Browse ROBO1

Summary
SymbolROBO1
Nameroundabout guidance receptor 1
Aliases DUTT1; FLJ21882; roundabout (axon guidance receptor, Drosophila) homolog 1; roundabout, axon guidance recept ......
Chromosomal Location3p12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane Single-pass type I membrane protein Cell projection, axon Note=Detected at growth cones in thalamus neurons.
Domain PF00041 Fibronectin type III domain
PF07679 Immunoglobulin I-set domain
Function

Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development (PubMed:10102268, PubMed:24560577). Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1 (PubMed:24560577). In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex (By similarity). Plays a role in the regulation of cell migration via its interaction with MYO9B; inhibits MYO9B-mediated stimulation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). May be required for lung development (By similarity).

> Gene Ontology
 
Biological Process GO:0001525 angiogenesis
GO:0001667 ameboidal-type cell migration
GO:0001959 regulation of cytokine-mediated signaling pathway
GO:0001960 negative regulation of cytokine-mediated signaling pathway
GO:0002040 sprouting angiogenesis
GO:0002042 cell migration involved in sprouting angiogenesis
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006929 substrate-dependent cell migration
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
GO:0007265 Ras protein signal transduction
GO:0007266 Rho protein signal transduction
GO:0007409 axonogenesis
GO:0007411 axon guidance
GO:0007507 heart development
GO:0008037 cell recognition
GO:0008038 neuron recognition
GO:0010631 epithelial cell migration
GO:0010720 positive regulation of cell development
GO:0010769 regulation of cell morphogenesis involved in differentiation
GO:0010770 positive regulation of cell morphogenesis involved in differentiation
GO:0010950 positive regulation of endopeptidase activity
GO:0010952 positive regulation of peptidase activity
GO:0010975 regulation of neuron projection development
GO:0010976 positive regulation of neuron projection development
GO:0016198 axon choice point recognition
GO:0016199 axon midline choice point recognition
GO:0021537 telencephalon development
GO:0021543 pallium development
GO:0021772 olfactory bulb development
GO:0021795 cerebral cortex cell migration
GO:0021800 cerebral cortex tangential migration
GO:0021823 cerebral cortex tangential migration using cell-cell interactions
GO:0021825 substrate-dependent cerebral cortex tangential migration
GO:0021827 postnatal olfactory bulb interneuron migration
GO:0021836 chemorepulsion involved in postnatal olfactory bulb interneuron migration
GO:0021872 forebrain generation of neurons
GO:0021879 forebrain neuron differentiation
GO:0021884 forebrain neuron development
GO:0021885 forebrain cell migration
GO:0021889 olfactory bulb interneuron differentiation
GO:0021891 olfactory bulb interneuron development
GO:0021953 central nervous system neuron differentiation
GO:0021954 central nervous system neuron development
GO:0021987 cerebral cortex development
GO:0021988 olfactory lobe development
GO:0022028 tangential migration from the subventricular zone to the olfactory bulb
GO:0022029 telencephalon cell migration
GO:0022604 regulation of cell morphogenesis
GO:0030336 negative regulation of cell migration
GO:0030879 mammary gland development
GO:0030900 forebrain development
GO:0031346 positive regulation of cell projection organization
GO:0032102 negative regulation of response to external stimulus
GO:0033598 mammary gland epithelial cell proliferation
GO:0033599 regulation of mammary gland epithelial cell proliferation
GO:0033600 negative regulation of mammary gland epithelial cell proliferation
GO:0035023 regulation of Rho protein signal transduction
GO:0035025 positive regulation of Rho protein signal transduction
GO:0035385 Roundabout signaling pathway
GO:0040013 negative regulation of locomotion
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043534 blood vessel endothelial cell migration
GO:0043542 endothelial cell migration
GO:0045666 positive regulation of neuron differentiation
GO:0045862 positive regulation of proteolysis
GO:0046578 regulation of Ras protein signal transduction
GO:0046579 positive regulation of Ras protein signal transduction
GO:0048514 blood vessel morphogenesis
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0048732 gland development
GO:0050673 epithelial cell proliferation
GO:0050678 regulation of epithelial cell proliferation
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050769 positive regulation of neurogenesis
GO:0050770 regulation of axonogenesis
GO:0050772 positive regulation of axonogenesis
GO:0050919 negative chemotaxis
GO:0050920 regulation of chemotaxis
GO:0050922 negative regulation of chemotaxis
GO:0050923 regulation of negative chemotaxis
GO:0050925 negative regulation of negative chemotaxis
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0051057 positive regulation of small GTPase mediated signal transduction
GO:0051271 negative regulation of cellular component movement
GO:0051962 positive regulation of nervous system development
GO:0052547 regulation of peptidase activity
GO:0052548 regulation of endopeptidase activity
GO:0060759 regulation of response to cytokine stimulus
GO:0060761 negative regulation of response to cytokine stimulus
GO:0061180 mammary gland epithelium development
GO:0061564 axon development
GO:0070098 chemokine-mediated signaling pathway
GO:0070099 regulation of chemokine-mediated signaling pathway
GO:0070100 negative regulation of chemokine-mediated signaling pathway
GO:0090130 tissue migration
GO:0090132 epithelium migration
GO:0097485 neuron projection guidance
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules
GO:2000116 regulation of cysteine-type endopeptidase activity
GO:2000146 negative regulation of cell motility
GO:2001056 positive regulation of cysteine-type endopeptidase activity
Molecular Function GO:0008046 axon guidance receptor activity
GO:0030275 LRR domain binding
Cellular Component GO:0030424 axon
> KEGG and Reactome Pathway
 
KEGG hsa04360 Axon guidance
Reactome R-HSA-428540: Activation of Rac
R-HSA-422475: Axon guidance
R-HSA-1266738: Developmental Biology
R-HSA-428543: Inactivation of Cdc42 and Rac
R-HSA-373752: Netrin-1 signaling
R-HSA-428542: Regulation of Commissural axon pathfinding by Slit and Robo
R-HSA-428890: Role of Abl in Robo-Slit signaling
R-HSA-376176: Signaling by Robo receptor
Summary
SymbolROBO1
Nameroundabout guidance receptor 1
Aliases DUTT1; FLJ21882; roundabout (axon guidance receptor, Drosophila) homolog 1; roundabout, axon guidance recept ......
Chromosomal Location3p12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between ROBO1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolROBO1
Nameroundabout guidance receptor 1
Aliases DUTT1; FLJ21882; roundabout (axon guidance receptor, Drosophila) homolog 1; roundabout, axon guidance recept ......
Chromosomal Location3p12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of ROBO1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen Total # shRNA with >= 4-fold: 1 Resistant to T-cell proliferation
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolROBO1
Nameroundabout guidance receptor 1
Aliases DUTT1; FLJ21882; roundabout (axon guidance receptor, Drosophila) homolog 1; roundabout, axon guidance recept ......
Chromosomal Location3p12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of ROBO1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.1740.68
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.0820.954
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.3720.763
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.3170.257
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.3370.885
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.2890.924
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.5320.399
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.0130.994
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11121.1680.554
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.4080.683
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.0670.371
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.1790.249
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of ROBO1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141721.4021.40.081
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103300300.528
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.41.460.177
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.41.75.70.231
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211723.817.66.20.709
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.516.7-4.21
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131130.818.212.60.649
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.1011.10.36
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.63.7-1.11
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 161407.1-7.10.467
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolROBO1
Nameroundabout guidance receptor 1
Aliases DUTT1; FLJ21882; roundabout (axon guidance receptor, Drosophila) homolog 1; roundabout, axon guidance recept ......
Chromosomal Location3p12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ROBO1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolROBO1
Nameroundabout guidance receptor 1
Aliases DUTT1; FLJ21882; roundabout (axon guidance receptor, Drosophila) homolog 1; roundabout, axon guidance recept ......
Chromosomal Location3p12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ROBO1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ROBO1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolROBO1
Nameroundabout guidance receptor 1
Aliases DUTT1; FLJ21882; roundabout (axon guidance receptor, Drosophila) homolog 1; roundabout, axon guidance recept ......
Chromosomal Location3p12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ROBO1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolROBO1
Nameroundabout guidance receptor 1
Aliases DUTT1; FLJ21882; roundabout (axon guidance receptor, Drosophila) homolog 1; roundabout, axon guidance recept ......
Chromosomal Location3p12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of ROBO1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolROBO1
Nameroundabout guidance receptor 1
Aliases DUTT1; FLJ21882; roundabout (axon guidance receptor, Drosophila) homolog 1; roundabout, axon guidance recept ......
Chromosomal Location3p12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between ROBO1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolROBO1
Nameroundabout guidance receptor 1
Aliases DUTT1; FLJ21882; roundabout (axon guidance receptor, Drosophila) homolog 1; roundabout, axon guidance recept ......
Chromosomal Location3p12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting ROBO1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.