Browse RCHY1

Summary
SymbolRCHY1
Namering finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
Aliases CHIMP; DKFZp586C1620; PRO1996; RNF199; ARNIP; PIRH2; ZCHY; androgen-receptor N-terminal-interacting protein; ......
Chromosomal Location4q21.1-q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus. Nucleus speckle. Cytoplasm.
Domain PF05495 CHY zinc finger
PF13639 Ring finger domain
Function

Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Monoubiquitinates the translesion DNA polymerase POLH. Contributes to the regulation of the cell cycle progression. Increases AR transcription factor activity.

> Gene Ontology
 
Biological Process GO:0000731 DNA synthesis involved in DNA repair
GO:0006301 postreplication repair
GO:0009894 regulation of catabolic process
GO:0009896 positive regulation of catabolic process
GO:0010498 proteasomal protein catabolic process
GO:0019985 translesion synthesis
GO:0031329 regulation of cellular catabolic process
GO:0031331 positive regulation of cellular catabolic process
GO:0031396 regulation of protein ubiquitination
GO:0031398 positive regulation of protein ubiquitination
GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0042176 regulation of protein catabolic process
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045732 positive regulation of protein catabolic process
GO:0045862 positive regulation of proteolysis
GO:0061136 regulation of proteasomal protein catabolic process
GO:0070987 error-free translesion synthesis
GO:0071897 DNA biosynthetic process
GO:1901800 positive regulation of proteasomal protein catabolic process
GO:1903050 regulation of proteolysis involved in cellular protein catabolic process
GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process
GO:1903320 regulation of protein modification by small protein conjugation or removal
GO:1903322 positive regulation of protein modification by small protein conjugation or removal
GO:1903362 regulation of cellular protein catabolic process
GO:1903364 positive regulation of cellular protein catabolic process
Molecular Function GO:0002039 p53 binding
GO:0004842 ubiquitin-protein transferase activity
GO:0016874 ligase activity
GO:0019787 ubiquitin-like protein transferase activity
Cellular Component GO:0000151 ubiquitin ligase complex
GO:0016604 nuclear body
GO:0016607 nuclear speck
> KEGG and Reactome Pathway
 
KEGG hsa04115 p53 signaling pathway
hsa04120 Ubiquitin mediated proteolysis
Reactome R-HSA-1280218: Adaptive Immune System
R-HSA-983168: Antigen processing
R-HSA-983169: Class I MHC mediated antigen processing & presentation
R-HSA-73893: DNA Damage Bypass
R-HSA-73894: DNA Repair
R-HSA-168256: Immune System
R-HSA-110320: Translesion Synthesis by POLH
R-HSA-110313: Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
Summary
SymbolRCHY1
Namering finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
Aliases CHIMP; DKFZp586C1620; PRO1996; RNF199; ARNIP; PIRH2; ZCHY; androgen-receptor N-terminal-interacting protein; ......
Chromosomal Location4q21.1-q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between RCHY1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolRCHY1
Namering finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
Aliases CHIMP; DKFZp586C1620; PRO1996; RNF199; ARNIP; PIRH2; ZCHY; androgen-receptor N-terminal-interacting protein; ......
Chromosomal Location4q21.1-q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of RCHY1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolRCHY1
Namering finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
Aliases CHIMP; DKFZp586C1620; PRO1996; RNF199; ARNIP; PIRH2; ZCHY; androgen-receptor N-terminal-interacting protein; ......
Chromosomal Location4q21.1-q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of RCHY1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.6360.0372
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.8870.502
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.4530.644
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.4850.304
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.2080.846
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.8290.55
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0480.878
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.0280.984
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.0590.969
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.2130.873
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.5390.797
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0130.808
> Mutation difference between responders and non-responders
 

There is no record.
Summary
SymbolRCHY1
Namering finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
Aliases CHIMP; DKFZp586C1620; PRO1996; RNF199; ARNIP; PIRH2; ZCHY; androgen-receptor N-terminal-interacting protein; ......
Chromosomal Location4q21.1-q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of RCHY1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolRCHY1
Namering finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
Aliases CHIMP; DKFZp586C1620; PRO1996; RNF199; ARNIP; PIRH2; ZCHY; androgen-receptor N-terminal-interacting protein; ......
Chromosomal Location4q21.1-q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of RCHY1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by RCHY1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolRCHY1
Namering finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
Aliases CHIMP; DKFZp586C1620; PRO1996; RNF199; ARNIP; PIRH2; ZCHY; androgen-receptor N-terminal-interacting protein; ......
Chromosomal Location4q21.1-q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of RCHY1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolRCHY1
Namering finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
Aliases CHIMP; DKFZp586C1620; PRO1996; RNF199; ARNIP; PIRH2; ZCHY; androgen-receptor N-terminal-interacting protein; ......
Chromosomal Location4q21.1-q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of RCHY1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolRCHY1
Namering finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
Aliases CHIMP; DKFZp586C1620; PRO1996; RNF199; ARNIP; PIRH2; ZCHY; androgen-receptor N-terminal-interacting protein; ......
Chromosomal Location4q21.1-q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between RCHY1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolRCHY1
Namering finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
Aliases CHIMP; DKFZp586C1620; PRO1996; RNF199; ARNIP; PIRH2; ZCHY; androgen-receptor N-terminal-interacting protein; ......
Chromosomal Location4q21.1-q21.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting RCHY1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.