TISIDB

Summary
Symbol	SERPINH1
Name	serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
Aliases	HSP47; colligen; CBP2; SERPINH2; serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), ......
Chromosomal Location	11q13.5
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Endoplasmic reticulum lumen.
Domain	PF00079 Serpin (serine protease inhibitor)
Function	Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen.

> Gene Ontology [ TOP ]
Biological Process	GO:0001501 skeletal system development GO:0002062 chondrocyte differentiation GO:0002063 chondrocyte development GO:0003413 chondrocyte differentiation involved in endochondral bone morphogenesis GO:0003433 chondrocyte development involved in endochondral bone morphogenesis GO:0006986 response to unfolded protein GO:0010466 negative regulation of peptidase activity GO:0010951 negative regulation of endopeptidase activity GO:0030198 extracellular matrix organization GO:0030199 collagen fibril organization GO:0032963 collagen metabolic process GO:0032964 collagen biosynthetic process GO:0035966 response to topologically incorrect protein GO:0043062 extracellular structure organization GO:0044236 multicellular organism metabolic process GO:0044259 multicellular organismal macromolecule metabolic process GO:0045861 negative regulation of proteolysis GO:0048705 skeletal system morphogenesis GO:0051216 cartilage development GO:0051346 negative regulation of hydrolase activity GO:0051604 protein maturation GO:0052547 regulation of peptidase activity GO:0052548 regulation of endopeptidase activity GO:0060348 bone development GO:0060349 bone morphogenesis GO:0060350 endochondral bone morphogenesis GO:0060351 cartilage development involved in endochondral bone morphogenesis GO:0061448 connective tissue development
Molecular Function	GO:0004857 enzyme inhibitor activity GO:0004866 endopeptidase inhibitor activity GO:0004867 serine-type endopeptidase inhibitor activity GO:0005518 collagen binding GO:0030414 peptidase inhibitor activity GO:0051082 unfolded protein binding GO:0061134 peptidase regulator activity GO:0061135 endopeptidase regulator activity
Cellular Component	GO:0005788 endoplasmic reticulum lumen GO:0005793 endoplasmic reticulum-Golgi intermediate compartment GO:0045121 membrane raft GO:0098589 membrane region GO:0098857 membrane microdomain

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-3371568: Attenuation phase R-HSA-3371556: Cellular response to heat stress R-HSA-2262752: Cellular responses to stress R-HSA-1650814: Collagen biosynthesis and modifying enzymes R-HSA-1474290: Collagen formation R-HSA-1474244: Extracellular matrix organization R-HSA-3371511: HSF1 activation R-HSA-3371571: HSF1-dependent transactivation R-HSA-3371453: Regulation of HSF1-mediated heat shock response

> KEGG and Reactome Pathway

[ TOP ]

KEGG

Reactome

R-HSA-3371568: Attenuation phase
R-HSA-3371556: Cellular response to heat stress
R-HSA-2262752: Cellular responses to stress
R-HSA-1650814: Collagen biosynthesis and modifying enzymes
R-HSA-1474290: Collagen formation
R-HSA-1474244: Extracellular matrix organization
R-HSA-3371511: HSF1 activation
R-HSA-3371571: HSF1-dependent transactivation
R-HSA-3371453: Regulation of HSF1-mediated heat shock response

Summary
Symbol	SERPINH1
Name	serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
Aliases	HSP47; colligen; CBP2; SERPINH2; serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), ......
Chromosomal Location	11q13.5
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between SERPINH1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	SERPINH1
Name	serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
Aliases	HSP47; colligen; CBP2; SERPINH2; serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), ......
Chromosomal Location	11q13.5
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of SERPINH1 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	SERPINH1
Name	serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
Aliases	HSP47; colligen; CBP2; SERPINH2; serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), ......
Chromosomal Location	11q13.5
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the expression difference of SERPINH1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-1.037	0.0145
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-1.85	0.583
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.453	0.863
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-0.208	0.62
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-0.312	0.891
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	-0.071	0.981
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	-0.248	0.668
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-0.51	0.812
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0.072	0.975
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	1.222	0.598
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	1.945	0.587
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.243	0.0316

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of SERPINH1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	0	0	1
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	0	0	1
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	5.9	-5.9	0.447
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	9.1	-9.1	0.458
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	0	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	0	0	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	1

Summary
Symbol	SERPINH1
Name	serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
Aliases	HSP47; colligen; CBP2; SERPINH2; serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), ......
Chromosomal Location	11q13.5
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SERPINH1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	SERPINH1
Name	serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
Aliases	HSP47; colligen; CBP2; SERPINH2; serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), ......
Chromosomal Location	11q13.5
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SERPINH1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SERPINH1. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	SERPINH1
Name	serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
Aliases	HSP47; colligen; CBP2; SERPINH2; serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), ......
Chromosomal Location	11q13.5
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SERPINH1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	SERPINH1
Name	serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
Aliases	HSP47; colligen; CBP2; SERPINH2; serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), ......
Chromosomal Location	11q13.5
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of SERPINH1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	SERPINH1
Name	serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
Aliases	HSP47; colligen; CBP2; SERPINH2; serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), ......
Chromosomal Location	11q13.5
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between SERPINH1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	SERPINH1
Name	serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
Aliases	HSP47; colligen; CBP2; SERPINH2; serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), ......
Chromosomal Location	11q13.5
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting SERPINH1 collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

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