TISIDB

Summary
Symbol	RIPK1
Name	receptor (TNFRSF)-interacting serine-threonine kinase 1
Aliases	cell death protein RIP; receptor interacting protein; receptor-interacting protein 1; serine/threonine-prote ......
Chromosomal Location	6p25.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Cytoplasm. Cell membrane
Domain	PF00531 Death domain PF07714 Protein tyrosine kinase PF12721 RIP homotypic interaction motif
Function	Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex.

> Gene Ontology [ TOP ]
Biological Process	GO:0000187 activation of MAPK activity GO:0000302 response to reactive oxygen species GO:0001819 positive regulation of cytokine production GO:0001959 regulation of cytokine-mediated signaling pathway GO:0002218 activation of innate immune response GO:0002221 pattern recognition receptor signaling pathway GO:0002224 toll-like receptor signaling pathway GO:0002521 leukocyte differentiation GO:0002573 myeloid leukocyte differentiation GO:0002756 MyD88-independent toll-like receptor signaling pathway GO:0002757 immune response-activating signal transduction GO:0002758 innate immune response-activating signal transduction GO:0002761 regulation of myeloid leukocyte differentiation GO:0002763 positive regulation of myeloid leukocyte differentiation GO:0002764 immune response-regulating signaling pathway GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006979 response to oxidative stress GO:0007249 I-kappaB kinase/NF-kappaB signaling GO:0007254 JNK cascade GO:0007257 activation of JUN kinase activity GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors GO:0010035 response to inorganic substance GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway GO:0010939 regulation of necrotic cell death GO:0010940 positive regulation of necrotic cell death GO:0010950 positive regulation of endopeptidase activity GO:0010952 positive regulation of peptidase activity GO:0015858 nucleoside transport GO:0015931 nucleobase-containing compound transport GO:0018105 peptidyl-serine phosphorylation GO:0018209 peptidyl-serine modification GO:0022898 regulation of transmembrane transporter activity GO:0030099 myeloid cell differentiation GO:0030198 extracellular matrix organization GO:0030225 macrophage differentiation GO:0031098 stress-activated protein kinase signaling cascade GO:0031349 positive regulation of defense response GO:0032147 activation of protein kinase activity GO:0032239 regulation of nucleobase-containing compound transport GO:0032242 regulation of nucleoside transport GO:0032409 regulation of transporter activity GO:0032637 interleukin-8 production GO:0032640 tumor necrosis factor production GO:0032677 regulation of interleukin-8 production GO:0032680 regulation of tumor necrosis factor production GO:0032757 positive regulation of interleukin-8 production GO:0032760 positive regulation of tumor necrosis factor production GO:0032872 regulation of stress-activated MAPK cascade GO:0032874 positive regulation of stress-activated MAPK cascade GO:0033209 tumor necrosis factor-mediated signaling pathway GO:0033674 positive regulation of kinase activity GO:0034599 cellular response to oxidative stress GO:0034612 response to tumor necrosis factor GO:0034614 cellular response to reactive oxygen species GO:0034762 regulation of transmembrane transport GO:0035666 TRIF-dependent toll-like receptor signaling pathway GO:0036289 peptidyl-serine autophosphorylation GO:0036473 cell death in response to oxidative stress GO:0036474 cell death in response to hydrogen peroxide GO:0038034 signal transduction in absence of ligand GO:0042542 response to hydrogen peroxide GO:0043062 extracellular structure organization GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043405 regulation of MAP kinase activity GO:0043406 positive regulation of MAP kinase activity GO:0043410 positive regulation of MAPK cascade GO:0043506 regulation of JUN kinase activity GO:0043507 positive regulation of JUN kinase activity GO:0045088 regulation of innate immune response GO:0045089 positive regulation of innate immune response GO:0045637 regulation of myeloid cell differentiation GO:0045639 positive regulation of myeloid cell differentiation GO:0045649 regulation of macrophage differentiation GO:0045651 positive regulation of macrophage differentiation GO:0045860 positive regulation of protein kinase activity GO:0045862 positive regulation of proteolysis GO:0046328 regulation of JNK cascade GO:0046330 positive regulation of JNK cascade GO:0046777 protein autophosphorylation GO:0051090 regulation of sequence-specific DNA binding transcription factor activity GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051092 positive regulation of NF-kappaB transcription factor activity GO:0051259 protein oligomerization GO:0051260 protein homooligomerization GO:0051291 protein heterooligomerization GO:0051403 stress-activated MAPK cascade GO:0052547 regulation of peptidase activity GO:0052548 regulation of endopeptidase activity GO:0060544 regulation of necroptotic process GO:0060545 positive regulation of necroptotic process GO:0060759 regulation of response to cytokine stimulus GO:0070227 lymphocyte apoptotic process GO:0070231 T cell apoptotic process GO:0070265 necrotic cell death GO:0070266 necroptotic process GO:0070301 cellular response to hydrogen peroxide GO:0070302 regulation of stress-activated protein kinase signaling cascade GO:0070304 positive regulation of stress-activated protein kinase signaling cascade GO:0070926 regulation of ATP:ADP antiporter activity GO:0071356 cellular response to tumor necrosis factor GO:0071550 death-inducing signaling complex assembly GO:0071706 tumor necrosis factor superfamily cytokine production GO:0071887 leukocyte apoptotic process GO:0071900 regulation of protein serine/threonine kinase activity GO:0071902 positive regulation of protein serine/threonine kinase activity GO:0072593 reactive oxygen species metabolic process GO:0097191 extrinsic apoptotic signaling pathway GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097300 programmed necrotic cell death GO:0097343 ripoptosome assembly GO:0097435 fibril organization GO:0097527 necroptotic signaling pathway GO:1900407 regulation of cellular response to oxidative stress GO:1900409 positive regulation of cellular response to oxidative stress GO:1901026 ripoptosome assembly involved in necroptotic process GO:1901031 regulation of response to reactive oxygen species GO:1901033 positive regulation of response to reactive oxygen species GO:1901099 negative regulation of signal transduction in absence of ligand GO:1901264 carbohydrate derivative transport GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902105 regulation of leukocyte differentiation GO:1902107 positive regulation of leukocyte differentiation GO:1902532 negative regulation of intracellular signal transduction GO:1902882 regulation of response to oxidative stress GO:1902884 positive regulation of response to oxidative stress GO:1903201 regulation of oxidative stress-induced cell death GO:1903205 regulation of hydrogen peroxide-induced cell death GO:1903209 positive regulation of oxidative stress-induced cell death GO:1903555 regulation of tumor necrosis factor superfamily cytokine production GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production GO:1903706 regulation of hemopoiesis GO:1903708 positive regulation of hemopoiesis GO:1905206 positive regulation of hydrogen peroxide-induced cell death GO:1990000 amyloid fibril formation GO:2000116 regulation of cysteine-type endopeptidase activity GO:2000377 regulation of reactive oxygen species metabolic process GO:2000379 positive regulation of reactive oxygen species metabolic process GO:2001056 positive regulation of cysteine-type endopeptidase activity GO:2001233 regulation of apoptotic signaling pathway GO:2001234 negative regulation of apoptotic signaling pathway GO:2001235 positive regulation of apoptotic signaling pathway GO:2001236 regulation of extrinsic apoptotic signaling pathway GO:2001237 negative regulation of extrinsic apoptotic signaling pathway GO:2001238 positive regulation of extrinsic apoptotic signaling pathway GO:2001239 regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001267 regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
Molecular Function	GO:0004674 protein serine/threonine kinase activity GO:0005123 death receptor binding GO:0005126 cytokine receptor binding GO:0031625 ubiquitin protein ligase binding GO:0032813 tumor necrosis factor receptor superfamily binding GO:0044389 ubiquitin-like protein ligase binding GO:0070513 death domain binding
Cellular Component	GO:0031264 death-inducing signaling complex GO:0043235 receptor complex GO:0044445 cytosolic part GO:0045121 membrane raft GO:0097342 ripoptosome GO:0098589 membrane region GO:0098857 membrane microdomain

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04064 NF-kappa B signaling pathway hsa04210 Apoptosis hsa04620 Toll-like receptor signaling pathway hsa04621 NOD-like receptor signaling pathway hsa04622 RIG-I-like receptor signaling pathway hsa04623 Cytosolic DNA-sensing pathway hsa04668 TNF signaling pathway
Reactome	R-HSA-166054: Activated TLR4 signalling R-HSA-109581: Apoptosis R-HSA-5218900: CASP8 activity is inhibited R-HSA-5357769: Caspase activation via extrinsic apoptotic signalling pathway R-HSA-1834949: Cytosolic sensors of pathogen-associated DNA R-HSA-73887: Death Receptor Signalling R-HSA-5688426: Deubiquitination R-HSA-69416: Dimerization of procaspase-8 R-HSA-937041: IKK complex recruitment mediated by RIP1 R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-140534: Ligand-dependent caspase activation R-HSA-392499: Metabolism of proteins R-HSA-166166: MyD88-independent TLR3/TLR4 cascade R-HSA-933543: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-5689896: Ovarian tumor domain proteases R-HSA-597592: Post-translational protein modification R-HSA-5357801: Programmed Cell Death R-HSA-168928: RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways R-HSA-1810476: RIP-mediated NFkB activation via ZBP1 R-HSA-5213460: RIPK1-mediated regulated necrosis R-HSA-5218859: Regulated Necrosis R-HSA-3371378: Regulation by c-FLIP R-HSA-5357905: Regulation of TNFR1 signaling R-HSA-5675482: Regulation of necroptotic cell death R-HSA-162582: Signal Transduction R-HSA-75893: TNF signaling R-HSA-5357956: TNFR1-induced NFkappaB signaling pathway R-HSA-5357786: TNFR1-induced proapoptotic signaling R-HSA-937061: TRIF-mediated TLR3/TLR4 signaling R-HSA-2562578: TRIF-mediated programmed cell death R-HSA-168164: Toll Like Receptor 3 (TLR3) Cascade R-HSA-166016: Toll Like Receptor 4 (TLR4) Cascade R-HSA-168898: Toll-Like Receptors Cascades R-HSA-5689880: Ub-specific processing proteases R-HSA-1606322: ZBP1(DAI) mediated induction of type I IFNs

> KEGG and Reactome Pathway

[ TOP ]

KEGG

hsa04064 NF-kappa B signaling pathway
hsa04210 Apoptosis
hsa04620 Toll-like receptor signaling pathway
hsa04621 NOD-like receptor signaling pathway
hsa04622 RIG-I-like receptor signaling pathway
hsa04623 Cytosolic DNA-sensing pathway
hsa04668 TNF signaling pathway

Reactome

R-HSA-166054: Activated TLR4 signalling
R-HSA-109581: Apoptosis
R-HSA-5218900: CASP8 activity is inhibited
R-HSA-5357769: Caspase activation via extrinsic apoptotic signalling pathway
R-HSA-1834949: Cytosolic sensors of pathogen-associated DNA
R-HSA-73887: Death Receptor Signalling
R-HSA-5688426: Deubiquitination
R-HSA-69416: Dimerization of procaspase-8
R-HSA-937041: IKK complex recruitment mediated by RIP1
R-HSA-168256: Immune System
R-HSA-168249: Innate Immune System
R-HSA-140534: Ligand-dependent caspase activation
R-HSA-392499: Metabolism of proteins
R-HSA-166166: MyD88-independent TLR3/TLR4 cascade
R-HSA-933543: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
R-HSA-5689896: Ovarian tumor domain proteases
R-HSA-597592: Post-translational protein modification
R-HSA-5357801: Programmed Cell Death
R-HSA-168928: RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
R-HSA-1810476: RIP-mediated NFkB activation via ZBP1
R-HSA-5213460: RIPK1-mediated regulated necrosis
R-HSA-5218859: Regulated Necrosis
R-HSA-3371378: Regulation by c-FLIP
R-HSA-5357905: Regulation of TNFR1 signaling
R-HSA-5675482: Regulation of necroptotic cell death
R-HSA-162582: Signal Transduction
R-HSA-75893: TNF signaling
R-HSA-5357956: TNFR1-induced NFkappaB signaling pathway
R-HSA-5357786: TNFR1-induced proapoptotic signaling
R-HSA-937061: TRIF-mediated TLR3/TLR4 signaling
R-HSA-2562578: TRIF-mediated programmed cell death
R-HSA-168164: Toll Like Receptor 3 (TLR3) Cascade
R-HSA-166016: Toll Like Receptor 4 (TLR4) Cascade
R-HSA-168898: Toll-Like Receptors Cascades
R-HSA-5689880: Ub-specific processing proteases
R-HSA-1606322: ZBP1(DAI) mediated induction of type I IFNs

Summary
Symbol	RIPK1
Name	receptor (TNFRSF)-interacting serine-threonine kinase 1
Aliases	cell death protein RIP; receptor interacting protein; receptor-interacting protein 1; serine/threonine-prote ......
Chromosomal Location	6p25.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between RIPK1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining

[ TOP ]

Literatures describing the relation between RIPK1 and anti-tumor immunity in human cancer.

PMID	Cancer type	Relation to immunity	Evidence sentences
21282461	Bladder Carcinoma	Promote immunity	We demonstrate that receptor-interacting protein 1 (RIP1) is an integral component of this complex and is required for CD40 ligand-induced caspase-8 activation and tumor cell killing.

Summary
Symbol	RIPK1
Name	receptor (TNFRSF)-interacting serine-threonine kinase 1
Aliases	cell death protein RIP; receptor interacting protein; receptor-interacting protein 1; serine/threonine-prote ......
Chromosomal Location	6p25.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of RIPK1 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	Second most enriched score: 0.98	Sensitive to T cell-mediated killing
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	STARS Score: 8.95; FDR: 0.000	Resistant to T cell-mediated killing
28723893	CRISPR-Cas9	melanoma	B16	GVAX	STARS Score: 8.57; FDR: 0.000	Resistant to T cell-mediated killing
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	RIPK1
Name	receptor (TNFRSF)-interacting serine-threonine kinase 1
Aliases	cell death protein RIP; receptor interacting protein; receptor-interacting protein 1; serine/threonine-prote ......
Chromosomal Location	6p25.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the expression difference of RIPK1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0.111	0.618
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	0.18	0.914
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	0.062	0.96
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.191	0.429
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0.09	0.962
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.318	0.894
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.108	0.753
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	0.263	0.871
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-0.089	0.962
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.538	0.676
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	1.015	0.59
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	0.027	0.626

> Mutation difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the mutation difference of RIPK1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	7.1	0	7.1	0.452
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	25	0	25	0.222
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	3.7	1.4	2.3	0.469
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	3.7	1.7	2	0.532
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	0	0	0	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	6.2	-6.2	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	11.1	-11.1	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	0	0	0	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	RIPK1
Name	receptor (TNFRSF)-interacting serine-threonine kinase 1
Aliases	cell death protein RIP; receptor interacting protein; receptor-interacting protein 1; serine/threonine-prote ......
Chromosomal Location	6p25.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of RIPK1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	RIPK1
Name	receptor (TNFRSF)-interacting serine-threonine kinase 1
Aliases	cell death protein RIP; receptor interacting protein; receptor-interacting protein 1; serine/threonine-prote ......
Chromosomal Location	6p25.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of RIPK1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by RIPK1. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	RIPK1
Name	receptor (TNFRSF)-interacting serine-threonine kinase 1
Aliases	cell death protein RIP; receptor interacting protein; receptor-interacting protein 1; serine/threonine-prote ......
Chromosomal Location	6p25.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of RIPK1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	RIPK1
Name	receptor (TNFRSF)-interacting serine-threonine kinase 1
Aliases	cell death protein RIP; receptor interacting protein; receptor-interacting protein 1; serine/threonine-prote ......
Chromosomal Location	6p25.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of RIPK1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	RIPK1
Name	receptor (TNFRSF)-interacting serine-threonine kinase 1
Aliases	cell death protein RIP; receptor interacting protein; receptor-interacting protein 1; serine/threonine-prote ......
Chromosomal Location	6p25.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between RIPK1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	RIPK1
Name	receptor (TNFRSF)-interacting serine-threonine kinase 1
Aliases	cell death protein RIP; receptor interacting protein; receptor-interacting protein 1; serine/threonine-prote ......
Chromosomal Location	6p25.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting RIPK1 collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

Browse RIPK1