TISIDB

Summary
Symbol	RB1CC1
Name	RB1-inducible coiled-coil 1
Aliases	KIAA0203; Cc1; DRAGOU14; FIP200; ATG17; PPP1R131; 200 kDa FAK family kinase-interacting protein; phosphatase ......
Chromosomal Location	8q11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Nucleus Cytoplasm Cytoplasm, cytosol Preautophagosomal structure Note=Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane that sequesters a portion of the cytoplasm resulting in the formation of an autophagosome.
Domain	PF10377 Autophagy-related protein 11
Function	Involved in autophagy (PubMed:21775823). Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 (PubMed:23392225). Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy (By similarity). Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis (By similarity). Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways (PubMed:10769033, PubMed:12221124). Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111 (By similarity). Functions as a DNA-binding transcription factor (PubMed:12095676). Is a potent regulator of the RB1 pathway through induction of RB1 expression (PubMed:14533007). Plays a crucial role in muscular differentiation (PubMed:12163359). Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity).

> Gene Ontology [ TOP ]
Biological Process	GO:0000045 autophagosome assembly GO:0000422 mitophagy GO:0001889 liver development GO:0006914 autophagy GO:0006995 cellular response to nitrogen starvation GO:0007031 peroxisome organization GO:0007033 vacuole organization GO:0007254 JNK cascade GO:0007507 heart development GO:0008361 regulation of cell size GO:0009267 cellular response to starvation GO:0009991 response to extracellular stimulus GO:0016236 macroautophagy GO:0030242 pexophagy GO:0031098 stress-activated protein kinase signaling cascade GO:0031667 response to nutrient levels GO:0031668 cellular response to extracellular stimulus GO:0031669 cellular response to nutrient levels GO:0032535 regulation of cellular component size GO:0032872 regulation of stress-activated MAPK cascade GO:0032874 positive regulation of stress-activated MAPK cascade GO:0042594 response to starvation GO:0043410 positive regulation of MAPK cascade GO:0043562 cellular response to nitrogen levels GO:0045793 positive regulation of cell size GO:0046328 regulation of JNK cascade GO:0046330 positive regulation of JNK cascade GO:0048732 gland development GO:0051403 stress-activated MAPK cascade GO:0061008 hepaticobiliary system development GO:0061709 reticulophagy GO:0061723 glycophagy GO:0061726 mitochondrion disassembly GO:0070302 regulation of stress-activated protein kinase signaling cascade GO:0070304 positive regulation of stress-activated protein kinase signaling cascade GO:0071496 cellular response to external stimulus GO:0090066 regulation of anatomical structure size GO:0097191 extrinsic apoptotic signaling pathway GO:1903008 organelle disassembly GO:1905037 autophagosome organization GO:2001233 regulation of apoptotic signaling pathway GO:2001234 negative regulation of apoptotic signaling pathway GO:2001236 regulation of extrinsic apoptotic signaling pathway GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Molecular Function	GO:0032947 protein complex scaffold
Cellular Component	GO:0000407 pre-autophagosomal structure GO:0005635 nuclear envelope GO:0031965 nuclear membrane GO:0034045 pre-autophagosomal structure membrane GO:0061695 transferase complex, transferring phosphorus-containing groups GO:1902554 serine/threonine protein kinase complex GO:1902911 protein kinase complex GO:1990316 ATG1/ULK1 kinase complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04140 Regulation of autophagy
Reactome	R-HSA-2262752: Cellular responses to stress R-HSA-1632852: Macroautophagy

Summary
Symbol	RB1CC1
Name	RB1-inducible coiled-coil 1
Aliases	KIAA0203; Cc1; DRAGOU14; FIP200; ATG17; PPP1R131; 200 kDa FAK family kinase-interacting protein; phosphatase ......
Chromosomal Location	8q11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between RB1CC1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining

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Literatures describing the relation between RB1CC1 and anti-tumor immunity in human cancer.

PMID	Cancer type	Relation to immunity	Evidence sentences
22082959	Breast Carcinoma	Promote immunity	In our recent study, we show that conditional knockout (KO) of FIP200 in the well-characterized MMTV-PyMT mouse model of human breast cancer significantly suppresses mammary tumorigenesis and progression. In addition to the intrinsic defects in proliferation of FIP200-null tumor cells, we also showed that FIP200 deletion in mammary tumor cells triggers increased host anti-tumor immune surveillance, which also contributes to the decreased mammary tumorigenesis and progression.

Summary
Symbol	RB1CC1
Name	RB1-inducible coiled-coil 1
Aliases	KIAA0203; Cc1; DRAGOU14; FIP200; ATG17; PPP1R131; 200 kDa FAK family kinase-interacting protein; phosphatase ......
Chromosomal Location	8q11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of RB1CC1 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	RB1CC1
Name	RB1-inducible coiled-coil 1
Aliases	KIAA0203; Cc1; DRAGOU14; FIP200; ATG17; PPP1R131; 200 kDa FAK family kinase-interacting protein; phosphatase ......
Chromosomal Location	8q11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of RB1CC1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-0.243	0.405
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-0.479	0.75
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.076	0.949
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-0.078	0.833
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-0.048	0.983
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	-0.113	0.969
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.09	0.839
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	0.012	0.995
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0.138	0.949
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.086	0.929
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	1.017	0.455
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	0.087	0.182

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of RB1CC1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	14.8	0	14.8	0.00448
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	14.8	0	14.8	0.00826
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	9.5	0	9.5	0.492
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	15.4	0	15.4	0.482
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	12.5	-12.5	0.52
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	11.1	-11.1	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	14.3	-14.3	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	7.9	0	7.9	0.26
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	13.6	0	13.6	0.279
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	7.7	-7.7	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	8.3	-8.3	1

Summary
Symbol	RB1CC1
Name	RB1-inducible coiled-coil 1
Aliases	KIAA0203; Cc1; DRAGOU14; FIP200; ATG17; PPP1R131; 200 kDa FAK family kinase-interacting protein; phosphatase ......
Chromosomal Location	8q11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of RB1CC1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	RB1CC1
Name	RB1-inducible coiled-coil 1
Aliases	KIAA0203; Cc1; DRAGOU14; FIP200; ATG17; PPP1R131; 200 kDa FAK family kinase-interacting protein; phosphatase ......
Chromosomal Location	8q11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of RB1CC1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by RB1CC1. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	RB1CC1
Name	RB1-inducible coiled-coil 1
Aliases	KIAA0203; Cc1; DRAGOU14; FIP200; ATG17; PPP1R131; 200 kDa FAK family kinase-interacting protein; phosphatase ......
Chromosomal Location	8q11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of RB1CC1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	RB1CC1
Name	RB1-inducible coiled-coil 1
Aliases	KIAA0203; Cc1; DRAGOU14; FIP200; ATG17; PPP1R131; 200 kDa FAK family kinase-interacting protein; phosphatase ......
Chromosomal Location	8q11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of RB1CC1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	RB1CC1
Name	RB1-inducible coiled-coil 1
Aliases	KIAA0203; Cc1; DRAGOU14; FIP200; ATG17; PPP1R131; 200 kDa FAK family kinase-interacting protein; phosphatase ......
Chromosomal Location	8q11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between RB1CC1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	RB1CC1
Name	RB1-inducible coiled-coil 1
Aliases	KIAA0203; Cc1; DRAGOU14; FIP200; ATG17; PPP1R131; 200 kDa FAK family kinase-interacting protein; phosphatase ......
Chromosomal Location	8q11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting RB1CC1 collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

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