Summary | |
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Symbol | RNF152 |
Name | ring finger protein 152 |
Aliases | FLJ39176; E3 ubiquitin-protein ligase RNF152 |
Chromosomal Location | 18q21.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Lysosome membrane Single-pass membrane protein |
Domain |
PF14634 zinc-RING finger domain |
Function |
E3 ubiquitin-protein ligase mediating 'Lys-63'-linked polyubiquitination of RRAGA in response to amino acid starvation. Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability (PubMed:25936802). Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation. Induces apoptosis when overexpressed (PubMed:21203937). |
Biological Process |
GO:0000209 protein polyubiquitination GO:0006914 autophagy GO:0009267 cellular response to starvation GO:0009991 response to extracellular stimulus GO:0010506 regulation of autophagy GO:0010508 positive regulation of autophagy GO:0031667 response to nutrient levels GO:0031668 cellular response to extracellular stimulus GO:0031669 cellular response to nutrient levels GO:0031929 TOR signaling GO:0032006 regulation of TOR signaling GO:0032007 negative regulation of TOR signaling GO:0034198 cellular response to amino acid starvation GO:0038202 TORC1 signaling GO:0042594 response to starvation GO:0070534 protein K63-linked ubiquitination GO:0070936 protein K48-linked ubiquitination GO:0071496 cellular response to external stimulus GO:1902532 negative regulation of intracellular signal transduction GO:1903432 regulation of TORC1 signaling GO:1904262 negative regulation of TORC1 signaling |
Molecular Function |
GO:0004842 ubiquitin-protein transferase activity GO:0016874 ligase activity GO:0019787 ubiquitin-like protein transferase activity GO:0031267 small GTPase binding GO:0051020 GTPase binding GO:0061630 ubiquitin protein ligase activity GO:0061659 ubiquitin-like protein ligase activity |
Cellular Component |
GO:0005765 lysosomal membrane GO:0031300 intrinsic component of organelle membrane GO:0031301 integral component of organelle membrane GO:0098852 lytic vacuole membrane |
KEGG |
hsa04150 mTOR signaling pathway |
Reactome |
R-HSA-8866654: E3 ubiquitin ligases ubiquitinate target proteins R-HSA-392499: Metabolism of proteins R-HSA-597592: Post-translational protein modification R-HSA-8852135: Protein ubiquitination |
Summary | |
---|---|
Symbol | RNF152 |
Name | ring finger protein 152 |
Aliases | FLJ39176; E3 ubiquitin-protein ligase RNF152 |
Chromosomal Location | 18q21.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between RNF152 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | RNF152 |
Name | ring finger protein 152 |
Aliases | FLJ39176; E3 ubiquitin-protein ligase RNF152 |
Chromosomal Location | 18q21.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of RNF152 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | RNF152 |
Name | ring finger protein 152 |
Aliases | FLJ39176; E3 ubiquitin-protein ligase RNF152 |
Chromosomal Location | 18q21.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of RNF152 in various data sets.
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Points in the above scatter plot represent the mutation difference of RNF152 in various data sets.
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Summary | |
---|---|
Symbol | RNF152 |
Name | ring finger protein 152 |
Aliases | FLJ39176; E3 ubiquitin-protein ligase RNF152 |
Chromosomal Location | 18q21.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of RNF152. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | RNF152 |
Name | ring finger protein 152 |
Aliases | FLJ39176; E3 ubiquitin-protein ligase RNF152 |
Chromosomal Location | 18q21.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of RNF152. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by RNF152. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | RNF152 |
Name | ring finger protein 152 |
Aliases | FLJ39176; E3 ubiquitin-protein ligase RNF152 |
Chromosomal Location | 18q21.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of RNF152. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | RNF152 |
Name | ring finger protein 152 |
Aliases | FLJ39176; E3 ubiquitin-protein ligase RNF152 |
Chromosomal Location | 18q21.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of RNF152 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | RNF152 |
Name | ring finger protein 152 |
Aliases | FLJ39176; E3 ubiquitin-protein ligase RNF152 |
Chromosomal Location | 18q21.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between RNF152 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |