Summary | |
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Symbol | S100P |
Name | S100 calcium binding protein P |
Aliases | S100 calcium-binding protein P; MIG9; migration-inducing gene 9 protein; protein S100-E; Protein S100-P |
Chromosomal Location | 4p16 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus. Cytoplasm. Cell projection, microvillus membrane. Note=Colocalizes with S100PBP in the nucleus. Colocolizes with EZR in the microvilli in a calcium-dependent manner. |
Domain |
PF01023 S-100/ICaBP type calcium binding domain |
Function |
May function as calcium sensor and contribute to cellular calcium signaling. In a calcium-dependent manner, functions by interacting with other proteins, such as EZR and PPP5C, and indirectly plays a role in physiological processes like the formation of microvilli in epithelial cells. May stimulate cell proliferation in an autocrine manner via activation of the receptor for activated glycation end products (RAGE). |
Biological Process |
GO:0001667 ameboidal-type cell migration GO:0010631 epithelial cell migration GO:0043542 endothelial cell migration GO:0090130 tissue migration GO:0090132 epithelium migration |
Molecular Function |
GO:0000287 magnesium ion binding GO:0045296 cadherin binding GO:0048306 calcium-dependent protein binding GO:0050786 RAGE receptor binding GO:0050839 cell adhesion molecule binding GO:0098631 protein binding involved in cell adhesion GO:0098632 protein binding involved in cell-cell adhesion GO:0098641 cadherin binding involved in cell-cell adhesion |
Cellular Component |
GO:0005902 microvillus GO:0005913 cell-cell adherens junction GO:0031253 cell projection membrane GO:0031528 microvillus membrane GO:0098858 actin-based cell projection |
KEGG | - |
Reactome |
R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-6798695: Neutrophil degranulation |
Summary | |
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Symbol | S100P |
Name | S100 calcium binding protein P |
Aliases | S100 calcium-binding protein P; MIG9; migration-inducing gene 9 protein; protein S100-E; Protein S100-P |
Chromosomal Location | 4p16 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between S100P and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | S100P |
Name | S100 calcium binding protein P |
Aliases | S100 calcium-binding protein P; MIG9; migration-inducing gene 9 protein; protein S100-E; Protein S100-P |
Chromosomal Location | 4p16 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of S100P in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | S100P |
Name | S100 calcium binding protein P |
Aliases | S100 calcium-binding protein P; MIG9; migration-inducing gene 9 protein; protein S100-E; Protein S100-P |
Chromosomal Location | 4p16 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of S100P in various data sets.
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Points in the above scatter plot represent the mutation difference of S100P in various data sets.
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Summary | |
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Symbol | S100P |
Name | S100 calcium binding protein P |
Aliases | S100 calcium-binding protein P; MIG9; migration-inducing gene 9 protein; protein S100-E; Protein S100-P |
Chromosomal Location | 4p16 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of S100P. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | S100P |
Name | S100 calcium binding protein P |
Aliases | S100 calcium-binding protein P; MIG9; migration-inducing gene 9 protein; protein S100-E; Protein S100-P |
Chromosomal Location | 4p16 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of S100P. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by S100P. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | S100P |
Name | S100 calcium binding protein P |
Aliases | S100 calcium-binding protein P; MIG9; migration-inducing gene 9 protein; protein S100-E; Protein S100-P |
Chromosomal Location | 4p16 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of S100P. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | S100P |
Name | S100 calcium binding protein P |
Aliases | S100 calcium-binding protein P; MIG9; migration-inducing gene 9 protein; protein S100-E; Protein S100-P |
Chromosomal Location | 4p16 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of S100P expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | S100P |
Name | S100 calcium binding protein P |
Aliases | S100 calcium-binding protein P; MIG9; migration-inducing gene 9 protein; protein S100-E; Protein S100-P |
Chromosomal Location | 4p16 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between S100P and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | S100P |
Name | S100 calcium binding protein P |
Aliases | S100 calcium-binding protein P; MIG9; migration-inducing gene 9 protein; protein S100-E; Protein S100-P |
Chromosomal Location | 4p16 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting S100P collected from DrugBank database. |
Details on drugs targeting S100P.
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