Browse RRS1

Summary
SymbolRRS1
Nameribosome biogenesis regulator homolog
Aliases KIAA0112; RRS1 ribosome biogenesis regulator homolog (S. cerevisiae); RRS1 ribosome biogenesis regulator hom ......
Chromosomal Location8q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus, nucleolus
Domain PF04939 Ribosome biogenesis regulatory protein (RRS1)
Function

Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus.

> Gene Ontology
 
Biological Process GO:0000054 ribosomal subunit export from nucleus
GO:0000055 ribosomal large subunit export from nucleus
GO:0000070 mitotic sister chromatid segregation
GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000460 maturation of 5.8S rRNA
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000469 cleavage involved in rRNA processing
GO:0000478 endonucleolytic cleavage involved in rRNA processing
GO:0000479 endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000819 sister chromatid segregation
GO:0002244 hematopoietic progenitor cell differentiation
GO:0006364 rRNA processing
GO:0006913 nucleocytoplasmic transport
GO:0007059 chromosome segregation
GO:0007067 mitotic nuclear division
GO:0007080 mitotic metaphase plate congression
GO:0016072 rRNA metabolic process
GO:0022613 ribonucleoprotein complex biogenesis
GO:0030490 maturation of SSU-rRNA
GO:0033750 ribosome localization
GO:0033753 establishment of ribosome localization
GO:0034470 ncRNA processing
GO:0042254 ribosome biogenesis
GO:0042273 ribosomal large subunit biogenesis
GO:0042274 ribosomal small subunit biogenesis
GO:0050000 chromosome localization
GO:0051168 nuclear export
GO:0051169 nuclear transport
GO:0051303 establishment of chromosome localization
GO:0051310 metaphase plate congression
GO:0051640 organelle localization
GO:0051656 establishment of organelle localization
GO:0071166 ribonucleoprotein complex localization
GO:0071426 ribonucleoprotein complex export from nucleus
GO:0071428 rRNA-containing ribonucleoprotein complex export from nucleus
GO:0090305 nucleic acid phosphodiester bond hydrolysis
GO:0090501 RNA phosphodiester bond hydrolysis
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic
GO:0098813 nuclear chromosome segregation
Molecular Function -
Cellular Component GO:0000793 condensed chromosome
GO:0000794 condensed nuclear chromosome
GO:0030684 preribosome
GO:0030687 preribosome, large subunit precursor
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolRRS1
Nameribosome biogenesis regulator homolog
Aliases KIAA0112; RRS1 ribosome biogenesis regulator homolog (S. cerevisiae); RRS1 ribosome biogenesis regulator hom ......
Chromosomal Location8q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between RRS1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolRRS1
Nameribosome biogenesis regulator homolog
Aliases KIAA0112; RRS1 ribosome biogenesis regulator homolog (S. cerevisiae); RRS1 ribosome biogenesis regulator hom ......
Chromosomal Location8q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of RRS1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.54 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolRRS1
Nameribosome biogenesis regulator homolog
Aliases KIAA0112; RRS1 ribosome biogenesis regulator homolog (S. cerevisiae); RRS1 ribosome biogenesis regulator hom ......
Chromosomal Location8q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of RRS1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.1210.635
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.1670.941
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.0920.958
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.220.534
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.140.932
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.3240.869
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.1610.656
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.2360.86
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.6120.678
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.7180.542
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.0890.527
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0010.989
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of RRS1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.703.70.27
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.703.70.314
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolRRS1
Nameribosome biogenesis regulator homolog
Aliases KIAA0112; RRS1 ribosome biogenesis regulator homolog (S. cerevisiae); RRS1 ribosome biogenesis regulator hom ......
Chromosomal Location8q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of RRS1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolRRS1
Nameribosome biogenesis regulator homolog
Aliases KIAA0112; RRS1 ribosome biogenesis regulator homolog (S. cerevisiae); RRS1 ribosome biogenesis regulator hom ......
Chromosomal Location8q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of RRS1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by RRS1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolRRS1
Nameribosome biogenesis regulator homolog
Aliases KIAA0112; RRS1 ribosome biogenesis regulator homolog (S. cerevisiae); RRS1 ribosome biogenesis regulator hom ......
Chromosomal Location8q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of RRS1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolRRS1
Nameribosome biogenesis regulator homolog
Aliases KIAA0112; RRS1 ribosome biogenesis regulator homolog (S. cerevisiae); RRS1 ribosome biogenesis regulator hom ......
Chromosomal Location8q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of RRS1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolRRS1
Nameribosome biogenesis regulator homolog
Aliases KIAA0112; RRS1 ribosome biogenesis regulator homolog (S. cerevisiae); RRS1 ribosome biogenesis regulator hom ......
Chromosomal Location8q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between RRS1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolRRS1
Nameribosome biogenesis regulator homolog
Aliases KIAA0112; RRS1 ribosome biogenesis regulator homolog (S. cerevisiae); RRS1 ribosome biogenesis regulator hom ......
Chromosomal Location8q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting RRS1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.