Browse SFRP2

Summary
SymbolSFRP2
Namesecreted frizzled-related protein 2
Aliases SARP1; SDF-5; SARP-1; sFRP-2; secreted apoptosis related protein 1; secreted apoptosis-related protein 1
Chromosomal Location4q31.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Secreted
Domain PF01392 Fz domain
PF01759 UNC-6/NTR/C345C module
Function

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis.

> Gene Ontology
 
Biological Process GO:0001501 skeletal system development
GO:0001503 ossification
GO:0001525 angiogenesis
GO:0001558 regulation of cell growth
GO:0001569 patterning of blood vessels
GO:0001649 osteoblast differentiation
GO:0001704 formation of primary germ layer
GO:0001707 mesoderm formation
GO:0001708 cell fate specification
GO:0001710 mesodermal cell fate commitment
GO:0001736 establishment of planar polarity
GO:0001738 morphogenesis of a polarized epithelium
GO:0001756 somitogenesis
GO:0001763 morphogenesis of a branching structure
GO:0001837 epithelial to mesenchymal transition
GO:0001838 embryonic epithelial tube formation
GO:0001841 neural tube formation
GO:0001843 neural tube closure
GO:0001933 negative regulation of protein phosphorylation
GO:0002062 chondrocyte differentiation
GO:0002063 chondrocyte development
GO:0003002 regionalization
GO:0003007 heart morphogenesis
GO:0003151 outflow tract morphogenesis
GO:0003205 cardiac chamber development
GO:0003206 cardiac chamber morphogenesis
GO:0003208 cardiac ventricle morphogenesis
GO:0003214 cardiac left ventricle morphogenesis
GO:0003231 cardiac ventricle development
GO:0003401 axis elongation
GO:0003402 planar cell polarity pathway involved in axis elongation
GO:0006469 negative regulation of protein kinase activity
GO:0006606 protein import into nucleus
GO:0006913 nucleocytoplasmic transport
GO:0007164 establishment of tissue polarity
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007254 JNK cascade
GO:0007369 gastrulation
GO:0007389 pattern specification process
GO:0007498 mesoderm development
GO:0007501 mesodermal cell fate specification
GO:0007507 heart development
GO:0007548 sex differentiation
GO:0007584 response to nutrient
GO:0008406 gonad development
GO:0008584 male gonad development
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009314 response to radiation
GO:0009952 anterior/posterior pattern specification
GO:0009991 response to extracellular stimulus
GO:0009996 negative regulation of cell fate specification
GO:0010165 response to X-ray
GO:0010212 response to ionizing radiation
GO:0010453 regulation of cell fate commitment
GO:0010454 negative regulation of cell fate commitment
GO:0010466 negative regulation of peptidase activity
GO:0010470 regulation of gastrulation
GO:0010656 negative regulation of muscle cell apoptotic process
GO:0010657 muscle cell apoptotic process
GO:0010658 striated muscle cell apoptotic process
GO:0010659 cardiac muscle cell apoptotic process
GO:0010660 regulation of muscle cell apoptotic process
GO:0010662 regulation of striated muscle cell apoptotic process
GO:0010664 negative regulation of striated muscle cell apoptotic process
GO:0010665 regulation of cardiac muscle cell apoptotic process
GO:0010667 negative regulation of cardiac muscle cell apoptotic process
GO:0010717 regulation of epithelial to mesenchymal transition
GO:0010719 negative regulation of epithelial to mesenchymal transition
GO:0010950 positive regulation of endopeptidase activity
GO:0010951 negative regulation of endopeptidase activity
GO:0010952 positive regulation of peptidase activity
GO:0010975 regulation of neuron projection development
GO:0014020 primary neural tube formation
GO:0016049 cell growth
GO:0016055 Wnt signaling pathway
GO:0016331 morphogenesis of embryonic epithelium
GO:0017038 protein import
GO:0017145 stem cell division
GO:0018105 peptidyl-serine phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0018209 peptidyl-serine modification
GO:0018212 peptidyl-tyrosine modification
GO:0021915 neural tube development
GO:0021953 central nervous system neuron differentiation
GO:0030111 regulation of Wnt signaling pathway
GO:0030177 positive regulation of Wnt signaling pathway
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030198 extracellular matrix organization
GO:0030199 collagen fibril organization
GO:0030278 regulation of ossification
GO:0030307 positive regulation of cell growth
GO:0030308 negative regulation of cell growth
GO:0030326 embryonic limb morphogenesis
GO:0030336 negative regulation of cell migration
GO:0030509 BMP signaling pathway
GO:0030510 regulation of BMP signaling pathway
GO:0030514 negative regulation of BMP signaling pathway
GO:0030901 midbrain development
GO:0031098 stress-activated protein kinase signaling cascade
GO:0031667 response to nutrient levels
GO:0031668 cellular response to extracellular stimulus
GO:0032386 regulation of intracellular transport
GO:0032388 positive regulation of intracellular transport
GO:0032872 regulation of stress-activated MAPK cascade
GO:0032873 negative regulation of stress-activated MAPK cascade
GO:0033135 regulation of peptidyl-serine phosphorylation
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033157 regulation of intracellular protein transport
GO:0033627 cell adhesion mediated by integrin
GO:0033628 regulation of cell adhesion mediated by integrin
GO:0033630 positive regulation of cell adhesion mediated by integrin
GO:0033673 negative regulation of kinase activity
GO:0034504 protein localization to nucleus
GO:0035107 appendage morphogenesis
GO:0035108 limb morphogenesis
GO:0035113 embryonic appendage morphogenesis
GO:0035148 tube formation
GO:0035239 tube morphogenesis
GO:0035282 segmentation
GO:0035411 catenin import into nucleus
GO:0035412 regulation of catenin import into nucleus
GO:0035413 positive regulation of catenin import into nucleus
GO:0035567 non-canonical Wnt signaling pathway
GO:0036342 post-anal tail morphogenesis
GO:0040013 negative regulation of locomotion
GO:0042249 establishment of planar polarity of embryonic epithelium
GO:0042306 regulation of protein import into nucleus
GO:0042307 positive regulation of protein import into nucleus
GO:0042326 negative regulation of phosphorylation
GO:0042493 response to drug
GO:0042659 regulation of cell fate specification
GO:0042661 regulation of mesodermal cell fate specification
GO:0042662 negative regulation of mesodermal cell fate specification
GO:0042733 embryonic digit morphogenesis
GO:0043062 extracellular structure organization
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043405 regulation of MAP kinase activity
GO:0043407 negative regulation of MAP kinase activity
GO:0043409 negative regulation of MAPK cascade
GO:0043506 regulation of JUN kinase activity
GO:0043508 negative regulation of JUN kinase activity
GO:0044744 protein targeting to nucleus
GO:0045137 development of primary sexual characteristics
GO:0045165 cell fate commitment
GO:0045444 fat cell differentiation
GO:0045598 regulation of fat cell differentiation
GO:0045600 positive regulation of fat cell differentiation
GO:0045667 regulation of osteoblast differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045765 regulation of angiogenesis
GO:0045766 positive regulation of angiogenesis
GO:0045778 positive regulation of ossification
GO:0045785 positive regulation of cell adhesion
GO:0045861 negative regulation of proteolysis
GO:0045862 positive regulation of proteolysis
GO:0045926 negative regulation of growth
GO:0045927 positive regulation of growth
GO:0045992 negative regulation of embryonic development
GO:0045995 regulation of embryonic development
GO:0046328 regulation of JNK cascade
GO:0046329 negative regulation of JNK cascade
GO:0046546 development of primary male sexual characteristics
GO:0046661 male sex differentiation
GO:0046822 regulation of nucleocytoplasmic transport
GO:0046824 positive regulation of nucleocytoplasmic transport
GO:0048332 mesoderm morphogenesis
GO:0048333 mesodermal cell differentiation
GO:0048514 blood vessel morphogenesis
GO:0048546 digestive tract morphogenesis
GO:0048565 digestive tract development
GO:0048608 reproductive structure development
GO:0048638 regulation of developmental growth
GO:0048640 negative regulation of developmental growth
GO:0048705 skeletal system morphogenesis
GO:0048736 appendage development
GO:0048754 branching morphogenesis of an epithelial tube
GO:0048762 mesenchymal cell differentiation
GO:0050673 epithelial cell proliferation
GO:0050678 regulation of epithelial cell proliferation
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation
GO:0051169 nuclear transport
GO:0051170 nuclear import
GO:0051216 cartilage development
GO:0051222 positive regulation of protein transport
GO:0051271 negative regulation of cellular component movement
GO:0051302 regulation of cell division
GO:0051346 negative regulation of hydrolase activity
GO:0051348 negative regulation of transferase activity
GO:0051403 stress-activated MAPK cascade
GO:0052547 regulation of peptidase activity
GO:0052548 regulation of endopeptidase activity
GO:0055123 digestive system development
GO:0060026 convergent extension
GO:0060028 convergent extension involved in axis elongation
GO:0060070 canonical Wnt signaling pathway
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0060173 limb development
GO:0060348 bone development
GO:0060349 bone morphogenesis
GO:0060485 mesenchyme development
GO:0060560 developmental growth involved in morphogenesis
GO:0060562 epithelial tube morphogenesis
GO:0060606 tube closure
GO:0060795 cell fate commitment involved in formation of primary germ layer
GO:0060828 regulation of canonical Wnt signaling pathway
GO:0061053 somite development
GO:0061054 dermatome development
GO:0061056 sclerotome development
GO:0061138 morphogenesis of a branching epithelium
GO:0061183 regulation of dermatome development
GO:0061185 negative regulation of dermatome development
GO:0061448 connective tissue development
GO:0061458 reproductive system development
GO:0070302 regulation of stress-activated protein kinase signaling cascade
GO:0070303 negative regulation of stress-activated protein kinase signaling cascade
GO:0071214 cellular response to abiotic stimulus
GO:0071425 hematopoietic stem cell proliferation
GO:0071478 cellular response to radiation
GO:0071479 cellular response to ionizing radiation
GO:0071481 cellular response to X-ray
GO:0071496 cellular response to external stimulus
GO:0071542 dopaminergic neuron differentiation
GO:0071772 response to BMP
GO:0071773 cellular response to BMP stimulus
GO:0071900 regulation of protein serine/threonine kinase activity
GO:0071901 negative regulation of protein serine/threonine kinase activity
GO:0072089 stem cell proliferation
GO:0072175 epithelial tube formation
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0090175 regulation of establishment of planar polarity
GO:0090177 establishment of planar polarity involved in neural tube closure
GO:0090178 regulation of establishment of planar polarity involved in neural tube closure
GO:0090179 planar cell polarity pathway involved in neural tube closure
GO:0090244 Wnt signaling pathway involved in somitogenesis
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:0090287 regulation of cellular response to growth factor stimulus
GO:0090288 negative regulation of cellular response to growth factor stimulus
GO:0090316 positive regulation of intracellular protein transport
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097193 intrinsic apoptotic signaling pathway
GO:0198738 cell-cell signaling by wnt
GO:1900180 regulation of protein localization to nucleus
GO:1900182 positive regulation of protein localization to nucleus
GO:1901342 regulation of vasculature development
GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902229 regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:1902532 negative regulation of intracellular signal transduction
GO:1902593 single-organism nuclear import
GO:1903533 regulation of protein targeting
GO:1903829 positive regulation of cellular protein localization
GO:1904018 positive regulation of vasculature development
GO:1904338 regulation of dopaminergic neuron differentiation
GO:1904589 regulation of protein import
GO:1904591 positive regulation of protein import
GO:1904948 midbrain dopaminergic neuron differentiation
GO:1904951 positive regulation of establishment of protein localization
GO:1904956 regulation of midbrain dopaminergic neuron differentiation
GO:1905276 regulation of epithelial tube formation
GO:1905330 regulation of morphogenesis of an epithelium
GO:2000027 regulation of organ morphogenesis
GO:2000035 regulation of stem cell division
GO:2000040 regulation of planar cell polarity pathway involved in axis elongation
GO:2000041 negative regulation of planar cell polarity pathway involved in axis elongation
GO:2000050 regulation of non-canonical Wnt signaling pathway
GO:2000051 negative regulation of non-canonical Wnt signaling pathway
GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway
GO:2000116 regulation of cysteine-type endopeptidase activity
GO:2000117 negative regulation of cysteine-type endopeptidase activity
GO:2000146 negative regulation of cell motility
GO:2000380 regulation of mesoderm development
GO:2000381 negative regulation of mesoderm development
GO:2000542 negative regulation of gastrulation
GO:2001020 regulation of response to DNA damage stimulus
GO:2001021 negative regulation of response to DNA damage stimulus
GO:2001233 regulation of apoptotic signaling pathway
GO:2001234 negative regulation of apoptotic signaling pathway
GO:2001236 regulation of extrinsic apoptotic signaling pathway
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
GO:2001242 regulation of intrinsic apoptotic signaling pathway
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
Molecular Function GO:0001968 fibronectin binding
GO:0005178 integrin binding
GO:0008047 enzyme activator activity
GO:0016504 peptidase activator activity
GO:0017147 Wnt-protein binding
GO:0030545 receptor regulator activity
GO:0030546 receptor activator activity
GO:0042813 Wnt-activated receptor activity
GO:0048018 receptor agonist activity
GO:0050839 cell adhesion molecule binding
GO:0061133 endopeptidase activator activity
GO:0061134 peptidase regulator activity
GO:0061135 endopeptidase regulator activity
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa04310 Wnt signaling pathway
Reactome R-HSA-3772470: Negative regulation of TCF-dependent signaling by WNT ligand antagonists
R-HSA-162582: Signal Transduction
R-HSA-195721: Signaling by Wnt
R-HSA-201681: TCF dependent signaling in response to WNT
Summary
SymbolSFRP2
Namesecreted frizzled-related protein 2
Aliases SARP1; SDF-5; SARP-1; sFRP-2; secreted apoptosis related protein 1; secreted apoptosis-related protein 1
Chromosomal Location4q31.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between SFRP2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolSFRP2
Namesecreted frizzled-related protein 2
Aliases SARP1; SDF-5; SARP-1; sFRP-2; secreted apoptosis related protein 1; secreted apoptosis-related protein 1
Chromosomal Location4q31.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of SFRP2 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolSFRP2
Namesecreted frizzled-related protein 2
Aliases SARP1; SDF-5; SARP-1; sFRP-2; secreted apoptosis related protein 1; secreted apoptosis-related protein 1
Chromosomal Location4q31.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of SFRP2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-2.1230.0197
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-1.9420.466
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-2.2220.167
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-1.1770.186
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.8890.714
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-1.5370.62
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.4010.713
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.5880.742
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.190.921
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 481.6830.489
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 283.5940.255
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.7130.117
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of SFRP2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.703.70.27
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.703.70.314
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolSFRP2
Namesecreted frizzled-related protein 2
Aliases SARP1; SDF-5; SARP-1; sFRP-2; secreted apoptosis related protein 1; secreted apoptosis-related protein 1
Chromosomal Location4q31.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SFRP2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolSFRP2
Namesecreted frizzled-related protein 2
Aliases SARP1; SDF-5; SARP-1; sFRP-2; secreted apoptosis related protein 1; secreted apoptosis-related protein 1
Chromosomal Location4q31.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SFRP2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SFRP2.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolSFRP2
Namesecreted frizzled-related protein 2
Aliases SARP1; SDF-5; SARP-1; sFRP-2; secreted apoptosis related protein 1; secreted apoptosis-related protein 1
Chromosomal Location4q31.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SFRP2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolSFRP2
Namesecreted frizzled-related protein 2
Aliases SARP1; SDF-5; SARP-1; sFRP-2; secreted apoptosis related protein 1; secreted apoptosis-related protein 1
Chromosomal Location4q31.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of SFRP2 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolSFRP2
Namesecreted frizzled-related protein 2
Aliases SARP1; SDF-5; SARP-1; sFRP-2; secreted apoptosis related protein 1; secreted apoptosis-related protein 1
Chromosomal Location4q31.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between SFRP2 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolSFRP2
Namesecreted frizzled-related protein 2
Aliases SARP1; SDF-5; SARP-1; sFRP-2; secreted apoptosis related protein 1; secreted apoptosis-related protein 1
Chromosomal Location4q31.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting SFRP2 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.