NameRAP1A, member of RAS oncogene family
Aliases KREV-1; SMGP21; C21KG; G-22K; KREV1; GTP-binding protein smg p21A; Ras-related protein Krev-1; Ras-related p ......
Chromosomal Location1p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of RAP1A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolRAP1A
NameRAP1A, member of RAS oncogene family
Aliases KREV-1; SMGP21; C21KG; G-22K; KREV1; GTP-binding protein smg p21A; Ras-related protein Krev-1; Ras-related p ......
Chromosomal Location1p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of RAP1A expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolRAP1A
NameRAP1A, member of RAS oncogene family
Aliases KREV-1; SMGP21; C21KG; G-22K; KREV1; GTP-binding protein smg p21A; Ras-related protein Krev-1; Ras-related p ......
Chromosomal Location1p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between RAP1A and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolRAP1A
NameRAP1A, member of RAS oncogene family
Aliases KREV-1; SMGP21; C21KG; G-22K; KREV1; GTP-binding protein smg p21A; Ras-related protein Krev-1; Ras-related p ......
Chromosomal Location1p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting RAP1A collected from DrugBank database.
> Drugs from DrugBank database
 

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