Browse SCN5A

Summary
SymbolSCN5A
Namesodium channel, voltage gated, type V alpha subunit
Aliases Nav1.5; LQT3; HBBD; PFHB1; IVF; CDCD2; ICCD; long QT syndrome 3; CMD1E; sodium channel, voltage-gated, type ......
Chromosomal Location3p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane Multi-pass membrane protein Cytoplasm, perinuclear region Note=RANGRF promotes trafficking to the cell membrane.
Domain PF00520 Ion transport protein
PF06512 Sodium ion transport-associated
PF11933 Cytoplasmic domain of voltage-gated Na+ ion channel
Function

This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (PubMed:1309946, PubMed:21447824, PubMed:25370050, PubMed:23420830, PubMed:23085483, PubMed:26279430, PubMed:26392562, PubMed:26776555). It is a tetrodotoxin-resistant Na(+) channel isoform (PubMed:1309946). This channel is responsible for the initial upstroke of the action potential. Channel inactivation is regulated by intracellular calcium levels (PubMed:19074138).

> Gene Ontology
 
Biological Process GO:0001508 action potential
GO:0002027 regulation of heart rate
GO:0002028 regulation of sodium ion transport
GO:0003012 muscle system process
GO:0003013 circulatory system process
GO:0003015 heart process
GO:0003205 cardiac chamber development
GO:0003231 cardiac ventricle development
GO:0003254 regulation of membrane depolarization
GO:0003360 brainstem development
GO:0006814 sodium ion transport
GO:0006936 muscle contraction
GO:0006937 regulation of muscle contraction
GO:0006941 striated muscle contraction
GO:0006942 regulation of striated muscle contraction
GO:0007507 heart development
GO:0008015 blood circulation
GO:0008016 regulation of heart contraction
GO:0010035 response to inorganic substance
GO:0010038 response to metal ion
GO:0010765 positive regulation of sodium ion transport
GO:0010959 regulation of metal ion transport
GO:0014854 response to inactivity
GO:0014870 response to muscle inactivity
GO:0014874 response to stimulus involved in regulation of muscle adaptation
GO:0014877 response to muscle inactivity involved in regulation of muscle adaptation
GO:0014894 response to denervation involved in regulation of muscle adaptation
GO:0015672 monovalent inorganic cation transport
GO:0019226 transmission of nerve impulse
GO:0019228 neuronal action potential
GO:0021537 telencephalon development
GO:0021549 cerebellum development
GO:0022037 metencephalon development
GO:0030048 actin filament-based movement
GO:0030900 forebrain development
GO:0030902 hindbrain development
GO:0032844 regulation of homeostatic process
GO:0032970 regulation of actin filament-based process
GO:0034762 regulation of transmembrane transport
GO:0034765 regulation of ion transmembrane transport
GO:0035637 multicellular organismal signaling
GO:0035725 sodium ion transmembrane transport
GO:0042391 regulation of membrane potential
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042476 odontogenesis
GO:0043270 positive regulation of ion transport
GO:0043502 regulation of muscle adaptation
GO:0044057 regulation of system process
GO:0045760 positive regulation of action potential
GO:0050673 epithelial cell proliferation
GO:0050678 regulation of epithelial cell proliferation
GO:0050679 positive regulation of epithelial cell proliferation
GO:0051592 response to calcium ion
GO:0051899 membrane depolarization
GO:0055117 regulation of cardiac muscle contraction
GO:0060047 heart contraction
GO:0060048 cardiac muscle contraction
GO:0060078 regulation of postsynaptic membrane potential
GO:0060306 regulation of membrane repolarization
GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization
GO:0060371 regulation of atrial cardiac muscle cell membrane depolarization
GO:0060372 regulation of atrial cardiac muscle cell membrane repolarization
GO:0060373 regulation of ventricular cardiac muscle cell membrane depolarization
GO:0061337 cardiac conduction
GO:0070252 actin-mediated cell contraction
GO:0071241 cellular response to inorganic substance
GO:0071248 cellular response to metal ion
GO:0071277 cellular response to calcium ion
GO:0086001 cardiac muscle cell action potential
GO:0086002 cardiac muscle cell action potential involved in contraction
GO:0086003 cardiac muscle cell contraction
GO:0086004 regulation of cardiac muscle cell contraction
GO:0086005 ventricular cardiac muscle cell action potential
GO:0086009 membrane repolarization
GO:0086010 membrane depolarization during action potential
GO:0086012 membrane depolarization during cardiac muscle cell action potential
GO:0086015 SA node cell action potential
GO:0086016 AV node cell action potential
GO:0086017 Purkinje myocyte action potential
GO:0086018 SA node cell to atrial cardiac muscle cell signalling
GO:0086019 cell-cell signaling involved in cardiac conduction
GO:0086027 AV node cell to bundle of His cell signaling
GO:0086028 bundle of His cell to Purkinje myocyte signaling
GO:0086029 Purkinje myocyte to ventricular cardiac muscle cell signaling
GO:0086043 bundle of His cell action potential
GO:0086045 membrane depolarization during AV node cell action potential
GO:0086046 membrane depolarization during SA node cell action potential
GO:0086047 membrane depolarization during Purkinje myocyte cell action potential
GO:0086048 membrane depolarization during bundle of His cell action potential
GO:0086065 cell communication involved in cardiac conduction
GO:0086067 AV node cell to bundle of His cell communication
GO:0086068 Purkinje myocyte to ventricular cardiac muscle cell communication
GO:0086069 bundle of His cell to Purkinje myocyte communication
GO:0086070 SA node cell to atrial cardiac muscle cell communication
GO:0086091 regulation of heart rate by cardiac conduction
GO:0090257 regulation of muscle system process
GO:0098900 regulation of action potential
GO:0099622 cardiac muscle cell membrane repolarization
GO:0099623 regulation of cardiac muscle cell membrane repolarization
GO:0099624 atrial cardiac muscle cell membrane repolarization
GO:0099625 ventricular cardiac muscle cell membrane repolarization
GO:1902305 regulation of sodium ion transmembrane transport
GO:1903115 regulation of actin filament-based movement
GO:1903522 regulation of blood circulation
GO:1904062 regulation of cation transmembrane transport
GO:2000021 regulation of ion homeostasis
Molecular Function GO:0005216 ion channel activity
GO:0005244 voltage-gated ion channel activity
GO:0005248 voltage-gated sodium channel activity
GO:0005261 cation channel activity
GO:0005272 sodium channel activity
GO:0005516 calmodulin binding
GO:0015077 monovalent inorganic cation transmembrane transporter activity
GO:0015081 sodium ion transmembrane transporter activity
GO:0015267 channel activity
GO:0017134 fibroblast growth factor binding
GO:0019838 growth factor binding
GO:0022803 passive transmembrane transporter activity
GO:0022832 voltage-gated channel activity
GO:0022836 gated channel activity
GO:0022838 substrate-specific channel activity
GO:0030506 ankyrin binding
GO:0031625 ubiquitin protein ligase binding
GO:0044325 ion channel binding
GO:0044389 ubiquitin-like protein ligase binding
GO:0046873 metal ion transmembrane transporter activity
GO:0050998 nitric-oxide synthase binding
GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential
GO:0086060 voltage-gated sodium channel activity involved in AV node cell action potential
GO:0086061 voltage-gated sodium channel activity involved in bundle of His cell action potential
GO:0086062 voltage-gated sodium channel activity involved in Purkinje myocyte action potential
GO:0086063 voltage-gated sodium channel activity involved in SA node cell action potential
GO:0097110 scaffold protein binding
GO:1905030 voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential
Cellular Component GO:0001518 voltage-gated sodium channel complex
GO:0005901 caveola
GO:0014704 intercalated disc
GO:0016328 lateral plasma membrane
GO:0030016 myofibril
GO:0030017 sarcomere
GO:0030018 Z disc
GO:0030315 T-tubule
GO:0031674 I band
GO:0034702 ion channel complex
GO:0034703 cation channel complex
GO:0034706 sodium channel complex
GO:0042383 sarcolemma
GO:0043292 contractile fiber
GO:0044291 cell-cell contact zone
GO:0044449 contractile fiber part
GO:0044853 plasma membrane raft
GO:0045121 membrane raft
GO:0098589 membrane region
GO:0098857 membrane microdomain
GO:1902495 transmembrane transporter complex
GO:1990351 transporter complex
> KEGG and Reactome Pathway
 
KEGG hsa04261 Adrenergic signaling in cardiomyocytes
Reactome R-HSA-422475: Axon guidance
R-HSA-5576891: Cardiac conduction
R-HSA-1266738: Developmental Biology
R-HSA-445095: Interaction between L1 and Ankyrins
R-HSA-373760: L1CAM interactions
R-HSA-397014: Muscle contraction
R-HSA-5576892: Phase 0 - rapid depolarisation
Summary
SymbolSCN5A
Namesodium channel, voltage gated, type V alpha subunit
Aliases Nav1.5; LQT3; HBBD; PFHB1; IVF; CDCD2; ICCD; long QT syndrome 3; CMD1E; sodium channel, voltage-gated, type ......
Chromosomal Location3p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between SCN5A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolSCN5A
Namesodium channel, voltage gated, type V alpha subunit
Aliases Nav1.5; LQT3; HBBD; PFHB1; IVF; CDCD2; ICCD; long QT syndrome 3; CMD1E; sodium channel, voltage-gated, type ......
Chromosomal Location3p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of SCN5A in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolSCN5A
Namesodium channel, voltage gated, type V alpha subunit
Aliases Nav1.5; LQT3; HBBD; PFHB1; IVF; CDCD2; ICCD; long QT syndrome 3; CMD1E; sodium channel, voltage-gated, type ......
Chromosomal Location3p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of SCN5A in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)141201
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)6501
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)8701
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.2730.521
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.320.842
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-1.030.57
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.0830.913
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.110.929
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.5560.718
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.10.799
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.10.869
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.1970.48
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of SCN5A in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277329.68.221.40.0187
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 01407.1-7.11
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275929.68.521.10.0202
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211742.95.9370.0124
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)86250250.473
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131153.89.144.70.0335
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91633.3033.30.0365
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59400400.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 382713.214.8-1.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22139.115.4-6.30.618
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 161418.814.34.51
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolSCN5A
Namesodium channel, voltage gated, type V alpha subunit
Aliases Nav1.5; LQT3; HBBD; PFHB1; IVF; CDCD2; ICCD; long QT syndrome 3; CMD1E; sodium channel, voltage-gated, type ......
Chromosomal Location3p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SCN5A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolSCN5A
Namesodium channel, voltage gated, type V alpha subunit
Aliases Nav1.5; LQT3; HBBD; PFHB1; IVF; CDCD2; ICCD; long QT syndrome 3; CMD1E; sodium channel, voltage-gated, type ......
Chromosomal Location3p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SCN5A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SCN5A.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolSCN5A
Namesodium channel, voltage gated, type V alpha subunit
Aliases Nav1.5; LQT3; HBBD; PFHB1; IVF; CDCD2; ICCD; long QT syndrome 3; CMD1E; sodium channel, voltage-gated, type ......
Chromosomal Location3p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SCN5A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolSCN5A
Namesodium channel, voltage gated, type V alpha subunit
Aliases Nav1.5; LQT3; HBBD; PFHB1; IVF; CDCD2; ICCD; long QT syndrome 3; CMD1E; sodium channel, voltage-gated, type ......
Chromosomal Location3p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of SCN5A expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolSCN5A
Namesodium channel, voltage gated, type V alpha subunit
Aliases Nav1.5; LQT3; HBBD; PFHB1; IVF; CDCD2; ICCD; long QT syndrome 3; CMD1E; sodium channel, voltage-gated, type ......
Chromosomal Location3p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between SCN5A and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolSCN5A
Namesodium channel, voltage gated, type V alpha subunit
Aliases Nav1.5; LQT3; HBBD; PFHB1; IVF; CDCD2; ICCD; long QT syndrome 3; CMD1E; sodium channel, voltage-gated, type ......
Chromosomal Location3p21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting SCN5A collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting SCN5A.
ID Name Drug Type Targets #Targets
DB00192IndecainideSmall MoleculeSCN5A1
DB00243RanolazineSmall MoleculeSCN5A, SCN9A2
DB00252PhenytoinSmall MoleculeNR1I2, SCN1A, SCN1B, SCN3A, SCN5A5
DB00280DisopyramideSmall MoleculeCHRM1, CHRM2, CHRM3, KCND2, KCND3, KCNH2, ORM2, SCN5A8
DB00281LidocaineSmall MoleculeEGFR, ORM1, ORM2, SCN10A, SCN4A, SCN5A, SCN9A7
DB00313Valproic AcidSmall MoleculeABAT, ACADSB, ALDH5A1, HDAC2, HDAC9, OGDH, PPARA, PPARD, PPARG, SC ......23
DB00379MexiletineSmall MoleculeAHR, SCN5A2
DB00473HexylcaineSmall MoleculeSCN10A, SCN5A2
DB00527CinchocaineSmall MoleculeSCN10A, SCN5A2
DB00532MephenytoinSmall MoleculeNR1I2, SCN5A2
DB00564CarbamazepineSmall MoleculeCHRNA4, CHRNB2, NR1I2, SCN5A4
DB00661VerapamilSmall MoleculeADRA1A, ADRA1B, ADRA1D, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1 ......19
DB00680MoricizineSmall MoleculeSCN5A1
DB00740RiluzoleSmall MoleculeSCN5A, SLC7A112
DB00750PrilocaineSmall MoleculeSCN5A1
DB00754EthotoinSmall MoleculeNR1I2, SCN5A2
DB00776OxcarbazepineSmall MoleculeSCN5A1
DB00868BenzonatateSmall MoleculeSCN5A1
DB00907CocaineSmall MoleculeCES1, CHRM1, CHRM2, SCN10A, SCN11A, SCN5A, SIGMAR1, SLC6A2, SLC6A3 ......10
DB00908QuinidineSmall MoleculeADRA1A, ADRA1B, ADRA1D, KCNH2, KCNK1, KCNK6, SCN5A7
DB00909ZonisamideSmall MoleculeCA1, CA10, CA11, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, ......31
DB01035ProcainamideSmall MoleculeDNMT1, KCNH2, SCN5A3
DB01056TocainideSmall MoleculeSCN5A1
DB01182PropafenoneSmall MoleculeADRB1, ADRB2, KCNH2, SCN5A4
DB01195FlecainideSmall MoleculeKCNH2, SCN4A, SCN5A3
DB01228EncainideSmall MoleculeSCN5A1
DB01320FosphenytoinSmall MoleculeSCN5A1
DB01346Quinidine barbiturateSmall MoleculeGABRA1, GABRA2, GRIA2, KCNK1, SCN5A5
DB01426AjmalineSmall MoleculeSCN5A1
DB01429AprindineSmall MoleculeSCN5A1
DB05541BrivaracetamSmall MoleculeSCN10A, SCN11A, SCN1A, SCN1B, SCN2A, SCN2B, SCN3A, SCN3B, SCN4A, S ......15
DB06217VernakalantSmall MoleculeKCNA5, KCND3, KCNH2, SCN5A4
DB11633IsavuconazoleSmall MoleculeCACNA1C, KCNA5, KCND3, KCNH2, KCNJ11, KCNJ6, KCNJ9, KCNQ1, SCN5A9