Browse SCGB1A1

Summary
SymbolSCGB1A1
Namesecretoglobin, family 1A, member 1 (uteroglobin)
Aliases CC10; CCSP; CC16; Uteroglobin (Clara-cell specific 10-kD protein); UGB; uteroglobin; CCPBP; UP-1; UP1; blast ......
Chromosomal Location11q12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Secreted.
Domain PF01099 Uteroglobin family
Function

Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2.

> Gene Ontology
 
Biological Process GO:0000302 response to reactive oxygen species
GO:0001101 response to acid chemical
GO:0001818 negative regulation of cytokine production
GO:0002237 response to molecule of bacterial origin
GO:0002683 negative regulation of immune system process
GO:0002694 regulation of leukocyte activation
GO:0002695 negative regulation of leukocyte activation
GO:0006979 response to oxidative stress
GO:0007159 leukocyte cell-cell adhesion
GO:0007162 negative regulation of cell adhesion
GO:0007565 female pregnancy
GO:0007566 embryo implantation
GO:0009410 response to xenobiotic stimulus
GO:0010035 response to inorganic substance
GO:0010193 response to ozone
GO:0010608 posttranscriptional regulation of gene expression
GO:0022407 regulation of cell-cell adhesion
GO:0022408 negative regulation of cell-cell adhesion
GO:0031960 response to corticosteroid
GO:0032496 response to lipopolysaccharide
GO:0032609 interferon-gamma production
GO:0032616 interleukin-13 production
GO:0032633 interleukin-4 production
GO:0032634 interleukin-5 production
GO:0032649 regulation of interferon-gamma production
GO:0032656 regulation of interleukin-13 production
GO:0032673 regulation of interleukin-4 production
GO:0032674 regulation of interleukin-5 production
GO:0032689 negative regulation of interferon-gamma production
GO:0032696 negative regulation of interleukin-13 production
GO:0032713 negative regulation of interleukin-4 production
GO:0032714 negative regulation of interleukin-5 production
GO:0032943 mononuclear cell proliferation
GO:0032944 regulation of mononuclear cell proliferation
GO:0032945 negative regulation of mononuclear cell proliferation
GO:0034021 response to silicon dioxide
GO:0042098 T cell proliferation
GO:0042110 T cell activation
GO:0042129 regulation of T cell proliferation
GO:0042130 negative regulation of T cell proliferation
GO:0042493 response to drug
GO:0043487 regulation of RNA stability
GO:0043488 regulation of mRNA stability
GO:0044706 multi-multicellular organism process
GO:0046651 lymphocyte proliferation
GO:0048545 response to steroid hormone
GO:0050670 regulation of lymphocyte proliferation
GO:0050672 negative regulation of lymphocyte proliferation
GO:0050727 regulation of inflammatory response
GO:0050863 regulation of T cell activation
GO:0050865 regulation of cell activation
GO:0050866 negative regulation of cell activation
GO:0050868 negative regulation of T cell activation
GO:0051249 regulation of lymphocyte activation
GO:0051250 negative regulation of lymphocyte activation
GO:0051384 response to glucocorticoid
GO:0070486 leukocyte aggregation
GO:0070489 T cell aggregation
GO:0070661 leukocyte proliferation
GO:0070663 regulation of leukocyte proliferation
GO:0070664 negative regulation of leukocyte proliferation
GO:0071593 lymphocyte aggregation
GO:0071774 response to fibroblast growth factor
GO:1903037 regulation of leukocyte cell-cell adhesion
GO:1903038 negative regulation of leukocyte cell-cell adhesion
Molecular Function GO:0004857 enzyme inhibitor activity
GO:0004859 phospholipase inhibitor activity
GO:0019834 phospholipase A2 inhibitor activity
GO:0055102 lipase inhibitor activity
GO:0097160 polychlorinated biphenyl binding
Cellular Component GO:0005635 nuclear envelope
GO:0005791 rough endoplasmic reticulum
GO:0030141 secretory granule
GO:0099503 secretory vesicle
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolSCGB1A1
Namesecretoglobin, family 1A, member 1 (uteroglobin)
Aliases CC10; CCSP; CC16; Uteroglobin (Clara-cell specific 10-kD protein); UGB; uteroglobin; CCPBP; UP-1; UP1; blast ......
Chromosomal Location11q12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between SCGB1A1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolSCGB1A1
Namesecretoglobin, family 1A, member 1 (uteroglobin)
Aliases CC10; CCSP; CC16; Uteroglobin (Clara-cell specific 10-kD protein); UGB; uteroglobin; CCPBP; UP-1; UP1; blast ......
Chromosomal Location11q12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of SCGB1A1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolSCGB1A1
Namesecretoglobin, family 1A, member 1 (uteroglobin)
Aliases CC10; CCSP; CC16; Uteroglobin (Clara-cell specific 10-kD protein); UGB; uteroglobin; CCPBP; UP-1; UP1; blast ......
Chromosomal Location11q12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of SCGB1A1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.9340.166
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-1.8560.0976
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.2740.767
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9161.6320.111
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 592.0720.151
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 471.0690.524
729033130MelanomaallAnti-PD-1 (nivolumab) 262301
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 151101
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 111201
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 4801
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 2801
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.8180.04
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of SCGB1A1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolSCGB1A1
Namesecretoglobin, family 1A, member 1 (uteroglobin)
Aliases CC10; CCSP; CC16; Uteroglobin (Clara-cell specific 10-kD protein); UGB; uteroglobin; CCPBP; UP-1; UP1; blast ......
Chromosomal Location11q12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SCGB1A1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolSCGB1A1
Namesecretoglobin, family 1A, member 1 (uteroglobin)
Aliases CC10; CCSP; CC16; Uteroglobin (Clara-cell specific 10-kD protein); UGB; uteroglobin; CCPBP; UP-1; UP1; blast ......
Chromosomal Location11q12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SCGB1A1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SCGB1A1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolSCGB1A1
Namesecretoglobin, family 1A, member 1 (uteroglobin)
Aliases CC10; CCSP; CC16; Uteroglobin (Clara-cell specific 10-kD protein); UGB; uteroglobin; CCPBP; UP-1; UP1; blast ......
Chromosomal Location11q12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SCGB1A1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolSCGB1A1
Namesecretoglobin, family 1A, member 1 (uteroglobin)
Aliases CC10; CCSP; CC16; Uteroglobin (Clara-cell specific 10-kD protein); UGB; uteroglobin; CCPBP; UP-1; UP1; blast ......
Chromosomal Location11q12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of SCGB1A1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolSCGB1A1
Namesecretoglobin, family 1A, member 1 (uteroglobin)
Aliases CC10; CCSP; CC16; Uteroglobin (Clara-cell specific 10-kD protein); UGB; uteroglobin; CCPBP; UP-1; UP1; blast ......
Chromosomal Location11q12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between SCGB1A1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolSCGB1A1
Namesecretoglobin, family 1A, member 1 (uteroglobin)
Aliases CC10; CCSP; CC16; Uteroglobin (Clara-cell specific 10-kD protein); UGB; uteroglobin; CCPBP; UP-1; UP1; blast ......
Chromosomal Location11q12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting SCGB1A1 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting SCGB1A1.
ID Name Drug Type Targets #Targets
DB083734,4'-BIS([H]METHYLSULFONYL)-2,2',5,5'-TETRACHLOROBIPHENYLSmall MoleculeSCGB1A11