TISIDB

Summary
Symbol	SCARB1
Name	scavenger receptor class B, member 1
Aliases	SRB1; CLA-1; SR-BI; CD36L1; CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1; HDLQTL6 ......
Chromosomal Location	12q24.32
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Cell membrane Multi-pass membrane protein. Membrane, caveola Multi-pass membrane protein. Note=Predominantly localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane, called caveolae.
Domain	PF01130 CD36 family
Function	Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells (PubMed:12016218, PubMed:12519372, PubMed:21226579). Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux (PubMed:26965621). Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity (PubMed:12016218). ; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes and appears to facilitate its cell entry (PubMed:12356718, PubMed:12913001, PubMed:18000990). Binding between SCARB1 and the hepatitis C virus glycoprotein E2 is independent of the genotype of the viral isolate (PubMed:12356718). Mediates uptake of M.fortuitum, E.coli and S.aureus (PubMed:16020694).

> Gene Ontology [ TOP ]
Biological Process	GO:0001667 ameboidal-type cell migration GO:0001935 endothelial cell proliferation GO:0002237 response to molecule of bacterial origin GO:0006066 alcohol metabolic process GO:0006638 neutral lipid metabolic process GO:0006639 acylglycerol metabolic process GO:0006641 triglyceride metabolic process GO:0006702 androgen biosynthetic process GO:0006706 steroid catabolic process GO:0006707 cholesterol catabolic process GO:0006869 lipid transport GO:0006898 receptor-mediated endocytosis GO:0006909 phagocytosis GO:0006910 phagocytosis, recognition GO:0007586 digestion GO:0008037 cell recognition GO:0008202 steroid metabolic process GO:0008203 cholesterol metabolic process GO:0008209 androgen metabolic process GO:0009595 detection of biotic stimulus GO:0009894 regulation of catabolic process GO:0010594 regulation of endothelial cell migration GO:0010595 positive regulation of endothelial cell migration GO:0010631 epithelial cell migration GO:0010632 regulation of epithelial cell migration GO:0010634 positive regulation of epithelial cell migration GO:0010817 regulation of hormone levels GO:0010866 regulation of triglyceride biosynthetic process GO:0010867 positive regulation of triglyceride biosynthetic process GO:0010876 lipid localization GO:0010878 cholesterol storage GO:0010883 regulation of lipid storage GO:0010884 positive regulation of lipid storage GO:0010885 regulation of cholesterol storage GO:0010886 positive regulation of cholesterol storage GO:0010899 regulation of phosphatidylcholine catabolic process GO:0015748 organophosphate ester transport GO:0015850 organic hydroxy compound transport GO:0015914 phospholipid transport GO:0015918 sterol transport GO:0015920 lipopolysaccharide transport GO:0016042 lipid catabolic process GO:0016125 sterol metabolic process GO:0016127 sterol catabolic process GO:0019058 viral life cycle GO:0019216 regulation of lipid metabolic process GO:0019432 triglyceride biosynthetic process GO:0019915 lipid storage GO:0022600 digestive system process GO:0030100 regulation of endocytosis GO:0030260 entry into host cell GO:0030301 cholesterol transport GO:0030335 positive regulation of cell migration GO:0031663 lipopolysaccharide-mediated signaling pathway GO:0032490 detection of molecule of bacterial origin GO:0032496 response to lipopolysaccharide GO:0032497 detection of lipopolysaccharide GO:0032768 regulation of monooxygenase activity GO:0032770 positive regulation of monooxygenase activity GO:0033344 cholesterol efflux GO:0034367 macromolecular complex remodeling GO:0034368 protein-lipid complex remodeling GO:0034369 plasma lipoprotein particle remodeling GO:0034375 high-density lipoprotein particle remodeling GO:0034381 plasma lipoprotein particle clearance GO:0034383 low-density lipoprotein particle clearance GO:0034384 high-density lipoprotein particle clearance GO:0034638 phosphatidylcholine catabolic process GO:0034754 cellular hormone metabolic process GO:0035376 sterol import GO:0035461 vitamin transmembrane transport GO:0040017 positive regulation of locomotion GO:0042157 lipoprotein metabolic process GO:0042445 hormone metabolic process GO:0042446 hormone biosynthetic process GO:0042632 cholesterol homeostasis GO:0043277 apoptotic cell clearance GO:0043534 blood vessel endothelial cell migration GO:0043542 endothelial cell migration GO:0043654 recognition of apoptotic cell GO:0043691 reverse cholesterol transport GO:0044282 small molecule catabolic process GO:0044406 adhesion of symbiont to host GO:0044409 entry into host GO:0045017 glycerolipid biosynthetic process GO:0045834 positive regulation of lipid metabolic process GO:0046164 alcohol catabolic process GO:0046460 neutral lipid biosynthetic process GO:0046463 acylglycerol biosynthetic process GO:0046470 phosphatidylcholine metabolic process GO:0046486 glycerolipid metabolic process GO:0046718 viral entry into host cell GO:0046889 positive regulation of lipid biosynthetic process GO:0046890 regulation of lipid biosynthetic process GO:0050673 epithelial cell proliferation GO:0050764 regulation of phagocytosis GO:0050892 intestinal absorption GO:0050999 regulation of nitric-oxide synthase activity GO:0051000 positive regulation of nitric-oxide synthase activity GO:0051180 vitamin transport GO:0051235 maintenance of location GO:0051272 positive regulation of cellular component movement GO:0051341 regulation of oxidoreductase activity GO:0051353 positive regulation of oxidoreductase activity GO:0051701 interaction with host GO:0051806 entry into cell of other organism involved in symbiotic interaction GO:0051828 entry into other organism involved in symbiotic interaction GO:0055088 lipid homeostasis GO:0055090 acylglycerol homeostasis GO:0055092 sterol homeostasis GO:0060627 regulation of vesicle-mediated transport GO:0070328 triglyceride homeostasis GO:0070508 cholesterol import GO:0071216 cellular response to biotic stimulus GO:0071219 cellular response to molecule of bacterial origin GO:0071222 cellular response to lipopolysaccharide GO:0071396 cellular response to lipid GO:0071825 protein-lipid complex subunit organization GO:0071827 plasma lipoprotein particle organization GO:0090130 tissue migration GO:0090132 epithelium migration GO:0090207 regulation of triglyceride metabolic process GO:0090208 positive regulation of triglyceride metabolic process GO:0097006 regulation of plasma lipoprotein particle levels GO:0097164 ammonium ion metabolic process GO:0098581 detection of external biotic stimulus GO:1901264 carbohydrate derivative transport GO:1901361 organic cyclic compound catabolic process GO:1901615 organic hydroxy compound metabolic process GO:1901616 organic hydroxy compound catabolic process GO:1902652 secondary alcohol metabolic process GO:2000147 positive regulation of cell motility
Molecular Function	GO:0001530 lipopolysaccharide binding GO:0001618 virus receptor activity GO:0001786 phosphatidylserine binding GO:0001875 lipopolysaccharide receptor activity GO:0005543 phospholipid binding GO:0005545 1-phosphatidylinositol binding GO:0008035 high-density lipoprotein particle binding GO:0008329 signaling pattern recognition receptor activity GO:0030169 low-density lipoprotein particle binding GO:0030228 lipoprotein particle receptor activity GO:0034185 apolipoprotein binding GO:0034186 apolipoprotein A-I binding GO:0035091 phosphatidylinositol binding GO:0038024 cargo receptor activity GO:0038187 pattern recognition receptor activity GO:0070506 high-density lipoprotein particle receptor activity GO:0071813 lipoprotein particle binding GO:0071814 protein-lipid complex binding GO:0072341 modified amino acid binding
Cellular Component	GO:0005765 lysosomal membrane GO:0005901 caveola GO:0005902 microvillus GO:0030139 endocytic vesicle GO:0030659 cytoplasmic vesicle membrane GO:0030666 endocytic vesicle membrane GO:0031253 cell projection membrane GO:0031528 microvillus membrane GO:0044853 plasma membrane raft GO:0045121 membrane raft GO:0098589 membrane region GO:0098852 lytic vacuole membrane GO:0098857 membrane microdomain GO:0098858 actin-based cell projection

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04145 Phagosome hsa04913 Ovarian steroidogenesis hsa04975 Fat digestion and absorption hsa04976 Bile secretion hsa04977 Vitamin digestion and absorption
Reactome	R-HSA-2173782: Binding and Uptake of Ligands by Scavenger Receptors R-HSA-194223: HDL-mediated lipid transport R-HSA-73923: Lipid digestion, mobilization, and transport R-HSA-174824: Lipoprotein metabolism R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins R-HSA-3000471: Scavenging by Class B Receptors R-HSA-5653656: Vesicle-mediated transport

Summary
Symbol	SCARB1
Name	scavenger receptor class B, member 1
Aliases	SRB1; CLA-1; SR-BI; CD36L1; CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1; HDLQTL6 ......
Chromosomal Location	12q24.32
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between SCARB1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining

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Literatures describing the relation between SCARB1 and anti-tumor immunity in human cancer.

PMID	Cancer type	Relation to immunity	Evidence sentences
28504304	Lung Carcinoma	Inhibit immunity (T cell function); essential for immunotherapy	We focus on the regulation of the anti-tumor immune response by two paradigmatic SRs: the lymphocyte receptor CD5 and the more broadly distributed scavenger receptor class B type 1 (SR-B1). Cancer immunity can be boosted by blockade of SRs working as immune checkpoint inhibitors (CD5) and/or by proper engagement of SRs working as innate danger receptor (SR-B1).

Summary
Symbol	SCARB1
Name	scavenger receptor class B, member 1
Aliases	SRB1; CLA-1; SR-BI; CD36L1; CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1; HDLQTL6 ......
Chromosomal Location	12q24.32
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of SCARB1 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	SCARB1
Name	scavenger receptor class B, member 1
Aliases	SRB1; CLA-1; SR-BI; CD36L1; CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1; HDLQTL6 ......
Chromosomal Location	12q24.32
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of SCARB1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-0.054	0.92
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	0.272	0.913
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.301	0.88
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-0.525	0.251
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-0.178	0.936
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	-0.97	0.715
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	-0.243	0.562
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	0.353	0.847
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-0.976	0.646
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	1.272	0.537
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	1.865	0.546
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	0.223	0.0495

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of SCARB1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	3.7	1.4	2.3	0.469
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	3.7	1.7	2	0.532
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	0	0	0	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	11.1	12.5	-1.4	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	11.1	-11.1	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	25	14.3	10.7	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	0	0	0	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	SCARB1
Name	scavenger receptor class B, member 1
Aliases	SRB1; CLA-1; SR-BI; CD36L1; CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1; HDLQTL6 ......
Chromosomal Location	12q24.32
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SCARB1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	SCARB1
Name	scavenger receptor class B, member 1
Aliases	SRB1; CLA-1; SR-BI; CD36L1; CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1; HDLQTL6 ......
Chromosomal Location	12q24.32
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SCARB1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SCARB1. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	SCARB1
Name	scavenger receptor class B, member 1
Aliases	SRB1; CLA-1; SR-BI; CD36L1; CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1; HDLQTL6 ......
Chromosomal Location	12q24.32
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SCARB1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	SCARB1
Name	scavenger receptor class B, member 1
Aliases	SRB1; CLA-1; SR-BI; CD36L1; CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1; HDLQTL6 ......
Chromosomal Location	12q24.32
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of SCARB1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	SCARB1
Name	scavenger receptor class B, member 1
Aliases	SRB1; CLA-1; SR-BI; CD36L1; CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1; HDLQTL6 ......
Chromosomal Location	12q24.32
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between SCARB1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	SCARB1
Name	scavenger receptor class B, member 1
Aliases	SRB1; CLA-1; SR-BI; CD36L1; CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1; HDLQTL6 ......
Chromosomal Location	12q24.32
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting SCARB1 collected from DrugBank database.

> Drugs from DrugBank database

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Details on drugs targeting SCARB1.

ID	Name	Drug Type	Targets	#Targets
DB00144	Phosphatidyl serine	Small Molecule	ATP8A1, DGKD, DGKG, PISD, PRKCA, PTDSS1, PTDSS2, SCARB1, SMPD3, SM ......	10

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