Browse SHH

Summary
SymbolSHH
Namesonic hedgehog
Aliases HHG1; SMMCI; TPTPS; MCOPCB5; HPE3; sonic hedgehog (Drosophila) homolog; sonic hedgehog homolog (Drosophila); ......
Chromosomal Location7q36
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Sonic hedgehog protein N-product: Cell membrane Lipid-anchor Note=The dual-lipidated sonic hedgehog protein N-product (ShhNp) is firmly tethered to the cell membrane where it forms multimers (PubMed:24522195). Further solubilization and release from the cell surface seem to be achieved through different mechanisms, including the interaction with DISP1 and SCUBE2, movement by lipoprotein particles, transport by cellular extensions called cytonemes or by the proteolytic removal of both terminal lipidated peptides (PubMed:26875496, PubMed:24522195).
Domain PF01085 Hedgehog amino-terminal signalling domain
PF01079 Hint module
Function

Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). ; FUNCTION: Sonic hedgehog protein N-product: The dually lipidated sonic hedgehog protein N-product (ShhNp) is a morphogen which is essential for a variety of patterning events during development. Induces ventral cell fate in the neural tube and somites (PubMed:24863049). Involved in the patterning of the anterior-posterior axis of the developing limb bud (By similarity). Essential for axon guidance (By similarity). Binds to the patched (PTCH1) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes (PubMed:10753901). In the absence of SHH, PTCH1 represses the constitutive signaling activity of SMO (PubMed:10753901).

> Gene Ontology
 
Biological Process GO:0001501 skeletal system development
GO:0001503 ossification
GO:0001525 angiogenesis
GO:0001569 patterning of blood vessels
GO:0001570 vasculogenesis
GO:0001649 osteoblast differentiation
GO:0001654 eye development
GO:0001655 urogenital system development
GO:0001656 metanephros development
GO:0001657 ureteric bud development
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001667 ameboidal-type cell migration
GO:0001708 cell fate specification
GO:0001755 neural crest cell migration
GO:0001763 morphogenesis of a branching structure
GO:0001822 kidney development
GO:0001823 mesonephros development
GO:0001942 hair follicle development
GO:0001947 heart looping
GO:0002052 positive regulation of neuroblast proliferation
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0002076 osteoblast development
GO:0002244 hematopoietic progenitor cell differentiation
GO:0002320 lymphoid progenitor cell differentiation
GO:0002360 T cell lineage commitment
GO:0002521 leukocyte differentiation
GO:0002683 negative regulation of immune system process
GO:0002694 regulation of leukocyte activation
GO:0002695 negative regulation of leukocyte activation
GO:0002696 positive regulation of leukocyte activation
GO:0003002 regionalization
GO:0003007 heart morphogenesis
GO:0003140 determination of left/right asymmetry in lateral mesoderm
GO:0003143 embryonic heart tube morphogenesis
GO:0003156 regulation of animal organ formation
GO:0003401 axis elongation
GO:0006354 DNA-templated transcription, elongation
GO:0006368 transcription elongation from RNA polymerase II promoter
GO:0006606 protein import into nucleus
GO:0006869 lipid transport
GO:0006913 nucleocytoplasmic transport
GO:0007159 leukocyte cell-cell adhesion
GO:0007162 negative regulation of cell adhesion
GO:0007163 establishment or maintenance of cell polarity
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007224 smoothened signaling pathway
GO:0007227 signal transduction downstream of smoothened
GO:0007228 positive regulation of hh target transcription factor activity
GO:0007368 determination of left/right symmetry
GO:0007389 pattern specification process
GO:0007398 ectoderm development
GO:0007405 neuroblast proliferation
GO:0007409 axonogenesis
GO:0007411 axon guidance
GO:0007418 ventral midline development
GO:0007423 sensory organ development
GO:0007431 salivary gland development
GO:0007435 salivary gland morphogenesis
GO:0007440 foregut morphogenesis
GO:0007442 hindgut morphogenesis
GO:0007498 mesoderm development
GO:0007507 heart development
GO:0007517 muscle organ development
GO:0007519 skeletal muscle tissue development
GO:0007548 sex differentiation
GO:0007596 blood coagulation
GO:0007599 hemostasis
GO:0008209 androgen metabolic process
GO:0008544 epidermis development
GO:0008589 regulation of smoothened signaling pathway
GO:0009798 axis specification
GO:0009799 specification of symmetry
GO:0009855 determination of bilateral symmetry
GO:0009880 embryonic pattern specification
GO:0009894 regulation of catabolic process
GO:0009895 negative regulation of catabolic process
GO:0009948 anterior/posterior axis specification
GO:0009949 polarity specification of anterior/posterior axis
GO:0009952 anterior/posterior pattern specification
GO:0009953 dorsal/ventral pattern formation
GO:0010001 glial cell differentiation
GO:0010035 response to inorganic substance
GO:0010038 response to metal ion
GO:0010226 response to lithium ion
GO:0010463 mesenchymal cell proliferation
GO:0010464 regulation of mesenchymal cell proliferation
GO:0010498 proteasomal protein catabolic process
GO:0010720 positive regulation of cell development
GO:0010721 negative regulation of cell development
GO:0010817 regulation of hormone levels
GO:0010874 regulation of cholesterol efflux
GO:0010876 lipid localization
GO:0014003 oligodendrocyte development
GO:0014013 regulation of gliogenesis
GO:0014015 positive regulation of gliogenesis
GO:0014031 mesenchymal cell development
GO:0014032 neural crest cell development
GO:0014033 neural crest cell differentiation
GO:0014706 striated muscle tissue development
GO:0014855 striated muscle cell proliferation
GO:0014856 skeletal muscle cell proliferation
GO:0014857 regulation of skeletal muscle cell proliferation
GO:0014858 positive regulation of skeletal muscle cell proliferation
GO:0014902 myotube differentiation
GO:0015850 organic hydroxy compound transport
GO:0015918 sterol transport
GO:0016055 Wnt signaling pathway
GO:0016202 regulation of striated muscle tissue development
GO:0016331 morphogenesis of embryonic epithelium
GO:0016485 protein processing
GO:0016539 intein-mediated protein splicing
GO:0017038 protein import
GO:0021510 spinal cord development
GO:0021511 spinal cord patterning
GO:0021513 spinal cord dorsal/ventral patterning
GO:0021515 cell differentiation in spinal cord
GO:0021517 ventral spinal cord development
GO:0021522 spinal cord motor neuron differentiation
GO:0021532 neural tube patterning
GO:0021534 cell proliferation in hindbrain
GO:0021536 diencephalon development
GO:0021537 telencephalon development
GO:0021782 glial cell development
GO:0021794 thalamus development
GO:0021871 forebrain regionalization
GO:0021904 dorsal/ventral neural tube patterning
GO:0021915 neural tube development
GO:0021924 cell proliferation in external granule layer
GO:0021930 cerebellar granule cell precursor proliferation
GO:0021936 regulation of cerebellar granule cell precursor proliferation
GO:0021937 cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation
GO:0021938 smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation
GO:0021940 positive regulation of cerebellar granule cell precursor proliferation
GO:0021953 central nervous system neuron differentiation
GO:0021978 telencephalon regionalization
GO:0022404 molting cycle process
GO:0022405 hair cycle process
GO:0022407 regulation of cell-cell adhesion
GO:0022408 negative regulation of cell-cell adhesion
GO:0022409 positive regulation of cell-cell adhesion
GO:0022612 gland morphogenesis
GO:0030010 establishment of cell polarity
GO:0030098 lymphocyte differentiation
GO:0030111 regulation of Wnt signaling pathway
GO:0030177 positive regulation of Wnt signaling pathway
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030217 T cell differentiation
GO:0030301 cholesterol transport
GO:0030323 respiratory tube development
GO:0030324 lung development
GO:0030326 embryonic limb morphogenesis
GO:0030336 negative regulation of cell migration
GO:0030539 male genitalia development
GO:0030850 prostate gland development
GO:0030878 thyroid gland development
GO:0030900 forebrain development
GO:0030901 midbrain development
GO:0030902 hindbrain development
GO:0030908 protein splicing
GO:0031016 pancreas development
GO:0031069 hair follicle morphogenesis
GO:0031329 regulation of cellular catabolic process
GO:0031330 negative regulation of cellular catabolic process
GO:0032368 regulation of lipid transport
GO:0032369 negative regulation of lipid transport
GO:0032371 regulation of sterol transport
GO:0032372 negative regulation of sterol transport
GO:0032374 regulation of cholesterol transport
GO:0032375 negative regulation of cholesterol transport
GO:0032386 regulation of intracellular transport
GO:0032388 positive regulation of intracellular transport
GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032784 regulation of DNA-templated transcription, elongation
GO:0032785 negative regulation of DNA-templated transcription, elongation
GO:0032924 activin receptor signaling pathway
GO:0032925 regulation of activin receptor signaling pathway
GO:0032943 mononuclear cell proliferation
GO:0032944 regulation of mononuclear cell proliferation
GO:0032945 negative regulation of mononuclear cell proliferation
GO:0032946 positive regulation of mononuclear cell proliferation
GO:0033002 muscle cell proliferation
GO:0033077 T cell differentiation in thymus
GO:0033079 immature T cell proliferation
GO:0033080 immature T cell proliferation in thymus
GO:0033081 regulation of T cell differentiation in thymus
GO:0033083 regulation of immature T cell proliferation
GO:0033084 regulation of immature T cell proliferation in thymus
GO:0033089 positive regulation of T cell differentiation in thymus
GO:0033091 positive regulation of immature T cell proliferation
GO:0033092 positive regulation of immature T cell proliferation in thymus
GO:0033157 regulation of intracellular protein transport
GO:0033344 cholesterol efflux
GO:0034243 regulation of transcription elongation from RNA polymerase II promoter
GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter
GO:0034504 protein localization to nucleus
GO:0034754 cellular hormone metabolic process
GO:0035050 embryonic heart tube development
GO:0035107 appendage morphogenesis
GO:0035108 limb morphogenesis
GO:0035113 embryonic appendage morphogenesis
GO:0035115 embryonic forelimb morphogenesis
GO:0035116 embryonic hindlimb morphogenesis
GO:0035136 forelimb morphogenesis
GO:0035137 hindlimb morphogenesis
GO:0035148 tube formation
GO:0035239 tube morphogenesis
GO:0035265 organ growth
GO:0035270 endocrine system development
GO:0035272 exocrine system development
GO:0038092 nodal signaling pathway
GO:0038107 nodal signaling pathway involved in determination of left/right asymmetry
GO:0040013 negative regulation of locomotion
GO:0040019 positive regulation of embryonic development
GO:0042063 gliogenesis
GO:0042098 T cell proliferation
GO:0042102 positive regulation of T cell proliferation
GO:0042110 T cell activation
GO:0042129 regulation of T cell proliferation
GO:0042130 negative regulation of T cell proliferation
GO:0042176 regulation of protein catabolic process
GO:0042177 negative regulation of protein catabolic process
GO:0042303 molting cycle
GO:0042306 regulation of protein import into nucleus
GO:0042307 positive regulation of protein import into nucleus
GO:0042445 hormone metabolic process
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042476 odontogenesis
GO:0042481 regulation of odontogenesis
GO:0042633 hair cycle
GO:0042692 muscle cell differentiation
GO:0042733 embryonic digit morphogenesis
GO:0043010 camera-type eye development
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043368 positive T cell selection
GO:0043369 CD4-positive or CD8-positive, alpha-beta T cell lineage commitment
GO:0043383 negative T cell selection
GO:0043583 ear development
GO:0043588 skin development
GO:0044744 protein targeting to nucleus
GO:0045058 T cell selection
GO:0045059 positive thymic T cell selection
GO:0045060 negative thymic T cell selection
GO:0045061 thymic T cell selection
GO:0045103 intermediate filament-based process
GO:0045104 intermediate filament cytoskeleton organization
GO:0045109 intermediate filament organization
GO:0045165 cell fate commitment
GO:0045445 myoblast differentiation
GO:0045580 regulation of T cell differentiation
GO:0045581 negative regulation of T cell differentiation
GO:0045582 positive regulation of T cell differentiation
GO:0045619 regulation of lymphocyte differentiation
GO:0045620 negative regulation of lymphocyte differentiation
GO:0045621 positive regulation of lymphocyte differentiation
GO:0045665 negative regulation of neuron differentiation
GO:0045685 regulation of glial cell differentiation
GO:0045687 positive regulation of glial cell differentiation
GO:0045785 positive regulation of cell adhesion
GO:0045844 positive regulation of striated muscle tissue development
GO:0045861 negative regulation of proteolysis
GO:0045880 positive regulation of smoothened signaling pathway
GO:0045995 regulation of embryonic development
GO:0046631 alpha-beta T cell activation
GO:0046632 alpha-beta T cell differentiation
GO:0046634 regulation of alpha-beta T cell activation
GO:0046635 positive regulation of alpha-beta T cell activation
GO:0046636 negative regulation of alpha-beta T cell activation
GO:0046637 regulation of alpha-beta T cell differentiation
GO:0046638 positive regulation of alpha-beta T cell differentiation
GO:0046639 negative regulation of alpha-beta T cell differentiation
GO:0046651 lymphocyte proliferation
GO:0046661 male sex differentiation
GO:0046822 regulation of nucleocytoplasmic transport
GO:0046824 positive regulation of nucleocytoplasmic transport
GO:0048368 lateral mesoderm development
GO:0048514 blood vessel morphogenesis
GO:0048538 thymus development
GO:0048546 digestive tract morphogenesis
GO:0048557 embryonic digestive tract morphogenesis
GO:0048562 embryonic organ morphogenesis
GO:0048565 digestive tract development
GO:0048566 embryonic digestive tract development
GO:0048568 embryonic organ development
GO:0048608 reproductive structure development
GO:0048617 embryonic foregut morphogenesis
GO:0048634 regulation of muscle organ development
GO:0048636 positive regulation of muscle organ development
GO:0048641 regulation of skeletal muscle tissue development
GO:0048643 positive regulation of skeletal muscle tissue development
GO:0048645 animal organ formation
GO:0048663 neuron fate commitment
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0048706 embryonic skeletal system development
GO:0048708 astrocyte differentiation
GO:0048709 oligodendrocyte differentiation
GO:0048713 regulation of oligodendrocyte differentiation
GO:0048714 positive regulation of oligodendrocyte differentiation
GO:0048730 epidermis morphogenesis
GO:0048732 gland development
GO:0048736 appendage development
GO:0048745 smooth muscle tissue development
GO:0048754 branching morphogenesis of an epithelial tube
GO:0048762 mesenchymal cell differentiation
GO:0048806 genitalia development
GO:0048839 inner ear development
GO:0048859 formation of anatomical boundary
GO:0048863 stem cell differentiation
GO:0048864 stem cell development
GO:0050670 regulation of lymphocyte proliferation
GO:0050671 positive regulation of lymphocyte proliferation
GO:0050672 negative regulation of lymphocyte proliferation
GO:0050673 epithelial cell proliferation
GO:0050678 regulation of epithelial cell proliferation
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050768 negative regulation of neurogenesis
GO:0050769 positive regulation of neurogenesis
GO:0050817 coagulation
GO:0050863 regulation of T cell activation
GO:0050865 regulation of cell activation
GO:0050866 negative regulation of cell activation
GO:0050867 positive regulation of cell activation
GO:0050868 negative regulation of T cell activation
GO:0050870 positive regulation of T cell activation
GO:0050878 regulation of body fluid levels
GO:0051051 negative regulation of transport
GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051145 smooth muscle cell differentiation
GO:0051146 striated muscle cell differentiation
GO:0051147 regulation of muscle cell differentiation
GO:0051148 negative regulation of muscle cell differentiation
GO:0051149 positive regulation of muscle cell differentiation
GO:0051150 regulation of smooth muscle cell differentiation
GO:0051151 negative regulation of smooth muscle cell differentiation
GO:0051152 positive regulation of smooth muscle cell differentiation
GO:0051153 regulation of striated muscle cell differentiation
GO:0051155 positive regulation of striated muscle cell differentiation
GO:0051169 nuclear transport
GO:0051170 nuclear import
GO:0051222 positive regulation of protein transport
GO:0051249 regulation of lymphocyte activation
GO:0051250 negative regulation of lymphocyte activation
GO:0051251 positive regulation of lymphocyte activation
GO:0051271 negative regulation of cellular component movement
GO:0051302 regulation of cell division
GO:0051604 protein maturation
GO:0051781 positive regulation of cell division
GO:0051961 negative regulation of nervous system development
GO:0051962 positive regulation of nervous system development
GO:0055123 digestive system development
GO:0060020 Bergmann glial cell differentiation
GO:0060021 palate development
GO:0060070 canonical Wnt signaling pathway
GO:0060173 limb development
GO:0060174 limb bud formation
GO:0060425 lung morphogenesis
GO:0060428 lung epithelium development
GO:0060438 trachea development
GO:0060439 trachea morphogenesis
GO:0060441 epithelial tube branching involved in lung morphogenesis
GO:0060442 branching involved in prostate gland morphogenesis
GO:0060445 branching involved in salivary gland morphogenesis
GO:0060447 bud outgrowth involved in lung branching
GO:0060458 right lung development
GO:0060459 left lung development
GO:0060462 lung lobe development
GO:0060463 lung lobe morphogenesis
GO:0060484 lung-associated mesenchyme development
GO:0060485 mesenchyme development
GO:0060512 prostate gland morphogenesis
GO:0060513 prostatic bud formation
GO:0060516 primary prostatic bud elongation
GO:0060523 prostate epithelial cord elongation
GO:0060537 muscle tissue development
GO:0060538 skeletal muscle organ development
GO:0060541 respiratory system development
GO:0060560 developmental growth involved in morphogenesis
GO:0060562 epithelial tube morphogenesis
GO:0060571 morphogenesis of an epithelial fold
GO:0060572 morphogenesis of an epithelial bud
GO:0060601 lateral sprouting from an epithelium
GO:0060602 branch elongation of an epithelium
GO:0060605 tube lumen cavitation
GO:0060662 salivary gland cavitation
GO:0060664 epithelial cell proliferation involved in salivary gland morphogenesis
GO:0060675 ureteric bud morphogenesis
GO:0060684 epithelial-mesenchymal cell signaling
GO:0060685 regulation of prostatic bud formation
GO:0060688 regulation of morphogenesis of a branching structure
GO:0060736 prostate gland growth
GO:0060737 prostate gland morphogenetic growth
GO:0060738 epithelial-mesenchymal signaling involved in prostate gland development
GO:0060740 prostate gland epithelium morphogenesis
GO:0060767 epithelial cell proliferation involved in prostate gland development
GO:0060768 regulation of epithelial cell proliferation involved in prostate gland development
GO:0060769 positive regulation of epithelial cell proliferation involved in prostate gland development
GO:0060781 mesenchymal cell proliferation involved in prostate gland development
GO:0060782 regulation of mesenchymal cell proliferation involved in prostate gland development
GO:0060783 mesenchymal smoothened signaling pathway involved in prostate gland development
GO:0060828 regulation of canonical Wnt signaling pathway
GO:0060840 artery development
GO:0060916 mesenchymal cell proliferation involved in lung development
GO:0060993 kidney morphogenesis
GO:0061005 cell differentiation involved in kidney development
GO:0061053 somite development
GO:0061056 sclerotome development
GO:0061136 regulation of proteasomal protein catabolic process
GO:0061138 morphogenesis of a branching epithelium
GO:0061189 positive regulation of sclerotome development
GO:0061190 regulation of sclerotome development
GO:0061326 renal tubule development
GO:0061333 renal tubule morphogenesis
GO:0061351 neural precursor cell proliferation
GO:0061371 determination of heart left/right asymmetry
GO:0061458 reproductive system development
GO:0061525 hindgut development
GO:0061564 axon development
GO:0065001 specification of axis polarity
GO:0070486 leukocyte aggregation
GO:0070489 T cell aggregation
GO:0070661 leukocyte proliferation
GO:0070663 regulation of leukocyte proliferation
GO:0070664 negative regulation of leukocyte proliferation
GO:0070665 positive regulation of leukocyte proliferation
GO:0071241 cellular response to inorganic substance
GO:0071248 cellular response to metal ion
GO:0071285 cellular response to lithium ion
GO:0071542 dopaminergic neuron differentiation
GO:0071593 lymphocyte aggregation
GO:0071594 thymocyte aggregation
GO:0072001 renal system development
GO:0072006 nephron development
GO:0072009 nephron epithelium development
GO:0072028 nephron morphogenesis
GO:0072073 kidney epithelium development
GO:0072074 kidney mesenchyme development
GO:0072075 metanephric mesenchyme development
GO:0072078 nephron tubule morphogenesis
GO:0072080 nephron tubule development
GO:0072088 nephron epithelium morphogenesis
GO:0072089 stem cell proliferation
GO:0072091 regulation of stem cell proliferation
GO:0072111 cell proliferation involved in kidney development
GO:0072135 kidney mesenchymal cell proliferation
GO:0072136 metanephric mesenchymal cell proliferation involved in metanephros development
GO:0072163 mesonephric epithelium development
GO:0072164 mesonephric tubule development
GO:0072171 mesonephric tubule morphogenesis
GO:0072189 ureter development
GO:0072191 ureter smooth muscle development
GO:0072193 ureter smooth muscle cell differentiation
GO:0072194 kidney smooth muscle tissue development
GO:0072195 kidney smooth muscle cell differentiation
GO:0072198 mesenchymal cell proliferation involved in ureter development
GO:0072199 regulation of mesenchymal cell proliferation involved in ureter development
GO:0072203 cell proliferation involved in metanephros development
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0090183 regulation of kidney development
GO:0090184 positive regulation of kidney development
GO:0090185 negative regulation of kidney development
GO:0090316 positive regulation of intracellular protein transport
GO:0090370 negative regulation of cholesterol efflux
GO:0097152 mesenchymal cell apoptotic process
GO:0097485 neuron projection guidance
GO:0098773 skin epidermis development
GO:0198738 cell-cell signaling by wnt
GO:1900094 regulation of transcription from RNA polymerase II promoter involved in determination of left/right symmetry
GO:1900107 regulation of nodal signaling pathway
GO:1900145 regulation of nodal signaling pathway involved in determination of left/right asymmetry
GO:1900164 nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
GO:1900175 regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
GO:1900180 regulation of protein localization to nucleus
GO:1900182 positive regulation of protein localization to nucleus
GO:1901799 negative regulation of proteasomal protein catabolic process
GO:1901861 regulation of muscle tissue development
GO:1901862 negative regulation of muscle tissue development
GO:1901863 positive regulation of muscle tissue development
GO:1902105 regulation of leukocyte differentiation
GO:1902106 negative regulation of leukocyte differentiation
GO:1902107 positive regulation of leukocyte differentiation
GO:1902593 single-organism nuclear import
GO:1902692 regulation of neuroblast proliferation
GO:1903037 regulation of leukocyte cell-cell adhesion
GO:1903038 negative regulation of leukocyte cell-cell adhesion
GO:1903039 positive regulation of leukocyte cell-cell adhesion
GO:1903050 regulation of proteolysis involved in cellular protein catabolic process
GO:1903051 negative regulation of proteolysis involved in cellular protein catabolic process
GO:1903362 regulation of cellular protein catabolic process
GO:1903363 negative regulation of cellular protein catabolic process
GO:1903533 regulation of protein targeting
GO:1903706 regulation of hemopoiesis
GO:1903707 negative regulation of hemopoiesis
GO:1903708 positive regulation of hemopoiesis
GO:1903829 positive regulation of cellular protein localization
GO:1904338 regulation of dopaminergic neuron differentiation
GO:1904339 negative regulation of dopaminergic neuron differentiation
GO:1904589 regulation of protein import
GO:1904591 positive regulation of protein import
GO:1904951 positive regulation of establishment of protein localization
GO:1905330 regulation of morphogenesis of an epithelium
GO:2000027 regulation of organ morphogenesis
GO:2000061 regulation of ureter smooth muscle cell differentiation
GO:2000062 negative regulation of ureter smooth muscle cell differentiation
GO:2000063 positive regulation of ureter smooth muscle cell differentiation
GO:2000146 negative regulation of cell motility
GO:2000177 regulation of neural precursor cell proliferation
GO:2000179 positive regulation of neural precursor cell proliferation
GO:2000241 regulation of reproductive process
GO:2000243 positive regulation of reproductive process
GO:2000356 regulation of kidney smooth muscle cell differentiation
GO:2000357 negative regulation of kidney smooth muscle cell differentiation
GO:2000358 positive regulation of kidney smooth muscle cell differentiation
GO:2000380 regulation of mesoderm development
GO:2000398 regulation of thymocyte aggregation
GO:2000400 positive regulation of thymocyte aggregation
GO:2000648 positive regulation of stem cell proliferation
GO:2000729 positive regulation of mesenchymal cell proliferation involved in ureter development
GO:2001053 regulation of mesenchymal cell apoptotic process
GO:2001054 negative regulation of mesenchymal cell apoptotic process
Molecular Function GO:0001948 glycoprotein binding
GO:0005113 patched binding
GO:0005539 glycosaminoglycan binding
GO:0016015 morphogen activity
GO:0043236 laminin binding
GO:0043237 laminin-1 binding
GO:0050840 extracellular matrix binding
Cellular Component GO:0005578 proteinaceous extracellular matrix
GO:0005788 endoplasmic reticulum lumen
GO:0045121 membrane raft
GO:0098589 membrane region
GO:0098857 membrane microdomain
> KEGG and Reactome Pathway
 
KEGG hsa04340 Hedgehog signaling pathway
hsa04360 Axon guidance
Reactome R-HSA-5635838: Activation of SMO
R-HSA-373080: Class B/2 (Secretin family receptors)
R-HSA-1643685: Disease
R-HSA-5663202: Diseases of signal transduction
R-HSA-500792: GPCR ligand binding
R-HSA-5658034: HHAT G278V abrogates palmitoylation of Hh-Np
R-HSA-5632684: Hedgehog 'on' state
R-HSA-5358346: Hedgehog ligand biogenesis
R-HSA-5387390: Hh mutants abrogate ligand secretion
R-HSA-5362768: Hh mutants that don't undergo autocatalytic processing are degraded by ERAD
R-HSA-5632681: Ligand-receptor interactions
R-HSA-5362798: Release of Hh-Np from the secreting cell
R-HSA-162582: Signal Transduction
R-HSA-372790: Signaling by GPCR
R-HSA-5358351: Signaling by Hedgehog
Summary
SymbolSHH
Namesonic hedgehog
Aliases HHG1; SMMCI; TPTPS; MCOPCB5; HPE3; sonic hedgehog (Drosophila) homolog; sonic hedgehog homolog (Drosophila); ......
Chromosomal Location7q36
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between SHH and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between SHH and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
29581846Non-Small Cell Lung CarcinomaInhibit immunity; immunotherapy targetCollectively, our results provide early demonstration of the antitumor utility of antibodies specific for the C-terminal region of Shh, and support continued development to evaluate their potential efficacy in cancers in which Shh activity is elevated.
18829539MedulloblastomaInhibit immunityHepatocyte growth factor and sonic Hedgehog expression in cerebellar neural progenitor cells costimulate medulloblastoma initiation and growth. In genetically engineered mice, activation of Sonic Hedgehog (Shh) signaling in neural stem cells in the developing cerebellum induces medulloblastomas.
Summary
SymbolSHH
Namesonic hedgehog
Aliases HHG1; SMMCI; TPTPS; MCOPCB5; HPE3; sonic hedgehog (Drosophila) homolog; sonic hedgehog homolog (Drosophila); ......
Chromosomal Location7q36
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of SHH in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolSHH
Namesonic hedgehog
Aliases HHG1; SMMCI; TPTPS; MCOPCB5; HPE3; sonic hedgehog (Drosophila) homolog; sonic hedgehog homolog (Drosophila); ......
Chromosomal Location7q36
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of SHH in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.060.727
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.2280.653
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.2730.509
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.0540.934
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.1440.922
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.080.954
729033130MelanomaallAnti-PD-1 (nivolumab) 262301
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 151101
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 111201
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.3640.62
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.6460.503
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.4840.293
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of SHH in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 414250250.222
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.305.30.507
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22139.109.10.519
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolSHH
Namesonic hedgehog
Aliases HHG1; SMMCI; TPTPS; MCOPCB5; HPE3; sonic hedgehog (Drosophila) homolog; sonic hedgehog homolog (Drosophila); ......
Chromosomal Location7q36
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SHH. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolSHH
Namesonic hedgehog
Aliases HHG1; SMMCI; TPTPS; MCOPCB5; HPE3; sonic hedgehog (Drosophila) homolog; sonic hedgehog homolog (Drosophila); ......
Chromosomal Location7q36
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SHH. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SHH.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolSHH
Namesonic hedgehog
Aliases HHG1; SMMCI; TPTPS; MCOPCB5; HPE3; sonic hedgehog (Drosophila) homolog; sonic hedgehog homolog (Drosophila); ......
Chromosomal Location7q36
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SHH. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolSHH
Namesonic hedgehog
Aliases HHG1; SMMCI; TPTPS; MCOPCB5; HPE3; sonic hedgehog (Drosophila) homolog; sonic hedgehog homolog (Drosophila); ......
Chromosomal Location7q36
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of SHH expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolSHH
Namesonic hedgehog
Aliases HHG1; SMMCI; TPTPS; MCOPCB5; HPE3; sonic hedgehog (Drosophila) homolog; sonic hedgehog homolog (Drosophila); ......
Chromosomal Location7q36
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between SHH and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolSHH
Namesonic hedgehog
Aliases HHG1; SMMCI; TPTPS; MCOPCB5; HPE3; sonic hedgehog (Drosophila) homolog; sonic hedgehog homolog (Drosophila); ......
Chromosomal Location7q36
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting SHH collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.