| Summary | |
|---|---|
| Symbol | SHC1 |
| Name | SHC (Src homology 2 domain containing) transforming protein 1 |
| Aliases | ShcA; SHC; SHC (Src homology 2 domain-containing) transforming protein 1; SH2 domain protein C1; SHC-transfo ...... |
| Chromosomal Location | 1q21 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
| Subcellular Location | Cytoplasm.; SUBCELLULAR LOCATION: Isoform p46Shc: Mitochondrion matrix Note=Localized to the mitochondria matrix. Targeting of isoform p46Shc to mitochondria is mediated by its first 32 amino acids, which behave as a bona fide mitochondrial targeting sequence. Isoform p52Shc and isoform p66Shc, that contain the same sequence but more internally located, display a different subcellular localization.; SUBCELLULAR LOCATION: Isoform p66Shc: Mitochondrion Note=In case of oxidative conditions, phosphorylation at 'Ser-36' of isoform p66Shc, leads to mitochondrial accumulation. |
| Domain |
PF00640 Phosphotyrosine interaction domain (PTB/PID) PF00017 SH2 domain |
| Function |
Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis. |
| Biological Process |
GO:0000187 activation of MAPK activity GO:0001525 angiogenesis GO:0002764 immune response-regulating signaling pathway GO:0002768 immune response-regulating cell surface receptor signaling pathway GO:0006260 DNA replication GO:0006275 regulation of DNA replication GO:0006986 response to unfolded protein GO:0007173 epidermal growth factor receptor signaling pathway GO:0007176 regulation of epidermal growth factor-activated receptor activity GO:0007265 Ras protein signal transduction GO:0007507 heart development GO:0008286 insulin receptor signaling pathway GO:0010469 regulation of receptor activity GO:0018108 peptidyl-tyrosine phosphorylation GO:0018212 peptidyl-tyrosine modification GO:0030968 endoplasmic reticulum unfolded protein response GO:0031532 actin cytoskeleton reorganization GO:0032147 activation of protein kinase activity GO:0032868 response to insulin GO:0032869 cellular response to insulin stimulus GO:0033674 positive regulation of kinase activity GO:0034620 cellular response to unfolded protein GO:0034976 response to endoplasmic reticulum stress GO:0035966 response to topologically incorrect protein GO:0035967 cellular response to topologically incorrect protein GO:0036498 IRE1-mediated unfolded protein response GO:0038093 Fc receptor signaling pathway GO:0038095 Fc-epsilon receptor signaling pathway GO:0038127 ERBB signaling pathway GO:0038128 ERBB2 signaling pathway GO:0042058 regulation of epidermal growth factor receptor signaling pathway GO:0043405 regulation of MAP kinase activity GO:0043406 positive regulation of MAP kinase activity GO:0043410 positive regulation of MAPK cascade GO:0043434 response to peptide hormone GO:0045740 positive regulation of DNA replication GO:0045860 positive regulation of protein kinase activity GO:0048514 blood vessel morphogenesis GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO:0050900 leukocyte migration GO:0051052 regulation of DNA metabolic process GO:0051054 positive regulation of DNA metabolic process GO:0061097 regulation of protein tyrosine kinase activity GO:0071375 cellular response to peptide hormone stimulus GO:0071417 cellular response to organonitrogen compound GO:0071900 regulation of protein serine/threonine kinase activity GO:0071902 positive regulation of protein serine/threonine kinase activity GO:1901184 regulation of ERBB signaling pathway GO:1901652 response to peptide GO:1901653 cellular response to peptide |
| Molecular Function |
GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity GO:0005085 guanyl-nucleotide exchange factor activity GO:0005088 Ras guanyl-nucleotide exchange factor activity GO:0005126 cytokine receptor binding GO:0005154 epidermal growth factor receptor binding GO:0005158 insulin receptor binding GO:0005159 insulin-like growth factor receptor binding GO:0005165 neurotrophin receptor binding GO:0005167 neurotrophin TRK receptor binding GO:0005168 neurotrophin TRKA receptor binding GO:0005543 phospholipid binding GO:0019838 growth factor binding GO:0030674 protein binding, bridging GO:0030971 receptor tyrosine kinase binding GO:0035591 signaling adaptor activity GO:0042562 hormone binding GO:0046875 ephrin receptor binding GO:0048408 epidermal growth factor binding GO:0060090 binding, bridging GO:0070851 growth factor receptor binding GO:1990782 protein tyrosine kinase binding |
| Cellular Component |
GO:0005759 mitochondrial matrix GO:0070435 Shc-EGFR complex |
| KEGG |
hsa04012 ErbB signaling pathway hsa04014 Ras signaling pathway hsa04062 Chemokine signaling pathway hsa04510 Focal adhesion hsa04650 Natural killer cell mediated cytotoxicity hsa04722 Neurotrophin signaling pathway hsa04910 Insulin signaling pathway hsa04915 Estrogen signaling pathway hsa04917 Prolactin signaling pathway |
| Reactome |
R-HSA-170984: ARMS-mediated activation R-HSA-1280218: Adaptive Immune System R-HSA-983695: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-422475: Axon guidance R-HSA-202733: Cell surface interactions at the vascular wall R-HSA-5637810: Constitutive Signaling by EGFRvIII R-HSA-1236382: Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-2172127: DAP12 interactions R-HSA-2424491: DAP12 signaling R-HSA-1266738: Developmental Biology R-HSA-1643685: Disease R-HSA-5663202: Diseases of signal transduction R-HSA-186763: Downstream signal transduction R-HSA-5654687: Downstream signaling of activated FGFR1 R-HSA-5654696: Downstream signaling of activated FGFR2 R-HSA-5654708: Downstream signaling of activated FGFR3 R-HSA-5654716: Downstream signaling of activated FGFR4 R-HSA-2871809: FCERI mediated Ca+2 mobilization R-HSA-2871796: FCERI mediated MAPK activation R-HSA-2454202: Fc epsilon receptor (FCERI) signaling R-HSA-170968: Frs2-mediated activation R-HSA-392451: G beta R-HSA-397795: G-protein beta R-HSA-388396: GPCR downstream signaling R-HSA-114604: GPVI-mediated activation cascade R-HSA-179812: GRB2 events in EGFR signaling R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-109582: Hemostasis R-HSA-2428924: IGF1R signaling cascade R-HSA-381070: IRE1alpha activates chaperones R-HSA-112399: IRS-mediated signalling R-HSA-2428928: IRS-related events triggered by IGF1R R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-74751: Insulin receptor signalling cascade R-HSA-354192: Integrin alphaIIb beta3 signaling R-HSA-912526: Interleukin receptor SHC signaling R-HSA-451927: Interleukin-2 signaling R-HSA-512988: Interleukin-3, 5 and GM-CSF signaling R-HSA-5683057: MAPK family signaling cascades R-HSA-5684996: MAPK1/MAPK3 signaling R-HSA-8851805: MET activates RAS signaling R-HSA-392499: Metabolism of proteins R-HSA-375165: NCAM signaling for neurite out-growth R-HSA-187037: NGF signalling via TRKA from the plasma membrane R-HSA-76009: Platelet Aggregation (Plug Formation) R-HSA-76002: Platelet activation, signaling and aggregation R-HSA-169893: Prolonged ERK activation events R-HSA-5673001: RAF/MAP kinase cascade R-HSA-8853659: RET signaling R-HSA-2730905: Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-5654688: SHC-mediated cascade R-HSA-5654699: SHC-mediated cascade R-HSA-5654704: SHC-mediated cascade R-HSA-5654719: SHC-mediated cascade R-HSA-2428933: SHC-related events triggered by IGF1R R-HSA-180336: SHC1 events in EGFR signaling R-HSA-1250196: SHC1 events in ERBB2 signaling R-HSA-1250347: SHC1 events in ERBB4 signaling R-HSA-112412: SOS-mediated signalling R-HSA-162582: Signal Transduction R-HSA-74749: Signal attenuation R-HSA-177929: Signaling by EGFR R-HSA-1643713: Signaling by EGFR in Cancer R-HSA-5637812: Signaling by EGFRvIII in Cancer R-HSA-1227986: Signaling by ERBB2 R-HSA-1236394: Signaling by ERBB4 R-HSA-190236: Signaling by FGFR R-HSA-5654736: Signaling by FGFR1 R-HSA-5654738: Signaling by FGFR2 R-HSA-5654741: Signaling by FGFR3 R-HSA-5654743: Signaling by FGFR4 R-HSA-372790: Signaling by GPCR R-HSA-74752: Signaling by Insulin receptor R-HSA-449147: Signaling by Interleukins R-HSA-2586552: Signaling by Leptin R-HSA-5637815: Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-6806834: Signaling by MET R-HSA-186797: Signaling by PDGF R-HSA-1433557: Signaling by SCF-KIT R-HSA-2404192: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-194138: Signaling by VEGF R-HSA-983705: Signaling by the B Cell Receptor (BCR) R-HSA-166520: Signalling by NGF R-HSA-187687: Signalling to ERKs R-HSA-167044: Signalling to RAS R-HSA-187706: Signalling to p38 via RIT and RIN R-HSA-210993: Tie2 Signaling R-HSA-381119: Unfolded Protein Response (UPR) R-HSA-4420097: VEGFA-VEGFR2 Pathway R-HSA-5218921: VEGFR2 mediated cell proliferation R-HSA-381038: XBP1(S) activates chaperone genes |
| Summary | |
|---|---|
| Symbol | SHC1 |
| Name | SHC (Src homology 2 domain containing) transforming protein 1 |
| Aliases | ShcA; SHC; SHC (Src homology 2 domain-containing) transforming protein 1; SH2 domain protein C1; SHC-transfo ...... |
| Chromosomal Location | 1q21 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content | Literatures that report relations between SHC1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
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Literatures describing the relation between SHC1 and anti-tumor immunity in human cancer.
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| Summary | |
|---|---|
| Symbol | SHC1 |
| Name | SHC (Src homology 2 domain containing) transforming protein 1 |
| Aliases | ShcA; SHC; SHC (Src homology 2 domain-containing) transforming protein 1; SH2 domain protein C1; SHC-transfo ...... |
| Chromosomal Location | 1q21 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
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> High-throughput Screening
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Statistical results of SHC1 in screening data sets for detecting immune reponses.
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| Summary | |
|---|---|
| Symbol | SHC1 |
| Name | SHC (Src homology 2 domain containing) transforming protein 1 |
| Aliases | ShcA; SHC; SHC (Src homology 2 domain-containing) transforming protein 1; SH2 domain protein C1; SHC-transfo ...... |
| Chromosomal Location | 1q21 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
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Points in the above scatter plot represent the expression difference of SHC1 in various data sets.
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Points in the above scatter plot represent the mutation difference of SHC1 in various data sets.
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| Summary | |
|---|---|
| Symbol | SHC1 |
| Name | SHC (Src homology 2 domain containing) transforming protein 1 |
| Aliases | ShcA; SHC; SHC (Src homology 2 domain-containing) transforming protein 1; SH2 domain protein C1; SHC-transfo ...... |
| Chromosomal Location | 1q21 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SHC1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
| Summary | |
|---|---|
| Symbol | SHC1 |
| Name | SHC (Src homology 2 domain containing) transforming protein 1 |
| Aliases | ShcA; SHC; SHC (Src homology 2 domain-containing) transforming protein 1; SH2 domain protein C1; SHC-transfo ...... |
| Chromosomal Location | 1q21 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SHC1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SHC1. > Immunoinhibitor > Immunostimulator > MHC molecule |
| Summary | |
|---|---|
| Symbol | SHC1 |
| Name | SHC (Src homology 2 domain containing) transforming protein 1 |
| Aliases | ShcA; SHC; SHC (Src homology 2 domain-containing) transforming protein 1; SH2 domain protein C1; SHC-transfo ...... |
| Chromosomal Location | 1q21 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SHC1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
| Summary | |
|---|---|
| Symbol | SHC1 |
| Name | SHC (Src homology 2 domain containing) transforming protein 1 |
| Aliases | ShcA; SHC; SHC (Src homology 2 domain-containing) transforming protein 1; SH2 domain protein C1; SHC-transfo ...... |
| Chromosomal Location | 1q21 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Distribution of SHC1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
| Summary | |
|---|---|
| Symbol | SHC1 |
| Name | SHC (Src homology 2 domain containing) transforming protein 1 |
| Aliases | ShcA; SHC; SHC (Src homology 2 domain-containing) transforming protein 1; SH2 domain protein C1; SHC-transfo ...... |
| Chromosomal Location | 1q21 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Associations between SHC1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
| Summary | |
|---|---|
| Symbol | SHC1 |
| Name | SHC (Src homology 2 domain containing) transforming protein 1 |
| Aliases | ShcA; SHC; SHC (Src homology 2 domain-containing) transforming protein 1; SH2 domain protein C1; SHC-transfo ...... |
| Chromosomal Location | 1q21 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content | Drugs targeting SHC1 collected from DrugBank database. |
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There is no record. |